scholarly journals Histopathological Changes Associated with Experimental Infection of Arcobacter butzleri in Albino Rats

2010 ◽  
Vol 1 (2) ◽  
Author(s):  
O Adesiji ◽  
O Benjamin ◽  
O Olaitan
Keyword(s):  
Experimental Infection ◽  
Albino Rats ◽  
Histopathological Changes ◽  
Arcobacter Butzleri

scholarly journals Histopathological Study of Cyclosporine Pulmonary Toxicity in Rats

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Said Said Elshama ◽  
Ayman El-Meghawry EL-Kenawy ◽  
Hosam-Eldin Hussein Osman
Keyword(s):  
Body Weight ◽  
Periodic Acid ◽  
Physiological Saline ◽  
Immunosuppressive Drugs ◽  
Albino Rats ◽  
Histopathological Study ◽  
Histopathological Changes ◽  
Periodic Acid Schiff ◽  
Male Adult ◽  
Body Weight Reduction

Cyclosporine is considered one of the common worldwide immunosuppressive drugs that are used for allograft rejection prevention. However, articles that address adverse effects of cyclosporine use on the vital organs such as lung are still few. This study aims to investigate pulmonary toxic effect of cyclosporine in rats by assessment of pulmonary histopathological changes using light and electron microscope examination. Sixty male adult albino rats were divided into three groups; each group consists of twenty rats. The first received physiological saline while the second and third groups received 25 and 40 mg/kg/day of cyclosporine, respectively, by gastric gavage for forty-five days. Cyclosporine reduced the lung and body weight with shrinkage or pyknotic nucleus of pneumocyte type II, degeneration of alveoli and interalveolar septum beside microvilli on the alveolar surface, emphysema, inflammatory cellular infiltration, pulmonary blood vessels congestion, and increase of fibrous tissues in the interstitial tissues and around alveoli with negative Periodic Acid-Schiff staining. Prolonged use of cyclosporine induced pulmonary ultrastructural and histopathological changes with the lung and body weight reduction depending on its dose.

Pharmacological and Pathological Studies on Taiwan Folk Medicine (IX): The Hepatoprotective Effect of the Methanolic Extract from Echinops Grijisii

1993 ◽  
Vol 21 (01) ◽  
pp. 33-44 ◽  
Author(s):  
Chun-Ching Lin ◽  
Cheng-Hung Lin
Keyword(s):  
Liver Biopsy ◽  
Ethyl Acetate ◽  
Liver Damage ◽  
Methanol Extract ◽  
Methanolic Extract ◽  
Folk Medicine ◽  
Hepatoprotective Activity ◽  
Albino Rats ◽  
Histopathological Changes ◽  
Wistar Albino Rats

In order to isolate the main hepatoprotective component of Echinops grijisii, the crude drug was extracted with methanol and subjected to continuous extractions using n-hexane chloroform, ethyl acetate and n-butanol. The hepatoprotective studies of each fraction from the methanol extract of E. grijisii was conducted in Wistar albino rats with CC14-induced liver damage. Hepatoprotective activity was evaluated in terms of the modification of serum transaminase values such as SGOT and SGPT, and histopathological changes of liver biopsy. The results indicated that the main hepatoprotective component was concentrated in n-butanol and aqueous fractions.

scholarly journals STANDARDIZATION OF MODEL OF INDUCTION OF HEPATOTOXICITY WITH ANTI-TUBERCULOSIS DRUGS IN WISTAR ALBINO RATS

2017 ◽  
Vol 10 (6) ◽  
pp. 150
Author(s):  
Sarita M Kapgate ◽  
Abhijit B Patil
Keyword(s):  
Liver Injury ◽  
Animal Studies ◽  
Hepatic Injury ◽  
Albino Rats ◽  
Histopathological Changes ◽  
First Line ◽  
Drug Induced ◽  
Significant Development ◽  
Reported Study ◽  
Wistar Albino Rats

Objective: The objective of the study to standardize the model of hepatotoxicity induced by ATT drugs in Wistar Albino rats. Isoniazid (INH), rifampicin (RMP), pyrazinamide (PZA), the first line drugs used in the treatment of tuberculosis (TB) associated with the potential adverse effect. Numerous animal studies were reported endeavoring induction and cure of anti-TB (ATT) drug-induced hepatotoxicity using herbal and chemical drugs. However, the previous reported study failed to replicate where Wistar albino rats were treated with INH, RMP, and PZA and had shown the significant development of liver injury. Hence in present paper, aimed to develop a standardize model of induction of hepatotoxicity with ATT drugs.Methods: Wistar rats were treated with ATT drugs in combination in various doses up to 4-8 weeks. Total nine experiments were conducted to achieve successful hepatotoxicity. The aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) were the biochemical parameters of assessment. Histopathological changes in the liver were also examined.Results: No evidence of any liver injury or an inflammatory infiltrate has been observed as had been reported in the previous studies. Rather decrease in serum ALT levels has been observed by researcher. In short, hepatic injury cannot be developed with the doses used in previous reported papers. The successful attempt to induce hepatotoxicity can be achieved with the doses of INH - 100, RMP - 300, PZA - 700 mg/kg. The findings were confirmed by the raised ALT, AST, and ALP levels compared with baseline. The histopathological changes also support the findings.Conclusion: The dose of INH - 100, RMP – 300 and PZM - 700 mg/kg. Succeeds to induce hepatotoxicity in Wistar albino rats and Swiss albino mice as well.

scholarly journals Effect of Newly Synthesized Polypropylene/Silver Nonwoven Fabric Dressing on Incisional Wound Healing in Rats

2014 ◽  
Vol 2 (3) ◽  
pp. 395-403 ◽  
Author(s):  
Samiha M. Gawish ◽  
Amina A. Gamal El Din ◽  
Hanaa H. Ahmed ◽  
Abdel Razik H. Farrag ◽  
Amira Abou-El Kheir
Keyword(s):  
Wound Healing ◽  
Granulation Tissue ◽  
Nonwoven Fabric ◽  
Complete Healing ◽  
Albino Rats ◽  
Tissue Formation ◽  
Histopathological Changes ◽  
Granulation Tissue Formation ◽  
Wound Length ◽  
Incision Wound

AIM: The present work aimed to investigate the effect of the antimicrobial nano Ag/polypropylene (PP\Ag) dressing on incisional wound healing on the experimental level.MATERIALS AND METHODS: Male albino rats were divided into, control, PP/Ag dressing, Silver Sulfadiazine (Ag-SD) cream, blank PP dressing and undressed groups. Animals were sacrificed after 5, 10 and 15 days of incisional wound event.RESULTS: Reduction was found in incision wound length in PP/Ag dressed rats, Ag-SD cream treated rats, and blank PP dressed rats after 5, 10 and 15 days compared to undressed rats. Skin of PP/Ag group showed less adverse histopathological changes, enhanced granulation tissue formation, enhanced angiogenesis, accelerated re-epithelialization and quick complete healing; compared to all other groups. Significant decrease in TGF-β level was recorded in PP\Ag and Ag-SD cream groups as compared to blank PP group on day 5. While, significant decrease in TGF-β level was detected in PP\Ag group when compared with undressed and blank PP groups on day 10. TGF-β showed significant in PP\Ag group as compared to undressed, Ag-SD cream and blank PP groups on day 15. CONCLUSION: The present results suggest that PP/Ag dressing enhances, promotes and plays an important role in wound healing.

scholarly journals Assessment of Nephroprotective Potential of Ethanolic Extract Premna Tomentosa (Ept) in Alcohol Toxicity in Male Albino Rats

2020 ◽  
Vol 11 (SPL4) ◽  
pp. 3099-3103
Author(s):  
Gomathi Priyadharsini T ◽  
Kavimani M ◽  
Sathiya Narayana Murthy S ◽  
Prabhu K ◽  
Arudyuti Chowdhury
Keyword(s):  
Wistar Rats ◽  
Ethanolic Extract ◽  
Ethanol Extract ◽  
Blood Parameters ◽  
Positive Control ◽  
Negative Control ◽  
Albino Rats ◽  
Phytochemical Analysis ◽  
Histopathological Changes

The nephroprotective prospective of Premna tomentosa extract against Alcohol induced nephrotoxicity in rats was investigated in the present study. The characterization of ethanol extract of Premna tomentosa (EPT) was performed using standard phytochemical analysis. Male albino wistar rats 36 in numbers were divided into 6 groups including control, negative control, positive control and various doses of EPT Treated groups; Nephrotoxicity was induced by alcohol (1ml/100gm b.wt) in animals. Rats intoxicated with Alcohol were fed with 500, 750 mg/kg dose of EPT and Liv 52 (1ml/100gm b.wt) for 60 days. Results show that EPT (500mg/kg b.wt) had a significant effect against alcohol induced nephrotoxicity in rats than EPT (750mg/kg b.wt) in blood parameters and consonantly good histopathological changes in kidney. The deleterious histopathological alterations in kidney associated with glomerular and tubular changes in alcohol intoxicated rats was evident. This result shows Premna tomentosa may be used as supplementary drug for alcoholics.

The protective and therapeutic effects of linalool against doxorubicin-induced cardiotoxicity in Wistar albino rats

2019 ◽  
Vol 38 (7) ◽  
pp. 803-813 ◽  
Author(s):  
Z Oner ◽  
E Altınoz ◽  
H Elbe ◽  
N Ekinci
Keyword(s):  
Caspase 3 ◽  
Inflammatory Cell ◽  
Cardiac Tissue ◽  
Saline Solution ◽  
Albino Rats ◽  
Therapeutic Effects ◽  
Histopathological Changes ◽  
Treatment Groups ◽  
Wistar Albino Rats ◽  
Plasma Creatine Kinase

The aim of the present study was to determine the protective and therapeutic effects of linalool (LIN) against doxorubicin (DOX)-induced cardiotoxicity in rats histologically and biochemically. In experiments, 64 male Wistar albino rats were randomly divided into eight groups ( n = 8). These groups were control (C) (0.9% saline solution), DOX (20 mg/kg DOX), LIN50 (50 mg/kg LIN), LIN100 (100 mg/kg LIN), DOX + LIN50 (20 mg/kg DOX and 50 mg/kg LIN), DOX + LIN100 (20 mg/kg DOX and 100 mg/kg LIN), LIN50 + DOX (50 mg/kg LIN and 20 mg/kg DOX), and LIN100 + DOX (100 mg/kg LIN and 20 mg/kg DOX). It was determined that necrosis and extensive inflammatory cell infiltration were observed in the DOX group. It was determined that histopathological changes significantly decreased in groups treated with LIN after DOX administration. While the caspase-3 immunostaining was highly evident in DOX group apoptotic cells ( p < 0.001, for all), the intensity of caspase-3 immunostaining in the treatment groups decreased ( p < 0.05). While DOX administration resulted in a significant increase in malondialdehyde (MDA) levels and plasma Creatine kinase (CK) and lactate dehydrogenase (LDH) levels in cardiac tissue when compared to the C groups, it was observed that DOX + LIN administration led to a significant decrease in MDA, plasma CK and LDH levels and a significant increase in glutathione (GSH), superoxide dismutase, and catalase enzyme levels. Finally, it was concluded that DOX led to heavy cardiotoxicity and DOX + LIN administration could remove cardiomyopathy symptoms.

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