Association of prenatal antibiotics and the etiology of early neonatal sepsis in a neonatal care unit

Objectives: The objective of this study was to take a look at main causes associated with highest neonatal morbidity and mortality in neonatal care unit of People’s medical college hospital Nawabshah. Study Design: Retrospective study. Period: January 2015 to December 2015. Setting: Paediatric medicine ward of People’s medical college hospital Nawabshah. Methods: The data collected included; sex, gestational age, postnatal age atadmission, weight at admission, main cause of admission, outcome, cause of death. Results: The number of neonates admitted in NICU was 2863 (14.4%) of the total admissions (19882) to the paediatric unit including neonatal unit during the study period. There were more males 1750 (61.9%) than females. Prematurity, neonatal sepsis and birth asphyxia were the most common morbidities (27.5%, 14.9% and 14.6%, respectively). The overall mortality was 21.93% (628 out of 2863 babies). The morbidities with the highest mortality were birth asphyxia 244(38.85%), neonatal sepsis and meningitis 77 (12.26%), and V.L.B.W (9.03%). Conclusion: Birth Asphyxia, neonatal sepsis and meningitis, and low birth weight were the major contributors in admission as well as mortality of newborns, depicting a lack of care and attention in antenatal duration and there is a major lack of training and retraining of birth attendants.

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Clinical and bacteriological profile of neonates admitted in the neonatal care unit of western regional hospital

Medical Journal of Pokhara Academy of Health Sciences ◽

10.3126/mjpahs.v1i1.22450 ◽

2018 ◽

Vol 1 (1) ◽

pp. 4-7

Author(s):

Shree Krishna Shrestha ◽

Jagat Jeevan Ghimire ◽

Ramchandra Bastola ◽

Rupa Gurung

Keyword(s):

Staphylococcus Aureus ◽

Neonatal Sepsis ◽

Antibiotic Sensitivity ◽

Neonatal Care ◽

Regional Hospital ◽

Common Organism ◽

Bacteriological Profile ◽

Sensitivity Pattern ◽

Western Regional ◽

Neonatal Care Unit

Background: Neonatal sepsis is leading cause of mortality in neonates. The organism responsible for sepsis differed depending on the site of Neonatal care unit and country. In this study, we aimed to look at cause of sepsis and antibiotic sensitivity. Materials and Methods: Neonates admitted in the neonatal care unit of western regional hospital from 14th August 2012 to 14th July 2014were included in the study. Septic workup was done and culture was sent. Results of culture sensitivity were noted along with the sensitivity pattern. Results: Neonatal sepsis accounted for 38 percent of total admission in the neonatal unit. Staphylococcus aureus was the most common organism isolated which was followed by Escherichia coli (E coli). Staphylococcus aureus isolated was sensitive to Cloxacillin in 97% of cases. There were 5 % mortalities during the study period. Conclusion: Neonatal sepsis was the most common reason for admission and staphylococcus aureus was the most common organism.

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Neonatal Sepsis: A 6-Year Analysis in a Neonatal Care Unit in Taiwan

Pediatrics & Neonatology ◽

10.1016/s1875-9572(09)60042-5 ◽

2009 ◽

Vol 50 (3) ◽

pp. 88-95 ◽

Cited By ~ 48

Author(s):

Jun-Ho Wu ◽

Chien-Yi Chen ◽

Po-Nien Tsao ◽

Wu-Shiun Hsieh ◽

Hung-Chieh Chou

Keyword(s):

Neonatal Sepsis ◽

Neonatal Care ◽

Neonatal Care Unit

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Neonatal Sepsis in A Tertiary Care Hospital: Evaluation of Causative Agents and Antimicrobial Susceptibilities

Bangladesh Journal of Child Health ◽

10.3329/bjch.v37i1.15346 ◽

2013 ◽

Vol 37 (1) ◽

pp. 14-17

Author(s):

Begum Sharifun Nahar ◽

Syeda Afroza ◽

Sunirmol Roy ◽

Nurun Nahar ◽

Tarok Nath Kundu

Keyword(s):

Antibiotic Therapy ◽

Neonatal Sepsis ◽

Neonatal Care ◽

Gram Positive ◽

Gram Negative ◽

Medical College ◽

Causative Agents ◽

The Common ◽

Neonatal Care Unit ◽

Gram Negative Organisms

Background: Neonatal sepsis is an important issue with a high morbidity and mortality rate in spite of new advances in antibiotic therapy. Identifying the causative agents and their antibiotic sensitivity in a neonatal care unit (NCU) helps the physician to choose the most appropriate antibiotic therapy. Objectives: This study was aimed to find out the etiological agent and antibiotic susceptibilities in newborn with culture positive sepsis. Methodology: This was a cross sectional study carried out in the neonatal care unit (NCU) of Sir Salimullah Medical College Mitford Hospital (SSMC) from June 2010 to May 2011. Seventy five neonates both preterm and term with culture proven sepsis were analyzed from admitted sick newborn to find out their etiology and antimicrobial sensitivity pattern. Blood culture was done in the department of Microbiology of the same medical college hospital. Results: In this study, out of 75 cases, early onset sepsis was observed in 55(73.33%) cases. Whereas late onset sepsis was in 20(26.66%) cases. Gram negative organisms were isolated in 59 (78%) of 75 cases. Pseudomonas aeroginosa 27 (46.55%), E Coli 15(25.86%) and Serratia 8 (13.79%) were the common microbes. Coagulase negative staphylococcus (CONS) was 10 (62%), followed by Staphylococcus aureus 6 (38%) were the major Gram positive isolates. Gram negative isolates were sensitive to Imipenem, Ceftazidime and Ciprofloxacin whereas 80 % gram positive isolates were sensitive to Amikacin. Conclusion : It was observed from this study that gram negative organisms like pseudomonas aeroginosa and E.coli were the common organisms for neonatal sepsis in hospitalized neonates and imipenem was the most sensitive drug against gram - ve septicaemia. DOI: http://dx.doi.org/10.3329/bjch.v37i1.15346 BANGLADESH J CHILD HEALTH 2013; VOL 37 (1) : 14-17

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Eradication of the epidemic ESBL-positive strain of Klebsiella pneumoniae from the bacterial flora of the intensive neonatal care unit of the University Hospital No. 2 in Bydgoszcz

10.26226/morressier.56d5ba31d462b80296c96972 ◽

2016 ◽

Author(s):

Arkadiusz Kuziemski

Keyword(s):

Klebsiella Pneumoniae ◽

Bacterial Flora ◽

Neonatal Care ◽

University Hospital ◽

Positive Strain ◽

Neonatal Care Unit ◽

The University

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Point of Care Neonatal Ultrasound in Late-Onset Neonatal Sepsis

Journal of Neonatology ◽

10.1177/09732179211007599 ◽

2021 ◽

pp. 097321792110075

Author(s):

Rameshwor Yengkhom ◽

Pradeep Suryawanshi ◽

Rahul Murugkar ◽

Bhavya Gupta ◽

Sujata Deshpande ◽

...

Keyword(s):

Neonatal Sepsis ◽

Late Onset ◽

Point Of Care ◽

Cardiac Contractility ◽

Free Fluid ◽

Ultrasound Screening ◽

Laboratory Findings ◽

Late Onset Sepsis ◽

Pulmonary Arterial ◽

Neonatal Care Unit

Background and Objectives: Point of care neonatal ultrasound is a useful tool in evaluation of heart, brain, lungs, and abdomen in neonatal sepsis. The objective of our study was to perform bedside ultrasound screening of heart, brain, lungs, and abdomen in neonates with late onset culture positive sepsis and study the patterns of abnormalities and also their role in change of patient management. Methods: This prospective observational study was conducted at a tertiary level neonatal care unit from March 2017 to May 2018. All neonates with suspected late onset sepsis on the basis of clinical and laboratory findings underwent point of care neonatal ultrasound of heart, brain, lungs, and abdomen. Results: Of 153 suspected and eligible late-onset neonatal sepsis (LONS) cases, 67 (44%) had positive blood culture and were analyzed. Of this 67 neonates, 30 (45%) had abnormal neurosonography, 38 (57%) had abnormal cardiac output, 14 (20%) had abnormal cardiac contractility, 17 (25%) had abnormal pulmonary pressure, 18 (27%) had pulmonary arterial hypertension, 19 (28%) had pneumonia, and 7 (10%) had free fluid in abdomen. Clinical management was changed in 26 (39%) neonates. Conclusion: Bedside point of care neonatal ultrasound is a useful tool in assessment of heart, brain, lungs, and abdomen in a LONS. It could help in making appropriate decisions in the management, and therefore potentially reduce morbidity and mortality.

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