Culture-Proven Neonatal Sepsis in Japanese Neonatal Care Units in 2006–2008

Neonatology ◽  
2012 ◽  
Vol 102 (1) ◽  
pp. 75-80 ◽  
Author(s):  
Ichiro Morioka ◽  
Satoru Morikawa ◽  
Akihiro Miwa ◽  
Hirotaka Minami ◽  
Katsuhiko Yoshii ◽  
...  
Keyword(s):  
Neonatal Sepsis ◽  
Neonatal Care

Association of prenatal antibiotics and the etiology of early neonatal sepsis in a neonatal care unit

2018 ◽  
Vol 36 (7) ◽  
pp. 460-461
Author(s):  
Juan Carlos Lona-Reyes ◽  
René Oswaldo Pérez-Ramírez ◽  
Edith Adriana Benítez-Vázquez ◽  
Virginia Rodríguez-Patiño ◽  
Ana Rosa González-Sánchez ◽  
...  
Keyword(s):  
Neonatal Sepsis ◽  
Neonatal Care ◽  
Early Neonatal Sepsis ◽  
Neonatal Care Unit

scholarly journals Blood culture positive sepsis and sensitivity pattern in a tertiary care neonatal centre in eastern India

2019 ◽  
Vol 6 (2) ◽  
pp. 487
Author(s):  
Soumini Rath ◽  
Santosh Kumar Panda ◽  
Manas Kumar Nayak ◽  
Deepti Damayanty Pradhan
Keyword(s):  
Blood Culture ◽  
Neonatal Sepsis ◽  
Early Onset ◽  
Tertiary Care ◽  
Neonatal Care ◽  
Care Practice ◽  
Klebsiella Pneumonia ◽  
Gram Positive ◽  
Gram Negative ◽  
Culture Positive

Background: The objective of this study is to evaluate sensitive pattern of causative organisms of neonatal sepsis with its clinical outcome in a tertiary neonatal care unit of eastern India.Methods: This retrospective observational cohort study was done in a tertiary care hospital of Odisha. All the blood culture positive neonatal sepsis cases, excluding neonates with multiple congenital malformations, diagnosed during January 2017 to December 2018 were analysed using descriptive summary statistics.Results: A total of 73 neonatal sepsis cases were diagnosed by BacT/Alert and VITEK-2 blood culture method. Among them, 50 (68%) babies had gram negative sepsis,14 (19%) cases of gram-positive sepsis and nine (13%) cases of fungal sepsis. In present study 38 (52%) cases were early onset sepsis, 38(52 %) babies were term, 55(75%) were male and 44 (60%) babies were out born. Klebsiella pneumonia and Acinetobacter were the most common organism in early onset and late onset sepsis respectively. Among gram negative organism (GNB), 66% were multi drug resistant. A fifty percent of gram-negative organism were sensitive to meropenem and 28% were sensitive to piperacillin/tazobactam. The sensitivity of GNB to colistin, ciprofloxacin, amikacin was 76%, 64% and 56% respectively. The sensitivity of gram-positive organisms to linezolid, vancomycin, teicoplanin and penicillin were 92%, 85%,85% and 20% respectively. Survival rate among culture positive sepsis was 83%.Conclusions: Multi drug organisms are emerging in modern neonatal care practice. Practice of antibiotic stewardship may save the babies from multidrug resistance organism in future.

scholarly journals NEONATAL CARE UNIT

2018 ◽  
Vol 25 (12) ◽  
pp. 1945-1948
Author(s):  
Juveriya Shah ◽  
Ali Akbar Siyal ◽  
Tabinda Taqi
Keyword(s):  
Neonatal Sepsis ◽  
Birth Asphyxia ◽  
Neonatal Morbidity ◽  
Neonatal Care ◽  
Medical College Hospital ◽  
College Hospital ◽  
Medical College ◽  
Birth Attendants ◽  
Paediatric Unit ◽  
Neonatal Care Unit

Objectives: The objective of this study was to take a look at main causes associated with highest neonatal morbidity and mortality in neonatal care unit of People’s medical college hospital Nawabshah. Study Design: Retrospective study. Period: January 2015 to December 2015. Setting: Paediatric medicine ward of People’s medical college hospital Nawabshah. Methods: The data collected included; sex, gestational age, postnatal age atadmission, weight at admission, main cause of admission, outcome, cause of death. Results: The number of neonates admitted in NICU was 2863 (14.4%) of the total admissions (19882) to the paediatric unit including neonatal unit during the study period. There were more males 1750 (61.9%) than females. Prematurity, neonatal sepsis and birth asphyxia were the most common morbidities (27.5%, 14.9% and 14.6%, respectively). The overall mortality was 21.93% (628 out of 2863 babies). The morbidities with the highest mortality were birth asphyxia 244(38.85%), neonatal sepsis and meningitis 77 (12.26%), and V.L.B.W (9.03%). Conclusion: Birth Asphyxia, neonatal sepsis and meningitis, and low birth weight were the major contributors in admission as well as mortality of newborns, depicting a lack of care and attention in antenatal duration and there is a major lack of training and retraining of birth attendants. 

scholarly journals Clinical and bacteriological profile of neonates admitted in the neonatal care unit of western regional hospital

2018 ◽  
Vol 1 (1) ◽  
pp. 4-7
Author(s):  
Shree Krishna Shrestha ◽  
Jagat Jeevan Ghimire ◽  
Ramchandra Bastola ◽  
Rupa Gurung
Keyword(s):  
Staphylococcus Aureus ◽  
Neonatal Sepsis ◽  
Antibiotic Sensitivity ◽  
Neonatal Care ◽  
Regional Hospital ◽  
Common Organism ◽  
Bacteriological Profile ◽  
Sensitivity Pattern ◽  
Western Regional ◽  
Neonatal Care Unit

Background: Neonatal sepsis is leading cause of mortality in neonates. The organism responsible for sepsis differed depending on the site of Neonatal care unit and country. In this study, we aimed to look at cause of sepsis and antibiotic sensitivity. Materials and Methods: Neonates admitted in the neonatal care unit of western regional hospital from 14th August 2012 to 14th July 2014were included in the study. Septic workup was done and culture was sent. Results of culture sensitivity were noted along with the sensitivity pattern. Results: Neonatal sepsis accounted for 38 percent of total admission in the neonatal unit. Staphylococcus aureus was the most common organism isolated which was followed by Escherichia coli (E coli). Staphylococcus aureus isolated was sensitive to Cloxacillin in 97% of cases. There were 5 % mortalities during the study period. Conclusion: Neonatal sepsis was the most common reason for admission and staphylococcus aureus was the most common organism.

scholarly journals Neonatal Sepsis: A 6-Year Analysis in a Neonatal Care Unit in Taiwan

2009 ◽  
Vol 50 (3) ◽  
pp. 88-95 ◽  
Author(s):  
Jun-Ho Wu ◽  
Chien-Yi Chen ◽  
Po-Nien Tsao ◽  
Wu-Shiun Hsieh ◽  
Hung-Chieh Chou
Keyword(s):  
Neonatal Sepsis ◽  
Neonatal Care ◽  
Neonatal Care Unit

scholarly journals Neonatal Sepsis in A Tertiary Care Hospital: Evaluation of Causative Agents and Antimicrobial Susceptibilities

2013 ◽  
Vol 37 (1) ◽  
pp. 14-17
Author(s):  
Begum Sharifun Nahar ◽  
Syeda Afroza ◽  
Sunirmol Roy ◽  
Nurun Nahar ◽  
Tarok Nath Kundu
Keyword(s):  
Antibiotic Therapy ◽  
Neonatal Sepsis ◽  
Neonatal Care ◽  
Gram Positive ◽  
Gram Negative ◽  
Medical College ◽  
Causative Agents ◽  
The Common ◽  
Neonatal Care Unit ◽  
Gram Negative Organisms

Background: Neonatal sepsis is an important issue with a high morbidity and mortality rate in spite of new advances in antibiotic therapy. Identifying the causative agents and their antibiotic sensitivity in a neonatal care unit (NCU) helps the physician to choose the most appropriate antibiotic therapy. Objectives: This study was aimed to find out the etiological agent and antibiotic susceptibilities in newborn with culture positive sepsis. Methodology: This was a cross sectional study carried out in the neonatal care unit (NCU) of Sir Salimullah Medical College Mitford Hospital (SSMC) from June 2010 to May 2011. Seventy five neonates both preterm and term with culture proven sepsis were analyzed from admitted sick newborn to find out their etiology and antimicrobial sensitivity pattern. Blood culture was done in the department of Microbiology of the same medical college hospital. Results: In this study, out of 75 cases, early onset sepsis was observed in 55(73.33%) cases. Whereas late onset sepsis was in 20(26.66%) cases. Gram negative organisms were isolated in 59 (78%) of 75 cases. Pseudomonas aeroginosa 27 (46.55%), E Coli 15(25.86%) and Serratia 8 (13.79%) were the common microbes. Coagulase negative staphylococcus (CONS) was 10 (62%), followed by Staphylococcus aureus 6 (38%) were the major Gram positive isolates. Gram negative isolates were sensitive to Imipenem, Ceftazidime and Ciprofloxacin whereas 80 % gram positive isolates were sensitive to Amikacin. Conclusion : It was observed from this study that gram negative organisms like pseudomonas aeroginosa and E.coli were the common organisms for neonatal sepsis in hospitalized neonates and imipenem was the most sensitive drug against gram - ve septicaemia. DOI: http://dx.doi.org/10.3329/bjch.v37i1.15346 BANGLADESH J CHILD HEALTH 2013; VOL 37 (1) : 14-17

scholarly journals Sepsis calculator to support antibiotic stewardship in early-onset neonatal sepsis: a meta-analysis

2018 ◽  
Vol 58 (6) ◽  
pp. 286-97 ◽  
Author(s):  
Rinawati Rohsiswatmo ◽  
Hardya Gustada Hikmahrachim ◽  
Dinarda Ulf Nadobudskaya ◽  
Sonia Miyajima Anjani ◽  
Albert You
Keyword(s):  
Blood Culture ◽  
Neonatal Sepsis ◽  
Early Onset ◽  
Literature Search ◽  
Meta Analysis ◽  
Neonatal Care ◽  
Antibiotic Administration ◽  
Maternal Risk ◽  
The Impact ◽  
Sepsis Calculator

Background Establishing a diagnosis of neonatal sepsis is difficult. As such, appropriate timing of antibiotic therapy remains the biggest challenge. As a consequence of non-definitive diagnoses, inappropriate antibiotic administration is common. Recently, a sepsis calculator to estimate risk of early-onset sepsis (EOS) based on both maternal risk factors and infants’ clinical presentation was established. Objective To determine the impact of the sepsis calculator in daily clinical settings, especially with regards to antibiotic usage. Methods A literature search of Pubmed, EBSCO, Embase, and Scopus database from January 2011 (after sepsis calculator was established) to June 2018 was performed. We included observational studies that compared the sepsis calculator to recent neonatal sepsis guidelines in terms of antibiotic administration, blood culture, and admission to the neonatal intensive care unit (NICU). The literature search, validation study, and assessment risk of bias were done independently by our four authors, while the first author did the statistical analysis. Results Of the 35 studies identified, 5 cohort studies met the criteria, with a total sample size of 18,352 infants from various countries. We developed a fixed-effect meta analysis of the data. The use of the sepsis calculator significantly reduced inappropriate use of antibiotics [RR 0.46; 95%CI 0.41 to 0.51; z=13.57; P<0.001], blood culture sampling [RR 0.46; 95%CI 0.40 to 0.52; z=12.11; P<0.001), and higher neonatal care level admissions [RR 0.68; 95%CI 0.59 to 0.78); z=5.47; P<0.001). No safety issues were reported from studies using the sepsis calculator. Conclusion The new EOS risk estimation using a neonatal sepsis calculator is an easy, effective, and safe tool to improve appropriate antibiotic use and outcomes. This calculator is ready to be implemented in all levels of neonatal care units.  

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