Corrigendum to “Controlling the functional performance of emulsion-based delivery systems using multi-component biopolymer coatings”

There are many areas in medicine and industry where it would be advantageous to orally deliver bioactive proteins and peptides (BPPs), including ACE inhibitors, antimicrobials, antioxidants, hormones, enzymes, and vaccines. A major challenge in this area is that many BPPs degrade during storage of the product or during passage through the human gut, thereby losing their activity. Moreover, many BPPs have undesirable taste profiles (such as bitterness or astringency), which makes them unpleasant to consume. These challenges can often be overcome by encapsulating them within colloidal particles that protect them from any adverse conditions in their environment, but then release them at the desired site-of-action, which may be inside the gut or body. This article begins with a discussion of BPP characteristics and the hurdles involved in their delivery. It then highlights the characteristics of colloidal particles that can be manipulated to create effective BPP-delivery systems, including particle composition, size, and interfacial properties. The factors impacting the functional performance of colloidal delivery systems are then highlighted, including their loading capacity, encapsulation efficiency, protective properties, retention/release properties, and stability. Different kinds of colloidal delivery systems suitable for encapsulation of BPPs are then reviewed, such as microemulsions, emulsions, solid lipid particles, liposomes, and microgels. Finally, some examples of the use of colloidal delivery systems for delivery of specific BPPs are given, including hormones, enzymes, vaccines, antimicrobials, and ACE inhibitors. An emphasis is on the development of food-grade colloidal delivery systems, which could be used in functional or medical food applications. The knowledge presented should facilitate the design of more effective vehicles for the oral delivery of bioactive proteins and peptides.

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Influence of oil phase composition on the antifungal and mycotoxin inhibitory activity of clove oil nanoemulsions

Food & Function ◽

10.1039/c7fo02073b ◽

2018 ◽

Vol 9 (5) ◽

pp. 2872-2882 ◽

Cited By ~ 15

Author(s):

Jing Wan ◽

Shaobin Zhong ◽

Paul Schwarz ◽

Bingcan Chen ◽

Jiajia Rao

Keyword(s):

Phase Composition ◽

Inhibitory Activity ◽

Functional Performance ◽

Delivery Systems ◽

Clove Oil

The functional performance, including antifungal and mycotoxin inhibitory activity, of clove oil can be enhanced by nanoemulsion based delivery systems.

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Contribution of Procurement Function on the Public Services Delivery System: The Case of Tanzania

Journal of Public Administration and Governance ◽

10.5296/jpag.v7i1.10539 ◽

2017 ◽

Vol 7 (1) ◽

Author(s):

Bakari Maligwa Mohamed

Keyword(s):

Economic Development ◽

Value Chain ◽

Public Services ◽

Central Government ◽

Functional Performance ◽

Delivery Systems ◽

The Public ◽

Services Delivery ◽

Development Agenda ◽

Socio Economic Development

Procurement function is a facilitator and enabler of every value chain. This paper is a result of a study on the contribution of procurement function on the public services delivery systems and on the national socio-economic development. Specific foci were on: assessing the contribution of procurement function on the public services delivery systems; and assessing the contribution of procurement function on the attainment of the objectives of the national socio-economic development. The study used a survey of value-laden opinions. Localities surveyed were deliberately selected and sampled. The study covered one metropolis and business city (Dar es Salaam), three regional administrative cities (Arusha, Mbeya and Mwanza), one central government municipal (Dodoma), and one local municipal council (Morogoro). A deliberate sample of 150 case respondents was envisaged. However, the study covered 129 case respondents. Data management and analysis were qualitative in which thematic analysis, documentary reviews and content analysis were applied upon the specific study objectives. This paper provides value-laden opinions generated out of the case respondents’ perceptions on the specific themes and issues related thereto. The results of assessment show a significant contribution of the procurement function on the Tanzania public services delivery systems and on the national socio-economic development agenda. The assessments show a positive marginal contribution of the procurement functional performance on the national economic development agenda by more than 70%.

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Controlling the functional performance of emulsion-based delivery systems using multi-component biopolymer coatings

European Journal of Pharmaceutics and Biopharmaceutics ◽

10.1016/j.ejpb.2010.05.004 ◽

2010 ◽

Vol 76 (1) ◽

pp. 38-47 ◽

Cited By ~ 84

Author(s):

Yan Li ◽

Min Hu ◽

Hang Xiao ◽

Yumin Du ◽

Eric Andrew Decker ◽

...

Keyword(s):

Functional Performance ◽

Delivery Systems

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Plant-Based Colloidal Delivery Systems for Bioactives

Molecules ◽

10.3390/molecules26226895 ◽

2021 ◽

Vol 26 (22) ◽

pp. 6895

Author(s):

Yunbing Tan ◽

David Julian McClements

Keyword(s):

Colloidal Particles ◽

Functional Performance ◽

Delivery Systems ◽

In Vivo Studies ◽

Electrical Characteristics ◽

Structure Surface ◽

Water Dispersibility ◽

Bioactive Agents ◽

Selection Of

The supplementation of plant-based foods and beverages with bioactive agents may be an important strategy for increasing human healthiness. Numerous kinds of colloidal delivery systems have been developed to encapsulate bioactives with the goal of improving their water dispersibility, chemical stability, and bioavailability. In this review, we focus on colloidal delivery systems assembled entirely from plant-based ingredients, such as lipids, proteins, polysaccharides, phospholipids, and surfactants isolated from botanical sources. In particular, the utilization of these ingredients to create plant-based nanoemulsions, nanoliposomes, nanoparticles, and microgels is covered. The utilization of these delivery systems to encapsulate, protect, and release various kinds of bioactives is highlighted, including oil-soluble vitamins (like vitamin D), ω-3 oils, carotenoids (vitamin A precursors), curcuminoids, and polyphenols. The functionality of these delivery systems can be tailored to specific applications by careful selection of ingredients and processing operations, as this enables the composition, size, shape, internal structure, surface chemistry, and electrical characteristics of the colloidal particles to be controlled. The plant-based delivery systems discussed in this article may be useful for introducing active ingredients into the next generation of plant-based foods, meat, seafood, milk, and egg analogs. Nevertheless, there is still a need to systematically compare the functional performance of different delivery systems for specific applications to establish the most appropriate one. In addition, there is a need to test their efficacy at delivering bioavailable forms of bioactives using in vivo studies.

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Techniques For The Preparation of Tissue Samples Containing Injectable Polymer Microcapsules

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100120242 ◽

1985 ◽

Vol 43 ◽

pp. 710-711

Author(s):

G.E. Visscher ◽

R. L. Robison ◽

G. J. Argentieri

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Gastrocnemius Muscle ◽

Degradation Process ◽

Delivery Systems ◽

Tissue Reaction ◽

Electron Microscopic ◽

Tissue Samples ◽

Injectable Polymer ◽

Microscopic Techniques

The use of various bioerodable polymers as drug delivery systems has gained considerable interest in recent years. Among some of the shapes used as delivery systems are films, rods and microcapsules. The work presented here will deal with the techniques we have utilized for the analysis of the tissue reaction to and actual biodegradation of injectable microcapsules. This work has utilized light microscopic (LM), transmission (TEM) and scanning (SEM) electron microscopic techniques. The design of our studies has utilized methodology that would; 1. best characterize the actual degradation process without artifacts introduced by fixation procedures and 2. allow for reproducible results.In our studies, the gastrocnemius muscle of the rat was chosen as the injection site. Prior to the injection of microcapsules the skin above the sites was shaved and tattooed for later recognition and recovery. 1.0 cc syringes were loaded with the desired quantity of microcapsules and the vehicle (0.5% hydroxypropylmethycellulose) drawn up. The syringes were agitated to suspend the microcapsules in the injection vehicle.

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