SUN-063 Evaluation of serum selenium level and its related factors in hemodialysis patients

Background: Acute stress response to heart surgery can cause major morbidity in patients. The trace of selenium is useful for preventing heart damage. Although the trend of selenium changes is of high importance for body balance, the usefulness of routine use and effectiveness of this element for patients under open-heart surgery is still unclear. Objectives: This study aimed at assessing serum selenium level before and after open-heart surgery and the relationship between selenium trace and patient outcome. Methods: This prospective analytical study was performed on 100 patients undergoing open-heart surgery using cardiopulmonary bypass (CPB). In all patients, the serum level was measured at a predetermined time (before surgery and one and two days after surgery). Then, the relationship between serum selenium and patient outcome was assessed. Results: The mean serum selenium level in patients on admission was 72.90 ± 14.62 μg/L, one day after surgery was 71.20 ± 15.84 μg/L, and two days after surgery was 71.54 ± 15.97 μg/L. Serum selenium levels were inversely and significantly associated with age (r = -0.183; P = 0.034, 013) duration of surgery (r = -221 and P = 0.014), duration of intensive care unit stay (r = 0.204, P = 0.021), and duration of CPB (r = 0.223, P = 013). Conclusions: Based on this study’s results, a low level of selenium can affect patients’ outcomes after open-heart surgery.

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Serum Selenium Level and 10-Year Survival after Melanoma

Biomedicines ◽

10.3390/biomedicines9080991 ◽

2021 ◽

Vol 9 (8) ◽

pp. 991

Author(s):

Emilia Rogoża-Janiszewska ◽

Karolina Malińska ◽

Piotr Baszuk ◽

Wojciech Marciniak ◽

Róża Derkacz ◽

...

Keyword(s):

Selenium Level ◽

Serum Selenium ◽

Lower Survival Rate ◽

Treatment Regimens ◽

Melanoma Diagnosis ◽

Serum Selenium Levels ◽

Melanoma Prognosis ◽

Level I ◽

Low Selenium ◽

Serum Selenium Level

Melanoma is one of the most aggressive human malignancies. The determination of prognostic biomarkers is important for the early detection of recurrence and for the enrollment of the patients into different treatment regimens. Herein, we report the 10-year survival of 375 melanoma patients depending on their serum selenium levels. The study group was followed up from the date of melanoma diagnosis until death or 2020. Patients were assigned to one of four categories, in accordance with the increasing selenium level (I–IV quartiles). The subgroup with low selenium levels had a significant lower survival rate in relation to patients with high selenium levels, HR = 8.42; p = 0.005 and HR = 5.83; p = 0.02, for uni- and multivariable models, respectively. In the univariable analysis, we also confirmed the association between Breslow thickness, Clark classification and age at melanoma prognosis. In conclusion, a low serum selenium level was associated with an increased mortality rate in the 10 years following melanoma diagnosis. Future studies in other geographic regions with low soil selenium levels should be conducted to confirm our findings.

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Effect of smoking and alcohol consumption on the serum selenium level of Lower Silesian population

The Science of The Total Environment ◽

10.1016/s0048-9697(01)00898-1 ◽

2002 ◽

Vol 285 (1-3) ◽

pp. 89-95 ◽

Cited By ~ 18

Author(s):

Anna Luty-Frąckiewicz ◽

Zbigniew Jethon ◽

Lidia Januszewska

Keyword(s):

Alcohol Consumption ◽

Selenium Level ◽

Serum Selenium ◽

Serum Selenium Level

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Serum selenium level and other risk factors for breast cancer among patients in a Malaysian hospital

Environmental Health and Preventive Medicine ◽

10.1007/bf02898024 ◽

2007 ◽

Vol 12 (3) ◽

pp. 105-110 ◽

Cited By ~ 12

Author(s):

Lokman Rejali ◽

Mohd Hasni Jaafar ◽

Noor Hassim Ismail

Keyword(s):

Breast Cancer ◽

Risk Factors ◽

Selenium Level ◽

Serum Selenium ◽

Serum Selenium Level

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Study of the correlation of serum selenium level with Behcet’s disease

International Journal of Rheumatic Diseases ◽

10.1111/j.1756-185x.2011.01649.x ◽

2011 ◽

Vol 14 (4) ◽

pp. 375-378 ◽

Cited By ~ 6

Author(s):

Kamal ESALATMANESH ◽

Ahmadreza JAMSHIDI ◽

Farhad SHAHRAM ◽

Fereydun DAVATCHI ◽

Seyed Ali MASOUD ◽

...

Keyword(s):

Behçet’S Disease ◽

Behcet’S Disease ◽

Behçet's Disease ◽

Selenium Level ◽

Serum Selenium ◽

Behcet's Disease ◽

Serum Selenium Level

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Association of Initial Low Serum Selenium Level with Infectious Complications and 30-Day Mortality in Multiple Trauma Patients

Nutrients ◽

10.3390/nu11081844 ◽

2019 ◽

Vol 11 (8) ◽

pp. 1844 ◽

Cited By ~ 1

Author(s):

Soon Bo Choi ◽

Yun Tae Jung ◽

Jae Gil Lee

Keyword(s):

Multiple Trauma ◽

Selenium Deficiency ◽

Infectious Complications ◽

Selenium Level ◽

Trauma Patients ◽

Serum Selenium ◽

Serum Selenium Levels ◽

Multiple Trauma Patients ◽

Serum Selenium Level ◽

Low Serum

Low serum selenium levels are commonly observed in critically injured multiple trauma patients. This study aimed to identify the association between initial serum selenium levels and in-hospital infectious complications in multiple trauma patients. We retrospectively reviewed multiple trauma patients admitted between January 2015 and November 2017. We selected 135 patients whose serum selenium levels were checked within 48 h of admission. Selenium deficiency was defined as a serum selenium level <70 ng/mL. Survival analyses of selenium deficiency and 30-day mortality were performed. Multivariate logistic regression analysis was performed to identify the association between initial serum selenium level and in-hospital infectious complications. Thirty-day mortality (8.3% vs. 0.0%; p = 0.018) and incidence rates of pneumonia (66.7% vs. 28.3%; p < 0.001) and infectious complications (83.3% vs. 46.5%; p < 0.001) were higher in patients with selenium deficiency than in patients without selenium deficiency. Kaplan–Meier survival cures also showed similar results (log rank test, p = 0.021). Of 135 patients, 76 (56.3%) experienced at least one infectious complication during admission. High injury severity score (ISS, odds ratio (OR) 1.065, 95% confidence interval (CI) 1.024–1.108; p = 0.002) and selenium deficiency (OR 3.995, 95% CI 1.430–11.156; p = 0.008) increased the risk of in-hospital infectious complications in multiple trauma patients. Patients with selenium deficiency showed higher 30-day mortality and higher risks of pneumonia and infectious complications.

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