Blood mercury level and blood pressure among US women: results from the National Health and Nutrition Examination Survey 1999–2000

2005 ◽  
Vol 97 (2) ◽  
pp. 195-200 ◽  
Author(s):  
Suma Vupputuri ◽  
Matthew P. Longnecker ◽  
Julie L. Daniels ◽  
Xuguang Guo ◽  
Dale P. Sandler
Keyword(s):  
Blood Pressure ◽  
National Health ◽  
Mercury Level ◽  
Nutrition Examination Survey ◽  
Health And Nutrition ◽  
Blood Mercury

scholarly journals Blood Mercury Levels in Relation to Overweight in Korean Children and Adolescents: Results From The Korean National Health and Nutrition Examination Survey 2010-2013

2021 ◽  
Author(s):  
KY YOUNG CHO
Keyword(s):  
Children And Adolescents ◽  
National Health ◽  
Mercury Level ◽  
Overweight And Obesity ◽  
Mercury Exposure ◽  
Seafood Consumption ◽  
Nutrition Examination Survey ◽  
Korean Children ◽  
Health And Nutrition ◽  
Blood Mercury

Abstract Background: Previous researches for adults have demonstrated a substantial role of mercury exposure in the development of overweight and obesity development, but those findings are inconsistent. Although children and adolescents are more susceptible to the toxic effect of mercury compared to adults, the research of overweight and obesity related to mercury exposure in children and adolescent is scarce. This study aimed to investigate the association of blood mercury levels with body mass index (BMI) in Korean children and adolescents.Methods: The cross-sectional data analyzed were obtained from 1327 participants (age: 10-18 years, 672 males and 655 females) who completed the Korean National Health and Nutrition Examination Survey 2010-2013. The adjusted covariates were age, sex, household income, total intake of seafood in the previous 24 hours, and current status of alcohol consumption and smoking. Results: The adjusted geometric mean blood mercury level was 2.19 µg/L and increased significantly in the overweight group and the highest seafood consumption quartile compared with the level in the normal weight group and lowest seafood consumption quartile, respectively (P < 0.001). The adjusted blood mercury levels were significantly positively correlated with BMI in all participants and females (P < 0.05). When stratified by age and sex, all participants and males in the highest blood mercury level quartile were at higher risk of overweight than those in the lowest quartile (odds ratios [95% confidential intervals, CIs]: 1.78 [1.06-2.98], and 2.06 [1.01-4.23], respectively) after adjusting for the covariates (P < 0.05). Receiver operating characteristic analysis of blood mercury levels for predicting overweight revealed that the area under the curve was 0.603 (P < 0.001).Conclusions: Our study suggested a significant association between mercury exposure and the risk of overweight in Korean children and adolescents.

scholarly journals Association of Blood Mercury Level with the Risk of Depression According to Fish Intake Level in the General Korean Population: Findings from the Korean National Health and Nutrition Examination Survey (KNHANES) 2008–2013

Nutrients ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 189
Author(s):  
Kyung Won Kim ◽  
Sundara Raj Sreeja ◽  
Minji Kwon ◽  
Ye Lee Yu ◽  
Mi Kyung Kim
Keyword(s):  
National Health ◽  
Psychiatric Symptoms ◽  
Mercury Level ◽  
Fish Intake ◽  
Nutrition Examination Survey ◽  
Multivariate Logistic Regression ◽  
Health And Nutrition ◽  
Depression Risk ◽  
Increased Risk ◽  
Blood Mercury

Mercury is a cumulative neurotoxic agent, exposure to high levels of which may increase the risk of psychiatric symptoms. The purpose of this study was to examine the associations between blood mercury and depression risk in Korean adults. We analyzed the Korean National Health and Nutrition Examination Survey (KNHANES) with 11,754 participants (male: 5834 female: 5920) aged ≥19 years from 2008 to 2013. The associations of blood mercury with risk of depression were estimated using multivariate logistic regression after adjustment for potential confounders. We found a significantly increased risk of depression in the highest quintile for blood mercury (multivariate OR = 2.05; 95% CI = 1.20–3.48; p trend = 0.03) among female, but not male. A stratification analysis by fish intake showed that the association between depression and blood mercury was strengthened (OR = 4.00; 95% CI = 1.51–10.6; p trend = 0.015) among females with the lowest tertile of fish intake. The results of this study suggest that higher levels of blood mercury, especially in cases of lower fish intake, are positively associated with the risk of depression in Korean women.

scholarly journals Association of Blood Mercury Levels with the Risks of Overweight and High Waist-to-Height Raito in Children and Adolescents: Data from the Korean National Health and Nutrition Examination Survey

Children ◽  
2021 ◽  
Vol 8 (12) ◽  
pp. 1087
Author(s):  
Ky Young Cho
Keyword(s):  
Children And Adolescents ◽  
National Health ◽  
Mercury Level ◽  
Overweight And Obesity ◽  
Mercury Exposure ◽  
Dietary Factors ◽  
Nutrition Examination Survey ◽  
Korean Children ◽  
Health And Nutrition ◽  
Blood Mercury

A previous study in adults demonstrated the substantial role of mercury exposure in the development of overweight and obesity. Although children and adolescents are more susceptible to the toxic effects of mercury than adults, studies on the association of overweight and obesity with mercury exposure is limited. This study aimed to investigate the association of blood mercury levels with the body mass index (BMI) and waist-to-height ratio (WHtR) as obesity indices in Korean children and adolescents. The analyzed cross-sectional data were obtained from 1327 participants (age: 10–18 years; 672 male and 655 female) who completed the Korean National Health and Nutrition Examination Survey 2010–2013. The covariates included sociodemographic factors (age, sex, and household income), dietary factors (fish, shellfish, and seaweed consumption), lifestyle factors (alcohol consumption, smoking status, and exercise), and blood hematocrit levels. The adjusted geometric mean blood mercury level was 2.19 µg/L, and the level of mercury was significantly higher in the overweight (BMI ≥ 85th gender and age-specific percentiles) and high WHtR (cutoff: ≥0.5) groups than in the normal group. In all the participants, the blood mercury levels were significantly positively associated with the BMI and WHtR after adjusting for all covariates (p < 0.05). All the participants in the highest blood mercury level quartile were at a higher risk for overweight and a high WHtR than those in the lowest quartile after adjusting for all covariates (p < 0.05). Our study suggests a significant association between mercury exposure and the risks of overweight and high WHtR in Korean children and adolescents.

scholarly journals The association between serum copper concentrations and elevated blood pressure in US children and adolescents: National Health and Nutrition Examination Survey 2011–2016

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Changsong Liu ◽  
Yanfen Liao ◽  
Zongyuan Zhu ◽  
Lili Yang ◽  
Qin Zhang ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Children And Adolescents ◽  
National Health ◽  
Serum Copper ◽  
Elevated Blood Pressure ◽  
Nutrition Examination Survey ◽  
Elevated Blood ◽  
Cross Sectional ◽  
Health And Nutrition ◽  
Us Children

Abstract Background Copper is an essential trace metal with potential interest for cardiovascular effects. Few studies have explored the association between copper and blood pressure in children and adolescents. Method We conducted a cross-sectional analysis of 1242 children and adolescents aged 8–17 years who participated in the 2011 to 2016 National Health and Nutrition Examination Survey. Using 2017 American Academy of Pediatrics guidelines, elevated blood pressure (EBP) was defined as a mean systolic and/or diastolic blood pressure (BP) ≥ 90th percentile for sex, age, and height for children aged 1–12 years and systolic BP ≥ 120 mmHg or diastolic BP ≥ 80 mmHg for adolescent age 13–17 years. Mean serum copper was 114.17 μg/dL. Results After multiple adjustments, dose–response analyses revealed that EBP was associated with progressively higher serum copper concentrations in a nonlinear trend. In comparison with the lowest quartile of serum copper concentrations, the adjusted odds of EBP for the highest quartile was 5.26 (95% confidence interval, 2.76–10.03). Conclusion Our results suggested that high serum copper concentrations were significantly associated with EBP in US children and adolescents.

scholarly journals A data-zone scoring system to assess the generalizability of clinical trial results to individual patients

2018 ◽  
Vol 26 (6) ◽  
pp. 569-575 ◽  
Author(s):  
Luke J Laffin ◽  
Stephanie A Besser ◽  
Francis J Alenghat
Keyword(s):  
Blood Pressure ◽  
Clinical Trial ◽  
National Health ◽  
Hazard Ratio ◽  
Trial Participant ◽  
Nutrition Examination Survey ◽  
Specific Patient ◽  
Health And Nutrition ◽  
Baseline Characteristics ◽  
Event Rates

Introduction Evaluating the applicability of a clinical trial to a specific patient is difficult. A novel framework, the Trial Score, was created to quantify the generalizability of a trial's result based on participants' baseline characteristics and not on the trial's inclusion and exclusion criteria. Methods For each Systolic Blood Pressure Intervention Trial (SPRINT) participant, the Euclidean distance in six-dimensional space from the theoretical “average” participant was calculated to produce an individual Trial Score that incorporates multiple distinct continuous-variable baseline characteristics. We prospectively defined the “data-rich,” “data-limited,” and “data-free” zones as Trial Scores < 90th percentile, the 90th–97.5th percentile, and >97.5th percentile, respectively. Trial Scores were then calculated for National Health and Nutrition Examination Survey participants to map data zones of the general population. Individual participant data from the Action to Control Cardiovascular Risk in Diabetes blood pressure trial (ACCORD-BP) was used to test if participants further from the average SPRINT participant behave differently than the overall SPRINT results. Results The National Health and Nutrition Examination Survey cohort and the ACCORD-BP trial demonstrate large percentages of participants in SPRINT's data-free and data-limited zones. Time-to-event rates seen with intensive and standard blood pressure control in SPRINT were the same as ACCORD-BP participants within SPRINT's data-rich zone (hazard ratio 0.97, p = 0.84 and hazard ratio 0.95, p = 0.70). However, these rates were significantly different than those of ACCORD-BP participants outside SPRINT's data-rich zone (hazard ratio 0.64, p < 0.01 and hazard ratio 0.77, p < 0.01). Conclusions ACCORD-BP participants with SPRINT Trial Scores in the 90th percentile or below have similar event rates to SPRINT participants in both the intensive and standard blood pressure groups. Quantifying the difference between an individual patient and the average clinical trial participant holds promise as a tool to more precisely determine applicability of a specific trial to individual patients.

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