The effects of lacosamide on depression and anxiety in patients with epilepsy

Anxiety and depression in children and adolescents with epilepsy are common comorbidities which place a significant burden on patients and families and complicate the clinical management of epilepsy. This paper presents a narrative review on the aetiology, phenomenology, assessment, and management of depression and anxiety among paediatric patients with epilepsy. The recognition of affective comorbidity in paediatric epilepsy is limited at present, and the contributory role of antiepileptic medication towards such comorbidity must be considered by clinicians.

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EPA-1089 – Quality of life, depression and anxiety in patients with epilepsy

European Psychiatry ◽

10.1016/s0924-9338(14)78367-1 ◽

2014 ◽

Vol 29 ◽

pp. 1

Author(s):

N. Charfi ◽

K. Medhaffar ◽

J. Ben Thabet ◽

D. Trigui ◽

N. Zouari ◽

...

Keyword(s):

Quality Of Life ◽

Depression And Anxiety ◽

Patients With Epilepsy

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Depression and Anxiety in Patients with Epilepsy

Epilepsia ◽

10.1046/j.1528-1157.2001.00510.x ◽

2001 ◽

Vol 42 ◽

pp. 29-31 ◽

Cited By ~ 18

Author(s):

Ada Piazzini ◽

Raffaele Canger

Keyword(s):

Depression And Anxiety ◽

Patients With Epilepsy

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Fatigue in patients with epilepsy and its association with depression and sleep quality

Arquivos de Neuro-Psiquiatria ◽

10.1590/0004-282x20130075 ◽

2013 ◽

Vol 71 (8) ◽

pp. 533-536 ◽

Cited By ~ 8

Author(s):

Gisele S. M. Leite Neves ◽

Marleide da Mota Gomes

Keyword(s):

Sleep Quality ◽

Daytime Sleepiness ◽

Linear Regression Analysis ◽

Multiple Linear Regression Analysis ◽

Cross Sectional Study ◽

Depression And Anxiety ◽

Cross Sectional ◽

Tertiary Center ◽

Significant Difference ◽

Patients With Epilepsy

OBJECTIVE: It was to evaluate the relationships between fatigue and excessive daytime sleepiness, sleep quality, depression and anxiety. METHODS: This was a cross-sectional study on 98 unselected adult patients with epilepsy (PWE) at a tertiary center. It used clinical-sociodemographic characteristics, fatigue measured by the SF-36 vitality subscale (VsSF-36) and the Epworth Sleepiness Scale, Pittsburgh Sleep Quality Index and Beck Depression and Anxiety Inventories. RESULTS: We observed that our patients presented vitality or fatigue similar to drivers with chronic headaches evaluated in the same city. Fatigue was related to depression, anxiety and sleep quality, but not to daytime sleepiness. A multiple linear regression analysis was conducted and we observed that fatigue was independently correlated with depression and quality of sleep. However, no significant difference was observed regarding seizure frequency or number of antiepileptic drugs. CONCLUSION: Fatigue needs to be studied more in PWE, and its risk factors need to be controlled, along with sleep quality and psychiatric disorders.

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Relationship Between Epilepsy and Dreaming: Current Knowledge, Hypotheses, and Perspectives

Frontiers in Neuroscience ◽

10.3389/fnins.2021.717078 ◽

2021 ◽

Vol 15 ◽

Author(s):

Aurélien de la Chapelle ◽

Birgit Frauscher ◽

Amandine Valomon ◽

Perrine Marie Ruby ◽

Laure Peter-Derex

Keyword(s):

Cognitive Impairment ◽

Anxiety Disorders ◽

Current Knowledge ◽

Cognitive Activity ◽

Confounding Factors ◽

Depression And Anxiety ◽

Dream Recall ◽

Generalized Seizures ◽

Patients With Epilepsy ◽

The Impact

The interactions between epilepsy and sleep are numerous and the impact of epilepsy on cognition is well documented. Epilepsy is therefore likely to influence dreaming as one sleep-related cognitive activity. The frequency of dream recall is indeed decreased in patients with epilepsy, especially in those with primary generalized seizures. The content of dreams is also disturbed in epilepsy patients, being more negative and with more familiar settings. While several confounding factors (anti-seizure medications, depression and anxiety disorders, cognitive impairment) may partly account for these changes, some observations suggest an effect of seizures themselves on dreams. Indeed, the incorporation of seizure symptoms in dream content has been described, concomitant or not with a focal epileptic discharge during sleep, suggesting that epilepsy might directly or indirectly interfere with dreaming. These observations, together with current knowledge on dream neurophysiology and the links between epilepsy and sleep, suggest that epilepsy may impact not only wake- but also sleep-related cognition.

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Levetiracetam, piracetam, and brivaracetam

10.1093/med/9780198791577.003.0008 ◽

2018 ◽

Author(s):

Andrea E. Cavanna

Keyword(s):

Antiepileptic Drug ◽

Bipolar Depression ◽

Psychotic Symptoms ◽

Tolerability Profile ◽

Third Generation ◽

Emotional Lability ◽

Depression And Anxiety ◽

Nootropic Drug ◽

Wide Range ◽

Patients With Epilepsy

Levetiracetam is a third-generation antiepileptic drug characterized by a wide range of antiepileptic indications, with a very good interaction profile in polytherapy. Levetiracetam has an acceptable behavioural tolerability profile, but limited potential for psychiatric uses. Behavioural adverse events (irritability and emotional lability) are often reported by patients with epilepsy taking levetiracetam; psychotic symptoms and episodes of severe aggression have occasionally been reported. Initial reports suggesting a possible role for levetiracetam in the treatment of bipolar depression and anxiety disorders have not been confirmed by the findings of controlled trials. Two other pyrrolidone derivatives chemically related to levetiracetam, the nootropic drug piracetam and the third-generation antiepileptic drug brivaracetam, do not have psychiatric uses.

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Quality of Life, Depression and Anxiety in Patients With Epilepsy: Controlled Study With Short Form 36 Questionnaire, Beck Depression Inventory, and Hamilton Anxiety Scale

Neurosurgery Quarterly ◽

10.1097/wnq.0b013e3181dcb4ce ◽

2010 ◽

Vol 20 (2) ◽

pp. 95-99 ◽

Cited By ~ 2

Author(s):

Ayşe Kutlu ◽

Şehnaz Başaran ◽

Nur Saadet Altun ◽

Halil Ünalan ◽

Sezer Şener Komsuoğlu

Keyword(s):

Quality Of Life ◽

Beck Depression Inventory ◽

Short Form ◽

Anxiety Scale ◽

Controlled Study ◽

Depression And Anxiety ◽

Short Form 36 ◽

Hamilton Anxiety Scale ◽

Patients With Epilepsy

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Depression and Anxiety among Patients with Epilepsy and Multiple Sclerosis: UAE Comparative Study

Behavioural Neurology ◽

10.1155/2015/196373 ◽

2015 ◽

Vol 2015 ◽

pp. 1-4 ◽

Cited By ~ 5

Author(s):

Taoufik Alsaadi ◽

Khadija El Hammasi ◽

Tarek M. Shahrour ◽

Mustafa Shakra ◽

Lamya Turkawi ◽

...

Keyword(s):

Multiple Sclerosis ◽

Comparative Study ◽

Prevalence Rate ◽

The Other ◽

Screening Tools ◽

Depression And Anxiety ◽

Prevalence Rates ◽

Increased Risk ◽

Patients With Epilepsy ◽

Standardized Screening

Depression and anxiety are highly prevalent in patients with epilepsy (PWE), with prevalence rates ranging from 20% to 55%. The cause of this increased rate is multifactorial. Depression and epilepsy are thought to share the same pathogenic mechanism. Anxiety, on the other hand, seems to have a prevalence rate among PWE comparable to, or even higher than, those reported for depression, and it is closely linked to epilepsy. To test this hypothesis, we screened for depression and anxiety 186 and 160 patients attending the epilepsy and MS clinics, respectively, using standardized screening tools to determine the rates of both depression and anxiety, comparing these rates to 186 age, sex matched controls. Among the three groups, only patients with epilepsy were at increased risk of having depression (OR = 1.9), whereas anxiety was not. This finding could point to the shared pathogenic mechanisms hypothesis between depression and epilepsy.

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