Daily-life stress differentially impacts ventral striatal dopaminergic modulation of reward processing in first-degree relatives of individuals with psychosis

2018 ◽  
Vol 28 (12) ◽  
pp. 1314-1324 ◽  
Author(s):  
Zuzana Kasanova ◽  
Jenny Ceccarini ◽  
Michael J Frank ◽  
Thérèse van Amelsvoort ◽  
Jan Booij ◽  
...  
Keyword(s):  
Life Stress ◽  
Daily Life ◽  
Reward Processing ◽  
First Degree Relatives ◽  
Dopaminergic Modulation

Intact striatal dopaminergic modulation of reward learning and daily-life reward-oriented behavior in first-degree relatives of individuals with psychotic disorder

2017 ◽  
Vol 48 (11) ◽  
pp. 1909-1914 ◽  
Author(s):  
Zuzana Kasanova ◽  
Jenny Ceccarini ◽  
Michael J. Frank ◽  
Thérèse van Amelsvoort ◽  
Jan Booij ◽  
...  
Keyword(s):  
Reinforcement Learning ◽  
Psychotic Disorders ◽  
Daily Life ◽  
Familial Risk ◽  
Reward Processing ◽  
Reward Learning ◽  
Familial Predisposition ◽  
First Degree Relatives ◽  
Dopaminergic Modulation ◽  
Da Release

BackgroundAbnormalities in reward learning in psychotic disorders have been proposed to be linked to dysregulated subcortical dopaminergic (DA) neurotransmission, which in turn is a suspected mechanism for predisposition to psychosis. We therefore explored the striatal dopaminergic modulation of reward processing and its behavioral correlates in individuals at familial risk for psychosis.MethodsWe performed a DA D2/3 receptor [18F]fallypride positron emission tomography scan during a probabilistic reinforcement learning task in 16 healthy first-degree relatives of patients with psychosis and 16 healthy volunteers, followed by a 6-day ecological momentary assessment study capturing reward-oriented behavior in the everyday life.ResultsWe detected significant reward-induced DA release in bilateral caudate, putamen and ventral striatum of both groups, with no group differences in its magnitude nor spatial extent. In both groups alike, greater extent of reward-induced DA release in all regions of interest was associated with better performance in the task, as well as in greater tendency to be engaged in reward-oriented behavior in the daily life.ConclusionsThese findings suggest intact striatal dopaminergic modulation of reinforcement learning and reward-oriented behavior in individuals with familial predisposition to psychosis. Furthermore, this study points towards a key link between striatal reward-related DA release and pursuit of ecologically relevant rewards.

scholarly journals From Epidemiology to Daily Life: Linking Daily Life Stress Reactivity to Persistence of Psychotic Experiences in a Longitudinal General Population Study

PLoS ONE ◽  
2013 ◽  
Vol 8 (4) ◽  
pp. e62688 ◽  
Author(s):  
Dina Collip ◽  
Johanna T. W. Wigman ◽  
Inez Myin-Germeys ◽  
Nele Jacobs ◽  
Catherine Derom ◽  
...  
Keyword(s):  
General Population ◽  
Population Study ◽  
Life Stress ◽  
Stress Reactivity ◽  
Daily Life ◽  
Psychotic Experiences ◽  
General Population Study

scholarly journals Reward Processing under Chronic Pain from the Perspective of “Liking” and “Wanting”: A Narrative Review

2019 ◽  
Vol 2019 ◽  
pp. 1-8
Author(s):  
Xinhe Liu ◽  
Ning Wang ◽  
Lijia Gu ◽  
Jianyou Guo ◽  
Jinyan Wang ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Chronic Pain ◽  
Animal Studies ◽  
Daily Life ◽  
Reward Processing ◽  
Neural Mechanisms ◽  
Incentive Salience ◽  
Therapeutic Goals ◽  
Relieve Pain

The therapeutic goals of patients with chronic pain are not only to relieve pain but also to improve the quality of life. Chronic pain negatively affects various aspects of daily life, such as by decreasing the motivation to work and reward sensitivity, which may lead to difficulties in daily life or even unemployment. Human and animal studies have shown that chronic pain damages reward processing; the exploration of associated internal mechanisms may aid the development of treatments to repair this damage. Incentive salience theory, used widely to describe reward processing, divides this processing into “liking” (reward-induced hedonic sensory impact) and “wanting” (reward-induced motivation) components. It has been employed to explain pathological changes in reward processing induced by psychiatric disorders. In this review, we summarize the findings of studies of reward processing under chronic pain and examine the effects of chronic pain on “liking” and “wanting.” Evidence indicates that chronic pain compromises the “wanting” component of reward processing; we also discuss the neural mechanisms that may mediate this effect. We hope that this review aids the development of therapies to improve the quality of life of patients with chronic pain.

scholarly journals Microglial Function in the Effects of Early-Life Stress on Brain and Behavioral Development

2020 ◽  
Vol 9 (2) ◽  
pp. 468 ◽  
Author(s):  
Clarissa Catale ◽  
Stephen Gironda ◽  
Luisa Lo Iacono ◽  
Valeria Carola
Keyword(s):  
Life Stress ◽  
Early Life ◽  
Developmental Trajectories ◽  
Early Life Stress ◽  
Reward Processing ◽  
Social Stimuli ◽  
Behavioral Abnormalities ◽  
Clinical Literature ◽  
Environmental Agents ◽  
Time Point

The putative effects of early-life stress (ELS) on later behavior and neurobiology have been widely investigated. Recently, microglia have been implicated in mediating some of the effects of ELS on behavior. In this review, findings from preclinical and clinical literature with a specific focus on microglial alterations induced by the exposure to ELS (i.e., exposure to behavioral stressors or environmental agents and infection) are summarized. These studies were utilized to interpret changes in developmental trajectories based on the time at which the stress occurred, as well as the paradigm used. ELS and microglial alterations were found to be associated with a wide array of deficits including cognitive performance, memory, reward processing, and processing of social stimuli. Four general conclusions emerged: (1) ELS interferes with microglial developmental programs, including their proliferation and death and their phagocytic activity; (2) this can affect neuronal and non-neuronal developmental processes, which are dynamic during development and for which microglial activity is instrumental; (3) the effects are extremely dependent on the time point at which the investigation is carried out; and (4) both pre- and postnatal ELS can prime microglial reactivity, indicating a long-lasting alteration, which has been implicated in behavioral abnormalities later in life.

scholarly journals Daily life stress reactivity in remitted versus non-remitted depressed individuals

2015 ◽  
Vol 30 (4) ◽  
pp. 441-447 ◽  
Author(s):  
M. van Winkel ◽  
N.A. Nicolson ◽  
M. Wichers ◽  
W. Viechtbauer ◽  
I. Myin-Germeys ◽  
...  
Keyword(s):  
Life Stress ◽  
Social Stress ◽  
Stress Reactivity ◽  
Daily Life ◽  
Daily Stressors ◽  
Residual Symptoms ◽  
State Dependent ◽  
Before And After ◽  
Remitted Depression ◽  
Mood Reactivity

AbstractBackground:Little is known about how daily life mood reactivity to minor stressors (stress reactivity) might change following major depressive disorder (MDD) treatment. We investigate whether (i) mood states and appraisals of daily stressors change after treatment; (ii) stress reactivity to event, activity, or social stress differs; (iii) stress reactivity depends on severity of residual depressive symptoms; and (iv) stress reactivity in individuals with remitted or non-remitted depression differ from that of never-depressed individuals.Methods:Thirty depressed individuals participated in an experience sampling study before and after a treatment period of 18 months; 39 healthy individuals formed a comparison group. Reactivity of positive affect (PA) and negative affect (NA) to daily stressors were measured.Results:More residual symptoms were associated with larger NA responses to stress. Compared to healthy controls, participants with non-remitted MDD showed higher NA-reactivity to all stressors. In contrast, stress reactivity to event and activity stressors was normalized in remitted patients. However, they still showed heightened NA-reactivity to social stress.Conclusions:Greater stress reactivity to event and activity stress appears to be state-dependent. The heightened social stress reactivity in remitted patients suggests that sensitivity to social stress may reflect an underlying vulnerability in MDD.

Do life events have their effect on psychosis by influencing the emotional reactivity to daily life stress?

2003 ◽  
Vol 33 (2) ◽  
pp. 327-333 ◽  
Author(s):  
I. MYIN-GERMEYS ◽  
L. KRABBENDAM ◽  
P. A. E. G. DELESPAUL ◽  
J. VAN OS
Keyword(s):  
Life Events ◽  
Life Stress ◽  
Emotional Reactivity ◽  
Psychotic Disorders ◽  
Daily Life ◽  
Cumulative Effect ◽  
Emotional Reaction ◽  
Daily Hassles ◽  
Multilevel Regression ◽  
Daily Events

Background. Life events (LE) have consistently been found to influence course and outcome of psychotic disorders. However, the mechanism through which they operate is not known. The present study investigated whether LE have their effect by impacting on the emotional sensitivity for daily hassles.Method. Patients with clinically remitted psychotic illness (N=42) were studied with the Experience Sampling Method (a structured diary technique assessing current context and mood in daily life) to assess: (1) appraised subjective stress related to daily events and activities; and (2) emotional reactivity conceptualized as changes in both negative affect (NA) and positive affect (PA). LE were assessed with the Brown & Harris Life Event and Difficulties Schedule.Results. Multilevel regression analyses showed that previous exposure to LE influenced the appraised stressfulness of neither daily events nor the activities in which the subjects were involved. However, a history of LE did modify the emotional reaction to daily life stress, both in models predicting NA and in models predicting PA.Conclusions. By their cumulative effect on emotional reactivity to daily activities and events, LE may render individuals more vulnerable to the onset or persistence of psychotic experiences.

scholarly journals The association between self-reported stress and cardiovascular measures in daily life: A systematic review

PLoS ONE ◽  
2021 ◽  
Vol 16 (11) ◽  
pp. e0259557
Author(s):  
Thomas Vaessen ◽  
Aki Rintala ◽  
Natalya Otsabryk ◽  
Wolfgang Viechtbauer ◽  
Martien Wampers ◽  
...  
Keyword(s):  
Systematic Review ◽  
Perceived Stress ◽  
Life Stress ◽  
Daily Life ◽  
Physiological Data ◽  
Physiological Measures ◽  
Laboratory Studies ◽  
High Arousal ◽  
Future Studies ◽  
Life Conditions

Background Stress plays an important role in the development of mental illness, and an increasing number of studies is trying to detect moments of perceived stress in everyday life based on physiological data gathered using ambulatory devices. However, based on laboratory studies, there is only modest evidence for a relationship between self-reported stress and physiological ambulatory measures. This descriptive systematic review evaluates the evidence for studies investigating an association between self-reported stress and physiological measures under daily life conditions. Methods Three databases were searched for articles assessing an association between self-reported stress and cardiovascular and skin conductance measures simultaneously over the course of at least a day. Results We reviewed findings of 36 studies investigating an association between self-reported stress and cardiovascular measures with overall 135 analyses of associations between self-reported stress and cardiovascular measures. Overall, 35% of all analyses showed a significant or marginally significant association in the expected direction. The most consistent results were found for perceived stress, high-arousal negative affect scales, and event-related self-reported stress measures, and for frequency-domain heart rate variability physiological measures. There was much heterogeneity in measures and methods. Conclusion These findings confirm that daily-life stress-dynamics are complex and require a better understanding. Choices in design and measurement seem to play a role. We provide some guidance for future studies.

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