Aripiprazole in treatment of disability in social, professional and family life in schizophrenia patients

2017 ◽  
Vol 41 (S1) ◽  
pp. S391-S391
Author(s):  
N. Zivkovic ◽  
G. Djokic ◽  
D. Curcic
Keyword(s):  
Family Life ◽  
Social Life ◽  
Statistical Difference ◽  
Statistical Significance ◽  
Significant Statistical Difference ◽  
High Statistical Significance ◽  
Icd 10 ◽  
The Mean ◽  
Competing Interest ◽  
Overall Functioning

IntroductionEnhancement of overall functioning is one of most important goals in treatment of schizophrenia (SCH) patients.ObjectiveTo assess efficacy of aripiprazole in treatment of disability and impairment in social, professional and family life in SCH patients.MethodsThis study included 50 patients with SCH diagnosed by ICD-10 criteria, divided into H (Haloperidol, 5–20 mg/24 h) group (25 patients), and A (Aripiprazole, 10–30 mg/24 h) group (25 patients). Antipsychotics were tested for 12 months with Positive and Negative Symptom Schedule Scale (PANSS), Sheehan Disability Scale (SDS) and the number of withdrawals attributed to adverse event (AE).ResultsThe mean pretrial PANSS score was 103.6 in A and 105.3 in H group. The mean PANSS score after 12 months was 53.5 in A and 54.4 in H group. There were no significant statistical difference in PANSS pretrial scores and scores after 12 months between groups, P = 0.619; P = 0.364. There were significant statistical difference in PANSS score reduction after 12 months in both groups (P < 0.001). Aripiprazole improved all SDS scores in comparison to Haloperidol with high statistical significance. Work: A vs. H, P < 0.001; social life: A vs. H, P < 0.001; family life: A vs. H, P < 0.001; days lost: A vs. H, P = 0.012; days unproductive: A vs. H, P = 0.007; 8.0% AEs occurred in A, and 36.0% in H group.ConclusionsAripiprazole showed same efficacy as haloperidol in treatment of SCH. Aripiprazole showed significantly better efficacy in treatment of disability and impairment. Number of withdrawals was significantly higher in haloperidol group.Disclosure of interestThe authors have not supplied their declaration of competing interest.

Quetiapine in treatment of first episode schizophrenia

2017 ◽  
Vol 41 (S1) ◽  
pp. s809-s809
Author(s):  
N. Zivkovic ◽  
G. Djokic
Keyword(s):  
Statistical Difference ◽  
First Episode ◽  
Control Group ◽  
Dopamine Antagonist ◽  
Significant Statistical Difference ◽  
5Ht1a Receptors ◽  
Icd 10 ◽  
Competing Interest ◽  
First Episode Schizophrenia ◽  
Haloperidol Group

IntroductionAlthough there is no cure, schizophrenia is highly treatable disease. Successful first episode schizophrenia (FES) treatment is crucial to minimize personal, vocational and social deterioration. Quetiapine is atypical, second generation antipsychotic, serotonin-dopamine antagonist. Quetiapine is potent blocker of D2, 5HT2A and 5HT1A receptors.ObjectiveTo estimate efficacy of quetiapine in treatment of first episode schizophrenia.MethodsThis study included 70 patients with FES diagnosed by ICD-10 criteria, who are divided into haloperidol (H) 35 patients and quetiapine (Q) group 35 patients. Patients were observed for 6 months in hospital and extra hospital conditions, according to protocol which included Positive and Negative Symptom Schedule Scale (PANSS) and the number of withdrawals attributed to adverse event (AE). Control group was treated with haloperidol 5–20 mg/24 h and experimental group was treated with quetiapine 400–800 mg/24 h.ResultsAverage pretrial PANSS score was 110.1 in quetiapine and 108.5 in haloperidol group. Average PANSS score after 180 days was 50.6 in Q and 60.4 in H group. There is no statistical difference in pretrial scores between groups for PANSS score (P = 0.647). There is significant statistical difference in PANSS score reduction after 180 days in both groups (P < 0.001). There is significant statistical difference in PANSS score reduction between Q and H group after 180 days (P < 0.001). Overall, 8.6% AEs occurred in Q, and 25.8% in H group.ConclusionQuetiapine has shown better efficacy in treatment of FES comparing to haloperidol, with statistically significant lower adverse effects rate.Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals Postoperative analgesia effects of sulfentanyl plus dexmedetomidine in patients received VATS

Pteridines ◽  
2020 ◽  
Vol 31 (1) ◽  
pp. 55-60
Author(s):  
Haoyu Jiang ◽  
Ying Zheng ◽  
Chang Liu ◽  
Ying Bao
Keyword(s):  
Statistical Difference ◽  
Control Group ◽  
Control Groups ◽  
Significant Statistical Difference ◽  
Post Surgery ◽  
Intravenous Analgesia ◽  
The Mean ◽  
Nsclc Patients ◽  
And Control ◽  
Time Point

AbstractBackground To evaluate sulfentanyl combined with dexmedetomidine hydrochloride on postoperative analgesia in patients who received video-assisted thoracic surgery (VATS) and its effects on serum norepinephrine (NE), dopamine (DA), 5-hydroxytryptamine (5-HT), and prostaglandin (PGE2).Material and Methods Ninety-nine non-small cell lung cancer (NSCLC) patients who received VATS were included in the study. All the patients received intravenous inhalation compound anesthesia. Of the 99 cases, 49 subjects (control group) received sulfentanyl for patient controlled intravenous analgesia (PICA) and other 50 cases (experiment group) received sulfentanyl combined with dexmedetomidine hydrochloride for PICA after operation of VATS. The analgesic effects of the two groups were evaluated according to Visual Analogue Scales (VAS) and the Bruggrmann Comfort Scale (BCS). The serum pain mediator of NE, DA, 5-HT, and PGE2 were examined and compared between the two groups in the first 24 h post-surgery.Results The VAS scores for the experiment group were significant lower than that of control group on the time points of 8, 16, and 24 h post-surgery (pall<0.05), and the BCS scores of the experiment group in the time points of 8, 16, and 24 h were significantly higher than that of controls (p<0.05). However, the VAS and BCS scores were not statistical differently in the time point of 1, 2, and 4 h post-surgery (pall>0.05). The mean sulfentanyl dosage was 63.01 ± 5.14 μg and 67.12 ± 6.91 μg for the experiment and control groups respectively with significant statistical difference (p<0.05). The mean analgesic pump pressing times were 4.30 ± 1.31 and 5.31 ± 1.46 for experiment and control groups respectively with significant statistical difference (p<0.05). The serum NE, DA, 5-HT, and PGE2 levels were significantly lower in the experimental group compared to that of control group in the time point of 12 h post-surgery (pall<0.05). The side effects of nausea, vomiting, delirium, rash, and hypotension atrial fibrillation were not statistically different between the two groups (pall>0.05).Conclusion Patient controlled intravenous analgesia of sulfentanyl combined with dexmedetomidine hydrochloride was effective in reducing the VAS score and serum pain mediators in NSCLC patients who received VAST.

scholarly journals Evaluation of volume change in oral cavity proper before and after mandibular advancement:

2020 ◽  
Vol 91 (1) ◽  
pp. 81-87
Author(s):  
Balaji Rajkumar ◽  
Ratna Parameswaran ◽  
Anantanarayanan Parameswaran ◽  
Devaki Vijayalakshmi
Keyword(s):  
Oral Cavity ◽  
Statistical Significance ◽  
Mean Difference ◽  
Mandibular Advancement ◽  
Strong Positive Correlation ◽  
Positive Correlation ◽  
High Statistical Significance ◽  
Proper Volume ◽  
The Mean ◽  
Tongue Volume

ABSTRACT Objectives To evaluate the tongue and oral cavity proper volume in pre- and post-bilateral sagittal split osteotomy (BSSO) patients, and to establish whether there was a correlation between them. Materials and Methods A retrospective study that evaluated 12 patients' pre- and post-surgical computed tomography records satisfying the inclusion criteria. Borders were defined for measurement of tongue and oral cavity proper volume. The volume assessment was carried out using 3D slice software. Results The mean difference of tongue volume was 5.7 ± 1.7 cm3, which showed high statistical significance. The mean difference of oral cavity proper volume (OCVP) was 6.9 ± 3.4 cm3 and indicated high statistical significance. A very strong positive correlation existed between pre- and post-surgical tongue volume. Positive correlation was also evident between pre and post - surgical OCVP. Medium positive correlation was noted when the difference between pre- and post-surgical tongue and OCVP were assessed. Conclusions There was a significant change in volume of tongue and oral cavity proper after BSSO advancement surgery. The space around the tongue, position of tongue, and maxillary and mandibular relationship influence the volume of tongue and oral cavity proper.

scholarly journals Spinal biopsies: a clinicopathologic review of 53 cases diagnosed between 2011 and 2018 at a tertiary hospital in Kampala, Uganda

2021 ◽  
Vol 36 (1) ◽  
Author(s):  
James J. Yahaya
Keyword(s):  
Spinal Cord ◽  
Statistical Analysis ◽  
Early Diagnosis ◽  
Statistical Difference ◽  
Statistical Significance ◽  
Tertiary Hospital ◽  
Categorical Variables ◽  
Ethical Approval ◽  
The Mean ◽  
Malignant Neoplasia

Abstract Background Early diagnosis of spinal cord neoplasia serves patients from developing a number of complications and even death. Methods After obtaining ethical approval, retrospectively, a total of 53 tissue blocks of patients attended at the spinal ward were reviewed. Statistical analysis was done using SPSS version 20.0, and p value of less than 0.05 was applied to establish the existence of statistical significance between the compared categorical variables. Results The mean age of the patients was 30.7 ± 15.96 years. Most of the patients 32.1% (n = 17) were aged ≤ 19 years, and majority of the neoplasia 77.3% (n = 41) were extramedullary. Also, majority of the neoplasia 60.4% (n = 32) were benign and the malignant ones were 35.8% (n = 19). The mean duration of onset of symptoms for benign and malignant neoplasia in this study was 13.1 ± 16.4 and 3.4 ± 2.8 years, respectively, with statistical difference (95% CI 2.09–17.35, p = 0.014). Conclusion The patients with spinal cord neoplasia in the present study were of young age, and majority of them had benign neoplasia that were extramedullary located. The mean duration of onset of symptoms for patients with malignant neoplasia was significantly shorter than that of benign neoplasia.

15 years and counting – How are schizophrenic patients with long hospitalization time?

2016 ◽  
Vol 33 (S1) ◽  
pp. S576-S577
Author(s):  
M.A. Duarte ◽  
B. Lourenço ◽  
A. Ponte ◽  
A. Caixeiro
Keyword(s):  
Negative Symptoms ◽  
Psychiatric Hospitals ◽  
Therapeutic Approaches ◽  
Symptom Scale ◽  
Long Duration ◽  
Icd 10 ◽  
Schizophrenic Patients ◽  
The Mean ◽  
Competing Interest ◽  
Behaviour Changes

IntroductionCentro Hospitalar Psiquiátrico de Lisboa (C.H.P.L.), in Lisbon, Portugal, is the biggest psychiatric hospital in Portugal and one of the oldest still working. Along with acute inpatient clinics it has long duration inpatient units with 226 patients.Objectives/aimsCharacterize and improve the therapeutic approaches in patients committed to the long duration inpatient unit with long hospitalization times and the diagnose of schizophrenia.MethodsDuring the month of September 2015 all patients, committed before 2000 who fulfilled the diagnosis criteria ICD 10, F20.X (Schizophrenia) were characterized regarding age, gender, time of hospitalization and were evaluated using the Positive and Negative Symptom Scale (PANSS).ResultsFrom the original sample (n = 226), 31 patients were included in the study. The mean age was 64.4 years (min 50–max 91) and the majority were male (67.7%; n = 21). The mean years of hospitalization were 28.7 years (min 15–max 60). The average total PANSS score was 99.8 (positive symptoms: 25.4; negative symptoms: 29.9; general symptoms: 44.4).ConclusionsAlthough in last decades many psychiatric hospitals were closed and community approaches to treatment of the mentally ill were the direction preconized by several international organizations, some patients still “live” in the hospital. Mostly, as we found in our study, have a severe, refractory disease, sometimes with behaviour changes that unable them to be discharged. With the continuous evolution of psychopharmacological drug treatment, this paradigm may change. Meanwhile other therapeutic approaches should be used to improve the disease symptoms.Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals ASSESSMENT OF FLOW MEDIATED DILATATION OF BRACHIAL ARTERY BY ANGIODEFENDER DEVICE AS COMPARED TO BRACHIAL ARTERY ULTRASOUND IMAGING.

2019 ◽  
Vol 3 (6) ◽  
Author(s):  
Mukesh Kumar Sharma ◽  
Chandra Bhanu Chandan ◽  
Abhishek Shukla ◽  
Deepak Ameta ◽  
Pradeep Kurmi
Keyword(s):  
Correlation Coefficient ◽  
Ultrasound Imaging ◽  
Brachial Artery ◽  
Statistical Difference ◽  
P Value ◽  
Positive Correlation ◽  
Significant Statistical Difference ◽  
Flow Mediated Dilatation ◽  
The Mean ◽  
Flow Mediated Vasodilation

Aims & Objectives: To demonstrate, Angiodefender device, is comparable to “Brachial artery ultrasound imaging” (BAUI) in their abilities to quantify percentage flow mediated vasodilation (FMD) of the brachial artery. Methods: Study was conducted on 100 patients, flow mediated vasodilation was measured by BAUI as well as by the Angiodefender device and the results were compared. Results: The mean %FMD measured by the BAUI was found to be 7.46 ±  4.21 whereas mean %FMD measured by the Angiodefender was 8.24 ±  2.46, (p value 0.113). Positive correlation was found between both the tests with correlation coefficient of 0.65, p value < 0.0001 which is highly significant. Conclusion: Results obtained by both the methods were comparable there was no significant statistical difference. Positive correlation was highly significant between both the tests with correlation coefficient of 0.65. Keywords: Brachial artery ultrasound imaging, Angiodefender, Flow mediated vasodilation

scholarly journals DONOR CHARACTERISTICS AND THE ALLOCATION OF AID TO CLIMATE MITIGATION FINANCE

2015 ◽  
Vol 06 (03) ◽  
pp. 1550014 ◽  
Author(s):  
AIDY HALIMANJAYA ◽  
ELISSAIOS PAPYRAKIS
Keyword(s):  
Kyoto Protocol ◽  
Statistical Significance ◽  
Development Assistance ◽  
Climate Mitigation ◽  
High Statistical Significance ◽  
International Climate ◽  
Competing Interest ◽  
Donor Characteristics ◽  
Overseas Development ◽  
A Share

We make use of a panel dataset of 22 donor countries from 1998 to 2009 to examine the links between donor characteristics and the share of overseas development assistance allocated to climate mitigation finance. We find that donors with a larger green domestic budget tend to allocate a smaller portion of overseas aid to mitigation finance (possibly as a result of a competing interest between spending on domestic environmental projects and international climate projects). The opposite holds for donor countries with better institutions (governance) that have ratified the Kyoto Protocol. We also find important discrepancies when comparing the effects of donor characteristics on committed versus disbursed mitigation finance (as a share of aid). For the latter, only commitment to the Kyoto Protocol appears to be of high statistical significance.

scholarly journals Role of hepatic colour duplex ultrasound in assessment of non alcoholic fatty liver disease-nafld

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
S M Botrous ◽  
E M A Hafez ◽  
D A Sabry
Keyword(s):  
Hepatic Artery ◽  
Hepatic Vein ◽  
Statistical Significance ◽  
Subcutaneous Fat ◽  
Resistance Index ◽  
Wave Pattern ◽  
P Value ◽  
High Statistical Significance ◽  
The Mean ◽  
Waveform Pattern

Abstract Background Gray-scale ultrasonography (US) is an initial, easy to use and widely available imaging modality for NAFLD, the presence of fat infiltration in the liver in the absence of excessive alcohol consumption and other causes of liver disease, is the most common cause of fatty liver, with a prevalence as high as 15-25% in many populations. Objective to determine the effect of obesity and NAFLD on the Doppler waveform pattern of the liver vascularity. Methods A case control study, conducted at Ain Shams University in the period between july and December 2018 . In both groups, liver span & subcutaneous fat was measured by ultrasonographic examination. Hepatic vein waveform pattern & portal vein mean flow velocity were assessed & hepatic artery resistance index was measured by duplex Doppler ultrasonography examination. Results Our study included 50 patients , 20 were control & 30 were cases.. The mean age of cases was 45.30 ± 10.15 SD & the mean age of control was 32.70 ± 10.95 SD rendering the mean age of cases & control of high statistical significance (p value=0.000). The Subcutaneous fat showed high significant statistical difference between cases & control groups with mean subcutaneous fat in control =0.75 ± 0.14 SD & mean subcutaneous fat in cases= 1.23 ± 0.42 SD with p –value = 0.000. The liver span showed high significant statistical difference between cases & control groups with mean in control =15.11 ± 0.85 SD & mean liver span in cases= 17.46 ± 1.67SD ( p value = 0.000). Hepatic vein wave pattern was normal in all 20 control (100%). In the 30 cases,the Hepatic vein wave pattern was triphasic in 12 patients (40%) & biphasic or monophasic In 18 patients (60%) with high statistical significance (p-value =0.000). There was negative correlation between the hepatic vein velocity & BMI with ( p value=0.0032). There was no statistically significant difference between cases & control as regards all Doppler indices including the Hepatic artery RI(resistive index), Hepatic artery PSV(peak systolic velocity), Portal vein velocity(maximum & minimum)& hepatic vein velocity (maximum velocity) where the p value was more than 0.05. Conclusion Patients with NAFLD have a high rate of abnormal hepatic vein Doppler waveform patterns ,which can be biphasic or monophasic rather than alterations in hepatic artery resistance index values by duplex Doppler ultrasonography. Also the fatty infiltration of hepatocytes can increase liver span & the subcutaneous fat.

Comparison of Separation Patterns between Parents and Offspring in Psychiatric and Nonclinical Families

2007 ◽  
Vol 101 (1) ◽  
pp. 171-176
Author(s):  
Szymon Chrzastowski
Keyword(s):  
Young Adults ◽  
Mental Disorders ◽  
Personality Disorders ◽  
Young Adulthood ◽  
Statistical Significance ◽  
Mothers And Fathers ◽  
Icd 10 ◽  
The Mean ◽  
Family Groups

This study examined the specific separation patterns of binding and expelling in families with young adults. 103 families were divided into three groups according to the ICD–10 diagnosis of offspring (18-35 years old): (1) schizophrenia ( ns = 32 mothers and 30 fathers), (2) personality disorders ( ns = 34 mothers and 30 fathers), (3) control, nonclinical group ( ns=34 mothers and 32 fathers). The participants (mothers and fathers) independently completed the Relational Individuation Questionnaire designed for this study. Despite expectations, there was no statistical significance found between the mean scores of the parents' binding of offspring diagnosed with schizophrenia or personality disorders or from the nonclinical families. There was, however, a difference in the intensity of the mothers' expelling ( F2,97 = 10.90, p< .0001) and of the fathers' expelling ( F2,89 = 5.96, p<.005) from different family groups. The parents of offspring from clinical families expelled their offspring more intensively than parents from nonclinical families. The correlation between expelling by mothers and expelling by fathers in all families was positive. These results suggest that expelling may be a strategy used by parents with children with serious mental disorders when these children reach young adulthood.

Risperidone and olanzapine in treatment of delusional disorders

2011 ◽  
Vol 26 (S2) ◽  
pp. 1301-1301 ◽  
Author(s):  
N. Zivkovic ◽  
B. Bajovic ◽  
G. Djokic ◽  
D. Pavicevic ◽  
M. Nenadovic
Keyword(s):  
Adverse Effects ◽  
Statistical Difference ◽  
Psychotic Disorders ◽  
Statistical Significance ◽  
Control Group ◽  
High Statistical Significance ◽  
Delusional System ◽  
Scale Control

Delusional disorders are severe psychotic disorders with characteristic non-bizarre delusions often organized in permanent delusional system.AimTo estimate efficacy of risperidone and olanzapine in treatment of DD.Methods135 patients with DD were divided into Haloperidol-control (41), Risperidone (49) and Olanzapine group (45 patients). Patients were observed for 6 months according to protocol, which included PANSS Scale and CGI1-4 Scale. Control group was treated with haloperidol 5–30 mg/24 h. Experimental groups were treated with risperidone 2–6 mg/24 h and olanzapine 10–20 mg/24 h.ResultsPretrial PANSS score was 57.28 in risperidone(R), 60.47 in olanzapine(O) and 58.45 in control(H) group. PANSS score after 180 days was 34.32 in R, 35.58 in O and 37.97 in H group. There was no statistical difference in pretrial scores for PANSS (p = 0.691), CGI1 (p = 0.733), CGI2 (p = 1.000), and CGI3 (p = 1.000) scores. There was statistical significance in PANSS and CGI1-4 score reduction after 180 days in all groups (p = 0.000). There was no statistical difference in PANSS score reduction between R and H (p = 0.114) and O and H group (p = 0.136). CGI1-4 scores reduction: CGI1, Rvs.H, p = 0.019 and Ovs.H, p = 0.032 with high statistical significance; CGI2, Rvs.H, p = 0.153 and Ovs.H, p = 0.179 with no statistical significance; CGI3, Rvs.H, p = 0.183 and Ovs.H, p = 0.161 with no statistical significance; CGI4, Rvs.H, p = 0.000 and Ovs.H, p = 0.000 with high statistical significance. Adverse effects were significantly lower in Risperidone (21.42%) and Olanzapine (21.81%) than in Haloperidol (57.5%) group.ConclusionRisperidone and Olanzapine have slightly better efficacy in treatment of DD comparing to haloperidol, with statisticaly significant lower adverse effects rate.

Sign in / Sign up

Export Citation Format

Share Document