Taurine ameliorate alloxan induced oxidative stress and intrinsic apoptotic pathway in the hepatic tissue of diabetic rats

2013 ◽  
Vol 51 ◽  
pp. 317-329 ◽  
Author(s):  
Kahkashan Rashid ◽  
Joydeep Das ◽  
Parames C. Sil
Keyword(s):  
Oxidative Stress ◽  
Diabetic Rats ◽  
Hepatic Tissue ◽  
Intrinsic Apoptotic Pathway ◽  
Apoptotic Pathway

A Novel Cyclic Dinuclear Gold(I) Complex Induces Anticancer Activity via Oxidative Stress-Mediated Intrinsic Apoptotic Pathway in MDA-MB-231 Cancer Cells

2022 ◽  
Author(s):  
Ahmed K. Abogosh ◽  
Meshal Alghanem ◽  
Saeed Ahmad ◽  
Abdullah Alasmari ◽  
Homood M. As Sobeai ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Anticancer Activity ◽  
Cancer Cells ◽  
Elemental Analysis ◽  
Intrinsic Apoptotic Pathway ◽  
Apoptotic Pathway ◽  
X Ray ◽  
X Ray Crystallography ◽  
Ethyl Amine

A new dinuclear cyclic gold(I) complex [Au2(DCyPA)2](PF6)2, 1 based on bis[2-(dicyclohexylphosphano)ethyl]amine (DCyPA) has been synthesized and characterized by elemental analysis, IR and NMR spectroscopies, and X-ray crystallography. In the dinuclear...

Study on the relationships between molecular weights of chondroitin sulfate oligosaccharides and Aβ-induced oxidative stress and the related mechanisms

Glycobiology ◽  
2020 ◽  
Author(s):  
Na Zhao ◽  
Jie Meng ◽  
Wenjie Jiang ◽  
Wenjia Xu ◽  
Chunhui Liu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Chondroitin Sulfate ◽  
Gel Filtration ◽  
Intrinsic Apoptotic Pathway ◽  
Toll Like Receptor ◽  
Apoptotic Pathway ◽  
Molecular Weights ◽  
Bv2 Cells ◽  
Shark Cartilage

Abstract In the present study, we studied anti-Alzheimer′s disease (AD) activities of chondroitin sulfate (CS) oligosaccharides with different molecular weights. CS from shark cartilage was degraded by a recombinant CS endolyase, chondroitinase ABC I (CHSase ABC I), and CS disaccharide (DP2), tetrasaccharide (DP4), hexasaccharide (DP6), octasaccharide (DP8), decasaccharide (DP10) and dodecasaccharide (DP12) were obtained by separation with gel filtration. Anti-AD activities of CS oligosaccharides were assessed using Aβ-injured SH-SY5Y cells and BV2 cells. It was shown that CS oligosaccharides could block Aβ-induced oxidative stress, mitochondrial dysfunction and activation of intrinsic apoptotic pathway for SH-SY5Y cells. Furthermore, these activities increased with the increase of molecular weights. For Aβ-injured BV2 cells, CS oligosaccharides inhibited oxidative stress, the production of proinflammatory cytokines and the activation of toll-like receptor pathway, and CS DP2 had the best activity among them. In conclusion, CS oligosaccharides suppressed Aβ-induced oxidative stress and relevant injury in vitro, and these effects had different relationships with the molecular weights of CS oligosaccharides for different cell lines, which might be caused by different mechanisms.

scholarly journals 4-Methylcatechol-induced oxidative stress induces intrinsic apoptotic pathway in metastatic melanoma cells

2011 ◽  
Vol 81 (10) ◽  
pp. 1211-1218 ◽  
Author(s):  
Florastina Payton ◽  
Rumu Bose ◽  
William L. Alworth ◽  
Addanki P. Kumar ◽  
Rita Ghosh
Keyword(s):  
Oxidative Stress ◽  
Metastatic Melanoma ◽  
Melanoma Cells ◽  
Intrinsic Apoptotic Pathway ◽  
Apoptotic Pathway

scholarly journals Effect of Aerobic Training and L-Carnitine Supplementation on Hepatic Oxidative Stress Factors in Diabetic Rat

2020 ◽  
Author(s):  
SeyedEsmaeil Jabbari ◽  
Mandana Gholami ◽  
Hojatollah Nikbakht ◽  
Nader Shakeri ◽  
Farshad Ghazalian
Keyword(s):  
Oxidative Stress ◽  
Aerobic Exercise ◽  
Aerobic Training ◽  
Diabetic Rats ◽  
Diabetic Group ◽  
Stress Factors ◽  
Hepatic Tissue ◽  
Control Group ◽  
P Value ◽  
Combined Intervention

Objective: The use of non-enzymatic antioxidants in food supplements and proper exercise can have a positive effect on decreasing oxidative stress by free radical hunting. The purpose of this study was to investigate the effect of aerobic training and Lcarnitine supplementation on some of the oxidative stress factors in the liver of diabetic rats. Materials and Methods: In this experimental study, 45 male wistar rats (200-300 gr) were randomly divided into six groups: 1) sham group, 2) healthy control group 3) diabetic control group, 4) diabetic group receiving L-carnitine, 5) diabetic group of aerobic training, 6) diabetic group of aerobic training and receiving Lcarnitine. The aerobic exercise protocol included six weeks, five sessions per week on the treadmill. After intervention, malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione peroxidase (GPX) levels were determined in liver tissue. Results: Six weeks of aerobic exercise had a significant effect on MDA factor in hepatic tissue in diabetic rats (P-value: 0.024). However, supplementation (P-value: 0.868) and combined intervention of aerobic exercise and supplementation of L-carnitine (P-value: 0.465) did not have the significant effect on MDA factor. Also, 6 weeks of aerobic training, supplementation of L-carnitine, and combined intervention had no significant effect on SOD and GPX factors of hepatic tissue in diabetic rats (P-value> 0.05). Conclusion: L-carnitine supplementation with regular exercise can have beneficial effects on hepatic antioxidant defense system in rats with type 2 diabetes.

scholarly journals Green Tea Attenuates Oxidative Stress and Downregulates the Expression of Angiotensin II AT1Receptor in Renal and Hepatic Tissues of Streptozotocin-Induced Diabetic Rats

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Martha Thomson ◽  
Khaled Al-Qattan ◽  
Mohamed H. Mansour ◽  
Muslim Ali
Keyword(s):  
Oxidative Stress ◽  
Angiotensin Ii ◽  
Green Tea ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
Receptor Expression ◽  
Hepatic Tissue ◽  
Angiotensin Ii Signaling ◽  
Total Antioxidant ◽  
Antibody Levels

This study investigates the potential of green tea to modulate oxidative stress and angiotensin II AT1receptor expression in renal and hepatic tissues of diabetic rats. Three groups of rats were studied after 8 weeks following diabetes induction: normal, streptozotocin-induced diabetic (diabetic control), and green-tea-treated diabetic rats. Total antioxidant, catalase, and malondialdehyde levels were assayed by standard procedures. Levels of AT1receptor labeling, in renal and hepatic tissues of the three rat groups, were immunohistochemically investigated using an anti-AT1receptor antibody. Levels of total antioxidant and catalase were significantly reduced, whereas malondialdehyde levels and AT1receptor labeling were significantly increased in renal and hepatic tissues of diabetic control rats compared to normal rats. Compared to diabetic control rats, total antioxidant and catalase levels were significantly increased, whereas malondialdehyde levels and AT1receptor labeling in the green-tea-treated diabetic group were significantly reduced throughout hepatic lobules and renal cortical and medullary vascular and tubular segments to levels comparable to those observed in normal rats. The capacity of green tea to modulate diabetes-induced oxidative stress and AT1receptor upregulation may be beneficial in opposing the deleterious effects of excessive angiotensin II signaling, manifested by progressive renal and hepatic tissue damage.

scholarly journals Beneficial effects of N-acetylcysteine on hepatic oxidative stress in streptozotocin-induced diabetic rats

2018 ◽  
Vol 96 (4) ◽  
pp. 412-418 ◽  
Author(s):  
Lucas Rodolfo de Oliveira Rosa ◽  
Anderson Kiyoshi Kaga ◽  
Pedro Octavio Barbanera ◽  
Priscila Manfio Queiroz ◽  
Nágilla Orleanne Lima do Carmo ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Properties ◽  
Diabetic Complication ◽  
Diabetic Rats ◽  
Hepatic Tissue ◽  
Diabetes Research ◽  
Oxidative Stress Biomarkers ◽  
Alcoholic Fatty Liver ◽  
Hepatic Oxidative Stress ◽  
And Oxidative Stress

Diabetes is one of the leading diseases worldwide and, thus, finding new therapeutic alternatives is essential. The development of non-alcoholic fatty liver disease is a notable diabetic complication. Therefore, antioxidant therapy became a leading topic in the world of diabetes research. The objective of this present study was to evaluate the effects of antioxidant N-acetylcysteine (NAC) administration on serum biochemical parameters and oxidative stress parameters in hepatic tissue of the diabetic rats. Thirty-two animals were divided in 4 groups (n = 8): G1, normal rats; G2, normal rats + NAC; G3, diabetic rats; and G4, diabetic rats + NAC. Diabetes was induced in diabetic groups through streptozotocin. NAC administration was effective in improving hyperglycemia and hypoinsulinemia, as well as reducing serum alanine-aminotransferase and urea, hepatic triglycerides accumulation, and oxidative stress biomarkers in the diabetic liver, as well as improving the activity of hepatic antioxidant enzymes. This effect was likely due to NAC’s ability of restoring intracellular glutathione, an important compound for the antioxidant defense, as well as due to NAC’s direct antioxidant properties. Thus, NAC administration was useful for reducing hepatic oxidative stress and decreased the deposit of triacylglycerols, minimizing diabetic hepatic damage, making it a promising therapeutic adjuvant in the future.

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