Protective role of D-saccharic acid-1,4-lactone in alloxan induced oxidative stress in the spleen tissue of diabetic rats is mediated by suppressing mitochondria dependent apoptotic pathway

2012 ◽  
Vol 46 (3) ◽  
pp. 240-252 ◽  
Author(s):  
Kahkashan Rashid ◽  
Semantee Bhattacharya ◽  
Parames C. Sil
Keyword(s):  
Oxidative Stress ◽  
Protective Role ◽  
Diabetic Rats ◽  
Apoptotic Pathway ◽  
Spleen Tissue

Protective role of Sterculia tragacantha aqueous extract on pancreatic gene expression and oxidative stress parameters in streptozotocin-induced diabetic rats

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Basiru Olaitan Ajiboye ◽  
Babatunji Emmanuel Oyinloye ◽  
Jennifer Chidera Awurum ◽  
Sunday Amos Onikanni ◽  
Adedotun Adefolalu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Body Weight ◽  
Protective Role ◽  
Diabetic Rats ◽  
Gene Expressions ◽  
Ki 67 ◽  
Oxidative Stress Parameters ◽  
And Oxidative Stress ◽  
Stress Parameters

Abstract Objectives The current study evaluates the protective role of aqueous extract of Sterculia tragacantha leaf (AESTL) on pancreatic gene expressions (insulin, PCNA, PDX-1, KI-67 and GLP-1R) and oxidative stress parameters in streptozotocin-induced diabetic rats. Methods Diabetes mellitus was induced into the experimental Wistar animals via intraperitoneal (IP) injection of streptozotocin (35 mg/kg body weight) and 5% glucose water was given to the rats for 24 h after induction. The animals were categorized into five groups of 10 rats each as follows normal control, diabetic control, diabetic rats administered AESTL (150 and 300 mg/kg body weight) and diabetic rats administered metformin (200 mg/kg) orally for two weeks. Thereafter, the animals were euthanized, blood sample collected, pancreas harvested and some pancreatic gene expressions (such as insulin, PCNA, PDX-1, KI-67, and GLP-1R)s as well as oxidative stress parameters were analyzed. Results The results revealed that AESTL significantly (p<0.05) reduced fasting blood glucose level, food and water intake, and lipid peroxidation in diabetic rats. Diabetic rats administered different doses of AESTL showed a substantial upsurge in body weight, antioxidant enzyme activities, and pancreatic gene expressions (insulin, PCNA, PDX-1, KI-67, and GLP-1R). Conclusions It can therefore be concluded that AESTL has the ability to protect the pancreas during diabetes mellitus conditions.

scholarly journals The protective role of virgin coconut oil on the alloxan-induced oxidative stress in the liver, kidneys and heart of diabetic rats

2019 ◽  
Vol 10 (4) ◽  
pp. 2114-2124 ◽  
Author(s):  
Siniša Đurašević ◽  
Nebojša Jasnić ◽  
Marko Prokić ◽  
Ilijana Grigorov ◽  
Vesna Martinović ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Coconut Oil ◽  
Protective Role ◽  
Diabetic Rats ◽  
Toxic Effects ◽  
Virgin Coconut Oil ◽  
Tissue Specific

Our results show that VCO supplementation ameliorates some toxic effects of alloxan induced diabetes, and that the changes are tissue specific.

scholarly journals Liver Dysfunction and Oxidative Stress in Streptozotocin-Induced Diabetic Rats: Protective Role of Artemisia Turanica

2019 ◽  
Vol 22 (2) ◽  
pp. 109-114
Author(s):  
Hassan Bgheri Yazdi ◽  
Vida Hojati ◽  
Abdolhossein Shiravi ◽  
Sara Hosseinian ◽  
Gholamhassan Vaezi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Liver Dysfunction ◽  
Protective Role ◽  
Diabetic Rats ◽  
And Oxidative Stress

Role of sarcolemmal ATP-sensitive potassium channel in oxidative stress-induced apoptosis: mitochondrial connection

2008 ◽  
Vol 294 (3) ◽  
pp. H1317-H1325 ◽  
Author(s):  
Jasna Marinovic ◽  
Marko Ljubkovic ◽  
Anna Stadnicka ◽  
Zeljko J. Bosnjak ◽  
Martin Bienengraeber
Keyword(s):  
Oxidative Stress ◽  
Cell Death ◽  
Apoptotic Cell ◽  
Specific Interaction ◽  
Protective Role ◽  
Apoptotic Cell Death ◽  
Apoptotic Pathway ◽  
Neonatal Cardiomyocytes ◽  
Channel Inhibition

From time of their discovery, sarcolemmal ATP-sensitive K+ (sarcKATP) channels were thought to have an important protective role in the heart during stress whereby channel opening protects the heart from stress-induced Ca2+ overload and resulting damage. In contrast, some recent studies indicate that sarcKATP channel closing can lead to cardiac protection. Also, the role of the sarcKATP channel in apoptotic cell death is unclear. In the present study, the effects of channel inhibition on apoptosis and the specific interaction between the sarcKATP channel and mitochondria were investigated. Apoptotic cell death of cultured HL-1 and neonatal cardiomyocytes following exposure to oxidative stress was significantly increased in the presence of sarcKATP channel inhibitor HMR-1098 as evidenced by terminal deoxynucleotidyltransferase-mediated dUTP nick end labeling and caspase-3,7 assays. This was paralleled by an increased release of cytochrome c from mitochondria to cytosol, suggesting activation of the mitochondrial death pathway. sarcKATP channel inhibition during stress had no effect on Bcl-2, Bad, and phospho-Bad, indicating that the increase in apoptosis cannot be attributed to these modulators of the apoptotic pathway. However, monitoring of mitochondrial Ca2+ with rhod-2 fluorescent indicator revealed that mitochondrial Ca2+ accumulation during stress is potentiated in the presence of HMR-1098. In conclusion, this study provides novel evidence that opening of sarcKATP channels, through a specific Ca2+-related interaction with mitochondria, plays an important role in preventing cardiomyocyte apoptosis and mitochondrial damage during stress.

Protective role of aqueous extract of Phyllanthus amarus on oxidative stress in pancreas of streptozotocin induced diabetic male Wistar rats

2016 ◽  
Vol 2 (1) ◽  
pp. 23 ◽  
Author(s):  
Sasi Bhusana Rao Bongu ◽  
Saisree Sagree ◽  
Vijayabharathi Gudapareddy ◽  
Malliah Putakala ◽  
Sreenivasulu Nukala ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Aqueous Extract ◽  
Reduced Glutathione ◽  
Protective Role ◽  
Pancreatic Tissue ◽  
Diabetic Rats ◽  
Phyllanthus Amarus ◽  
Glutathione S Transferase ◽  
Male Wistar Rats

Diabetes mellitus has been associated with oxidative stress. The present study was performed to investigate the pancreas protective activities of Phyllanthus amarus aqueous extract (PAAEt) in streptozotocin (STZ) induced diabetic rats. Oral administration of PAAEt (200mg/kg bw) to diabetic rats for 60 days significantly (p<0.05) decreased antioxidant enzymes such as glutathione peroxidase, glutathione-s-transferase, glutathione reductase, superoxide dismutase, catalase and depletion of reduced glutathione in panceas which illustrates that increased lipid peroxidation (107 %) was restored to control levels. Co-treatment with PAAEt revealed the therapeutic efficacy against oxidative stress in pancreatic tissue. Hence extract of this plant could be used as an adjuvant therapy for the prevention and/or management of diabetes.

scholarly journals Evaluation of the Antihyperlipidemic and Antioxidant Effects of Catharanthus roseus Extracted from Vinca minor in Diabetic Rats

2021 ◽  
pp. 1-13
Author(s):  
Shimaa Mohammed Hasnin Aboelnaga
Keyword(s):  
Oxidative Stress ◽  
Protective Role ◽  
Diabetic Rats ◽  
The Body ◽  
Blood Analysis ◽  
Diabetic Patients ◽  
Defence Mechanism ◽  
Glucose Levels ◽  
Antioxidant Effects

The role of oxidative stress is known among the patients of diabetes as the level of reactive oxygen species was high among diabetic patients. This oxidative stress is generated in diabetic patients due to continuous high glucose levels that cause to decrease in the defence mechanism for antioxidant enzymes within the body. The reduction of the antioxidant defence mechanism leads towards the generation of hydroxyl radicals consequently results in lipid peroxidation. The objective of this study is to examine the efficacy of Vincamine extracts as antihyperlipidemic and antioxidant in diabetic rats. To evaluate the antihyperlipidemic and antioxidant effects of Vincamine, adult BB Wistar rats, weighing 150- 170 g were obtained and divided in six groups. Blood analysis was taken measure the observed parameters. The findings showed vincamine display antioxidant, hypoglycaemic and hypolipidemic activity.It is concluded that vincamine hasa protective role and acts as a good antioxidant activity along with effective antidiabetic effects.

scholarly journals Protective Role of Glutathione in the Hippocampus after Brain Ischemia

2021 ◽  
Vol 22 (15) ◽  
pp. 7765
Author(s):  
Youichirou Higashi ◽  
Takaaki Aratake ◽  
Takahiro Shimizu ◽  
Shogo Shimizu ◽  
Motoaki Saito
Keyword(s):  
Oxidative Stress ◽  
Neuronal Death ◽  
Excitatory Amino Acid ◽  
Ischemia Reperfusion ◽  
Thiol Group ◽  
Protective Role ◽  
Key Factor ◽  
Rate Limiting ◽  
Cysteine Uptake

Stroke is a major cause of death worldwide, leading to serious disability. Post-ischemic injury, especially in the cerebral ischemia-prone hippocampus, is a serious problem, as it contributes to vascular dementia. Many studies have shown that in the hippocampus, ischemia/reperfusion induces neuronal death through oxidative stress and neuronal zinc (Zn2+) dyshomeostasis. Glutathione (GSH) plays an important role in protecting neurons against oxidative stress as a major intracellular antioxidant. In addition, the thiol group of GSH can function as a principal Zn2+ chelator for the maintenance of Zn2+ homeostasis in neurons. These lines of evidence suggest that neuronal GSH levels could be a key factor in post-stroke neuronal survival. In neurons, excitatory amino acid carrier 1 (EAAC1) is involved in the influx of cysteine, and intracellular cysteine is the rate-limiting substrate for the synthesis of GSH. Recently, several studies have indicated that cysteine uptake through EAAC1 suppresses ischemia-induced neuronal death via the promotion of hippocampal GSH synthesis in ischemic animal models. In this article, we aimed to review and describe the role of GSH in hippocampal neuroprotection after ischemia/reperfusion, focusing on EAAC1.

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