Membrane polarization in non-neuronal cells as a potential mechanism of metabolic disruption by depolarizing insecticides

2022 ◽  
pp. 112804
Author(s):  
Yeonhwa Park ◽  
Alexander Suvorov ◽  
Steven B. Symington ◽  
John M. Clark
Keyword(s):  
Neuronal Cells ◽  
Potential Mechanism ◽  
Membrane Polarization ◽  
Metabolic Disruption

scholarly journals Cobalamin-Associated Superoxide Scavenging in Neuronal Cells Is a Potential Mechanism for Vitamin B12–Deprivation Optic Neuropathy

2018 ◽  
Vol 188 (1) ◽  
pp. 160-172 ◽  
Author(s):  
Wesley Chan ◽  
Mohammadali Almasieh ◽  
Maria-Magdalena Catrinescu ◽  
Leonard A. Levin
Keyword(s):  
Vitamin B12 ◽  
Optic Neuropathy ◽  
Neuronal Cells ◽  
Potential Mechanism

Cytoprotective Effect of Tocotrienol-Rich Fraction and α-Tocopherol Vitamin E Isoforms Against Glutamate-Induced Cell Death in Neuronal Cells

2014 ◽  
Vol 84 (3-4) ◽  
pp. 0140-0151 ◽  
Author(s):  
Thilaga Rati Selvaraju ◽  
Huzwah Khaza’ai ◽  
Sharmili Vidyadaran ◽  
Mohd Sokhini Abd Mutalib ◽  
Vasudevan Ramachandran ◽  
...  
Keyword(s):  
Vitamin E ◽  
Cell Viability ◽  
Neuronal Cells ◽  
Positive Control ◽  
Post Treatment ◽  
Mitochondrial Activity ◽  
Before And After ◽  
Pre Treatment ◽  
Tocotrienol Rich Fraction ◽  
Major Mediator

Glutamate is the major mediator of excitatory signals in the mammalian central nervous system. Extreme amounts of glutamate in the extracellular spaces can lead to numerous neurodegenerative diseases. We aimed to clarify the potential of the following vitamin E isomers, tocotrienol-rich fraction (TRF) and α-tocopherol (α-TCP), as potent neuroprotective agents against glutamate-induced injury in neuronal SK-N-SH cells. Cells were treated before and after glutamate injury (pre- and post-treatment, respectively) with 100 - 300 ng/ml TRF/α-TCP. Exposure to 120 mM glutamate significantly reduced cell viability to 76 % and 79 % in the pre- and post-treatment studies, respectively; however, pre- and post-treatment with TRF/α-TCP attenuated the cytotoxic effect of glutamate. Compared to the positive control (glutamate-injured cells not treated with TRF/α-TCP), pre-treatment with 100, 200, and 300 ng/ml TRF significantly improved cell viability following glutamate injury to 95.2 %, 95.0 %, and 95.6 %, respectively (p < 0.05).The isomers not only conferred neuroprotection by enhancing mitochondrial activity and depleting free radical production, but also increased cell viability and recovery upon glutamate insult. Our results suggest that vitamin E has potent antioxidant potential for protecting against glutamate injury and recovering glutamate-injured neuronal cells. Our findings also indicate that both TRF and α-TCP could play key roles as anti-apoptotic agents with neuroprotective properties.

Emotional Impact Feedback Changes How We Remember Negative Autobiographical Experiences

2010 ◽  
Vol 57 (5) ◽  
pp. 354-359 ◽  
Author(s):  
Melanie K. T. Takarangi ◽  
Deryn Strange
Keyword(s):  
Well Being ◽  
The Other ◽  
Personal Perspective ◽  
Emotional Impact ◽  
Potential Mechanism ◽  
Negative Experiences ◽  
Negative Memory ◽  
The Relationship ◽  
Negative Memories ◽  
Over Time

When people are told that their negative memories are worse than other people’s, do they later remember those events differently? We asked participants to recall a recent negative memory then, 24 h later, we gave some participants feedback about the emotional impact of their event – stating it was more or less negative compared to other people’s experiences. One week later, participants recalled the event again. We predicted that if feedback affected how participants remembered their negative experiences, their ratings of the memory’s characteristics should change over time. That is, when participants are told that their negative event is extremely negative, their memories should be more vivid, recollected strongly, and remembered from a personal perspective, compared to participants in the other conditions. Our results provide support for this hypothesis. We suggest that external feedback might be a potential mechanism in the relationship between negative memories and psychological well-being.

Delay Exposure as a Potential Mechanism to Increase Self-Control in Rats

2013 ◽  
Author(s):  
Aaron P. Smith ◽  
Kimberly Kirkpatrick
Keyword(s):  
Self Control ◽  
Potential Mechanism

Flavonoids from Deguelia duckeana inhibit the eukaryotic elongation factor 2 (eEF2) in SK-N-SH neuronal cells

Planta Medica ◽  
2015 ◽  
Vol 81 (16) ◽  
Author(s):  
LMC Cursino ◽  
NM Lima ◽  
R Murillo ◽  
I Merfort ◽  
M Humar ◽  
...  
Keyword(s):  
Neuronal Cells ◽  
Elongation Factor ◽  
Elongation Factor 2 ◽  
Eukaryotic Elongation Factor 2 ◽  
Eukaryotic Elongation Factor

Estrogen receptor subtype-specific repression of calpain-activation in neuronal cells

2005 ◽  
Vol 38 (05) ◽  
Author(s):  
M Gamerdinger ◽  
D Manthey ◽  
C Behl
Keyword(s):  
Estrogen Receptor ◽  
Neuronal Cells ◽  
Receptor Subtype ◽  
Calpain Activation

An investigation about metabolic disruption: organostannic compounds as PPAR gamma agonists

2013 ◽  
Author(s):  
Isabella Gontijo de Sa Leao ◽  
Angelica Amorim Amato ◽  
Natacha Thalita Santos Amorim ◽  
Leticia Mendes Cortes ◽  
Francisco Assis Rocha Neves
Keyword(s):  
Ppar Gamma ◽  
Metabolic Disruption

Low vitamin D is associated with increased bladder cancer risk; a systematic review and evidence of a potential mechanism

2016 ◽  
Author(s):  
Rosemary Bland ◽  
Corina Chivu ◽  
Kieran Jefferson ◽  
Donald MacDonald ◽  
Gulnaz Iqbal ◽  
...  
Keyword(s):  
Systematic Review ◽  
Vitamin D ◽  
Bladder Cancer ◽  
Cancer Risk ◽  
Potential Mechanism ◽  
Bladder Cancer Risk
Sign in / Sign up

Export Citation Format

Share Document