Antioxidant system in seminal plasma and its relationship to semen parameters in infertile men

2009 ◽  
Vol 92 (3) ◽  
pp. S208
Author(s):  
A.C. Varghese ◽  
R. Gutgutia ◽  
A.K. Bhattacharyya ◽  
S. Suresh ◽  
J. Bhattacharya ◽  
...  
Keyword(s):  
Antioxidant System ◽  
Seminal Plasma ◽  
Semen Parameters ◽  
Infertile Men

O206 Antioxidant system in seminal plasma and its relationship to clinical semen parameters in infertile men

2009 ◽  
Vol 107 ◽  
pp. S152-S152
Author(s):  
P. Dasgupta ◽  
A. Varghese ◽  
R. Gutgutia ◽  
S. S ◽  
A. Chatterjee ◽  
...  
Keyword(s):  
Antioxidant System ◽  
Seminal Plasma ◽  
Semen Parameters ◽  
Infertile Men

scholarly journals Impact of oxidative stress on semen parameters in normozoospermic infertile men: a case–control study

2020 ◽  
Vol 26 (1) ◽  
Author(s):  
Ayad Palani ◽  
Ahmed Alahmar
Keyword(s):  
Oxidative Stress ◽  
Uric Acid ◽  
Male Infertility ◽  
Seminal Plasma ◽  
Case Control Study ◽  
Case Control ◽  
Semen Parameters ◽  
Infertile Men ◽  
Total Antioxidant ◽  
Control Study

Abstract Background Oxidative stress has been implicated in male infertility through decrease in sperm quality. However, men with normal semen parameters (normozoospermia) may be unable to fertilize their partners even when they have normal sperm function. Thus, they would be considered infertile. The purpose of this study was to investigate the role of oxidative stress in the pathogenesis of unexplained male infertility. Methods In this case–control study, infertile men with normozoospermia (n = 46) and fertile control group (n = 21) underwent seminal fluid analyses according to WHO 2010 criteria. Serum and seminal plasma levels of total antioxidant capacity (TAC), glutathione, malondialdehyde, uric acid and albumin were also measured using colorimetric methods. Results The level of total antioxidant capacity in both serum and seminal plasma was significantly lower in normozoospermic infertile men in comparison with fertile group (p < 0.0001). However, no significant differences were observed in serum and seminal plasma levels of glutathione, uric acid, albumin and malondialdehyde between infertile and fertile groups. Conclusion Low TAC level induces oxidative stress and consequently causes sperm dysfunction and male infertility. Estimation of TAC can be a useful tool in the diagnosis of male infertility. Antioxidant supplementation should be considered in the treatment of oxidative stress-induced male infertility.

scholarly journals Mucuna pruriensReduces Stress and Improves the Quality of Semen in Infertile Men

2010 ◽  
Vol 7 (1) ◽  
pp. 137-144 ◽  
Author(s):  
Kamla Kant Shukla ◽  
Abbas Ali Mahdi ◽  
Mohammad Kaleem Ahmad ◽  
Shyam Pyari Jaiswar ◽  
Satya Narain Shankwar ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Psychological Stress ◽  
Seminal Plasma ◽  
Sperm Count ◽  
Plasma Lipid ◽  
Lipid Peroxide ◽  
Serum Cortisol ◽  
Semen Parameters ◽  
Infertile Men ◽  
Plasma Lipid Peroxide

The present investigation was undertaken to assess the role ofMucuna pruriensin infertile men who were under psychological stress. Study included 60 subjects who were undergoing infertility screening and were found to be suffering from psychological stress, assessed on the basis of a questionnaire and elevated serum cortisol levels. Age-matched 60 healthy men having normal semen parameters and who had previously initiated at least one pregnancy were included as controls. Infertile subjects were administered withM. pruriensseed powder (5 g day−1) orally. For carrying out morphological and biochemical analysis, semen samples were collected twice, first before starting treatment and second after 3 months of treatment. The results demonstrated decreased sperm count and motility in subjects who were under psychological stress. Moreover, serum cortisol and seminal plasma lipid peroxide levels were also found elevated along with decreased seminal plasma glutathione (GSH) and ascorbic acid contents and reduced superoxide dismutase (SOD) and catalase activity. Treatment withM. prurienssignificantly ameliorated psychological stress and seminal plasma lipid peroxide levels along with improved sperm count and motility. Treatment also restored the levels of SOD, catalase, GSH and ascorbic acid in seminal plasma of infertile men. On the basis of results of the present study, it may be concluded thatM. pruriensnot only reactivates the anti-oxidant defense system of infertile men but it also helps in the management of stress and improves semen quality.

scholarly journals Abnormal expression of acid glycosidases in seminal plasma and spermatozoa from infertile men with varicocele

Reproduction ◽  
2002 ◽  
pp. 411-417 ◽  
Author(s):  
JJ Corrales ◽  
RM Burgo ◽  
P Galindo ◽  
I Munoz-Barroso ◽  
JM Miralles ◽  
...  
Keyword(s):  
Sperm Motility ◽  
Seminal Plasma ◽  
Soluble Fraction ◽  
The Other ◽  
Semen Parameters ◽  
Obstructive Azoospermia ◽  
Infertile Men ◽  
Normal Fertility ◽  
Beta Galactosidase ◽  
Infertile Patients

The activities of acid beta-glucuronidase, alpha-mannosidase, alpha-glucosidase, alpha-galactosidase, beta-galactosidase and beta-N-acetylglucosaminidase were analysed in seminal plasma and spermatozoa from 26 infertile men with varicocele and from 36 men of normal fertility. Semen samples from ten men with non-obstructive azoospermia were used as control specimens that contained the other components of semen. Spermatozoa were solubilized by both physical (homogenization) and chemical (Triton-X100) methods to obtain the soluble and non-soluble fractions. The activities of several glycosidases measured both in seminal plasma and spermatozoa were directly correlated with the numbers of spermatozoa and sperm motility, confirming previous studies. As some infertile patients with varicocele have normal semen parameters, whereas others have low numbers of spermatozoa and low sperm motility, the varicocele patients were prospectively divided into two groups: one (n = 15) with normal spermiograms and the other (n = 11) with abnormal spermiograms. The activities (expressed in mU ml(-1)) of alpha-mannosidase, beta-galactosidase and beta-N-acetylglucosaminidase in seminal plasma of normozoospermic infertile patients with varicocele were significantly higher than those of fertile controls, but not when expressed in U per 10(8) spermatozoa. The activities of beta-glucuronidase, alpha-mannosidase, beta-galactosidase and beta-N-acetylglucosaminidase in seminal plasma when expressed in U per 10(8) spermatozoa in varicocele patients with abnormal spermiograms were significantly higher than in those of men of normal fertility. The activity of alpha-mannosidase in the soluble fraction of sperm homogenates, expressed as U per 10(8) spermatozoa, was significantly higher in infertile patients with varicocele and abnormal spermiograms than in controls. In the non-soluble fraction of spermatozoa from infertile patients with varicocele, there was an increase in the expression of beta-galactosidase and beta-N-acetylglucosaminidase activities compared with the fraction of spermatozoa from fertile subjects. In summary, infertile patients with varicocele displayed an overexpression of acid alpha-mannosidase, beta-galactosidase and beta-N-acetylglucosaminidase activities in seminal plasma and spermatozoa that may be associated with functional defects in spermatozoa as these glycosidases play an important role in mammalian fertilization.

The influence of Robertsonian translocations on semen parameters

2020 ◽  
pp. 87-88
Author(s):  
М.В. Андреева ◽  
М.И. Штаут ◽  
Т.М. Сорокина ◽  
Л.Ф. Курило ◽  
В.Б. Черных
Keyword(s):  
Male Infertility ◽  
Semen Parameters ◽  
Meiotic Arrest ◽  
Robertsonian Translocations ◽  
Prophase I ◽  
Infertile Men ◽  
Fertility Problems ◽  
Spermatogenesis Impairment

Обследованы 19 мужчин с нарушением фертильности, носителей транслокаций rob(13;14) и rob(13;15). Показано, что нарушение репродуктивной функции обусловлено блоком сперматогенеза в профазе I мейоза, приводящего к азооспермии или олигоастенотератозооспермии и мужскому бесплодию. We examined 19 infertile men, carriers of translocations rob (13;14) and rob (13;15). We assume that fertility problems are resulted from spermatogenesis impairment because of meiotic arrest at prophase I stages, that leads to azoospermia or oligoastenoteratozoospermia and male infertility.

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