Freeze-dried jaboticaba peel added to high-fat diet increases HDL-cholesterol and improves insulin resistance in obese rats

Our objective was to investigate and compare the effects of heat-killed (HK) and liveLactobacillus reuteriGMNL-263 (Lr263) on insulin resistance and its related complications in high-fat diet (HFD)-induced rats.

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Exercise ameliorates insulin resistance via regulating TGFβ-activated kinase 1 (TAK1)-mediated insulin signaling in liver of high-fat diet-induced obese rats

Journal of Cellular Physiology ◽

10.1002/jcp.27508 ◽

2018 ◽

Vol 234 (5) ◽

pp. 7467-7474 ◽

Cited By ~ 2

Author(s):

Yong Zhang ◽

Jianyong Wan ◽

Zhen Xu ◽

Tianmiao Hua ◽

Qingyan Sun

Keyword(s):

Insulin Resistance ◽

Insulin Signaling ◽

High Fat Diet ◽

High Fat ◽

Obese Rats

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Ping-tang Recipe (平糖方) improves insulin resistance and attenuates hepatic steatosis in high-fat diet-induced obese rats

Chinese Journal of Integrative Medicine ◽

10.1007/s11655-012-1023-0 ◽

2012 ◽

Vol 18 (4) ◽

pp. 262-268 ◽

Cited By ~ 7

Author(s):

Shu-yu Yang ◽

Neng-jiang Zhao ◽

Xue-jun Li ◽

Hui-jie Zhang ◽

Ke-ji Chen ◽

...

Keyword(s):

Insulin Resistance ◽

Hepatic Steatosis ◽

High Fat Diet ◽

High Fat ◽

Obese Rats

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Obesity induced by high-fat diet promotes insulin resistance in the ovary

Journal of Endocrinology ◽

10.1677/joe-09-0461 ◽

2010 ◽

Vol 206 (1) ◽

pp. 65-74 ◽

Cited By ~ 56

Author(s):

Eliana H Akamine ◽

Anderson C Marçal ◽

João Paulo Camporez ◽

Mara S Hoshida ◽

Luciana C Caperuto ◽

...

Keyword(s):

Insulin Resistance ◽

Signaling Pathway ◽

Insulin Signaling ◽

High Fat Diet ◽

Ovarian Function ◽

Polycystic Ovary ◽

Insulin Signaling Pathway ◽

Female Rats ◽

High Fat ◽

Obese Rats

Besides the effects on peripheral energy homeostasis, insulin also has an important role in ovarian function. Obesity has a negative effect on fertility, and may play a role in the development of the polycystic ovary syndrome in susceptible women. Since insulin resistance in the ovary could contribute to the impairment of reproductive function in obese women, we evaluated insulin signaling in the ovary of high-fat diet-induced obese rats. Female Wistar rats were submitted to a high-fat diet for 120 or 180 days, and the insulin signaling pathway in the ovary was evaluated by immunoprecipitation and immunoblotting. At the end of the diet period, we observed insulin resistance, hyperinsulinemia, an increase in progesterone serum levels, an extended estrus cycle, and altered ovarian morphology in obese female rats. Moreover, in female obese rats treated for 120 days with the high-fat diet, the increase in progesterone levels occurred together with enhancement of LH levels. The ovary from high-fat-fed female rats showed a reduction in the insulin receptor substrate/phosphatidylinositol 3-kinase/AKT intracellular pathway, associated with an increase in FOXO3a, IL1B, and TNFα protein expression. These changes in the insulin signaling pathway may have a role in the infertile state associated with obesity.

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Dyslipidemia’s influence on the secretion ovarian’s steroids in female mice

Research Society and Development ◽

10.33448/rsd-v10i13.21369 ◽

2021 ◽

Vol 10 (13) ◽

pp. e298101321369

Author(s):

Juliana Maganha Abreu ◽

Gérsika Bitencourt Santos ◽

Maria das Graças de Souza Carvalho ◽

Juliana Marques Mencarelli ◽

Bruna Rayanne Moreira Cândido ◽

...

Keyword(s):

Insulin Resistance ◽

Plasma Levels ◽

High Fat Diet ◽

Hdl Cholesterol ◽

Insulin Level ◽

Standard Diet ◽

High Fat ◽

Wild Female ◽

Female Mice ◽

Glucose Plasma

Introduction: The synthesis ovarian’s steroids is a process thats depends on the supply of cholesterol. Objective: to evaluate the influence of dyslipidemia on the secretion ovarian’s steroids. Methodology: wild female mice were used (C57BL6) and LDL (LDLR-/-), which they were separated into 4 groups (n = 10): WTS: fed a standard diet; WTHL: fed a high-fat diet; KOS: fed a standard diet; KOHL: fed a high-fat diet. After 60 days, the estrous cycle was analyzed and after anesthetized, blood was collected for the to assess the lipid profile, glucose, plasma insulin level and HOMA index was calculated. In addition, plasma levels of C-reactive protein, estrogen and progesterone were determined. Results: The hyperlipidic diet in both the WTHL and the KOHL group generated hypercholesterolemia when compared to the WTS and KOS, respectively, with a decrease in HDLc, associated with an increase in CRP levels. Severe hypercholesterolemia in the KOHL group generated insulin resistance, marked by an increase in HOMAir. Food hypercholesterolemia in the WTHL group, food and genetics in the KOHL group, compared to their WTS and KOS controls, was definitive in reducing plasma levels of estrogen and progesterone. The genetic hypercholesterolemia associated with insulin resistance observed in the KOS and KOHL groups reduced the levels of progesterone, this reduction being more severe in the KOHL group, which had the highest HOMAir. Conclusion: dyslipidemia affected ovarian steroidogenesis in mice by means of oxidative stress, inflammation and insulin resistance and / or by decreasing HDL cholesterol levels.

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Hibiscus sabdariffa L. calyx extract prevents the adipogenesis of 3T3-L1 adipocytes, and obesity-related insulin resistance in high-fat diet-induced obese rats

Biomedicine & Pharmacotherapy ◽

10.1016/j.biopha.2021.111438 ◽

2021 ◽

Vol 138 ◽

pp. 111438

Author(s):

Benjarat Janson ◽

Janjira Prasomthong ◽

Wachirawadee Malakul ◽

Tantip Boonsong ◽

Sakara Tunsophon

Keyword(s):

Insulin Resistance ◽

High Fat Diet ◽

Hibiscus Sabdariffa ◽

High Fat ◽

Obese Rats

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Shrimp oil extracted from the shrimp processing waste reduces the development of insulin resistance and metabolic phenotypes in diet-induced obese rats

Applied Physiology Nutrition and Metabolism ◽

10.1139/apnm-2016-0644 ◽

2017 ◽

Vol 42 (8) ◽

pp. 841-849 ◽

Cited By ~ 8

Author(s):

Sandhya Nair ◽

Jacques Gagnon ◽

Claude Pelletier ◽

Nadia Tchoukanova ◽

Junzeng Zhang ◽

...

Keyword(s):

Oxidative Stress ◽

Insulin Resistance ◽

Glucose Tolerance ◽

Chronic Inflammation ◽

High Fat Diet ◽

High Fat ◽

Low Fat ◽

Low Fat Diet ◽

Obese Rats ◽

Shrimp Oil

Diet-induced obesity, insulin resistance, impaired glucose tolerance, chronic inflammation, and oxidative stress represent the main features of type 2 diabetes mellitus. The present study was conducted to examine the efficacy and mechanisms of shrimp oil on glucose homeostasis in obese rats. Male CD rats fed a high-fat diet (52 kcal% fat) and 20% fructose drinking water were divided into 4 groups and treated with the dietary replacement of 0%, 10%, 15%, or 20% of lard with shrimp oil for 10 weeks. Age-matched rats fed a low-fat diet (10 kcal% fat) were used as the normal control. Rats on the high-fat diet showed impaired (p < 0.05) glucose tolerance and insulin resistance compared with rats fed the low-fat diet. Shrimp oil improved (p < 0.05) oral glucose tolerance, insulin response, and homeostatic model assessment-estimated insulin resistance index; decreased serum insulin, leptin, hemoglobin A1c, and free fatty acids; and increased adiponectin. Shrimp oil also increased (p < 0.05) antioxidant capacity and reduced oxidative stress and chronic inflammation. The results demonstrated that shrimp oil dose-dependently improved glycemic control in obese rats through multiple mechanisms.

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Dietary Glycotoxins Impair Hepatic Lipidemic Profile in Diet-Induced Obese Rats Causing Hepatic Oxidative Stress and Insulin Resistance

Oxidative Medicine and Cellular Longevity ◽

10.1155/2019/6362910 ◽

2019 ◽

Vol 2019 ◽

pp. 1-14 ◽

Cited By ~ 3

Author(s):

C. Neves ◽

T. Rodrigues ◽

J. Sereno ◽

C. Simões ◽

J. Castelhano ◽

...

Keyword(s):

Oxidative Stress ◽

Insulin Resistance ◽

Fatty Acid ◽

High Fat Diet ◽

De Novo ◽

Liver Lipid ◽

Lipid Fraction ◽

De Novo Lipogenesis ◽

High Fat ◽

Obese Rats

Nonalcoholic fatty liver disease (NAFLD) is caused by excessive liver lipid accumulation, but insulin resistance is specifically associated with impaired lipid saturation, oxidation, and storage (esterification), besides increased de novo lipogenesis. We hypothesized that dietary glycotoxins could impair hepatic lipid metabolism in obesity contributing to lipotoxicity-driven insulin resistance and thus to the onset of nonalcoholic steatohepatitis (NASH). In diet-induced obese rats with methylglyoxal-induced glycation, magnetic resonance spectroscopy, mass spectrometry, and gas chromatography were used to assess liver composition in fatty acyl chains and phospholipids. High-fat diet-induced obesity increased liver lipid fraction and suppressed de novo lipogenesis but did not change fatty acid esterification and saturation or insulin sensitivity. Despite a similar increase in total lipid fraction when supplementing the high-fat diet with dietary glycotoxins, impairment in the suppression of de novo lipogenesis and decreased fatty acid unsaturation and esterification were observed. Moreover, glycotoxins also decreased polyunsaturated cardiolipins and caused oxidative stress, portal inflammation, and insulin resistance in high-fat diet-induced obese rats. Dietary glycated products do not change total lipid levels in the liver of obese rats but dramatically modify the lipidemic profile, leading to oxidative stress, hepatic lipotoxicity, and insulin resistance in obesity and thus contribute to the onset of NASH.

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Hypermethylation of Hepatic Glucokinase and L-Type Pyruvate Kinase Promoters in High-Fat Diet–Induced Obese Rats

Endocrinology ◽

10.1210/en.2010-1162 ◽

2011 ◽

Vol 152 (4) ◽

pp. 1284-1289 ◽

Cited By ~ 48

Author(s):

Minghong Jiang ◽

Yuhao Zhang ◽

Meng Liu ◽

Michael Shihli Lan ◽

Jing Fei ◽

...

Keyword(s):

Diabetes Mellitus ◽

Insulin Resistance ◽

Type 2 Diabetes ◽

Dna Methylation ◽

Type 2 Diabetes Mellitus ◽

High Fat Diet ◽

High Fat ◽

Dna Hypermethylation ◽

Obese Rats

Abstract Obesity-dependent insulin resistance and type 2 diabetes mellitus are closely associated with decreased glucose utilization and down-regulation of hepatic glycolytic enzymes expression. Previously, we showed that DNA hypermethylation is involved in age-dependent susceptibility to hepatic insulin resistance and diabetes. However, what we cannot distinguish is whether the age-related obesity contributes to DNA hypermethylation in those natural aging rats. In the present study, we hypothesize that DNA methylation plays a crucial role in the regulation of glycolytic enzymes in the high-fat diet–induced obesity. Here, we report that DNA hypermethylation is correlated with a decline in hepatic glucokinase (Gck) and L-type pyruvate kinase (LPK) expression in high-fat diet–induced obese rats as compared with the control diet group. Down-regulation of Gck and LPK expression are reversed by the 5-aza-2′-deoxycytidine in the cell model of steatosis. These novel observations indicate that DNA methylation is involved in the development of metabolic diseases, such as obesity, insulin resistance, type 2 diabetes mellitus, and nonalcoholic steatohepatitis, suggesting that the hypermethylation level of Gck and LPK promoters may be a useful parameter for the evaluation of obesity-induced insulin resistance and fatty liver.

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