Gamma-tocopherol, a major form of vitamin E in diets: Insights into antioxidant and anti-inflammatory effects, mechanisms, and roles in disease management

2021 ◽  
Author(s):  
Qing Jiang ◽  
Suji Im ◽  
James G. Wagner ◽  
Michele L. Hernandz ◽  
David B. Peden
Keyword(s):  
Vitamin E ◽  
Disease Management ◽  
Gamma Tocopherol ◽  
Major Form ◽  
Anti Inflammatory

scholarly journals Peyronie’s Disease: Management and New Therapeutic Acquisitions

2021 ◽  
Keyword(s):  
Vitamin E ◽  
Disease Management ◽  
Shock Waves ◽  
Erectile Function ◽  
Metabolic Diseases ◽  
Peyronie’S Disease ◽  
Simple Observation ◽  
Long Time ◽  
Peyronie's Disease ◽  
Anti Inflammatory

Peyronie's disease is a condition known for a long time but which has long been stigmatized as a malformation, misunderstood and generating shame and embarrassment on the part of patients. Because of its multifactorial aspect and its association with certain metabolic diseases, the treatment for many years consisted of a simple observation, the prescription of vitamin E or other anti-inflammatory or vasodilator molecules. We present here à new acquisition thanks to the application of linear shock waves, a promising and quite interesting element in the therapeutic arsenal. This technique, especially when coupled with the use of PDE-5 inhibitors and electroporation should make it possible to treat and improve not only punctually the fibrous nodule by improving the elasticity of the tissues concerned, but also of activate the circulation of the cavernous bodies of the penis thus improving erectile function allowing to give hope to many patients who are desperately seeking a solution to their problem.

scholarly journals Peyronie’s Disease: Management and New Therapeutic Acquisitions

2020 ◽  
Vol I (2) ◽  
pp. 25-30
Author(s):  
Alain Bitton
Keyword(s):  
Vitamin E ◽  
Disease Management ◽  
Shock Waves ◽  
Erectile Function ◽  
Metabolic Diseases ◽  
Peyronie’S Disease ◽  
Simple Observation ◽  
Long Time ◽  
Peyronie's Disease ◽  
Anti Inflammatory

Peyronie’s disease is a condition known for a long time but which has long been stigmatized as a malformation, misunderstood and generating shame and embarrassment on the part of patients. Because of its multifactorial aspect and its association with certain metabolic diseases, the treatment for many years consisted of a simple observation, the prescription of vitamin E or other anti-inflammatory or vasodilator molecules. We present here a new acquisition thanks to the application of linear shock waves, a promising and quite interesting element in the therapeutic arsenal. This technique, especially when coupled with the use of PDE-5 inhibitors and electroporation should make it possible to treat and improve not only punctually the fibrous nodule by improving the elasticity of the tissues concerned, but also of activate the circulation of the cavernous bodies of the penis thus improving erectile function allowing to give hope to many patients who are desperately seeking a solution to their problem.

scholarly journals Effect of Vitamin E Isoforms on Bone Metabolism in C57BL/6 J Mice Fed a High Fat Diet

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1795-1795
Author(s):  
Chen Du ◽  
Gina Tran ◽  
Victorine Imrhan ◽  
Chandan Prasad ◽  
Parakat Vijayagopal ◽  
...  
Keyword(s):  
Vitamin E ◽  
Bone Loss ◽  
Bone Metabolism ◽  
Bone Mineral ◽  
High Fat Diet ◽  
Alpha Tocopherol ◽  
Type I ◽  
High Fat ◽  
Mineral Density ◽  
Gamma Tocopherol

Abstract Objectives The purpose of this study was to compare the effects of alpha tocopherol, gamma tocopherol, and the combination of alpha and gamma tocopherols on bone mineral density (BMD), bone mineral content (BMC), and bone metabolism in C57BL/6 J mice fed a high-fat diet. Methods A total of 75 male C57BL/6 mice were randomized to either a low fat diet (LFD) with 6% fat, a high fat diet (HFD) with 20% fat, HFD supplemented with alpha tocopherol (AT), gamma tocopherol (GT), or the combination of AT and GT. LFD and HFD were provided to corresponding groups of mice without vitamin E isoform supplements for 15 weeks to induce bone loss. At the end of the 15 weeks, AT, GT, and a combination of AT and GT were added to 3 of the HFD groups and fed for 10 weeks. LFD group and one of the HFD groups were continued on the same diet for another 10 weeks without additional supplements. All mice were euthanized at the end of the 25 weeks period. Left and right fibula bones were excised, cleaned, and scanned using the Lunar PIXImus dual-energy x-ray absorptiometry (DEXA) densitometer to assess BMD, BMC, lean tissue, and fat tissue content. Serum biomarkers of bone metabolism were evaluated post euthanization. Results HFD resulted in significantly lower fibular BMD and higher tibial bone fat content in comparison to LFD. Animals in the HFD supplemented with GT, but not AT, showed significantly reduced effect of HFD in lowering BMD. Additionally, in the group fed HFD supplemented with GT, a significantly higher concentration of alkaline phosphatase (ALP) and N-terminal propeptide of type I procollagen (PINP) were noted, compared to LFD. This may be indicative of increased bone formation resulting from GT incorporated into the HFD diet. Conclusions The findings of the study suggest that different isoforms of vitamin E affect bone density and bone metabolism differently. Within the different isoforms of vitamin E, gamma tocopherol may have protective effects in bone, especially in the situation of high fat diet induced bone loss. Further examination of the mechanistic action of vitamin E isoforms on skeletal health is warranted. Funding Sources Texas Woman's University.

Relative Bioavailabilities of Natural and Synthetic Vitamin E Formulations Containing Mixed Tocopherols in Human Subjects

1999 ◽  
Vol 69 (2) ◽  
pp. 92-95 ◽  
Author(s):  
Chopra ◽  
Bhagavan
Keyword(s):  
Vitamin E ◽  
Animal Models ◽  
Human Subjects ◽  
Alpha Tocopherol ◽  
Tocopheryl Acetate ◽  
Normal Male ◽  
Gamma Tocopherol ◽  
Synthetic Vitamin ◽  
Male Subjects ◽  
Natural And Synthetic

There are several reports in the literature on the relative bioavailabilities of RRR (natural) vs. all-rac (synthetic) forms of vitamin E in humans and animal models but none on the bioavailability of alpha-tocopherol in mixed vitamin E formulations. In the present study we examined the bioavailability of alpha-tocopherol in a typical commercially available product containing mixed tocopherols. We also tested a formulation containing all-rac-alpha-tocopherol with mixed tocopherols for purposes of comparison along with straight RRR-and all-rac-alpha-tocopheryl acetate as reference products. Normal male subjects were given one of the four formulations of vitamin E (800 IU per day in softgel capsule form for 10 days): 1. All-rac-alpha-tocopheryl acetate, 2. RRR-alpha-tocopheryl acetate, 3. RRR-alpha-tocopherol with mixed tocopherols, and 4. all-rac-alpha-tocopherol with mixed tocopherols. Both serum alpha- and gamma-tocopherols were determined by HPLC at baseline, and at days 2, 4, 7 and 10. The values for alpha- at baseline and 10 days were 0.80, 0.80, 0.80 & 0.79 mg/dl and 1.67, 1.72, 1.76 & 1.62 mg/dl. The values for gamma- were 0.28, 0.29, 0.30 & 0.29 mg/dl and 0.11, 0.08, 0.10 & 0.10 mg/dl. Thus the data show that a) the bioavailability of RRR-and all-rac-alpha-tocopherols is not affected by other tocopherols, and b) both RRR-and all-rac-alpha-tocopherol (free or esterified) significantly suppress the serum gamma tocopherol to the same extent. Furthermore, since there was no difference in the serum values of alpha-tocopherol between RRR-and all-rac-vitamin E given the same dose as IUs, the data also support the currently accepted ratio of 1.36 for the biopotency of RRR- vs. all-rac-alpha-tocopheryl acetate.

Anti-inflammatory effects of vitamin E on experimental lens-induced uveitis

1992 ◽  
Vol 16 (1) ◽  
pp. 27-32 ◽  
Author(s):  
Lilet Cid ◽  
Geeta Pararajasegaram ◽  
Alex Sevanian ◽  
William Gauderman ◽  
Jorge L. Romero ◽  
...  
Keyword(s):  
Vitamin E ◽  
Anti Inflammatory

scholarly journals Acai Extract Transiently Upregulates Erythropoietin by Inducing a Renal Hypoxic Condition in Mice

Nutrients ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 533 ◽  
Author(s):  
Shuichi Shibuya ◽  
Toshihiko Toda ◽  
Yusuke Ozawa ◽  
Mario Jose Villegas Yata ◽  
Takahiko Shimizu
Keyword(s):  
Gene Expression ◽  
Fatty Acids ◽  
Vitamin E ◽  
Unsaturated Fatty Acids ◽  
Single Injection ◽  
Hypoxic Condition ◽  
Brazilian Amazon ◽  
Euterpe Oleracea ◽  
Anti Inflammatory ◽  
Euterpe Oleracea Mart

Acai (Euterpe oleracea Mart. Palmae, Arecaceae) is a palm plant native to the Brazilian Amazon. It contains many nutrients, such as polyphenols, iron, vitamin E, and unsaturated fatty acids, so in recent years, many of the antioxidant and anti-inflammatory effects of acai have been reported. However, the effects of acai on hematopoiesis have not been investigated yet. In the present study, we administered acai extract to mice and evaluated its hematopoietic effects. Acai treatment significantly increased the erythrocytes, hemoglobin, and hematocrit contents compared to controls for four days. Then, we examined the hematopoietic-related markers following a single injection. Acai administration significantly increased the levels of the hematopoietic-related hormone erythropoietin in blood compared to controls and also transiently upregulated the gene expression of Epo in the kidney. Furthermore, in the mice treated with acai extract, the kidneys were positively stained with the hypoxic probe pimonidazole in comparison to the controls. These results demonstrated that acai increases the erythropoietin expression via hypoxic action in the kidney. Acai can be expected to improve motility through hematopoiesis.

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