Anti-inflammatory effects of vitamin E on experimental lens-induced uveitis

1992 ◽  
Vol 16 (1) ◽  
pp. 27-32 ◽  
Author(s):  
Lilet Cid ◽  
Geeta Pararajasegaram ◽  
Alex Sevanian ◽  
William Gauderman ◽  
Jorge L. Romero ◽  
...  
Keyword(s):  
Vitamin E ◽  
Anti Inflammatory

scholarly journals Acai Extract Transiently Upregulates Erythropoietin by Inducing a Renal Hypoxic Condition in Mice

Nutrients ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 533 ◽  
Author(s):  
Shuichi Shibuya ◽  
Toshihiko Toda ◽  
Yusuke Ozawa ◽  
Mario Jose Villegas Yata ◽  
Takahiko Shimizu
Keyword(s):  
Gene Expression ◽  
Fatty Acids ◽  
Vitamin E ◽  
Unsaturated Fatty Acids ◽  
Single Injection ◽  
Hypoxic Condition ◽  
Brazilian Amazon ◽  
Euterpe Oleracea ◽  
Anti Inflammatory ◽  
Euterpe Oleracea Mart

Acai (Euterpe oleracea Mart. Palmae, Arecaceae) is a palm plant native to the Brazilian Amazon. It contains many nutrients, such as polyphenols, iron, vitamin E, and unsaturated fatty acids, so in recent years, many of the antioxidant and anti-inflammatory effects of acai have been reported. However, the effects of acai on hematopoiesis have not been investigated yet. In the present study, we administered acai extract to mice and evaluated its hematopoietic effects. Acai treatment significantly increased the erythrocytes, hemoglobin, and hematocrit contents compared to controls for four days. Then, we examined the hematopoietic-related markers following a single injection. Acai administration significantly increased the levels of the hematopoietic-related hormone erythropoietin in blood compared to controls and also transiently upregulated the gene expression of Epo in the kidney. Furthermore, in the mice treated with acai extract, the kidneys were positively stained with the hypoxic probe pimonidazole in comparison to the controls. These results demonstrated that acai increases the erythropoietin expression via hypoxic action in the kidney. Acai can be expected to improve motility through hematopoiesis.

Extended delivery of non-steroidal anti-inflammatory drugs through contact lenses loaded with Vitamin E and cationic surfactants

2019 ◽  
Vol 42 (5) ◽  
pp. 546-552 ◽  
Author(s):  
Cesar Torres-Luna ◽  
Naiping Hu ◽  
Tejaswi Tammareddy ◽  
Roman Domszy ◽  
Jeffrey Yang ◽  
...  
Keyword(s):  
Vitamin E ◽  
Cationic Surfactants ◽  
Contact Lenses ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

scholarly journals Anti-Inflammatory Effects of Vitamin E in Response to Candida albicans

2020 ◽  
Vol 8 (6) ◽  
pp. 804
Author(s):  
Silvana Barros ◽  
Ana Paula D. Ribeiro ◽  
Steven Offenbacher ◽  
Zvi G. Loewy
Keyword(s):  
Candida Albicans ◽  
Vitamin E ◽  
Inflammatory Responses ◽  
Arachidonic Acid Metabolism ◽  
Experimental Conditions ◽  
Mrna Extraction ◽  
Anti Inflammatory ◽  
Nf Kappab ◽  
Pathway Analyses

Oral mucositis, inflammation, and ulceration that occur in the oral cavity can manifest in significant pain. A formulation was designed to investigate the potential of vitamin E to ameliorate inflammation resulting from Candida albicans in cell-based systems. Human gingival fibroblasts and THP1 cells were stimulated with heat killed C. albicans and Porphyromonas gingivalis LPS (agonists). Unstimulated cells were included as controls. Cells were also simultaneously treated with a novel denture adhesive formulation that contains vitamin E (antagonist). The experimental conditions included cells exposed to the experimental formulation or the vehicle for 2 h for mRNA extraction and analysis, and cells left for 24 h under those experimental conditions for analysis of protein expression by ELISA. ssAffymetrix expression microarray pathway analyses demonstrated that the tested formulation exhibited a statistically significant (p < 0.05) inhibition of the following key inflammatory pathways: TLR 6, IL-1 signaling (IRAK, A20), NF-kappaB, IL-6 signaling (gp130, JK2 and GRB2), TNF signaling (TNF receptor) and Arachidonic acid metabolism (PLA2). Quantitative PCR array analysis confirmed the downregulation of key inflammatory genes when cells under adhesive treatment were challenged with heat killed C. albicans. PGE2 secretion was inhibited by the tested formulation only on THP1 cells after 24 h stimulation with C. albicans. These results suggest that the active formulation containing vitamin E acetate can modulate inflammatory responses, through anti-inflammatory actions as indicated by in vitro experimental conditions.

scholarly journals In vitro blood compatibility evaluation method: incubating while rotating hemodialyzers filled with fresh human blood

2020 ◽  
Author(s):  
Kinue Kamata ◽  
Yoshihiro Hatanaka ◽  
Hiromi Tanaka ◽  
Satoru Inoue ◽  
Yusuke Tokimizu ◽  
...  
Keyword(s):  
Vitamin E ◽  
Blood Cell ◽  
Experimental Method ◽  
Human Blood ◽  
Evaluation Method ◽  
Blood Compatibility ◽  
In Vitro Evaluation ◽  
Dialysis Membranes ◽  
Anti Inflammatory

AbstractOne of the often-used methods for in vitro evaluation of the blood compatibility of hemodialysis membranes is the circulation of human blood through a miniaturized hemodialyzer. The use of a rather small amount of human blood in its evaluation is one advantage of this method. However, because it is manufactured by a different process than actual ones, a miniaturized hemodialyzer membrane cannot always preserve the properties of actual hemodialyzers. To address this problem, we established a new experimental method that uses a relatively small amount of human blood and actual dialyzers. In this method, a test hemodialyzer and a control hemodialyzer filled with human blood obtained from the same donor is slowly rotated to prevent spontaneous blood cell sedimentation for 4 h at 37 °C. By use of this method, we were able to compare blood compatibility between a polysulfone (PS) membrane and a vitamin E (VE)-bonded PS membrane in terms of their relative antithrombotic, antioxidative, and anti-inflammatory properties. Consistent with many previous reports, the results clearly showed that compared with the PS membrane, VE-bonded PS membrane is more blood compatible. These findings suggest that our method is applicable, at least to in vitro blood compatibility evaluation of PS type dialysis membranes.

The anti-inflammatory effects of hydroxytyrosol and vitamin e on paediatric NAFLD

2020 ◽  
Vol 52 ◽  
pp. e42-e43 ◽  
Author(s):  
A. Mosca ◽  
A. Crudele ◽  
G. Tozzi ◽  
T. Alterio ◽  
A. Smeriglio ◽  
...  
Keyword(s):  
Vitamin E ◽  
Anti Inflammatory

scholarly journals Peyronie’s Disease: Management and New Therapeutic Acquisitions

2021 ◽  
Keyword(s):  
Vitamin E ◽  
Disease Management ◽  
Shock Waves ◽  
Erectile Function ◽  
Metabolic Diseases ◽  
Peyronie’S Disease ◽  
Simple Observation ◽  
Long Time ◽  
Peyronie's Disease ◽  
Anti Inflammatory

Peyronie's disease is a condition known for a long time but which has long been stigmatized as a malformation, misunderstood and generating shame and embarrassment on the part of patients. Because of its multifactorial aspect and its association with certain metabolic diseases, the treatment for many years consisted of a simple observation, the prescription of vitamin E or other anti-inflammatory or vasodilator molecules. We present here à new acquisition thanks to the application of linear shock waves, a promising and quite interesting element in the therapeutic arsenal. This technique, especially when coupled with the use of PDE-5 inhibitors and electroporation should make it possible to treat and improve not only punctually the fibrous nodule by improving the elasticity of the tissues concerned, but also of activate the circulation of the cavernous bodies of the penis thus improving erectile function allowing to give hope to many patients who are desperately seeking a solution to their problem.

Sign in / Sign up

Export Citation Format

Share Document