Constitutive expression of PPARγ inhibits proliferation and migration of gastric cancer cells and down-regulates Wnt/β-Catenin signaling pathway downstream target genes TERT and ENAH

Gene ◽  
2016 ◽  
Vol 584 (1) ◽  
pp. 31-37 ◽  
Author(s):  
Fang Guo ◽  
Xiyun Ren ◽  
Yingzi Dong ◽  
Xiaomeng Hu ◽  
Dan Xu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Target Genes ◽  
Constitutive Expression ◽  
Gastric Cancer Cells ◽  
Downstream Target ◽  
And Migration ◽  
Proliferation And Migration

scholarly journals ATM Signaling Pathway Is Implicated in the SMYD3-mediated Proliferation and Migration of Gastric Cancer Cells

2017 ◽  
Vol 17 (4) ◽  
pp. 295 ◽  
Author(s):  
Lei Wang ◽  
Qiu-Tong Wang ◽  
Yu-Peng Liu ◽  
Qing-Qing Dong ◽  
Hai-Jie Hu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Gastric Cancer Cells ◽  
And Migration ◽  
Atm Signaling Pathway ◽  
Atm Signaling ◽  
Proliferation And Migration

Exosomal miR-155-5p promotes proliferation and migration of gastric cancer cells by inhibiting TP53INP1 expression

2020 ◽  
Vol 216 (6) ◽  
pp. 152986
Author(s):  
Shuai-Shuai Shi ◽  
Hui-Peng Zhang ◽  
Chang-Qing Yang ◽  
Li-Na Li ◽  
Yu Shen ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Gastric Cancer Cells ◽  
And Migration ◽  
Proliferation And Migration

scholarly journals TRAF6 Promotes Gastric Cancer Cell Self-Renewal, Proliferation, and Migration

2020 ◽  
Vol 2020 ◽  
pp. 1-11
Author(s):  
Mengting Yang ◽  
Meng Jin ◽  
Kailong Li ◽  
Haifeng Liu ◽  
Xiaxia Yang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Epithelial Mesenchymal Transition ◽  
Tumor Necrosis Factor Receptor ◽  
Gastric Cancer Cells ◽  
Mesenchymal Transition ◽  
In The Wild ◽  
And Migration ◽  
Exact Effect ◽  
Proliferation And Migration

Gastric cancer is the third most common type of tumor associated with death. TRAF6 belongs to the tumor necrosis factor receptor-associated factor family and has been demonstrated to be involved in tumor progression in various cancers. However, the exact effect of TRAF6 on gastric cancer stem cells has not been extensively studied. In this study, abnormal expression of TRAF6 was found in gastric cancer tissues. Overexpression of TRAF6 enhanced proliferation and migration, and TRAF6 knockdown reversed this phenomenon in gastric cancer cells. Moreover, TRAF6 may inhibit differentiation and promote stemness and epithelial-mesenchymal transition (EMT). Transcriptome profiles revealed 701 differentially expressed genes in the wild-type group and the TRAF6 knockout group. Potential molecules associated with cell proliferation and migration were identified, including MAPK, FOXO, and IL-17. In conclusion, TRAF6 is a significant factor promoting proliferation and migration in gastric cancer cells and may provide a new target for the accurate treatment of gastric cancer.

RUNX3-mediated up-regulation of miR-29b suppresses the proliferation and migration of gastric cancer cells by targeting KDM2A

2016 ◽  
Vol 381 (1) ◽  
pp. 138-148 ◽  
Author(s):  
Ye Kong ◽  
Shuiyan Zou ◽  
Fenghua Yang ◽  
Xia Xu ◽  
Wenhong Bu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Gastric Cancer Cells ◽  
And Migration ◽  
Proliferation And Migration
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