The relationship analysis of microRNA-146a rs2910164 polymorphism with risk of colorectal cancer in province of South-Khorasan, Iran

Gene Reports ◽  
2020 ◽  
Vol 21 ◽  
pp. 100953
Author(s):  
Mansoore Saharkhiz ◽  
Tahmine Tavakoli ◽  
Tahereh Fakharian ◽  
Ehsan Soltaninejad ◽  
Mohsen Naseri
2020 ◽  
Vol 7 (2) ◽  
pp. 40-49
Author(s):  
Abdul Rivai

This study aims to determine and understand the relationship between work motivation and participatory leadership with the work behavior of the Functional Staff of the Education and Culture Office of East Nusa Tenggara Province because the Province of East Nusa Tenggara is one of the provinces whose development and growth is relatively slower compared to other provinces in Indonesia. The study population was the functional staff who did not have a structural position of 94 people. Samples were taken as many as 75 people. Data collection using a questionnaire instrument.Based on hypothesis testing, this study found: (1) there was a relationship between work motivation and work behavior in which work motivation contributed 49.29% to work behavior, (2) there was a positive relationship between participative leadership and work behavior in which participative leadership contributed 51.49% of work behavior, and there is a positive relationship between work motivation and participatory leadership together with work behavior. Where work motivation and participatory leadership together contribute 67.01% to work behavior. From the three findings, the conclusions of this study are stated that: (a) Work behavior provides a good relationship to increase work motivation, (b) Work behavior can be improved by considering participatory leadership, by involving employees in every decision making, respecting opinions and proposals employees, and enhance collaboration.


Author(s):  
Richard Culliford ◽  
Alex J. Cornish ◽  
Philip J. Law ◽  
Susan M. Farrington ◽  
Kimmo Palin ◽  
...  

Abstract Background Epidemiological studies of the relationship between gallstone disease and circulating levels of bilirubin with risk of developing colorectal cancer (CRC) have been inconsistent. To address possible confounding and reverse causation, we examine the relationship between these potential risk factors and CRC using Mendelian randomisation (MR). Methods We used two-sample MR to examine the relationship between genetic liability to gallstone disease and circulating levels of bilirubin with CRC in 26,397 patients and 41,481 controls. We calculated the odds ratio per genetically predicted SD unit increase in log bilirubin levels (ORSD) for CRC and tested for a non-zero causal effect of gallstones on CRC. Sensitivity analysis was applied to identify violations of estimator assumptions. Results No association between either gallstone disease (P value = 0.60) or circulating levels of bilirubin (ORSD = 1.00, 95% confidence interval (CI) = 0.96–1.03, P value = 0.90) with CRC was shown. Conclusions Despite the large scale of this study, we found no evidence for a causal relationship between either circulating levels of bilirubin or gallstone disease with risk of developing CRC. While the magnitude of effect suggested by some observational studies can confidently be excluded, we cannot exclude the possibility of smaller effect sizes and non-linear relationships.


2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Keita Tanaka ◽  
Yoichiro Yoshida ◽  
Teppei Yamada ◽  
Takaomi Hayashi ◽  
Hideki Shimaoka ◽  
...  

AbstractThe detection of circulating cell-free DNA (cfDNA) by liquid biopsy is reported to provide prognostic information in colorectal cancer (CRC). Although the frequency of BRAF V600E mutation in CRC is less than 10%, it is associated with poor responses to conventional chemotherapy. We conducted a prospective study to investigate the relationship between the perioperative mutant allele frequency (MAF) of BRAF V600E and tumor recurrence, and to evaluate the possibility of early detection of recurrence. Among 362 patients who underwent radical resection, cfDNA was extracted from the perioperative blood of 11 CRC patients with BRAF V600E mutation and analyzed using the digital polymerase chain reaction (dPCR) system. The median follow-up time was 22 months, and there were four cases of recurrence. Although there was no correlation between recurrence and the perioperative MAF of BRAF V600E, tumor diameter was correlated with the MAF (p = 0.024), and the MAF increased with time in two patients from whom additional samples were obtained prior to recurrence. In this study, we identified a correlation between the pathological tumor diameter and the MAF, but it was difficult to predict recurrence by measuring cfDNA with BRAF V600E mutation in the perioperative period of radical resection of CRC.


Energies ◽  
2021 ◽  
Vol 14 (4) ◽  
pp. 1200
Author(s):  
Yong-Joon Jun ◽  
Seung-ho Ahn ◽  
Kyung-Soon Park

The Green Remodeling Project under South Korea’s Green New Deal policy is a government-led project intended to strengthen the performance sector directly correlated with energy performance among various elements of improvement applicable to building remodeling by replacing insulation materials, introducing new and renewable energy, introducing high-efficiency equipment, etc., with public buildings taking the lead in green remodeling in order to induce energy efficiency enhancement in private buildings. However, there is an ongoing policy that involves the application of a fragmentary value judgment criterion, i.e., whether to apply technical elements confined to the enhancement of the energy performance of target buildings and the prediction of improvement effects according thereto, thus resulting in the phenomenon of another important value criterion for green remodeling, i.e., the enhancement of the occupant (user) comfort performance of target buildings as one of its purposes, being neglected instead. In order to accurately grasp the current status of these problems and to promote ‘expansion of the value judgment criteria for green remodeling’ as an alternative, this study collected energy usage data of buildings actually used by public institutions and then conducted a total analysis. After that, the characteristics of energy usage were analyzed for each of the groups of buildings classified by year of completion, thereby carrying out an analysis of the correlation between the non-architectural elements affecting the actual energy usage and the actual energy usage data. The correlation between the improvement performance of each technical element and the actual improvement effect was also analyzed, thereby ascertaining the relationship between the direction of major policy strategies and the actual energy usage. As a result of the relationship analysis, it was confirmed that the actual energy usage is more affected by the operating conditions of the relevant building than the application of individual strategic elements such as the performance of the envelope insulation and the performance of the high-efficiency system. In addition, it was also confirmed that the usage of public buildings does not increase in proportion to their aging. The primary goal of reducing energy usage in target buildings can be achieved if public sector (government)-led green remodeling is pushed ahead with in accordance with biased value judgment criteria, just as in the case of a campaign to refrain from operating cooling facilities in aging public buildings. However, it was possible to grasp through the progress of this study that the remodeling may also result in the deterioration of environmental comfort and stability, such as the numerical value of the indoor thermal environment. The results of this study have the significance of providing basic data for pushing ahead with a green remodeling policy in which the value judgment criteria for aging existing public buildings are more expanded, and it is necessary to continue research in such a direction that the quantitative purpose of green remodeling, which is to reduce energy usage in aging public buildings, and its qualitative purpose, which is to enhance their environmental performance for occupants’ comfort, can be mutually balanced and secured at the same time.


2019 ◽  
Vol 26 (13) ◽  
pp. 4397-4404 ◽  
Author(s):  
Hester C. van Wyk ◽  
Antonia Roseweir ◽  
Peter Alexander ◽  
James H. Park ◽  
Paul G. Horgan ◽  
...  

Abstract Background Tumor budding is an independent prognostic factor in colorectal cancer (CRC) and has recently been well-defined by the International Tumour Budding Consensus Conference (ITBCC). Objective The aim of the present study was to use the ITBCC budding evaluation method to examine the relationship between tumor budding, tumor factors, tumor microenvironment, and survival in patients with primary operable CRC. Methods Hematoxylin and eosin-stained slides of 952 CRC patients diagnosed between 1997 and 2007 were evaluated for tumor budding according to the ITBCC criteria. The tumor microenvironment was evaluated using tumor stroma percentage (TSP) and Klintrup–Makinen (KM) grade to assess the tumor inflammatory cell infiltrate. Results High budding (n = 268, 28%) was significantly associated with TNM stage (p < 0.001), competent mismatch repair (MMR; p < 0.05), venous invasion (p < 0.001), weak KM grade (p < 0.001), high TSP (p < 0.001), and reduced cancer-specific survival (CSS) (hazard ratio 8.68, 95% confidence interval 6.30–11.97; p < 0.001). Tumor budding effectively stratifies CSS stage T1 through to T4 (all p < 0.05) independent of associated factors. Conclusions Tumor budding effectively stratifies patients’ survival in primary operable CRC independent of other phenotypic features. In particular, the combination of T stage and budding should form the basis of a new staging system for primary operable CRC.


1996 ◽  
Vol 73 (8) ◽  
pp. 902-908 ◽  
Author(s):  
AN Freedman ◽  
AM Michalek ◽  
JR Marshall ◽  
CJ Mettlin ◽  
NJ Petrelli ◽  
...  

2009 ◽  
Vol 18 (7) ◽  
pp. 995-1001 ◽  
Author(s):  
Karen J. Wernli ◽  
Yinghui Wang ◽  
Yingye Zheng ◽  
John D. Potter ◽  
Polly A. Newcomb

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