Urinary arsenic concentration among residents of an arsenic-endemic area in southern Thailand and its related factors: Three decades after mitigation attempts

2022 ◽  
pp. 100725
Author(s):  
Udomsak Saengow ◽  
Surasak Vijitpongjinda ◽  
Supabhorn Yimthiang ◽  
Apichai Wattanapisit ◽  
Sirilak Thaicharoen
Keyword(s):  
Endemic Area ◽  
Arsenic Concentration ◽  
Related Factors ◽  
Urinary Arsenic ◽  
Southern Thailand

scholarly journals Elevated Urinary Arsenic Level among Residents of an Arsenic-Endemic Area of Southern Thailand and its Related Factors: Three Decades after Mitigation Attempts

2020 ◽  
Author(s):  
Udomsak Saengow ◽  
Surasak Vijitpongjinda ◽  
Supabhorn Yimthiang ◽  
Apichai Wattanapisit ◽  
Sirilak Thaicharoen
Keyword(s):  
Respiratory Diseases ◽  
Water Sources ◽  
Previous Survey ◽  
Arsenic Level ◽  
Related Factors ◽  
Urinary Arsenic ◽  
Southern Thailand ◽  
Use Behavior ◽  
Study Participants ◽  
Contamination Problem

Three decades ago, human arsenic (As) contamination has been recognized in Ron Phibun, a sub-district with tin mining activity in southern Thailand. Since then different government bodies have attempted to mitigate the As-contamination problem by providing safe water in households. The most recent study conducted during 2000-2002 reported only a small fraction of population still had high urinary As level. Less attention has been paid to this issue afterwards. The present study aimed to re-assess the current situation, including human As contamination, water use behavior as well as identify risk factors of elevated As concentration among residents of Ron Phibun. The survey of 560 participants living in Ron Phibun with urinary As assessment was conducted. The median urinary As concentration of study participants was higher than normal. Consumption of shallow well water, a source generally considered as As-contaminated, was higher than a previous survey. A significant association was observed between urinary As concentrations and water sources for drinking and cooking. Gender and educational level were found to be associated with urinary As concentration. Significant associations between urinary As concentration and certain diseases (respiratory diseases, dermatitis, and dyslipidemia) were observed. The findings suggested further investigation of all water sources in the area for As contamination.

scholarly journals Urinary arsenic concentration in a high arsenic area of south west England.

1997 ◽  
Vol 54 (11) ◽  
pp. 840-840 ◽  
Author(s):  
P Kavanagh ◽  
M E Farago ◽  
I Thornton ◽  
P Elliott ◽  
W Goessler ◽  
...  
Keyword(s):  
Arsenic Concentration ◽  
Urinary Arsenic ◽  
South West ◽  
South West England ◽  
High Arsenic

The Arsenic Concentration in Saliva, Urine and Drinking Water in Endemic Arsenicosis Area in Shanyin County of Shanxi Province, China

2011 ◽  
Vol 140 ◽  
pp. 465-468 ◽  
Author(s):  
Da Peng Wang ◽  
San Xiang Wang ◽  
Zheng Hui Wang ◽  
Li Ming Zhang ◽  
Jian Li ◽  
...  
Keyword(s):  
Drinking Water ◽  
Inductively Coupled Plasma ◽  
Arsenic Concentration ◽  
Positive Association ◽  
Shanxi Province ◽  
Atomic Fluorescence Spectrometry ◽  
Arsenic Level ◽  
Significant Positive Association ◽  
Inductively Coupled ◽  
Urinary Arsenic

Biological monitoring for arsenic(As) is usually based upon a determination of urine, blood, nail and hair arsenic concentration, however, saliva has been suggested as a non-invasive biological matrix for assessing exposure. To further evaluate the potential utility of saliva for arsenic biomonitoring, Atomic Fluorescence Spectrometry(AFS-230) and Inductively Coupled Plasma Mass Spectrometer (ICP-MS) were used to evaluate the concentration of arsenic in drinking water, saliva and urine in endemic arsenicosis area in Shanyin County of Shanxi Province. The results showed that the arsenic concentration in drinking water was 0.55-720.0ug/L, and there were 66.67% samples above the arsenic level (50μg/L) of standards for drinking water quality. The median value of arsenic in drinking water was 127.22 μg/L. The salivary and urinary arsenic both can reflect the exposure of arsenic in drinking water. Additionally, there was a significant positive association of salivary arsenic compared with arsenic in drinking water (r=0.674, P<0.05)and urinary arsenic(r=0.794, P<0.05). These results demonstrated that, similar to urinary arsenic, salivary arsenic also can be used as a biomarker for assessing human exposue to arsenic.

Chronic Kidney Disease and Its Related Factors in an Endemic Area of Dioxin Exposure in Southern Taiwan

Epidemiology ◽  
2011 ◽  
Vol 22 ◽  
pp. S130
Author(s):  
Chien-Yuan Huang ◽  
Jin-Shang Wu ◽  
Cheng-Long Wu ◽  
Jung-Wei Chang ◽  
Ching-Chang Lee ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Endemic Area ◽  
Related Factors ◽  
Southern Taiwan ◽  
Dioxin Exposure

scholarly journals Presence of Autoimmune Antibody in Chikungunya Infection

2009 ◽  
Vol 2009 ◽  
pp. 1-4 ◽  
Author(s):  
Wirach Maek-a-nantawat ◽  
Udomsak Silachamroon
Keyword(s):  
Muscle Weakness ◽  
Antinuclear Antibody ◽  
Endemic Area ◽  
Chikungunya Virus ◽  
Specific Treatment ◽  
Close Monitoring ◽  
Southern Thailand ◽  
Arbovirus Infection

Chikungunya infection has recently re-emerged as an important arthropod-borne disease in Thailand. Recently, Southern Thailand was identified as a potentially endemic area for the chikungunya virus. Here, we report a case of severe musculoskeletal complication, presenting with muscle weakness and swelling of the limbs. During the investigation to exclude autoimmune muscular inflammation, high titers of antinuclear antibody were detected. This is the report of autoimmunity detection associated with an arbovirus infection. The symptoms can mimic autoimmune polymyositis disease, and the condition requires close monitoring before deciding to embark upon prolonged specific treatment with immunomodulators.

Urinary arsenic profile in residents of blackfoot disease-endemic area in Taiwan: Role of GSTO1 and GSTO2 polymorphisms

2006 ◽  
Vol 164 ◽  
pp. S201
Author(s):  
Wan-Fen Li ◽  
Chien-Wen Sun ◽  
Kuang-Hsi Chang ◽  
Shu-Li Wang
Keyword(s):  
Endemic Area ◽  
Blackfoot Disease ◽  
Urinary Arsenic

Association of arsenic levels in soil and water with urinary arsenic concentration of residents in the vicinity of closed metal mines

2013 ◽  
Vol 216 (3) ◽  
pp. 255-262 ◽  
Author(s):  
YongMin Cho ◽  
SungChul Seo ◽  
Seung-Hyun Choi ◽  
SeungKil Lee ◽  
KyungHee Kim ◽  
...  
Keyword(s):  
Arsenic Concentration ◽  
Urinary Arsenic ◽  
Metal Mines ◽  
Soil And Water

scholarly journals Variation in Arsenic metabolism in schistosomiasis associated bladder pathology in a rural community, Eggua, Ogun State, Nigeria

2021 ◽  
Vol 25 (9) ◽  
pp. 1645-1652
Author(s):  
A.T. Adeboye ◽  
H.O. Awobode ◽  
A.S. Adebayo ◽  
J.R. Djouaka ◽  
R.D. Isokpehi ◽  
...  
Keyword(s):  
Arsenic Concentration ◽  
Arsenic Exposure ◽  
Inorganic Arsenic ◽  
Urogenital Schistosomiasis ◽  
Arsenic Metabolism ◽  
Ogun State ◽  
Specific Pcr ◽  
Urinary Arsenic ◽  
Increased Risk ◽  
Bladder Pathology

Exposure to toxic inorganic Arsenic (iAs) in areas endemic for urogenital schistosomiasis may confer increased risk for bladder cancer. The severity of the adverse effects of iAs however depends on its metabolism, which is highly variable among individuals. Genetic polymorphism in Arsenic (+3) Methyl Transferase enzyme, accounts significantly for these variations. To investigate the relationship of AS3MT gene polymorphisms and Arsenic metabolism to schistosomiasis and/or associated bladder pathology, 119 individualsfrom Eggua in southwest Nigeria were recruited for this study. Screening for schistosomiasis and bladder pathology was done by microscopy and ultrasonography respectively. Wagtech Digital Arsenator was used to assess total urinary arsenic concentrations and thus determine the level of arsenic exposure. The single nucleotide polymorphism AS3MT/Met287Thr T>C (rs11191439) was genotyped using Alelle-Specific PCR. Of the participants who tested positive for schistosomiasis, 33.3% exhibited bladder pathology. Total urinary arsenic concentration in 80% of the participants was above the WHO limit of 0.05mg/L. The Met287Thr allelic distribution conformed to the Hardy-Weinberg equilibrium (X2= 0.161, P> 0.05). Observed allelic frequencies were 0.96 and 0.04 for wild-type T and mutant C alleles respectively. There was no significant relationship between AS3MT SNP, arsenic concentrations and schistosomiasis associated bladder pathology. In conclusion, the community is highly exposed to arsenic, although with a possible genetic advantage of increased AS3MT catalytic activity. However, we see the need for urgent intervention as inter-individual differences in arsenic metabolism may influence the bladder pathology status of individuals in the community. And although urogenital schistosomiasis is waning in Eggua, it is not known what synergy the infection and high arsenic exposure may wield on bladder pathology.

scholarly journals Determinants of arsenic methylation efficiency and urinary arsenic level in pregnant women in Bangladesh

2019 ◽  
Vol 18 (1) ◽  
Author(s):  
Shangzhi Gao ◽  
Pi-I Lin ◽  
Golam Mostofa ◽  
Quazi Quamruzzaman ◽  
Mahmudur Rahman ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Energy Intake ◽  
Protein Intake ◽  
Arsenic Concentration ◽  
Arsenic Species ◽  
Exposure Level ◽  
Arsenic Level ◽  
Arsenic Metabolism ◽  
Arsenic Methylation ◽  
Urinary Arsenic

Abstract Background Prenatal inorganic arsenic (iAs) exposure is associated with pregnancy outcomes. Maternal capabilities of arsenic biotransformation and elimination may influence the susceptibility of arsenic toxicity. Therefore, we examined the determinants of arsenic metabolism of pregnant women in Bangladesh who are exposed to high levels of arsenic. Methods In a prospective birth cohort, we followed 1613 pregnant women in Bangladesh and collected urine samples at two prenatal visits: one at 4–16 weeks, and the second at 21–37 weeks of pregnancy. We measured major arsenic species in urine, including iAs (iAs%) and methylated forms. The proportions of each species over the sum of all arsenic species were used as biomarkers of arsenic methylation efficiency. We examined the difference in arsenic methylation using a paired t-test between first and second visits. Using linear regression, we examined determinants of arsenic metabolism, including age, BMI at enrollment, education, financial provider income, arsenic exposure level, and dietary folate and protein intake, adjusted for daily energy intake. Results Comparing visit 2 to visit 1, iAs% decreased 1.1% (p <  0.01), and creatinine-adjusted urinary arsenic level (U-As) increased 21% (95% CI: 15, 26%; p <  0.01). Drinking water arsenic concentration was positively associated with iAs% at both visits. When restricted to participants with higher adjusted urinary arsenic levels (adjusted U-As > 50 μg/g-creatinine) gestational age at measurement was strongly associated with DMA% (β = 0.38, p <  0.01) only at visit 1. Additionally, DMA% was negatively associated with daily protein intake (β = − 0.02, p <  0.01) at visit 1, adjusting for total energy intake and other covariates. Conclusions Our findings indicate that arsenic metabolism and adjusted U-As level increase during pregnancy. We have identified determinants of arsenic methylation efficiency at visit 1.

Sign in / Sign up

Export Citation Format

Share Document