scholarly journals Determinants of arsenic methylation efficiency and urinary arsenic level in pregnant women in Bangladesh

2019 ◽  
Vol 18 (1) ◽  
Author(s):  
Shangzhi Gao ◽  
Pi-I Lin ◽  
Golam Mostofa ◽  
Quazi Quamruzzaman ◽  
Mahmudur Rahman ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Energy Intake ◽  
Protein Intake ◽  
Arsenic Concentration ◽  
Arsenic Species ◽  
Exposure Level ◽  
Arsenic Level ◽  
Arsenic Metabolism ◽  
Arsenic Methylation ◽  
Urinary Arsenic

Abstract Background Prenatal inorganic arsenic (iAs) exposure is associated with pregnancy outcomes. Maternal capabilities of arsenic biotransformation and elimination may influence the susceptibility of arsenic toxicity. Therefore, we examined the determinants of arsenic metabolism of pregnant women in Bangladesh who are exposed to high levels of arsenic. Methods In a prospective birth cohort, we followed 1613 pregnant women in Bangladesh and collected urine samples at two prenatal visits: one at 4–16 weeks, and the second at 21–37 weeks of pregnancy. We measured major arsenic species in urine, including iAs (iAs%) and methylated forms. The proportions of each species over the sum of all arsenic species were used as biomarkers of arsenic methylation efficiency. We examined the difference in arsenic methylation using a paired t-test between first and second visits. Using linear regression, we examined determinants of arsenic metabolism, including age, BMI at enrollment, education, financial provider income, arsenic exposure level, and dietary folate and protein intake, adjusted for daily energy intake. Results Comparing visit 2 to visit 1, iAs% decreased 1.1% (p <  0.01), and creatinine-adjusted urinary arsenic level (U-As) increased 21% (95% CI: 15, 26%; p <  0.01). Drinking water arsenic concentration was positively associated with iAs% at both visits. When restricted to participants with higher adjusted urinary arsenic levels (adjusted U-As > 50 μg/g-creatinine) gestational age at measurement was strongly associated with DMA% (β = 0.38, p <  0.01) only at visit 1. Additionally, DMA% was negatively associated with daily protein intake (β = − 0.02, p <  0.01) at visit 1, adjusting for total energy intake and other covariates. Conclusions Our findings indicate that arsenic metabolism and adjusted U-As level increase during pregnancy. We have identified determinants of arsenic methylation efficiency at visit 1.

scholarly journals Education Level, Energy Intake and Protein With Nutritional Status Of Pregnant Women In Bungoro Health Center Work Area

2019 ◽  
Vol 25 (2) ◽  
pp. 38
Author(s):  
Khaeriya Megauleng ◽  
Mustamin Mustamin ◽  
Sunarto Sunarto
Keyword(s):  
Nutritional Status ◽  
Pregnant Women ◽  
Health Center ◽  
Energy Intake ◽  
Protein Intake ◽  
Education Level ◽  
Level Energy ◽  
Cross Sectional ◽  
Work Area ◽  
The Relationship

Education influences a changes in knowledge, attitudes, and lifestyle patterns in the selection of the type and amount of food consumed. The health of a pregnant women affects the fetus in her womb. Nutrient content consumed by the mother will be absorbed by the fetus which is important for the growth of the fetus itself. This study aims to determine the relationship of education level, energy intake and protein nutritional status of pregnant women in the Bungoro Health Center Work Area of Bungoro District, Pangkep Regency. This research is an analytical study with cross-sectional design. Samples were pregnant women, amount to 40 people. The level of education is obtained through a questionnaire. Energy and protein intake was obtained through 2x24 hours recall and then processed using menu A software. To find out the relationship between variables of education level, energy and protein intake with nutritional status, Chi-Square was tested using the SPSS program. Data is presented in the form of tables and narratives. The results showed that 77.5% of the sample education level was high. Sample energy intake was classified as less than 82.5% and 17.5% classified as good. Sample protein intake of 95% classified as poor and 5% classified as good. Nutritional status of pregnant women is 70% experiencing KEK and 30% normal. Statistical test results show that there is no relationship between education level, energy and protein intake and nutritional status of pregnant women in the Bungoro Health Center Work Area, Bungoro District, Pangkep Regency.

Polymorphisms in arsenic metabolism genes, urinary arsenic methylation profile and cancer

2009 ◽  
Vol 20 (9) ◽  
pp. 1653-1661 ◽  
Author(s):  
Chi-Jung Chung ◽  
Yu-Mei Hsueh ◽  
Chyi-Huey Bai ◽  
Yung-Kai Huang ◽  
Ya-Li Huang ◽  
...  
Keyword(s):  
Methylation Profile ◽  
Arsenic Metabolism ◽  
Arsenic Methylation ◽  
Urinary Arsenic

The Arsenic Concentration in Saliva, Urine and Drinking Water in Endemic Arsenicosis Area in Shanyin County of Shanxi Province, China

2011 ◽  
Vol 140 ◽  
pp. 465-468 ◽  
Author(s):  
Da Peng Wang ◽  
San Xiang Wang ◽  
Zheng Hui Wang ◽  
Li Ming Zhang ◽  
Jian Li ◽  
...  
Keyword(s):  
Drinking Water ◽  
Inductively Coupled Plasma ◽  
Arsenic Concentration ◽  
Positive Association ◽  
Shanxi Province ◽  
Atomic Fluorescence Spectrometry ◽  
Arsenic Level ◽  
Significant Positive Association ◽  
Inductively Coupled ◽  
Urinary Arsenic

Biological monitoring for arsenic(As) is usually based upon a determination of urine, blood, nail and hair arsenic concentration, however, saliva has been suggested as a non-invasive biological matrix for assessing exposure. To further evaluate the potential utility of saliva for arsenic biomonitoring, Atomic Fluorescence Spectrometry(AFS-230) and Inductively Coupled Plasma Mass Spectrometer (ICP-MS) were used to evaluate the concentration of arsenic in drinking water, saliva and urine in endemic arsenicosis area in Shanyin County of Shanxi Province. The results showed that the arsenic concentration in drinking water was 0.55-720.0ug/L, and there were 66.67% samples above the arsenic level (50μg/L) of standards for drinking water quality. The median value of arsenic in drinking water was 127.22 μg/L. The salivary and urinary arsenic both can reflect the exposure of arsenic in drinking water. Additionally, there was a significant positive association of salivary arsenic compared with arsenic in drinking water (r=0.674, P<0.05)and urinary arsenic(r=0.794, P<0.05). These results demonstrated that, similar to urinary arsenic, salivary arsenic also can be used as a biomarker for assessing human exposue to arsenic.

scholarly journals Variation in Arsenic metabolism in schistosomiasis associated bladder pathology in a rural community, Eggua, Ogun State, Nigeria

2021 ◽  
Vol 25 (9) ◽  
pp. 1645-1652
Author(s):  
A.T. Adeboye ◽  
H.O. Awobode ◽  
A.S. Adebayo ◽  
J.R. Djouaka ◽  
R.D. Isokpehi ◽  
...  
Keyword(s):  
Arsenic Concentration ◽  
Arsenic Exposure ◽  
Inorganic Arsenic ◽  
Urogenital Schistosomiasis ◽  
Arsenic Metabolism ◽  
Ogun State ◽  
Specific Pcr ◽  
Urinary Arsenic ◽  
Increased Risk ◽  
Bladder Pathology

Exposure to toxic inorganic Arsenic (iAs) in areas endemic for urogenital schistosomiasis may confer increased risk for bladder cancer. The severity of the adverse effects of iAs however depends on its metabolism, which is highly variable among individuals. Genetic polymorphism in Arsenic (+3) Methyl Transferase enzyme, accounts significantly for these variations. To investigate the relationship of AS3MT gene polymorphisms and Arsenic metabolism to schistosomiasis and/or associated bladder pathology, 119 individualsfrom Eggua in southwest Nigeria were recruited for this study. Screening for schistosomiasis and bladder pathology was done by microscopy and ultrasonography respectively. Wagtech Digital Arsenator was used to assess total urinary arsenic concentrations and thus determine the level of arsenic exposure. The single nucleotide polymorphism AS3MT/Met287Thr T>C (rs11191439) was genotyped using Alelle-Specific PCR. Of the participants who tested positive for schistosomiasis, 33.3% exhibited bladder pathology. Total urinary arsenic concentration in 80% of the participants was above the WHO limit of 0.05mg/L. The Met287Thr allelic distribution conformed to the Hardy-Weinberg equilibrium (X2= 0.161, P> 0.05). Observed allelic frequencies were 0.96 and 0.04 for wild-type T and mutant C alleles respectively. There was no significant relationship between AS3MT SNP, arsenic concentrations and schistosomiasis associated bladder pathology. In conclusion, the community is highly exposed to arsenic, although with a possible genetic advantage of increased AS3MT catalytic activity. However, we see the need for urgent intervention as inter-individual differences in arsenic metabolism may influence the bladder pathology status of individuals in the community. And although urogenital schistosomiasis is waning in Eggua, it is not known what synergy the infection and high arsenic exposure may wield on bladder pathology.

scholarly journals Urinary arsenic species and methylation efficiency during pregnancy: Concentrations and associated factors in Spanish pregnant women

2021 ◽  
Vol 196 ◽  
pp. 110889
Author(s):  
Raquel Soler-Blasco ◽  
Mario Murcia ◽  
Manuel Lozano ◽  
Blanca Sarzo ◽  
Ana Esplugues ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Associated Factors ◽  
Arsenic Species ◽  
Urinary Arsenic ◽  
Urinary Arsenic Species

scholarly journals Effect of Arsenic on Breastfed Baby of Arsenic Affected Lactating Mother

2017 ◽  
Vol 13 (1) ◽  
pp. 99-102
Author(s):  
Ferdousi Hasnat ◽  
Selina Khatun ◽  
Farhana Noman ◽  
Mohammad Ibrahim Khalil ◽  
Nusrat Nahar ◽  
...  
Keyword(s):  
Drinking Water ◽  
Human Milk ◽  
Motor Skills ◽  
Arsenic Concentration ◽  
Armed Forces ◽  
Control Group ◽  
Arsenic Level ◽  
Gross Motor ◽  
Gross Motor Skills ◽  
Urinary Arsenic

Introduction: In the endemic areas of chronic arsenic poisoning of Bangladesh (Cumilla, Noakhali, Laksham, Matlab) drinking water is heavily contaminated with arsenic. An estimated of about 70 million people are at risk from drinking water contaminated with arsenic. There are numerous data on effects of arsenic in adults but a few reports are available on the adverse effect of arsenic on infants and arsenic concentration in human milk, as human milk is the primary source of nutrition during first 6 months of life. Arsenic level found in the urine of infants reflects the intake of arsenic through breast milk. Objective: To find out the effect of arsenic among the breastfed babies of arsenic affected mothers. Materials and Methods: This cross sectional study was conducted in the arsenic exposed area of Bangladesh from January 2007 to July 2008. Thirty exclusively breastfed babies of arsenic affected mothers were enrolled as cases and 30 exclusively breastfed babies from non affected mothers were taken as control. Urinary arsenic concentration was considered for measurement of arsenic status. Mothers with their babies were thoroughly examined for length, weight, occipitofrontal circumference (OFC) and gross motor skills. Results: Arsenic affected mothers excreted high concentration of arsenic (334.68μgm/L±108.02) in their urine than control group (19.17μgm/L±7.92) but the urinary arsenic concentrations from both groups of breast fed babies were found to be low. Growth and development parameters like length, weight, OFC and gross motor skills were also found to be normal in both groups of babies. Conclusion: Exclusive breast feeding should be practiced in arsenic affected area to protect the babies from exposure to arsenic from water sources. Journal of Armed Forces Medical College Bangladesh Vol.13(1) 2017: 99-102

Effects of low-level arsenic exposure on urinary N-acetyl-β-D-glucosaminidase activity

2011 ◽  
Vol 30 (12) ◽  
pp. 1885-1891 ◽  
Author(s):  
S-Y Eom ◽  
Y-C Lee ◽  
D-H Yim ◽  
C-H Lee ◽  
Y-D Kim ◽  
...  
Keyword(s):  
Arsenic Concentration ◽  
Arsenic Exposure ◽  
Inorganic Arsenic ◽  
Tubular Damage ◽  
Seafood Consumption ◽  
Arsenic Level ◽  
Urine Sampling ◽  
Low Level ◽  
Urinary Arsenic ◽  
Renal Tubular

This study was aimed to evaluate whether renal tubular function is impaired by exposure to relatively low concentrations of arsenic. Mean urinary arsenic concentrations and N-acetyl-β-d-glucosaminidase (NAG) activities were compared among 365 and 502 Korean men and women, respectively, in relation to gender, smoking, alcohol consumption, and recent seafood consumption. The study subjects were divided into 4 groups according to urinary NAG activity and seafood consumption prior to urine sampling, and the correlation between arsenic concentration and urinary NAG activity was tested for each group. The mean urinary arsenic level was higher in women, non-smokers, and non-drinkers in comparison to men, smokers, and drinkers, respectively. Individuals who consumed seafood within 3 days prior to urine sampling showed a higher mean urinary arsenic level than those who did not. The correlation between urinary arsenic concentration and NAG activity in urine was significant only in subjects who did not consume seafood within 3 days prior to urine sampling and whose urinary NAG activity was 7.44 U/g creatinine (75th percentile) or higher. The urinary arsenic concentration was a significant determinant of urinary NAG activity in subjects with NAG activity higher than 7.44 U/g creatinine and especially in those who had not consumed seafood recently. These facts suggest that a relatively low-level exposure to inorganic arsenic produces renal tubular damage in humans.

scholarly journals Nutritional Counseling On Energy, Protein, Vitamin C And Iron Intake.

2019 ◽  
Vol 25 (2) ◽  
pp. 26
Author(s):  
Halil Munawir ◽  
Mustamin Mustamin ◽  
Ramlan Asbar
Keyword(s):  
Vitamin C ◽  
Pregnant Women ◽  
Energy Intake ◽  
Protein Intake ◽  
Nutrient Intake ◽  
Iron Intake ◽  
Nutritional Counseling ◽  
Cross Sectional ◽  
Energy Deficiency ◽  
Chronic Energy Deficiency

Chronic energy deficiency is one of the nutritional problems of pregnant women where the body's condition experiences a severe lack of energy or is often showed by upper arm circumference <23.5. chronic energy deficiency of pregnant woman caused by many factors. one of the factors is low intake of nutrients such as energy, protein, vitamin c and iron. This study aims to determine the effect of nutritional counseling on energy, protein, vitamin c and iron intake. This type of research is a quasi experiment analytic research using cross sectional research design. sample was 30 pregnant women. extension data based on extension program unit then narrated nutrient intake obtained through 4X24 hour recall. the results of the study showed that before the extension of the sample energy intake was 96.7% less and 3.3% more. Sample protein intake as much as 100% less. Intake of vitamin C sample as much as 100% less. Sample iron intake is as much as 100% less. after counseling of sample energy intake as much as 3,3% good and 96,7% less. Sample protein intake as much as 100% less. Vitamin C intake was 3.3% good and 9.3% less and 6.7% more. Sample iron intake is as much as 100% less. Average intake before and after counseling of nutrients classified as less. It is recommended to increase nutrient intake. should be done further research on other factors that affect.

scholarly journals Tingkat asupan energi dan ketersediaan pangan berhubungan dengan risiko kekurangan energi kronik (KEK) pada ibu hamil

2016 ◽  
Vol 2 (3) ◽  
pp. 140
Author(s):  
Yanuarti Petrika ◽  
Hamam Hadi ◽  
Detty Siti Nurdiati
Keyword(s):  
Pregnant Women ◽  
Energy Intake ◽  
Food Availability ◽  
Protein Intake ◽  
Multivariable Analysis ◽  
Chi Square ◽  
Protein Food ◽  
Cross Sectional ◽  
Energy Deficiency ◽  
Chronic Energy Deficiency

<p>ABSTRACT</p><p>Background: Chronic energy deficiency (CED) is one of nutritional problems in pregnant women. One of the causes is inadequate energy and protein in food consumption, and low household food availability.</p><p>Objectives: To know association between energy and protein intakes, food availability with CED in pregnant women in Sedayu Subdistrict, Bantul, Yogyakarta.</p><p>Methods: This was an observational study with cross sectional design. This study was conducted in Sedayu Subdistrict, Bantul, Yogyakarta from March to May 2014 and 201 pregnant women were selected as samples by using total sampling methods. Independent variable was the level of energy intake, protein,and food availability while the dependent variable was the risk of CED in pregnant women. Data were collected by direct interview with questionnaire and direct measurement of mid upper arm circumference (MUAC) with MUAC tape. Data were then analyzed by using univariable analysis (descriptive), bivariable<br />(chi-square), and multivariable (multiple logistic regression).</p><p>Results: Bivariable test showed a significant association between level of energy intake (OR=3, 95% CI:1.3-6.8) and food availability (OR=2.9, 95% CI:1.1-7.1) with the risk of CED in pregnant women in Sedayu Subdistrict. However, no significant association between level of protein intake and the risk of CED (OR=2.1, 95% CI: 0.9-5.1). In multivariable analysis, level of energy intake had the strongest association with the risk of CED.</p><p>Conclusions: There was associaton between level of energy intake and food availability with the risk of CED in pregnant women. However, there was no association between level of protein intake and the risk of CED in pregnant women.</p><p>KEYWORDS: chronic energi deficiency, pregnant women, intake of energy intake of protein, food availability</p><p>ABSTRAK</p><p>Latar belakang: Kekurangan energi kronis (KEK) merupakan salah satu masalah gizi yang terjadi pada ibu hamil. Salah satu penyebab KEK adalah konsumsi makan yang tidak cukup mengandung energi dan protein serta ketersediaan pangan keluarga yang kurang.</p><p>Tujuan: Untuk mengetahui hubungan antara tingkat asupan energi, tingkat asupan protein, dan ketersediaan pangan dengan kejadian KEK pada ibu hamil di Kecamatan Sedayu, Bantul, Yogyakarta.</p><p>Metode: Desain penelitian ini adalah cross sectional yang dilakukan di Kecamatan Sedayu Bantul pada bulan Maret hingga Mei 2014. Populasi adalah seluruh ibu hamil di Kecamatan Sedayu yang diambil dengan metode total sampling dan didapatkan 201 orang. Variabel bebas yaitu tingkat asupan energi,<br />protein, dan ketersediaan pangan, sedangkan variabel terikat adalah risiko KEK pada ibu hamil. Data diambil dengan wawancara langsung menggunakan software kuesioner Commcare dan pengukuran lingkar lengan atas (LILA) dengan pita LILA. Data dianalisis dengan analisis univariabel (deskriptif), bivariat (chi-square), dan multivariat (regresi logistik berganda).</p><p>Hasil: Analisis bivariat menunjukkan bahwa terdapat hubungan yang signifikan antara tingkat asupan energi (OR=3, 95% CI:1,3-6,8) dan ketersediaan pangan (OR=2,9, 95% CI:1,1-7,1) dengan risiko KEK pada ibu hamil. Tidak terdapat hubungan yang signifikan antara tingkat asupan protein dengan risiko KEK (OR=2,1, 95% CI:0,9-5,1). Pada analisis multivariat, tingkat asupan energi memiliki hubungan paling kuat dengan risiko KEK dibandingkan dengan variabel lainnya.</p><p>Kesimpulan: Terdapat hubungan antara tingkat asupan energi dan ketersediaan pangan dengan risiko KEK pada ibu hamil. Namun tidak terdapat hubungan antara tingkat asupan protein dengan risiko KEK pada ibu hamil.</p><p>KATA KUNCI: kekurangan energi kronis, ibu hamil, asupan energi, asupan protein, ketersediaan pangan</p>

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