Doubly crosslinked biodegradable hydrogels based on gellan gum and chitosan for drug delivery and wound dressing

2020 ◽  
Vol 164 ◽  
pp. 2204-2214 ◽  
Author(s):  
Xiaomin Zhang ◽  
Yajin Pan ◽  
Shengke Li ◽  
Lian Xing ◽  
Shoukang Du ◽  
...  
2016 ◽  
Vol 5 (3) ◽  
pp. 151-162
Author(s):  
Ranjeet Pareek ◽  
Shakuntla Verma ◽  
Viney Lather ◽  
Deepti Pandita

Polymers ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1347
Author(s):  
Arbanah Muhammad ◽  
Dabin Lee ◽  
Yonghun Shin ◽  
Juhyun Park

Porous polysaccharides have recently attracted attention due to their porosity, abundance, and excellent properties such as sustainability and biocompatibility, thereby resulting in their numerous applications. Recent years have seen a rise in the number of studies on the utilization of polysaccharides such as cellulose, chitosan, chitin, and starch as aerogels due to their unique performance for the fabrication of porous structures. The present review explores recent progress in porous polysaccharides, particularly cellulose and chitosan, including their synthesis, application, and future outlook. Since the synthetic process is an important aspect of aerogel formation, particularly during the drying step, the process is reviewed in some detail, and a comparison is drawn between the supercritical CO2 and freeze drying processes in order to understand the aerogel formation of porous polysaccharides. Finally, the current applications of polysaccharide aerogels in drug delivery, wastewater, wound dressing, and air filtration are explored, and the limitations and outlook of the porous aerogels are discussed with respect to their future commercialization.


2021 ◽  
Author(s):  
Amlika Rungrod ◽  
Apichaya Kapanya ◽  
Winita Punyodom ◽  
Robert Molloy ◽  
Jomkhwan Meerak ◽  
...  

Author(s):  
Hesham M. Fahmy ◽  
Amal A. Aly ◽  
Shymaa M. Sayed ◽  
Ashraf Abou‐Okeil
Keyword(s):  

2018 ◽  
Vol 120 ◽  
pp. 1561-1571 ◽  
Author(s):  
Mukherjee Arjama ◽  
Sivaraj Mehnath ◽  
Mariappan Rajan ◽  
Murugaraj Jeyaraj

2016 ◽  
Vol 18 (20) ◽  
pp. 5607-5620 ◽  
Author(s):  
Xiaoping Shen ◽  
Paula Berton ◽  
Julia L. Shamshina ◽  
Robin D. Rogers

Lignin-based hydrogels in both bulk and membrane forms for potential drug delivery, food packaging, and wound dressing applications have been designed by crosslinking ionic-liquid-isolated lignin with epoxide-terminated polyethylene glycol (ETPEG) in alkaline solution.


2020 ◽  
Vol 8 (7) ◽  
pp. 481 ◽  
Author(s):  
Tatyana A. Kuznetsova ◽  
Boris G. Andryukov ◽  
Natalia N. Besednova ◽  
Tatyana S. Zaporozhets ◽  
Andrey V. Kalinin

The present review considers the physicochemical and biological properties of polysaccharides (PS) from brown, red, and green algae (alginates, fucoidans, carrageenans, and ulvans) used in the latest technologies of regenerative medicine (tissue engineering, modulation of the drug delivery system, and the design of wound dressing materials). Information on various types of modern biodegradable and biocompatible PS-based wound dressings (membranes, foams, hydrogels, nanofibers, and sponges) is provided; the results of experimental and clinical trials of some dressing materials in the treatment of wounds of various origins are analyzed. Special attention is paid to the ability of PS to form hydrogels, as hydrogel dressings meet the basic requirements set out for a perfect wound dressing. The current trends in the development of new-generation PS-based materials for designing drug delivery systems and various tissue-engineering scaffolds, which makes it possible to create human-specific tissues and develop target-oriented and personalized regenerative medicine products, are also discussed.


Polymers ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 1473 ◽  
Author(s):  
Ioana A. Duceac ◽  
Liliana Verestiuc ◽  
Cristina D. Dimitriu ◽  
Vasilica Maier ◽  
Sergiu Coseri

The dynamic evolution of materials with medical applications, particularly for drug delivery and wound dressing applications, gives impetus to design new proposed materials, among which, hydrogels represent a promising, powerful tool. In this context, multifunctional hydrogels have been obtained from chemically modified chitosan and acrylic polymers as cross-linkers, followed by subsequent conjugation with arginine. The hydrogels were finely tuned considering the variation of the synthetic monomer and the preparation conditions. The advantage of using both natural and synthetic polymers allowed porous networks with superabsorbent behavior, associated with a non-Fickian swelling mechanism. The in vitro release profiles for ibuprofen and the corresponding kinetics were studied, and the results revealed a swelling-controlled release. The biodegradability studies in the presence of lysozyme, along with the hemostatic evaluation and the induced fibroblast and stem cell proliferation, have shown that the prepared hydrogels exhibit characteristics that make them suitable for local drug delivery and wound dressing.


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