Chitosan: Structural modification, biological activity and application

Monoterpenes, comprising hydrocarbons, are the largest class of plant secondary metabolites and are commonly found in essential oils. Monoterpenes and their derivatives are key ingredients in the design and production of new biologically active compounds. This review focuses on selected aliphatic, monocyclic, and bicyclic monoterpenes like geraniol, thymol, myrtenal, pinene, camphor, borneol, and their modified structures. The compounds in question play a pivotal role in biological and medical applications. The review also discusses anti-inflammatory, antimicrobial, anticonvulsant, analgesic, antiviral, anticancer, antituberculosis, and antioxidant biological activities exhibited by monoterpenes and their derivatives. Particular attention is paid to the link between biological activity and the effect of structural modification of monoterpenes and monoterpenoids, as well as the introduction of various functionalized moieties into the molecules in question.

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Recent progress in andrographolide derivatization: structural modification and biological activity

Mini-Reviews in Medicinal Chemistry ◽

10.2174/1389557521666211022150032 ◽

2021 ◽

Vol 21 ◽

Author(s):

Wang Wang ◽

Yueying Yang ◽

Yang Liu ◽

Dejuan Sun ◽

Hua Li ◽

...

Keyword(s):

Biological Activity ◽

Chemical Modification ◽

Structural Modification ◽

Recent Progress ◽

Biological Activities ◽

Structural Diversity ◽

Traditional Chinese Medicines ◽

Chinese Medicines ◽

Novel Drugs ◽

Labdane Diterpenoid

: Natural products have remarkable structural diversity and biological characteristics, providing researchers with more possibilities to develop novel drugs for disease therapeutics. Andrographolide, an ent-labdane diterpenoid from traditional Chinese medicines, Andrographis paniculata, exhibits a broad range of biological activities, which has been a hot area of research for several years. Up to now, lots of its derivatives with multiple bioactivities have been prepared through chemical modification. This review summarizes andrographolide derivatives prepared in the last ten years (2006-present), classifies them by different biological activities, and provides some discussion about the design of novel and potent derivatives.

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The effect of specific structural modification on the biological activity of E.coli arginine tRNA

Nucleic Acids Research ◽

10.1093/nar/5.3.879 ◽

1978 ◽

Vol 5 (3) ◽

pp. 879-892 ◽

Cited By ~ 32

Author(s):

T.A. Kruse ◽

B.F.C. Clark ◽

M. Sprinzl

Keyword(s):

Biological Activity ◽

Structural Modification

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Bicyclic polyprenylated acylphloroglucinols and their derivatives: structural modification, structure-activity relationship, biological activity and mechanism of action

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2020.112646 ◽

2020 ◽

Vol 205 ◽

pp. 112646 ◽

Cited By ~ 1

Author(s):

Yeelin Phang ◽

Xueying Wang ◽

Yue Lu ◽

Wenwei Fu ◽

Changwu Zheng ◽

...

Keyword(s):

Biological Activity ◽

Mechanism Of Action ◽

Structural Modification ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Structure Activity

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Synthesis, Physical Characterization and Biological Activity of Some Schiff Base Complexes

E-Journal of Chemistry ◽

10.1155/2008/583487 ◽

2008 ◽

Vol 5 (3) ◽

pp. 620-626 ◽

Cited By ~ 19

Author(s):

R. Rajavel ◽

M. Senthil Vadivu ◽

C. Anitha

Keyword(s):

Antimicrobial Activity ◽

Biological Activity ◽

Schiff Base ◽

Organic Molecule ◽

Structural Modification ◽

Antimicrobial Agents ◽

Biological Activities ◽

Molar Conductance ◽

Molar Conductivity ◽

Schiff Base Complexes

Structural modification of organic molecule has considerable biological relevance. Further, coordination of a biomolecules to the metal ions significantly alters the effectiveness of the biomolecules. In view of the antimicrobial activity ligand [bis-(2-aminobenzaldehyde)] malonoyl dihydrazone], metal complexes with Cu(II), Ni(II), Zn(II) and oxovanadium(IV) have been synthesized and found to be potential antimicrobial agents. An attempt is also made to correlate the biological activities with geometry of the complexes. The complexes have been characterized by elemental analysis, molar conductance, spectra and cyclicvoltammetric measurements. The structural assessment of the complexes has been carried out based on electronic, infrared and molar conductivity values.

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Marine-Derived Natural Lead Compound Disulfide-Linked Dimer Psammaplin A: Biological Activity and Structural Modification

Marine Drugs ◽

10.3390/md17070384 ◽

2019 ◽

Vol 17 (7) ◽

pp. 384 ◽

Cited By ~ 5

Author(s):

Qinxue Jing ◽

Xu Hu ◽

Yanzi Ma ◽

Jiahui Mu ◽

Weiwei Liu ◽

...

Keyword(s):

Natural Products ◽

Biological Activity ◽

Total Synthesis ◽

Marine Natural Products ◽

Structural Modification ◽

Research Focus ◽

Chemical Structures ◽

Therapeutic Drugs ◽

Psammaplin A ◽

Derivatives Of

Marine natural products are considered to be valuable resources that are furnished with diverse chemical structures and various bioactivities. To date, there are seven compounds derived from marine natural products which have been approved as therapeutic drugs by the U.S. Food and Drug Administration. Numerous bromotyrosine derivatives have been isolated as a type of marine natural products. Among them, psammaplin A, including the oxime groups and carbon–sulfur bonds, was the first identified symmetrical bromotyrosine-derived disulfide dimer. It has been found to have a broad bioactive spectrum, especially in terms of antimicrobial and antiproliferative activities. The highest potential indole-derived psammaplin A derivative, UVI5008, is used as an epigenetic modulator with multiple enzyme inhibitory activities. Inspired by these reasons, psammaplin A has gradually become a research focus for pharmacologists and chemists. To the best of our knowledge, there is no systematic review about the biological activity and structural modification of psammaplin A. In this review, the pharmacological effects, total synthesis, and synthesized derivatives of psammaplin A are summarized.

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