Efficient Synthesis of Marine Alkaloid Ageladine A and its Structural Modification for Exploring New Biological Activity

2020 ◽  
Vol 78 (1) ◽  
pp. 51-59
Author(s):  
Takayuki Iwata ◽  
Koichi Fukase ◽  
Yoichi Nakao ◽  
Katsunori Tanaka
Keyword(s):  
Biological Activity ◽  
Structural Modification ◽  
Efficient Synthesis ◽  
Marine Alkaloid

Analogues of the marine alkaloids oroidin, clathrodin, and hymenidin induce apoptosis in human HepG2 and THP-1 cancer cells

MedChemComm ◽  
2015 ◽  
Vol 6 (1) ◽  
pp. 105-110 ◽  
Author(s):  
Tihomir Tomašič ◽  
Dominik Nabergoj ◽  
Sanja Vrbek ◽  
Nace Zidar ◽  
Žiga Jakopin ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Cell Lines ◽  
Structural Modification ◽  
Marine Alkaloids ◽  
Marine Alkaloid

Structural modification of the marine alkaloid oroidin resulted in improved apoptosis inducing activity in HepG2 and THP-1 cell lines.

Efficient synthesis of 3-O-thia-cPA and preliminary analysis of its biological activity toward autotaxin

2011 ◽  
Vol 21 (14) ◽  
pp. 4180-4182 ◽  
Author(s):  
Ryo Tanaka ◽  
Masaru Kato ◽  
Takahiro Suzuki ◽  
Atsuo Nakazaki ◽  
Emi Nozaki ◽  
...  
Keyword(s):  
Biological Activity ◽  
Preliminary Analysis ◽  
Efficient Synthesis

Dammarane-type leads panaxadiol and protopanaxadiol for drug discovery: Biological activity and structural modification

2020 ◽  
Vol 189 ◽  
pp. 112087 ◽  
Author(s):  
Mingying Wang ◽  
Haonan Li ◽  
Weiwei Liu ◽  
Hao Cao ◽  
Xu Hu ◽  
...  
Keyword(s):  
Biological Activity ◽  
Drug Discovery ◽  
Structural Modification

scholarly journals Monoterpenes and Their Derivatives—Recent Development in Biological and Medical Applications

2020 ◽  
Vol 21 (19) ◽  
pp. 7078
Author(s):  
Mariola Zielińska-Błajet ◽  
Joanna Feder-Kubis
Keyword(s):  
Biological Activity ◽  
Secondary Metabolites ◽  
Essential Oils ◽  
Structural Modification ◽  
Biological Activities ◽  
Plant Secondary Metabolites ◽  
Biologically Active ◽  
Pivotal Role ◽  
Medical Applications ◽  
Biological And Medical Applications

Monoterpenes, comprising hydrocarbons, are the largest class of plant secondary metabolites and are commonly found in essential oils. Monoterpenes and their derivatives are key ingredients in the design and production of new biologically active compounds. This review focuses on selected aliphatic, monocyclic, and bicyclic monoterpenes like geraniol, thymol, myrtenal, pinene, camphor, borneol, and their modified structures. The compounds in question play a pivotal role in biological and medical applications. The review also discusses anti-inflammatory, antimicrobial, anticonvulsant, analgesic, antiviral, anticancer, antituberculosis, and antioxidant biological activities exhibited by monoterpenes and their derivatives. Particular attention is paid to the link between biological activity and the effect of structural modification of monoterpenes and monoterpenoids, as well as the introduction of various functionalized moieties into the molecules in question.

Recent progress in andrographolide derivatization: structural modification and biological activity

2021 ◽  
Vol 21 ◽  
Author(s):  
Wang Wang ◽  
Yueying Yang ◽  
Yang Liu ◽  
Dejuan Sun ◽  
Hua Li ◽  
...  
Keyword(s):  
Biological Activity ◽  
Chemical Modification ◽  
Structural Modification ◽  
Recent Progress ◽  
Biological Activities ◽  
Structural Diversity ◽  
Traditional Chinese Medicines ◽  
Chinese Medicines ◽  
Novel Drugs ◽  
Labdane Diterpenoid

: Natural products have remarkable structural diversity and biological characteristics, providing researchers with more possibilities to develop novel drugs for disease therapeutics. Andrographolide, an ent-labdane diterpenoid from traditional Chinese medicines, Andrographis paniculata, exhibits a broad range of biological activities, which has been a hot area of research for several years. Up to now, lots of its derivatives with multiple bioactivities have been prepared through chemical modification. This review summarizes andrographolide derivatives prepared in the last ten years (2006-present), classifies them by different biological activities, and provides some discussion about the design of novel and potent derivatives.

scholarly journals Synthesis and Anti-HIV Activity of Carbamates of Antiviral Agent Stavudine

2002 ◽  
Vol 13 (5) ◽  
pp. 289-297
Author(s):  
TK Venkatachalam ◽  
P Samuel ◽  
IV Kourinov ◽  
FM Uckun
Keyword(s):  
Biological Activity ◽  
Antiviral Agent ◽  
Heterocyclic Amines ◽  
Efficient Synthesis ◽  
Hiv Replication ◽  
Derivatives Of ◽  
Anti Hiv

An efficient synthesis of carbamate analogues of the NRTI compound stavudine, has been achieved in five steps starting from commercially available thymidine. The synthesis involves conversion of thymidine into stavudine followed by condensation with carbaimidazole derivative obtained from various aromatic and heterocyclic amines in dimethylformamide solvent. The analogues thus obtained were further purified by crystallization to furnish analytically pure products. Examination of biological activity of these carbamate derivatives of stavudine showed that they inhibited HIV replication only at micro-molar concentrations.

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