Clinical, social and emotional implications of oral cancer therapeutics in Karachi population

2015 ◽  
Vol 44 ◽  
pp. e222
Author(s):  
S.A. Matloob ◽  
S.M. Haider ◽  
S. Ahmed ◽  
F. Hameed
Keyword(s):  
Oral Cancer ◽  
Cancer Therapeutics ◽  
Social And Emotional

Nano Drug Delivery in Treatment of Oral Cancer, A Review of the Literature

2019 ◽  
Vol 20 (10) ◽  
pp. 1008-1017 ◽  
Author(s):  
Vandita Kakkar ◽  
Manoj Kumar Verma ◽  
Komal Saini ◽  
Indu Pal Kaur
Keyword(s):  
Drug Delivery ◽  
Oral Cancer ◽  
Treatment Options ◽  
Oral Submucous Fibrosis ◽  
Survival Rates ◽  
Cancer Therapeutics ◽  
Developed Countries ◽  
Current Treatment ◽  
Poor Overall Survival ◽  
Hereditary Disorders

Oral Cancer (OC) is a serious and growing problem which constitutes a huge burden on people in more and less economically developed countries alike. The scenario is clearly depicted from the increase in the expected number of new cases in the US diagnosed with OC from 49,670 people in 2016, to 49,750 cases in 2017. The situation is even more alarming in India, with 75,000 to 80,000 new cases being reported every year, thus making it the OC capital of the world. Leukoplakia, erythroplakia, oral lichen planus, oral submucous fibrosis, discoid lupus erythmatosus, hereditary disorders such as dyskeratosis congenital and epidermolisys bullosa are highlighted by WHO expert working group as the predisposing factors increasing the risk of OC. Consumption of tobacco and alcohol, genetic factors, and human papilloma virus are assigned as the factors contributing to the aetiology of OC. On the other hand, pathogenesis of OC involves not only apoptosis but also pain, inflammation and oxidative stress. Inspite of current treatment options (surgery, radiotherapy, and chemotherapy), OC is often associated with recurrence and formation of secondary primary tumours resulting in poor overall survival rates (∼50%). The intervention of nano technology-based drug delivery systems as therapeutics for cancers is often viewed as a cutting edge for technologists. Though ample literature on the usefulness of nano-coutured cancer therapeutics, rarely any product is in pipeline. Yet, despite all the hype about nanotechnology, there are few ongoing trials. This review discusses the current and future trends of nano-based drug delivery for the treatment of OC.

scholarly journals Plant-Based Antioxidant Extracts and Compounds in the Management of Oral Cancer

Antioxidants ◽  
2021 ◽  
Vol 10 (9) ◽  
pp. 1358 ◽  
Author(s):  
Suraj Prakash ◽  
Radha ◽  
Manoj Kumar ◽  
Neeraj Kumari ◽  
Mamta Thakur ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Medicinal Plants ◽  
Treatment Plan ◽  
Treatment Options ◽  
Cancer Therapeutics ◽  
Defence Mechanisms ◽  
Comprehensive Overview ◽  
Oral Mucosal Lesions ◽  
Cellular Defence

Oral cancer continues to be a leading cause of death worldwide, and its prevalence is particularly high in developing countries, where people chew tobacco and betel nut on a regular basis. Radiation-, chemo-, targeted-, immuno-, and hormone-based therapies along with surgery are commonly used as part of a treatment plan. However, these treatments frequently result in various unwanted short- to long-term side effects. As a result, there is an urgent need to develop treatment options for oral cancer that have little or no adverse effects. Numerous bioactive compounds derived from various plants have recently attracted attention as therapeutic options for cancer treatment. Antioxidants found in medicinal plants, such as vitamins E, C, and A, reduce damage to the mucosa by neutralizing free radicals found in various oral mucosal lesions. Phytochemicals found in medicinal plants have the potential to modulate cellular signalling pathways that alter the cellular defence mechanisms to protect normal cells from reactive oxygen species (ROS) and induce apoptosis in cancer cells. This review aims to provide a comprehensive overview of various medicinal plants and phytoconstituents that have shown the potential to be used as oral cancer therapeutics.

scholarly journals Use of Tilapia Hepcidin in Oral Cancer Therapeutics: A Proposal

2019 ◽  
Vol 20 (4) ◽  
pp. 403-404
Author(s):  
Nikunj Maniyar ◽  
Prashanth Panta ◽  
Krithika Gupta
Keyword(s):  
Oral Cancer ◽  
Cancer Therapeutics

Reviewing the potential application of miR-21 inhibitors in oral cancer therapeutics

Oral Oncology ◽  
2022 ◽  
Vol 125 ◽  
pp. 105713
Author(s):  
Auxzilia Preethi K ◽  
Sushmaa Chandralekha Selvakumar ◽  
Jayaraman Selvaraj ◽  
Ullas Mony ◽  
Vishnu Priya Veeraraghavan ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Potential Application ◽  
Cancer Therapeutics

scholarly journals Layered nanoemulsions as mucoadhesive buccal systems for controlled delivery of oral cancer therapeutics

2015 ◽  
pp. 1569 ◽  
Author(s):  
Tamer Elbayoumi ◽  
Amy Gavin ◽  
Jimmy Tam Huy Pham ◽  
Dawei Wang ◽  
Bill Brownlow
Keyword(s):  
Oral Cancer ◽  
Cancer Therapeutics ◽  
Controlled Delivery

scholarly journals Sandensolide Induces Oxidative Stress-Mediated Apoptosis in Oral Cancer Cells and in Zebrafish Xenograft Model

Marine Drugs ◽  
2018 ◽  
Vol 16 (10) ◽  
pp. 387 ◽  
Author(s):  
Chung-I Yu ◽  
Chung-Yi Chen ◽  
Wangta Liu ◽  
Po-Chih Chang ◽  
Chiung-Wei Huang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Cycle ◽  
Oral Cancer ◽  
Cancer Cells ◽  
Xenograft Model ◽  
Cancer Therapeutics ◽  
Sinularia Flexibilis ◽  
Cell Death Pathways ◽  
Oral Cancer Cells

Presently, natural sources and herbs are being sought for the treatment of human oral squamous cell carcinoma (OSCC) in order to alleviate the side effects of chemotherapy. This study investigates the effect of sandensolide, a cembrane isolated from Sinularia flexibilis, to inhibit human OSCC cell growth with the aim of developing a new drug for the treatment of oral cancer. In vitro cultured human OSCC models (Ca9.22, SCC9 and HSC-3 cell lines) and oral normal cells (HGF-1), as well as a zebrafish xenograft model, were used to test the cytotoxicity of sandensolide (MTT assay), as well as to perform cell cycle analysis and Western blotting. Both the in vitro bioassay and the zebrafish xenograft model demonstrated the anti-oral cancer effect of sandensolide. Moreover, sandensolide was able to significantly suppress colony formation and induce apoptosis, as well as cell cycle arrest, in OSCC by regulating multiple key proteins. Induction of reactive oxygen species (ROS) was observed in sandensolide-treated oral cancer cells. However, these apoptotic changes were rescued by NAC pretreatment. These findings contribute to the knowledge of the model of action of sandensolide, which may induce oxidative stress-mediated cell death pathways as a potential agent in oral cancer therapeutics.

Ultrastructural features of prognostic significance in human oral cancer

1992 ◽  
Vol 50 (1) ◽  
pp. 618-619
Author(s):  
Karvita B. Ahluwalia ◽  
Nidhi Sharma
Keyword(s):  
Oral Cancer ◽  
Squamous Cell ◽  
Common Knowledge ◽  
Prognostic Significance ◽  
Growth Control ◽  
Terminal Differentiation ◽  
Squamous Cell Carcinomas ◽  
Effective Therapy ◽  
Invasive Potential ◽  
Biological Behaviour

It is common knowledge that apparently similar tumors often show different responses to therapy. This experience has generated the idea that histologically similar tumors could have biologically distinct behaviour. The development of effective therapy therefore, has the explicit challenge of understanding biological behaviour of a tumor. The question is which parameters in a tumor could relate to its biological behaviour ? It is now recognised that the development of malignancy requires an alteration in the program of terminal differentiation in addition to aberrant growth control. In this study therefore, ultrastructural markers that relate to defective terminal differentiation and possibly invasive potential of cells have been identified in human oral leukoplakias, erythroleukoplakias and squamous cell carcinomas of the tongue.

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