Polyethylene glycol-complexed cationic liposome for enhanced cellular uptake and anticancer activity

Nanosized calcium phosphate was prepared by a reverse microemulsion method, with a 20~40 nm diameter, which is pH-responsive, nontoxic and colloidally stable in physiological solution. Polyethylene glycol modified calcium phosphate nanoparticles shifted the zeta potential to a neutral charge, which prolonged the nanoparticle circulation time and increased cellular uptake efficacy to targeted cells. The PEG-functionalized nanoparticles exhibit a great potential for efficaciously delivering hydrophobic anticancer drug, such as paclitaxel, to cells and tumors.

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Synthesis, anticancer activity and cytotoxicity of 7‐ O ‐β‐ d ‐galactosyl‐polyethylene glycol‐epothilone B

Chemical Biology & Drug Design ◽

10.1111/cbdd.13447 ◽

2018 ◽

Vol 93 (4) ◽

pp. 539-543 ◽

Cited By ~ 6

Author(s):

Shiyu Huang ◽

Gangliang Huang

Keyword(s):

Polyethylene Glycol ◽

Anticancer Activity ◽

Epothilone B

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An 8-hydroxyquinoline–proline hybrid with multidrug resistance reversal activity and the solution chemistry of its half-sandwich organometallic Ru and Rh complexes

Dalton Transactions ◽

10.1039/d0dt01256d ◽

2020 ◽

Vol 49 (23) ◽

pp. 7977-7992

Author(s):

János P. Mészáros ◽

Jelena M. Poljarević ◽

István Szatmári ◽

Oszkár Csuvik ◽

Ferenc Fülöp ◽

...

Keyword(s):

Multidrug Resistance ◽

Complex Formation ◽

Anticancer Activity ◽

Cellular Uptake ◽

Solution Chemistry ◽

Synthesis And Characterization ◽

Resistance Reversal ◽

Organometallic Cations ◽

Half Sandwich

Synthesis and characterization of an 8-hydroxyquinoline–proline hybrid, and its complex formation with half-sandwich organometallic cations: aqueous chemistry, lipophilicity, cellular uptake and anticancer activity.

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Co-encapsulation of gemcitabine and tocotrienols in nanovesicles enhanced efficacy in pancreatic cancer

Nanomedicine ◽

10.2217/nnm-2020-0374 ◽

2021 ◽

Vol 16 (5) ◽

pp. 373-389

Author(s):

Geetha Maniam ◽

Chun-Wai Mai ◽

Mohd Zulkefeli ◽

Ju-Yen Fu

Keyword(s):

Pancreatic Cancer ◽

Polyethylene Glycol ◽

Cancer Cells ◽

Cellular Uptake ◽

Proof Of Concept ◽

Pancreatic Cancer Cells ◽

Polyethylene Glycol 1000 ◽

Span 60 ◽

Dual Drug

Aim: To synthesize niosomes co-encapsulating gemcitabine (GEM) and tocotrienols, and physicochemically characterize and evaluate the antipancreatic effects of the nanoformulation on Panc 10.05, SW 1990, AsPC-1 and BxPC-3 cells. Materials & methods: Niosomes-entrapping GEM and tocotrienols composed of Span 60, cholesterol and D-α-tocopheryl polyethylene glycol 1000 succinate were produced by Handjani-Vila and film hydration methods. Results: The film hydration produced vesicles measuring 161.9 ± 0.5 nm, approximately 50% smaller in size than Handjani-Vila method, with maximum entrapment efficiencies of 20.07 ± 0.22% for GEM and 34.52 ± 0.10% for tocotrienols. In Panc 10.05 cells, GEM’s antiproliferative effect was enhanced 2.78-fold in combination with tocotrienols. Niosomes produced a significant ninefold enhancement in cytotoxicity of the combination, supported by significantly higher cellular uptake of GEM in the cells. Conclusion: This study is a proof of concept on the synthesis of dual-drug niosomes and their efficacy on pancreatic cancer cells in vitro.

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Abstract 5376: Systematic analysis of peptide linker length and liposomal polyethylene glycol coating on cellular uptake of peptide-targeted liposomal nanoparticles

10.1158/1538-7445.am2014-5376 ◽

2014 ◽

Author(s):

Jared Stefanick ◽

Jonathan Ashley ◽

Tanyel Kiziltepe ◽

Basar Bilgicer

Keyword(s):

Polyethylene Glycol ◽

Cellular Uptake ◽

Systematic Analysis ◽

Linker Length ◽

Liposomal Nanoparticles

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Mechanisms of cellular uptake with hyaluronic acid—octadecylamine micelles as drug delivery nanocarriers

RSC Advances ◽

10.1039/c5ra27532f ◽

2016 ◽

Vol 6 (46) ◽

pp. 39896-39902 ◽

Cited By ~ 7

Author(s):

Lipeng Qiu ◽

Mengqin Zhu ◽

Yan Huang ◽

Kai Gong ◽

Jinghua Chen

Keyword(s):

Drug Delivery ◽

Particle Size ◽

Hyaluronic Acid ◽

Anticancer Activity ◽

Cellular Uptake ◽

Drug Concentration

DOX/HM23, based on appropriate DS and proper particle size, presented enhanced anticancer activity and efficient internalization to achieve the highest intracellular drug concentration.

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