Preparation of PEG Functionalized Nanoparticles for Drug Delivery to Cancer Cells

2014 ◽  
Vol 893 ◽  
pp. 194-197
Author(s):  
Yan Liu ◽  
Jie Ren ◽  
Jun Zhao Leng ◽  
Jian Bo Li ◽  
Li Deng
Keyword(s):  
Drug Delivery ◽  
Polyethylene Glycol ◽  
Calcium Phosphate ◽  
Zeta Potential ◽  
Cellular Uptake ◽  
Physiological Solution ◽  
Ph Responsive ◽  
Functionalized Nanoparticles ◽  
Calcium Phosphate Nanoparticles ◽  
Reverse Microemulsion Method

Nanosized calcium phosphate was prepared by a reverse microemulsion method, with a 20~40 nm diameter, which is pH-responsive, nontoxic and colloidally stable in physiological solution. Polyethylene glycol modified calcium phosphate nanoparticles shifted the zeta potential to a neutral charge, which prolonged the nanoparticle circulation time and increased cellular uptake efficacy to targeted cells. The PEG-functionalized nanoparticles exhibit a great potential for efficaciously delivering hydrophobic anticancer drug, such as paclitaxel, to cells and tumors.

Dual pH-responsive micelles with both charge-conversional property and hydrophobic–hydrophilic transition for effective cellular uptake and intracellular drug release

2016 ◽  
Vol 7 (12) ◽  
pp. 2202-2208 ◽  
Author(s):  
Shuai Li ◽  
Zhouxiang Zhao ◽  
Wei Wu ◽  
Chunmei Ding ◽  
Jianshu Li
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Cellular Uptake ◽  
Diblock Copolymers ◽  
Effective Drug ◽  
Ph Responsive ◽  
A Charge

Two types of diblock copolymers are synthesized to construct dual pH-responsive micelles with a charge-conversional property for effective drug delivery.

scholarly journals Polyethylene Glycol-Chitosan Oligosaccharide-Coated Superparamagnetic Iron Oxide Nanoparticles: A Novel Drug Delivery System for Curcumin Diglutaric Acid

Biomolecules ◽  
2020 ◽  
Vol 10 (1) ◽  
pp. 73 ◽  
Author(s):  
Feuangthit Niyamissara Sorasitthiyanukarn ◽  
Chawanphat Muangnoi ◽  
Wuttinont Thaweesest ◽  
Pahweenvaj Ratnatilaka Na Bhuket ◽  
Pongsakorn Jantaratana ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Polyethylene Glycol ◽  
Iron Oxide ◽  
Zeta Potential ◽  
Superparamagnetic Iron Oxide ◽  
Oxide Nanoparticles ◽  
Chitosan Oligosaccharide ◽  
Glycol Chitosan ◽  
Novel Drug Delivery System ◽  
Novel Drug

Curcumin diglutaric acid-loaded polyethylene glycol-chitosan oligosaccharide-coated superparamagnetic iron oxide nanoparticles (CG-PEG-CSO-SPIONs) were fabricated by co-precipitation and optimized using a Box–Behnken statistical design in order to achieve the minimum size, optimal zeta potential (≥ ±20 mV), and maximum loading efficiency and capacity. The results demonstrated that CG-PEG-CSO-SPIONs prepared under the optimal condition were almost spherical in shape with a smooth surface, a diameter of 130 nm, zeta potential of 30.6 mV, loading efficiency of 83.3%, and loading capacity of 8.3%. The vibrating sample magnetometer results of the optimized CG-PEG-CSO-SPIONs showed a superparamagnetic behavior. Fourier transform infrared spectroscopy and X-ray diffraction analyses indicated that the CG physically interacted with PEG-CSO-SPIONs. In addition, the CG-PEG-CSO-SPIONs could be stored dry for up to 12 weeks or in aqueous solution for up to 4 days at either 4 °C or 25 °C with no loss of stability. The CG-PEG-CSO-SPIONs exhibited a sustained release profile up to 72 h under simulated physiological (pH 7.4) and tumor extracellular (pH 5.5) environments. Furthermore, the CG-PEG-CSO-SPIONs showed little non-specific protein binding in the simulated physiological environment. The CG-PEG-CSO-SPIONs enhanced the cellular uptake and cytotoxicity of CG against human colorectal adenocarcinoma HT-29 cells compared to free CG, and more CG was delivered to the cells after applying an external magnetic field. The overall results suggest that PEG-CSO-SPIONs have potential to be used as a novel drug delivery system for CG.

A versatile pH-responsive platform for intracellular protein delivery using calcium phosphate nanoparticles

2015 ◽  
Vol 3 (47) ◽  
pp. 9115-9121 ◽  
Author(s):  
Bingru Zeng ◽  
Hongdong Shi ◽  
Yangzhong Liu
Keyword(s):  
Calcium Phosphate ◽  
Protein Delivery ◽  
Intracellular Delivery ◽  
Endosomal Escape ◽  
Ph Responsive ◽  
Intracellular Protein ◽  
Calcium Phosphate Nanoparticles ◽  
Intracellular Protein Delivery

A highly biocompatible nanoplatform for the intracellular delivery of different proteins, exhibiting pH-responsive release and efficient endosomal escape.

pH-responsive hydrogel cubes for release of doxorubicin in cancer cells

2014 ◽  
Vol 2 (17) ◽  
pp. 2494-2507 ◽  
Author(s):  
Veronika Kozlovskaya ◽  
Jun Chen ◽  
Chrysanty Tedjo ◽  
Xing Liang ◽  
Javier Campos-Gomez ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
Cellular Uptake ◽  
Methacrylic Acid ◽  
Ph Responsive

Doxorubicin (DOX)-loaded poly(methacrylic acid) hydrogel cubes release the drug at pH <5. These hydrogels are developed for shape-directed cellular uptake for drug delivery.

Sign in / Sign up

Export Citation Format

Share Document