scholarly journals Design of pressure-sensitive adhesive suitable for the preparation of transdermal patches by hot-melt printing

2020 ◽  
Vol 586 ◽  
pp. 119607
Author(s):  
Umberto M. Musazzi ◽  
Marco A. Ortenzi ◽  
Chiara G.M. Gennari ◽  
Antonella Casiraghi ◽  
Paola Minghetti ◽  
...  
Keyword(s):  
Pressure Sensitive Adhesive ◽  
Pressure Sensitive ◽  
Transdermal Patches ◽  
Hot Melt

Preparation and properties of polyisobutene/organic montmorillonite hot melt pressure-sensitive adhesive (HMPSA)

2019 ◽  
Vol 95 (13-14) ◽  
pp. 1134-1145
Author(s):  
Xing Peng ◽  
Yu Wang ◽  
Hui Chen ◽  
Jie Ying ◽  
Jikui Wang
Keyword(s):  
Pressure Sensitive Adhesive ◽  
Organic Montmorillonite ◽  
Pressure Sensitive ◽  
Hot Melt

Development of Acrylic Matrix Type Ketoprofen Patch

2012 ◽  
Vol 506 ◽  
pp. 533-536
Author(s):  
Nanthida Wonglertnirant ◽  
S. Tipwichai ◽  
Praneet Opanasopit ◽  
Theerasak Rojanarata ◽  
Suwannee Panomsuk ◽  
...  
Keyword(s):  
Drug Release ◽  
Release Rate ◽  
Pressure Sensitive Adhesive ◽  
Drug Release Rate ◽  
Matrix Type ◽  
Adhesive Matrix ◽  
Pressure Sensitive ◽  
Transdermal Patches ◽  
Significant Difference

Ketoprofen transdermal patches (KTPs) were fabricated using an acrylic pressure sensitive adhesive (PSA) polymer. The influence of different factors (amount of PSA, drug content, and pressure applying on the backing membrane during preparation) on the characteristics of ketoprofen patch (thickness, W/A ratio, and adhesiveness of matrix film) and in vitro drug release behavior were investigated. The results revealed the successful fabrication and a good physical appearance of KTPs using acrylic PSA. Microscopic observations, FTIR spectra, and DSC thermograms were permitted to demonstrate that the drug was dispersed molecularly in the polymer. As the amount of PSA in the adhesive matrix was increased, the release rate of ketoprofen was decreased. Contrarily, the drug release rate was increased corresponding to the increase of ketoprofen content in the adhesive matrix. There was no significant difference in the release rate when the pressure applying on the backing membrane was varied. The kinetic of ketoprofen release from acrylic matrix type transdermal patches followed the Higuchis diffusion model.

Formulation and Evaluation of Isosorbide Dinitrate Acrylic Matrix Transdermal Patches

2011 ◽  
Vol 197-198 ◽  
pp. 1217-1220
Author(s):  
Ponwanit Jarenputtakrun ◽  
Praneet Opanasopit ◽  
Suwannee Panomsuk ◽  
Tanasait Ngawhirunpat
Keyword(s):  
Propylene Glycol ◽  
Isosorbide Dinitrate ◽  
Skin Permeation ◽  
Casting Method ◽  
Pressure Sensitive Adhesive ◽  
Transdermal Drug Delivery System ◽  
Pressure Sensitive Adhesives ◽  
Pressure Sensitive ◽  
Transdermal Patches

The aim of this study was to prepare and investigate the isosorbide dinitrate transdermal patches (IDPs) in the concentration of 40 mg/cm2. Acrylic pressure sensitive adhesives (PSA) were used to formulate IDPs. IDPs were prepared by casting method. The effect of content of PSA, and concentration of enhancer, propylene glycol, in the formulations were evaluated. IDPs were investigated for their thickness, weight/area ratio, adhesiveness and in vitro skin permeation. The higher the content of PSA in the formulation, the higher the thickness and the W/A ratio. Propylene glycol added in the formulation (2.5, 5, 10%) significantly enhanced the skin permeation of ISDN. The higher the content of PG, the higher the flux of ISDN through the skin. Our research suggests that isosorbide dinitrate loaded with 10% of propylene glycol in acrylic matrix pressure sensitive adhesive can be potentially used as a transdermal drug delivery system.

scholarly journals Feasibility of Processing Hot-Melt Pressure-Sensitive Adhesive (HMPSA) with Solvent in the Lab

Processes ◽  
2021 ◽  
Vol 9 (9) ◽  
pp. 1608
Author(s):  
Jing Xue ◽  
Jing Wang ◽  
Haofei Huang ◽  
Ming Wang ◽  
Yali Zhang ◽  
...  
Keyword(s):  
Bond Strength ◽  
Compositional Analysis ◽  
Weight Percent ◽  
Environmentally Benign ◽  
Pressure Sensitive Adhesive ◽  
Holding Power ◽  
Pressure Sensitive ◽  
Different Types ◽  
Physical Reasons ◽  
Hot Melt

Hot-melt pressure-sensitive adhesive (HMPSA) is an environmentally benign adhesive which is typically processed without solvent in industries. However, casting solution method is commonly used for experimental purposes in the lab for convenience. Therefore, seven types of solvent with different polarities, including toluene as the most commonly used solvent, were investigated in this work to study the feasibilities. Quick bond strength and holding power were tested with different types of solvents and different adhesive weight percent in the prepared solutions. Through viscosity measurement, thermal analysis, and compositional analysis, the correlation between the chosen solvents and adhesive performance was further explored. It was found that the differences in the obtained bond strength of HMPSA treated with a variety of solvents were due to physical reasons instead of chemical reactions, and a solvent with similar polarity to toluene (e.g., tetrachloride, octane) should be considered as an option because a similar polymer chain relaxation could be maintained as the original HMPSA without solvent treatment. In this study, the mechanism of choosing toluene as common solvent for HMPSA testing was analyzed, and the feasibility of optional solvents was discussed.

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