Linezolid for tympanostomy tube otorrhea caused by methicillin-resistant Staphylococcus aureus and multiple drug-resistant Streptococcus pneumoniae

2008 ◽  
Vol 72 (5) ◽  
pp. 647-651 ◽  
Author(s):  
Glenn Isaacson ◽  
Stephen C. Aronoff
Keyword(s):  
Staphylococcus Aureus ◽  
Streptococcus Pneumoniae ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Multiple Drug ◽  
Drug Resistant ◽  
Tympanostomy Tube ◽  
Methicillin Resistant ◽  
Multiple Drug Resistant

Bacteriological, Toxicological and Mutagenic Evaluations of the Formulated Ointment of Knobweed (Hyptis capitata Jacq.) Leaf Extract against Methicillin-Resistant Staphylococcus aureus

10.17158/339 ◽  
2014 ◽  
Vol 18 (2) ◽  
Author(s):  
Judee N. Nogodula ◽  
Rose Ann S. Mancenido ◽  
Ivana Lee M. Miranda ◽  
Darlene S. Quiñon
Keyword(s):  
Staphylococcus Aureus ◽  
Clinical Isolate ◽  
Leaf Extract ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Multiple Drug ◽  
Zone Of Inhibition ◽  
Methicillin Resistant ◽  
Multiple Drug Resistant ◽  
Crude Leaf Extract ◽  
Observation Results

<p>The emergence of multiple drug resistant Methicillin-Resistant Staphylococcus aureus (MRSA) has become a global problem. Fortunately, many plants found from Mindanaon lumads have potential curative property for different ailments. Hence, the ethnopharmacologic practice of the knobweed (Hyptis capitata) was scientifically assessed for antibacterial activity, toxicity, mutagenicity and pharmacological screenings of crude leaf extract in formulation of ointment as treatment of MRSA infections. Acute Dermal Toxicity employed female albino rabbits for 14 days. Antibacterial screenings used Kirby Bauer, Minimum Inhibitory Concentration (MIC) and potency tests. Ames test used Salmonella typhimurium TA98. Pharmacological assay was limited to physical characteristics of ointment and sensitivity (patch) test using albino rabbits (24 to 72 hours of observation). Results revealed that leaf extract was not toxic and had promising antibacterial action with 19.22 mm (±0.82) zone of inhibition on MRSA ATCC 43300 and 17.41 mm ±0.77 on clinical isolate. It had similar potency with Vancomycin at 6.54ug. MIC established the reduction of cell viability at 0.0263g/mL without revertant colonies grown; hence, it was not mutagenic. Efficacy of ointment with a hydrophilic base exhibited 16.11 mm (±1.73) zone of inhibition on MRSA ATCC and 16.12 mm (± 2.08) for clinical isolate. Neither erythema nor edema was observed.</p>

In vitro evaluation of antibacterial potential of Andrographis paniculata against resistant bacterial pathogens methicillin resistant Staphylococcus aureus (MRSA) and multiple drug resistant Escherichia coli (MDR E. coli)

2016 ◽  
Vol 5 (03) ◽  
pp. 4879
Author(s):  
Srikala Ganapathy* ◽  
Karpagam S.
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Antibacterial Activity ◽  
Antibacterial Agents ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Ethanolic Extract ◽  
Multiple Drug ◽  
Drug Resistant ◽  
E Coli ◽  
Multiple Drug Resistant

Rise of antibiotic resistant pathogenic bacteria namely Methicillin Resistant Staphylococcus aureus (MRSA) and Multiple drug resistant Escherichia coli (MDR E. coli results in reduced efficacy of currently used antibacterial agents. Medicinal plants serve as potential targets for biologically effective antibacterial agents. The present study determined the phytochemical and invitro antibacterial activity of ethanol, chloroform, hexane and water extracts of whole plant of Andrographis paniculata against MRSA and MDR Escherichia coli. Zone of inhibition diameters were measured. Compared to all the extracts, ethanolic extract showed highest activity. The antibacterial activity was absent in hexane and water extracts. Chloroform extracts showed moderately good activity. The antibacterial compounds found in ethanolic extract were flavanoids, saponins and alkaloids.

scholarly journals Ceftaroline Desensitization Procedure in a Pregnant Patient With Multiple Drug Allergies

2015 ◽  
Vol 2 (1) ◽  
Author(s):  
James L. Kuhlen ◽  
Kimberly G. Blumenthal ◽  
Caroline L. Sokol ◽  
Diana S. Balekian ◽  
Ana A. Weil ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Staphylococcus Aureus ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Skin Testing ◽  
Pregnant Patient ◽  
Cross Reactivity ◽  
Multiple Drug ◽  
Methicillin Resistant ◽  
The Cross ◽  
Staphylococcus Aureus Pneumonia

Abstract Validated skin testing is lacking for many drugs, including ceftaroline. The cross-reactivity between ceftaroline and other β-lactam antibiotics is unknown. We report a case of a pregnant patient with cystic fibrosis and multiple drug allergies who required ceftaroline for methicillin-resistant Staphylococcus aureus pneumonia and underwent an uncomplicated empiric desensitization procedure.

MRSA REMAINS A GREAT PRIORITY DUE TO THE TREMENDOUS MORTALITY --- A BIRD'S EYE VIEW

2021 ◽  
pp. 114-118
Author(s):  
Raghavendra Rao M. V ◽  
Mubasheer Ali ◽  
Yogendra Kumar Verma ◽  
Dilip Mathai ◽  
Tina Priscilla ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Drug Resistance ◽  
Chronic Infection ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Multiple Drug Resistance ◽  
Multiple Drug ◽  
High Dose ◽  
Benzyl Penicillin ◽  
Methicillin Resistant ◽  
Antimicrobial Sensitivity

Methicillin-resistant Staphylococcus aureus (MRSA) is difcult to treat with methicillin, amoxicillin, penicillin, oxacillin, and other commonly used antibiotics because of its resistance. Staphylococcus organisms rapidly develop drug resistance as many as 50% of the domiciliary and 80% of the hospital strains are now penicillin resistant. Staphylococcus aureus also show multiple drug resistance. Therefore, Staphylococcal isolates should always be tested for antimicrobial sensitivity and chronic infection should be treated by more than one drug. Before 1960,when methicillin, is the rst penicillin's-resistant penicillin's, was brought into use, about 1%of the strains of the Staphylococcus aureus were "methicillin resistant" and by 1970 in Britain their proportion has risen to about 5%.These strains are tolerant of, low therapeutic concentrations of methicillin, cloxacillin, benzyl penicillin and ampicillin.They do not destroy methicillin and cloxacillin, but most of them are penicillinase-producing as well as being "methicillin resistant" and therefore inactivate benzyl penicillin and ampicillin. Its resistance is uncertain since infections may be cured with a high dose of methicillin.

scholarly journals Antibacterial activity of Taxodium ascendens Diterpenes against Methicillin-resistant Staphylococcus aureus

2014 ◽  
Vol 9 (8) ◽  
pp. 1934578X1400900 ◽  
Author(s):  
Courtney M. Starks ◽  
Vanessa L. Norman ◽  
Russell B. Williams ◽  
Matt G. Goering ◽  
Stephanie M. Rice ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Antibacterial Activity ◽  
Bacterial Infections ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Clinical Isolates ◽  
Drug Resistant ◽  
Methicillin Resistant

One new and seven known diterpenes were identified from an antibacterial chromatographic fraction of Taxodium ascendens. Of these, demethylcryptojaponol (2), 6-hydroxysalvinolone (3), hydroxyferruginol (4), and hinokiol (5) demonstrated potent activity against clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA). These compounds represent a class of synthetically accessible compounds that could be further developed for treatment of drug-resistant bacterial infections.

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