Radiation Biology: Targeting CD47 in Cancer Growth Inhibition and Normal Tissue Protection

5BMF is a new fluorescent mitochondria-accumulating delocalized lipophilic cations [DLC] that boasts significantly increased anti-cancer effects and low toxicity in comparison to previous DLCs, addressing current hurdles in DLC clinical translation.

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Toward Normalization of the Tumor Microenvironment for Cancer Therapy

Integrative Cancer Therapies ◽

10.1177/1534735419862352 ◽

2019 ◽

Vol 18 ◽

pp. 153473541986235 ◽

Cited By ~ 5

Author(s):

Jie Zheng ◽

Peng Gao

Keyword(s):

Stem Cells ◽

Extracellular Matrix ◽

Tumor Microenvironment ◽

Immune Cells ◽

Normal Tissue ◽

Cancer Growth ◽

Tissue Architecture ◽

Action Mechanisms ◽

Anticancer Effects ◽

Complex Ecosystem

The tumor microenvironment (TME) is a complex ecosystem, including blood vessels, immune cells, fibroblasts, extracellular matrix, cytokines, hormones, and so on. The TME differs from the normal tissue environment (NTE) in many aspects, such as tissue architecture, chronic inflammation, level of oxygen and pH, nutritional state of the cells, as well as tissue firmness. The NTE can inhibit the growth of cancer at the early tumorigenesis phase, whereas the TME promotes the growth of cancer in general, although it may have some anticancer effects. In particular, the TME plays a crucial role in the generation and maintenance of cancer stem cells, which lie at the root of cancer growth. Therefore, normalization of the TME to the NTE may inhibit cancer growth or improve cancer therapeutic efficiency. This review focuses on the recent emerging approaches for this normalization and the action mechanisms.

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Cardiac-Sparing Whole Lung Intensity Modulated Radiation Therapy in Children With Wilms Tumor: Final Report on Technique and Abdominal Field Matching to Maximize Normal Tissue Protection

Practical Radiation Oncology ◽

10.1016/j.prro.2018.07.005 ◽

2019 ◽

Vol 9 (1) ◽

pp. e62-e73 ◽

Cited By ~ 1

Author(s):

John A. Kalapurakal ◽

Bryan Lee ◽

Jonathan Bautista ◽

Cynthia Rigsby ◽

Irene Helenowski ◽

...

Keyword(s):

Radiation Therapy ◽

Normal Tissue ◽

Wilms Tumor ◽

Intensity Modulated Radiation Therapy ◽

Final Report ◽

Intensity Modulated ◽

Tissue Protection ◽

Field Matching ◽

Cardiac Sparing

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128 Normal tissue protection by Bowman-Birk proteinase inhibitor and phospho-tyrosine

Radiotherapy and Oncology ◽

10.1016/s0167-8140(04)81995-9 ◽

2004 ◽

Vol 73 ◽

pp. S59-S60

Keyword(s):

Proteinase Inhibitor ◽

Normal Tissue ◽

Tissue Protection

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Increased Expression of Dachshund Homolog 1 in Ovarian Cancer as a Predictor for Poor Outcome

International Journal of Gynecological Cancer ◽

10.1097/igc.0b013e31824311e6 ◽

2012 ◽

Vol 22 (3) ◽

pp. 386-393 ◽

Cited By ~ 10

Author(s):

Fei Liang ◽

Qingtao Lü ◽

Shuyu Sun ◽

Jie Zhou ◽

Vladimir M. Popov ◽

...

Keyword(s):

Ovarian Cancer ◽

Estrogen Receptor ◽

Immunohistochemical Staining ◽

Normal Tissue ◽

Prognostic Value ◽

Functional Relationship ◽

Estrogen Receptor Α ◽

Cancer Growth ◽

Protein Levels

ObjectiveThis study aimed to determine the functional relationship between the levels of dachshund homolog 1 (DACH1) expression and different subtypes of ovarian cancer and to investigate the possible prognostic value of DACH1 in ovarian cancer.MethodsImmunohistochemical staining was deployed to determine the protein levels of DACH1. Staining was performed on patient samples, for whom the detailed follow-up data have been acquired during the last 10 years. Normal, benign, borderline, cancer, and metastatic ovarian cancer samples were included in this study.ResultsThe results of our study show that DACH1 protein levels increase with the invasiveness of the ovarian cancer. As the cancer progresses from benign and borderline to metastatic, DACH1 protein expression increases as well. Moreover, with the increase in expression, the subcellular distribution of DACH1 changes from nucleus in normal tissue to cytoplasm in cancer. Finally, DACH1 expression levels were compared with estrogen receptor α (ERα) levels, and the results showed that overall DACH1 levels were higher, whereas also DACH1 exhibited increased cytoplasmic expression in ERα-positive ovarian cancer samples.ConclusionsThese results indicate that DACH1 is highly expressed in metastatic ovarian cancer compared with that of normal, benign, and borderline ovarian tissues and that it could play an important role in cancer growth.

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