TCT-530 Effectiveness of the Misago stent for the treatment of superficial femoral artery disease: 12-month Results of the First Japan and the United States Collaboration Trial (OSPREY)

Atherosclerosis is the leading cause of death in the United States. Studies in adults have shown that intervention with combined diet and medication can reduce atherosclerotic plaque formation and, as a result, the incidence of symptomatic coronary artery disease.1-4 With a strong tradition of preventive medicine, the pediatric community has begun exploring the prevention of adult atherosclerosis through intervention in childhood. Although issues such as universal vs selective high-risk screening, ideal age for screening and intervention, and treatment regimens remain unresolved and controversial, many preventive cardiology clinics, as well as individual pediatricians, have been screening and treating children.5,6 As part of an initial evaluation of hypercholesterolemic children and prior to any intervention, it is important to determine whether other disease processes are contributing to the child's dyslipoproteinemia.

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Prevalence and Clinical Correlates of Coronary Artery Disease among New Dialysis Patients in the United States: A Cross-Sectional Study

Journal of the American Society of Nephrology ◽

10.1681/asn.v1271516 ◽

2001 ◽

Vol 12 (7) ◽

pp. 1516-1523 ◽

Cited By ~ 1

Author(s):

AUSTIN G. STACK ◽

WENDY E. BLOEMBERGEN

Keyword(s):

United States ◽

Risk Factors ◽

Myocardial Infarction ◽

Coronary Artery Disease ◽

Coronary Artery ◽

The United States ◽

Comorbid Conditions ◽

Clinical Correlates ◽

History Of ◽

Artery Disease

Abstract. Despite the high prevalence of coronary artery disease (CAD) among patients with end-stage renal disease (ESRD), few studies have identified clinical correlates using national data. The purpose of this study was to determine the prevalence and clinical associations of CAD in a national random sample of new ESRD in the United States in 1996/1997 (n = 4025). Data on demographic characteristics and comorbidities were obtained from the Dialysis Morbidity and Mortality Study, Wave 2. The principal outcome was CAD, defined as the presence of a previous history of CAD, myocardial infarction, or angina, coronary artery bypass surgery, coronary angioplasty, or abnormal coronary angiographic findings. Multivariate logistic regression analysis was used to assess the relationship of conventional factors and proposed uremic factors to the presence of CAD. CAD was present in 38% of patients. Of the total cohort, 17% had a history of myocardial infarction and 23% had angina. Several conventional risk factors, including advancing age, male gender, diabetes mellitus, and smoking, were significantly associated with CAD. Of the proposed uremic factors, lower serum albumin levels but higher residual renal function and higher hematocrit values were significantly associated with the presence of CAD. Vascular comorbid conditions, structural cardiac abnormalities, white race, and geographic location were also strongly correlated with the presence of CAD. This national study suggests that several conventional CAD risk factors may also be risk factors for CAD among the ESRD population. This study identifies nonconventional factors such as serum albumin levels, vascular comorbid conditions, and structural cardiac abnormalities as important disease correlates. Future logitudinal studies are required to explore the relative importance of the relationships observed here.

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Orthopedic Problems in Overweight and Obese Children

Integrative Pediatrics and Child Care ◽

10.18314/ipcc.v1i1.1102 ◽

2018 ◽

Vol 1 (1) ◽

pp. 05-07

Author(s):

GL Di Gennaro

Keyword(s):

United States ◽

Coronary Artery Disease ◽

Body Mass Index ◽

Childhood Obesity ◽

Body Mass ◽

The United States ◽

Obese Children ◽

The World ◽

Prevalence Of Obesity ◽

Artery Disease

According to the data published by Haslam and James, about 10% of the world populations aged up to 18 areoverweight or obese [1]. In Europe, there are about 20% children with excessive body mass, 5% of whom sufferfrom obesity [2,3]. Childhood obesity is an ongoing epidemic in the United States [4,5]. The most recent data fromthe US indicate that 16.9% of children and adolescents are obese, defined as a body mass index (BMI) for age >95thpercentile [6,7] and there is evidence that the prevalence of obesity among children will reach 30% by 2030 [8].Childhood obesity is a risk factor for greater morbidity later in life, including diabetes, coronary artery disease andincreased mortality [4,5,9,10].

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USE OF DRUG-ELUTING STENTS VERSUS STANDARD NITINOL STENTS AFTER DRUG-COATED BALLOON ANGIOPLASTY OF THE SUPERFICIAL FEMORAL ARTERY: INSIGHTS FROM THE MULTICENTER EXCELLENCE IN PERIPHERAL ARTERY DISEASE (XLPAD) REGISTRY

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(18)31640-1 ◽

2018 ◽

Vol 71 (11) ◽

pp. A1099 ◽

Cited By ~ 1

Author(s):

Omar Jawaid ◽

Haekyung Jeon-Slaughter ◽

Damianos Kokkinidis ◽

Subhash Banerjee ◽

Ehrin J. Armstrong

Keyword(s):

Peripheral Artery Disease ◽

Femoral Artery ◽

Balloon Angioplasty ◽

Superficial Femoral Artery ◽

Drug Eluting Stents ◽

Peripheral Artery ◽

Nitinol Stents ◽

Drug Eluting ◽

Artery Disease ◽

Drug Coated Balloon

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Diagnosis of Dyslipidemia

10.2310/im.1161 ◽

2020 ◽

Author(s):

John D. Brunzell ◽

R Alan Failor

Keyword(s):

United States ◽

Physical Inactivity ◽

Hepatic Lipase ◽

Lipoprotein Metabolism ◽

Developed Countries ◽

The United States ◽

Atherosclerotic Cardiovascular Disease ◽

High Fat Diets ◽

Artery Disease ◽

Fat Diets

Disorders of lipoprotein metabolism, in conjunction with the prevalence of high-fat diets, obesity, and physical inactivity, have resulted in an epidemic of atherosclerotic disease in the United States and other developed countries. The interaction of common genetic and acquired disorders of lipoproteins with these adverse environmental factors leads to the premature development of atherosclerosis. In the United States, mortality from coronary artery disease (CAD), particularly in persons younger than 60 years, has been declining since 1970; however, atherosclerotic cardiovascular disease remains the most common cause of death among both men and women. This review contains 6 figures, 12 tables, and 47 references. Keywords: dyslipoproteinemias, hepatic lipase, hyperlipoproteinemia, hypoalphalipoproteinemia, lipoprotein,

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Abstract 264: Utilizing Risk Scoring for Prescribing Statins to Hospitalized Patients to Primarily Prevent Coronary Artery Disease

Circulation Cardiovascular Quality and Outcomes ◽

10.1161/hcq.13.suppl_1.264 ◽

2020 ◽

Vol 13 (Suppl_1) ◽

Author(s):

Muhammed Atere ◽

William Lim ◽

Vishnuveni Leelaruban ◽

Bhavya Narala ◽

Stephanie Herrera ◽

...

Keyword(s):

United States ◽

Cardiovascular Disease ◽

Coronary Artery Disease ◽

Coronary Artery ◽

High Risk ◽

Disease Risk ◽

The United States ◽

Intermediate Risk ◽

Peripheral Artery ◽

Artery Disease

Background: Cardiovascular disease is the leading cause of mortality in the United States. Approximately 25% of total deaths in the United States are attributed to cardiovascular diseases. Modification of risk factors has been shown to reduce mortality and morbidity in people with coronary artery disease. Medications such as statins are well known for reducing risks and recent data has shown that statins are beneficial in the primary prevention of coronary artery disease. The purpose of this study is to assess whether statins are being prescribed on discharge to patients who are identified as intermediate to high risk using the ACC/AHA Pooled Cohort Equations. Methodology: We reviewed and analyzed the charts of hospitalized patient’s ages 40 to 79 years who were discharged under the service of Internal Medicine at Richmond University Medical Center from September 2018 to August 2019. Exclusion criteria included: patients that expired before discharge or were admitted to the intensive or coronary care units, pregnancy, previous diagnosis of coronary/peripheral artery disease or stroke, already on statins or lipid-lowering medications, allergic to statins, discharged on statins for coronary/peripheral artery disease or stroke, and patients with liver disease or elevated liver enzymes. We used the ACC/AHA Pooled Cohort Equations risk to calculate the 10-year coronary artery disease risk for each patient. Results: The 10-year risk is grouped as low risk (<5%), borderline risk (5% to 7.4%), intermediate risk (7.5% to 19.9%) and high risk (≥20%). Among 898 patients, 10% had intermediate and high risk that were not discharged with statins. Among the 10%, about 6.6% were intermediate risk and 3.4% were high risk. Conclusions: A significant number of intermediate and high-risk patients were discharged without statins, although a CT coronary calcium may be helpful in further classifying the risk in some of them. We believe that a lipid profile should be checked in all hospitalized patients 40 years and older in order to calculate their atherosclerosis cardiovascular disease risk score and to possibly initiate statins after discussing the benefits and side effects, particularly in the intermediate risk group. The continuation of statins would be followed up by their primary care physicians. We plan to liaise with the information technology department in our facility to provide a link to the risk calculator in the electronic medical record so that the risk can be calculated and statins initiated as necessary. We will conduct a follow up review to assess for effectiveness.

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Acute Coronary Syndromes

The Brigham Intensive Review of Internal Medicine ◽

10.1093/med/9780199358274.003.0078 ◽

2014 ◽

pp. 806-818

Author(s):

Susan Cheng ◽

Marc S. Sabatine

Keyword(s):

United States ◽

Recurrent Events ◽

Hospital Admissions ◽

The United States ◽

Threatening Condition ◽

Life Threatening ◽

Coronary Syndromes ◽

Artery Disease ◽

Ventricular Dysrhythmias ◽

Key Aspects

In total, ACS presentations account for over 2 million annual hospital admissions in the United States. Almost 1.4 million people suffer an ACS each year, of which 55% are new events, 31% are recurrent events, and 14% are silent events. Of all diagnosed MIs, approximately 30% are STEMI and 70% are NSTE-ACS events. Despite recent declines in associated mortality, coronary artery disease causes one out of every five deaths in the United States. Notably, half of MI-related deaths occur within the first hour, primarily due to ventricular dysrhythmias. Therefore, the presentation of ACS challenges the clinician to rapidly integrate key aspects of the history, physical examination, and diagnostic tests in order to diagnose correctly and manage effectively this potentially life-threatening condition.

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