The mediating effect of microbial colonization on the effect of cesarean section delivery

2012 ◽  
Vol 129 (2) ◽  
pp. 584-585 ◽  
Author(s):  
Adrian J. Lowe ◽  
Elizabeth Williamson ◽  
Lennart Bråbäck ◽  
Caroline J. Lodge ◽  
Shyamali C. Dharmage
2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S68-S68
Author(s):  
Otto Helve ◽  
Katri Korpela ◽  
Kaija-Leena Kolho ◽  
Terhi Saisto ◽  
Kirsi Skogberg ◽  
...  

Abstract Background A complication of cesarean section delivery is its interference with the normal intestinal colonization of the infant, affecting the development of immune system in early life—a process that has been associated with long-term morbidity, such as allergy and diabetes. We evaluated, in CS-delivered infants, whether the normal intestinal microbiome and its early life development could be restored by immediate postnatal transfer of maternal fecal microbiota to the newborn. Methods Seventeen healthy mothers with planned elective CS were recruited and screened thoroughly for infections, after which 7 mothers were included in the study. A fecal sample was processed according to a transplantation protocol and an aliquot (3–7 mg) was orally administered in breast-milk to the newborn during the first feeding. The infants were followed and fecal samples were gathered during the first 12 weeks of age and subsequently at the age of 8–18 months. Results The bacterial communities in the fecal samples of the mothers and their offspring were analyzed by sequencing of 16S rRNA amplicons from isolated fecal DNA and compared with that of 11 nontreated CS-delivered infants and 34 vaginally delivered infants. The fecal microbiota at 3 and 12 weeks was similar between treated CS and vaginally delivered infants, in contrast to that of the untreated CS-delivered infants both in overall composition (P = 0.001, Figure) and development of early-life signature bacteria, i.e., bacteroides and bifidobacteria and clostridia (P < 0.0001). Conclusion The seeding of maternal fecal microbes to the newborn intestine can be safely and successfully mimicked in elective CS by transferring a small amount of maternal fecal microbiome orally to the newborn infant. In these infants, this process results in a microbial development that is highly similar to that of the vaginally born infants, and provides support for the hypothesis that microbial colonization in early life results from a maternal fecal transfer. Disclosures All Authors: No reported Disclosures.


2019 ◽  
Vol 4 (2) ◽  
Author(s):  
Rini Rahmayanti

In the world according to WHO 2014 there are (16%) SEKSIO SESARIA deliveries that exceed the recommended limits. Whereas in Indonesia according to the 2013 Riskesdas the method of cesarean section surgery was 9.8% of the total 49,603 births throughout 2010-2013. Based on the 2013 Riskesdas data in West Sumatra the rate of West Sumatra cesarean section delivery (14%) where the figure is almost close to the maximum WHO standard. One common complaint felt by post seksio sesaria mothers is surgical pain. The purpose of this study was to determine the analysis of the application of murottal therapy in post-secsio caesarea women on the indication of a history of heart disease to reduce postoperative pain in the obstetric room of RSUP Dr. M. Djamil Padang. Nursing implementation in accordance with the objectives and interventions that have been formulated. The implementation is carried out for 5 days, from 3-7 June 2018. Ny. A listens to the explanation, and demonstrates the explanation given, especially murottal Al-Qur'an therapy to reduce postoperative pain. From the results of observations and interviews that the author did, Ny.A understood what had been explained and demonstrated. It is hoped that this research will be useful for health workers to be able to apply murottal therapy as one of the complementary therapies in treating post-cesarean patients.


QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Hazem F El-Shahawy ◽  
Sherif F El-Mekkawi ◽  
. Haitham F Mohmmed ◽  
Hend M Afifi

Abstract Background Cesarean section delivery is becoming more frequent. Childbirth is an emotion-filled event and the mother needs to bond with her newborn baby as early as possible. Any intervention that leads to improvement in pain relief is worthy of investigation Aim of the Work to assess the efficacy and safety adding ef Epinephrine to lidocaine 2% in dose-related manner 1:200.000 in prolongation of anesthetic effect of lidocaine as a local anesthetic to reduce post; caesarean section pain after general anesthesia. Patients and Methods A total number of 200 women planned for elective caesarean section at Shams University Maternity Hospital Was recruited, 2 groups were randomized with a study group included 100 women received lidocaine 2% and epinephrine in dose-related manner and a control group included 100 women received lidocaine 2% only. Results women who received lidocaine and epinephrine were more satisfied and hadsignificant more time after caesarean section free of pain in comparison to women who received lidocaine only by 120 minutes. Also. adding Of epinephrine helped in decrease in amount of analgesic consumption after caesarean section. Women who received lidocaine and epinephrine started breast feeding and mobilization earlier than women who received lidocaine only. Epinephrine prolonged the action of lidocaine as a local anesthetic, this prolongation of action of local anesthetic had a significant effect in early mobilization and breast feeding and decrease in cost of analgesics. Nobody in our candidate had a post-operative infection, past operative pyrexia, Allergic reactions tar general anesthesia or complications with local anesthesia. Conclusion Adding of epinephrine to local anesthetics (such as lidocaine 2% in dose-related manner 1:200.0000) prolonged anesthetic effect by more than double of its original anesthetic time, This prolongation on anesthetic effect of local anesthesia by epinephrine helps in eariy mobilization; early breast feeding and less hospital duration stays. No complications (local nor systemic) developed with local infiltration of post-caesarean section incision with lidocaine 2% even aficr adding epinephrine in dose-related manner 1:200.000


2015 ◽  
Vol 3 (2) ◽  
pp. 237-240 ◽  
Author(s):  
Vlora Ademi Ibishi ◽  
Rozalinda Dusan Isjanovska

BACKGROUND: Pre-labour Rupture of Membranes (PROM) is an important cause of maternal and fetal morbidity and increased rate of cesarean section delivery. AIM: The aim of this study is to investigate the clinical characteristics, PROM-delivery interval, mode of delivery, and early maternal neonatal outcome among pregnant patients presenting with pre-labour rupture of membranes.MATERIAL AND METHODS: This prospective case control study is implemented at the Obstetric and Gynecology Clinic of the University Clinical Center of Kosovo. The study included 100 pregnant patients presenting with prelabour rupture of membranes of which 63 were primigravida and 37 patients were multigravida.RESULTS: The incidence of cesarean section in this study is 28 % and the most common indications for cesarean delivery were fetal distress, malpresentation, cephalopelvic disproportion, and failed induction. The most common maternal complications in this study are chorioamnionitis, retained placenta and postpartum hemorrhage. Neonatal infectious morbidity was present in 16 % of cases.CONCLUSION: PROM is a significant issue for obstetricians and an important cause of maternal and neonatal morbidity and increased rate of cesarean section delivery.


1994 ◽  
Vol 170 (2) ◽  
pp. 495-504 ◽  
Author(s):  
Francis C. Notzon ◽  
Sven Cnattingius ◽  
Per Bergsjø ◽  
Susan Cole ◽  
Selma Taffel ◽  
...  

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