Perceived stressfulness mediates the effects of subjective social support and negative coping style on suicide risk in Chinese patients with major depressive disorder

2020 ◽  
Vol 265 ◽  
pp. 32-38 ◽  
Author(s):  
Jingyu Lin ◽  
Yunai Su ◽  
Xiaozhen Lv ◽  
Qi Liu ◽  
Gang Wang ◽  
...  
2021 ◽  
Vol 12 ◽  
Author(s):  
Xuemei Qin ◽  
Mi Wang ◽  
Xiaowen Lu ◽  
Jinrong Sun ◽  
Qiangli Dong ◽  
...  

Background: Previous studies have shown that childhood maltreatment (CM) is closely associated with social support in the general population. However, little is known about the associations of different types of CM with social support in Chinese patients with major depressive disorder (MDD), which was the goal of the current study.Methods: One hundred and sixty-six patients with moderate-to-severe MDD were enrolled. Participants were assessed by the Childhood Trauma Questionnaire-28 item Short Form, Social Support Rating Scale (SSRS), the 24-item Hamilton rating scale for depression, and the 14-item Hamilton Anxiety Rating Scale. Correlation analysis and Hierarchical multiple linear regression analysis were adopted to investigate associations of types of CM with social support.Results: (1) Physical neglect (PN) and emotional neglect (EN) were the most commonly reported types of CM in patients with MDD. (2) EN was the only type of CM significant in the regression models of the SSRS total score, the score of subjective support, and the score of utilization of support.Limitations: The data of CM was collected retrospectively and recall bias may be introduced. Assessment of CM and social support were self-reported and could be influenced by the depression status.Conclusion: In Chinese patients with MDD, PN and EN are the most prevalent types of CM. EN is the only type of CM associated with low social support in regression models, calling for special attention in the assessment and intervention of EN.


2015 ◽  
Vol 228 (3) ◽  
pp. 277-282 ◽  
Author(s):  
Subin Park ◽  
Ahmad Hatim Sulaiman ◽  
Manit Srisurapanont ◽  
Sung-man Chang ◽  
Chia-Yih Liu ◽  
...  

Author(s):  
Fallon J. Richie ◽  
Joseph Bonner ◽  
Andrea Wittenborn ◽  
Lauren M. Weinstock ◽  
Caron Zlotnick ◽  
...  

2007 ◽  
Vol 68 (03) ◽  
pp. 380-383 ◽  
Author(s):  
Francesca Guzzetta ◽  
Leonardo Tondo ◽  
Franca Centorrino ◽  
Ross J. Baldessarini

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Jing-Xu Chen ◽  
Jun-Hui Feng ◽  
Li-Gang Zhang ◽  
Yan Liu ◽  
Fu-De Yang ◽  
...  

Abstract Background Individuals with major depressive disorder (MDD) have a high suicide risk. Some evidence suggests that uric acid (UA) may be involved in the pathophysiology of MDD. The purpose of this study was to evaluate whether serum UA levels were associated with suicide risk in MDD patients. Methods One hundred four female patients with MDD (52 patients with suicide risk and 52 patients without suicide risk) and 52 healthy individuals were included in this study. The suicide risk was evaluated by Mini International Neuropsychiatric Interview (M.I.N.I.). Fasting serum levels of UA, as well as glucose, lipid and renal function indicators were measured. Results Serum UA levels in MDD patients with suicide risk (245.01 ± 55.44 μmol/L) were significantly lower than those in MDD patients without suicide risk (274.17 ± 72.65 μmol/L) (p = 0.017) and healthy controls (271.42 ± 55.25 μmol/L) (p = 0.030). There was no difference in serum UA levels between the MDD patients without suicide risk and healthy controls (p = 0.821). Binary logistic regression analysis revealed a significant relationship between suicide risk and decreased serum UA levels (OR = 0.989, p = 0.010) in MDD patients. Conclusion Decreased serum UA levels were associated with suicide risk in MDD patients. Purinergic system dysfunction may be involved in the neurobiological basis of suicide risk in these patients.


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