P1-319: The impact of beta-amyloid deposition and vascular risk factors on cortical thickness and cognition

2013 ◽  
Vol 9 ◽  
pp. P274-P275
Author(s):  
Sylvia Villeneuve ◽  
Bruce Reed ◽  
Cindee Madison ◽  
Miranka Wirth ◽  
Stephen Kriger ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cortical Thickness ◽  
Beta Amyloid ◽  
Amyloid Deposition ◽  
Vascular Risk Factors ◽  
Vascular Risk ◽  
The Impact

IC-P-022: The impact of beta-amyloid deposition and vascular risk factors on cortical thickness and cognition

2013 ◽  
Vol 9 ◽  
pp. P21-P22
Author(s):  
Sylvia Villeneuve ◽  
Bruce Reed ◽  
Cindee Madison ◽  
Miranka Wirth ◽  
Stephen Kriger ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cortical Thickness ◽  
Beta Amyloid ◽  
Amyloid Deposition ◽  
Vascular Risk Factors ◽  
Vascular Risk ◽  
The Impact

scholarly journals The impact of vascular risk factors on the thickness and volume of the choroid in AMD patients

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Elżbieta Krytkowska ◽  
Aleksandra Grabowicz ◽  
Katarzyna Mozolewska-Piotrowska ◽  
Zofia Ulańczyk ◽  
Krzysztof Safranow ◽  
...  
Keyword(s):  
Risk Factors ◽  
Vascular Risk Factors ◽  
Age Related Macular Degeneration ◽  
Control Group ◽  
Vascular Risk ◽  
Average Volume ◽  
Central Ring ◽  
Age Related ◽  
The Impact ◽  
Wet Amd

AbstractDisturbances in choroidal microcirculation may lead to the onset and progression of age-related macular degeneration (AMD). We aimed to assess changes in the choroidal volume and thickness in the macular region in AMD eyes and to investigate whether coexisting vascular risk factors alter choroidal status. We enrolled 354 AMD patients (175 dry, 179 wet AMD) and 121 healthy controls. All participants underwent a complete ophthalmologic examination and assessment of choroidal thickness and volume. A multivariate analysis adjusted for age, sex, and smoking status revealed that wet AMD was an independent factor associated with higher average thickness of the central ring area (ATC) and average volume of the central ring area (AVC) and lower choroidal vascularity index (CVI) compared to controls (β =  + 0.18, p = 0.0007, β =  + 0.18, p = 0.0008, respectively) and to dry AMD (β =  + 0.17, p = 0.00003 for both ATC and AVC and β =  − 0.30 p < 0.0001 for CVI). ATC, AVC and average volume (AV) were lower in AMD patients with hypertension and ischaemic heart disease (IHD). The duration of hypertension was inversely correlated with ATC, AVC and AV (Rs =  − 0.13, p < 0.05; Rs =  − 0.12; p < 0.05, Rs =  − 0.12; p < 0.05, respectively) while IHD duration negatively correlated with AV (Rs =  − 0.15, p < 0.05). No such associations were observed in the control group. Our findings show that the choroidal vascular system in eyes with AMD is much more susceptible to damage in the presence than in the absence of systemic vascular disease.

scholarly journals The Impact of Vascular Risk Factors on Post-stroke Cognitive Impairment: The Nor-COAST Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Stina Aam ◽  
Mari Nordbø Gynnild ◽  
Ragnhild Munthe-Kaas ◽  
Ingvild Saltvedt ◽  
Stian Lydersen ◽  
...  
Keyword(s):  
Risk Factors ◽  
Atrial Fibrillation ◽  
Coronary Heart Disease ◽  
Cognitive Impairment ◽  
Vascular Risk Factors ◽  
Vascular Risk ◽  
Z Score ◽  
Cognitive Domains ◽  
Post Stroke ◽  
The Impact

Introduction: Post-stroke cognitive impairment (PSCI) is common, but evidence on the impact of vascular risk factors is lacking. We explored the association between pre-stroke vascular risk factors and PSCI and studied the course of PSCI.Materials and Methods: Vascular risk factors were collected at baseline in stroke survivors (n = 635). Cognitive assessments of attention, executive function, memory, language, and the Montreal Cognitive Assessment (MoCA) were performed at 3 and/or 18 months post-stroke. Stroke severity was assessed with the National Institutes of Health Stroke Scale (NIHSS). PSCI was measured with global z; MoCA z-score; and z-score of the four assessed cognitive domains. Mixed-effect linear regression was applied with global z, MoCA z-score, and z-scores of the cognitive domains as dependent variables. Independent variables were the vascular risk factors (hypertension, hypercholesterolemia, smoking, diabetes mellitus, atrial fibrillation, coronary heart disease, previous stroke), time, and the interaction between these. The analyses were adjusted for age, education, and sex. There were between 5 and 25% missing data for the variables for PSCI.Results: Mean age was 71.6 years (SD 11.7); 42% were females; and the mean NIHSS score at admittance was 3.8 (SD 4.8). Regardless of vascular risk factors, global z, MoCA, and all the assessed cognitive domains were impaired at 3 and 18 months, with MoCA being the most severely impaired. Atrial fibrillation (AF) was associated with poorer language at 18 months and coronary heart disease (CHD) with poorer MoCA at 18 months (LR = 12.80, p = 0.002, and LR = 8.32, p = 0.004, respectively). Previous stroke was associated with poorer global z and attention at 3 and 18 months (LR = 15.46, p &lt; 0.001, and LR = 16.20, p &lt; 0.001). In patients without AF, attention improved from 3 to 18 months, and in patients without CHD, executive function improved from 3 to 18 months (LR = 10.42, p &lt; 0.001, and LR = 9.33, p = 0.009, respectively).Discussion: Our findings indicate that a focal stroke lesion might be related to pathophysiological processes leading to global cognitive impairment. The poorer prognosis of PSCI in patients with vascular risk factors emphasizes the need for further research on complex vascular risk factor interventions to prevent PSCI.

Abstract TP166: The Topmost Modifiable Risk Factors for Stroke Among People of African Ancestry

Stroke ◽  
2017 ◽  
Vol 48 (suppl_1) ◽  
Author(s):  
Mayowa O Owolabi ◽  
Fred S Sarfo ◽  
Onoja Akpa ◽  
Mulugeta Gebregziabher ◽  
Rufus Akinyemi ◽  
...  
Keyword(s):  
Risk Factors ◽  
African Ancestry ◽  
Vascular Risk Factors ◽  
Systematic Evaluation ◽  
Modifiable Risk Factors ◽  
Large Artery ◽  
Vascular Risk ◽  
Geographical Variations ◽  
Catchment Areas ◽  
The Impact

Background: Regional and geographical variations exist in stroke burden and risk factor distribution. The unique and dominant risk factors for stroke among people of African ancestry where the burden of stroke is escalating, are poorly understood. Such information is crucial in prioritizing tailor-made interventions to tackle the menace of stroke in developing countries. Purpose: We aimed to identify and quantify the contributions of the topmost modifiable risk factors for stroke occurrence in people of African ancestry within the context of the Stroke Investigative Research and Educational Network (SIREN), the largest study of stroke in Africa. Methods: The SIREN study is an ongoing, multicenter, case-control study involving several sites in Nigeria and Ghana. Cases included adults aged >18 years with first clinical stroke within 8 days of current symptom onset with CT scan confirmation. Controls were stroke-free adults, mostly from the communities in the catchment areas of the SIREN hospitals where cases were recruited. A systematic evaluation of traditional vascular risk factors as well as lifestyle and behavioral factors were assessed for cases and controls. Results: 1,638 cases and 1,653 controls with mean ages of 58.52 and 57.76 years respectively were recruited. Ischemic and hemorrhagic stroke types constituted 62.4% and 36.1% of stroke respectively. Among ischemic stroke subjects, 45.7%, 36.3%, 13.6%, 1.0% and 3.4% had small-vessel, large-artery atherosclerosis, cardio-embolic, others and unknown subtypes according to the TOAST classification. Leading vascular risk factors identified among stroke subjects compared with controls were hypertension- 79.3% vs 34.6%, p<0.001; Dyslipidemia 20.8% vs 6.6%, p<0.001; Diabetes mellitus- 24.4% vs 12.8% and history of cardiac diseases 15.4% vs 7.9%, p<0.001. Adjusted ORs (95% CI) for hypertension, dyslipidemia, cardiac disease and diabetes among stroke subjects compared with controls were 6.43 (5.84-7.54), 2.08 (1.61-2.69), 1.48 (1.15-1.91) and 1.29 (1.05-1.60) respectively. Conclusion: Implementation of interventions towards mitigating the impact of vascular risk factors at the population level would be essential in curtailing the growing burden of stroke in Africans.

Abstract P80: Control of Vascular Risk Factors and Response to Stroke Symptoms During the Most Restrictive Period of the Covid-19 Quarantine. A Survey of Population Behavior in Argentina

Stroke ◽  
2021 ◽  
Vol 52 (Suppl_1) ◽  
Author(s):  
MARIA SOLEDAD RODRIGUEZ PEREZ ◽  
julieta s rosales ◽  
Daiana D Dossi ◽  
Sebastian F Ameriso
Keyword(s):  
Risk Factors ◽  
Buenos Aires ◽  
Large Population ◽  
Vascular Risk Factors ◽  
Urgent Care ◽  
Vascular Risk ◽  
Infection Rates ◽  
Distribution Company ◽  
The Impact ◽  
Control Medication

Background and objectives: In preparation for the influx of Covid-19 patients and as a contagion prevention strategy, healthcare systems reduced or discontinued provision of ‘‘non-urgent’’ care. This policy could potentially influence stroke prevention and management. We conducted a large population survey to assess the impact of mandatory social isolation on emergency consultations, routine health controls and the behavior of the population during the pandemic. Methods: We distributed multiple-choice anonymous questionnaires through the institutional email database and through the email database of clients of a beverage distribution company. Most respondents resided in the Metropolitan Area of Buenos Aires. This is the area where the infection rates were higher and restriction measures were stricter. The survey assessed demographic characteristics and actual and potential behaviors of people regarding medical checkups, risk factors control, medication provision and response to onset of symptoms consistent with stroke or TIA. Results: A total of 10,303 questionnaires were completed. Thirty-seven percent of the respondents were older than 60 years, 74% were women and 16% lived alone. One or more vascular risk factors were present in 39% of respondents. Seventy-six percent of participants did not continue to attend to their regular medical checkups during the mandatory social preventive isolation, 21% had difficulty obtaining medical prescriptions and only 38% considered hospitals were implementing appropriate measures to avoid Covid-19 infections. When asked about response in case of onset of stroke symptoms, 9% would not consult given the context of the pandemic. Six percent reported having had symptoms consistent with stroke or TIA and only 35% of those consulted in an Emergency Room. Most of the respondents (85%) reported they were waiting for the end of the quarantine to resume their usual medical care. Conclusions: The implementation of a strict quarantine may have some serious adverse effects on the proper prevention and treatment of stroke. Careful communication and better education strategies are needed to keep the population safe during the pandemic while avoiding increases in the risk of occurrence of other devastating diseases as stroke.

Obstructive Sleep Apnoea and Vascular Disease in Patients with Type 2 Diabetes

2015 ◽  
Vol 11 (02) ◽  
pp. 110
Author(s):  
Abd A Tahrani ◽  
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Vascular Disease ◽  
Obstructive Sleep Apnoea ◽  
Sleep Apnoea ◽  
Vascular Risk Factors ◽  
Vascular Risk ◽  
Obstructive Sleep ◽  
The Impact

Obstructive sleep apnoea (OSA) is common and is associated with many vascular risk factors, such as hypertension, insulin resistance, albuminuria, dyslipidaemia, increased inflammation and endothelial dysfunction. Epidemiological studies have shown that OSA is associated with increased cardiovascular disease (CVD) and that continuous positive airway pressure (CPAP) might reduce CVD events in patients with OSA. In addition, OSA has also been shown to be associated with albuminuria, chronic kidney disease, a wide range of ocular diseases and peripheral neuropathy. Considering that CVD and microvascular complications are major contributors to the morbidity, mortality and the economic burden of diabetes and that OSA is common in patients with type 2 diabetes (T2D), it is important to understand the role of OSA in the development and/or progression of vascular disease in patients with T2D and to explore the impact of CPAP on diabetes-related vascular outcomes. The purpose of this article is to review the evidence for the relationship and impact of OSA on vascular disease and vascular risk factors particularly in patients with T2D.

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