P3-085: Effects of the Apoe Gene on Cognitive Status and Hippocampus Atrophy Using Data from the Global Alzheimer's Association Interactive Network

2016 ◽  
Vol 12 ◽  
pp. P850-P851
Author(s):  
Scott C. Neu ◽  
Zachary Hobel ◽  
Judy Pa ◽  
Arthur W. Toga
Keyword(s):  
Cognitive Status ◽  
Apoe Gene ◽  
Interactive Network ◽  
Using Data ◽  
Hippocampus Atrophy

scholarly journals USING MOBILE TECHNOLOGY TO ELUCIDATE PSYCHOSOCIAL AND COGNITIVE FUNCTION IN OLDER ADULTS

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S809-S810
Author(s):  
Nelson A Roque ◽  
Jinshil Hyun ◽  
Stacey B Scott
Keyword(s):  
Older Adults ◽  
Cognitive Aging ◽  
Ecological Validity ◽  
Risk Groups ◽  
Cognitive Status ◽  
Cognitive Assessments ◽  
Longitudinal Data Collection ◽  
Aging Study ◽  
Physical Touch ◽  
Using Data

Abstract Ambulatory methods (AM) improve the reliability and ecological validity of cognitive assessments, and help to elucidate psychological influences through concurrent reports of pain, stress, and other psychosocial outcomes. Ecological momentary assessment (EMA) involves sampling of daily experiences in natural settings, including completing cognitive assessments, and answering questions related to, for example, social interactions and sleep. The purpose of this symposium is to present innovative methods and results, exploring questions at the intersection of intensive longitudinal data collection, cognition, and psychosocial influences, using data from two EMA studies, the Einstein Aging Study (EAS) and the Effects of Stress on Cognitive Aging, Physiology, and Emotion (ESCAPE) Study. The EAS (ages >= 70) and ESCAPE (ages 25 - 65) protocols, ask participants to complete an annual 14-day EMA measurement burst. A unique value of these methods is the ability to explore effects from moment-to-moment (or day-to-day; within-person effects) as we will present. We will also contrast these with conventional analyses of between-person differences, typical of clinic and in-person studies. Dickens (using ESCAPE data) examines end-of-day perceived stress and anticipation of next-day stress in predicting sleep quality. Hyun and colleagues (using EAS data) discuss the effects of affectionate physical touch on mitigating pain and emotional distress. Using a model-based cluster analysis approach (with EAS data), Roque unpacks differences in psychosocial factors, as a function of cognitive status risk groups. Stacey Scott will discuss these papers in the context of using ambulatory methods to improve the characterization of risk status in older adults.

Psychometric Properties of the Hooper Visual Organization Test

Assessment ◽  
2003 ◽  
Vol 10 (1) ◽  
pp. 66-70 ◽  
Author(s):  
Michael N. Lopez ◽  
Michael D. Lazar ◽  
Sindy Oh
Keyword(s):  
Psychometric Properties ◽  
Clinical Utility ◽  
Item Analysis ◽  
Total Sample ◽  
Cognitive Status ◽  
Cognitively Impaired ◽  
Using Data ◽  
Visual Organization ◽  
Cognitively Intact ◽  
Interrater Reliability Coefficients

The psychometric properties of the Hooper Visual Organization Test (VOT) have not been well investigated. Here the authors present internal consistency and interrater reliability coefficients, and an item analysis, using data from a sample ( N = 281) of "cognitively impaired" and "cognitively intact" patients, and patients with undetermined cognitive status. Coefficient alpha for the VOT total sample was .882. An item analysis found that 26 of the 30 items were good at discriminating among patients. Also, the interrater reliabilities for three raters (.992), two raters (.988), and one rater (.977) were excellent. Therefore, the judgmental scoring of the VOT does not interfere significantly with its clinical utility. The authors conclude that the VOT is a psychometrically sound test.

scholarly journals Effects of the Co-Occurrence of Diabetes and Tooth Loss on Cognitive Function

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 207-207
Author(s):  
Chenxin Tan ◽  
Brenda Plassman ◽  
Frank Sloan ◽  
Mark Schwartz ◽  
Samrachana Adhikari ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Cognitive Function ◽  
Fixed Effects ◽  
Tooth Loss ◽  
Telephone Interview ◽  
Cognitive Status ◽  
Additive Risk ◽  
Using Data ◽  
Poor Cognition ◽  
Retirement Study

Abstract Using data from the 2006, 2012, and 2018 waves of the Health and Retirement Study, we estimated effects of co-occurrence of diabetes mellitus (DM) and complete tooth loss (CTL), both self-reported, on cognitive function among 10,816 adults age 50+. Cognitive function was measured using a shortened version of the Telephone Interview for Cognitive Status. Results from the fixed effects linear regression model show that in comparison to those with neither condition, adults having both DM and CTL had the worst cognitive function (b = 1.49, p < 0.001), followed by having CTL alone (b = 0.78, p < 0.001), and having DM alone (b = 0.42, p < 0.001). Our study suggests that CTL is a stronger risk factor for lower cognitive function than DM, and the co-occurrence of DM and CTL poses additive risk. Further research is needed to investigate the pathway from DM and CTL to poor cognition.

scholarly journals Associations of Pulse and Blood Pressure with Hippocampal Volume by APOE and Cognitive Phenotype: The Alzheimer’s Disease Neuroimaging Initiative (ADNI)

2018 ◽  
Vol 45 (1-2) ◽  
pp. 66-78 ◽  
Author(s):  
Julius S. Ngwa ◽  
Thomas V. Fungwe ◽  
Oyonumo Ntekim ◽  
Joanne S. Allard ◽  
Sheree M. Johnson ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Blood Pressure ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Hippocampal Volume ◽  
Cognitive Status ◽  
Brain Volumes ◽  
Using Data

Background: It is increasingly evident that high blood pressure can promote reduction in global and regional brain volumes. While these effects may preferentially affect the hippocampus, reports are inconsistent. Methods: Using data from the Alzheimer’s Disease Neuroimaging Initiative (ADNI), we examined the relationships of hippocampal volume to pulse pressure (PPR) and systolic (SBP) and diastolic (DBP) blood pressure according to apolipoprotein (APOE) ɛ4 positivity and cognitive status. The ADNI data included 1,308 participants: Alzheimer disease (AD = 237), late mild cognitive impairment (LMCI = 454), early mild cognitive impairment (EMCI = 254), and cognitively normal (CN = 365), with up to 24 months of follow-up. Results: Higher quartiles of PPR were significantly associated with lower hippocampal volumes (Q1 vs. Q4, p = 0.034) in the CN and AD groups, but with increasing hippocampal volume (Q1, p = 0.008; Q2, p = 0.020; Q3, p = 0.017; Q4 = reference) in the MCI groups. In adjusted stratified analyses among non-APOE ɛ4 carriers, the effects in the CN (Q1 vs. Q4, p = 0.006) and EMCI groups (Q1, p = 0.002; Q2, p = 0.013; Q3, p = 0.002; Q4 = reference) remained statistically significant. Also, higher DBP was significantly associated with higher hippocampal volume (p = 0.002) while higher SBP was significantly associated with decreasing hippocampal volume in the EMCI group (p = 0.015). Conclusion: Changes in PPR, SBP, and DBP differentially influenced hippocampal volumes depending on the cognitive and APOE genotypic categories.

scholarly journals THE INCIDENCE AND IMPACT OF POLYPHARMACY IN AL RESIDENTS

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S236-S236
Author(s):  
Elizabeth Galik
Keyword(s):  
Emergency Room ◽  
Descriptive Study ◽  
Cognitive Status ◽  
Emergency Room Visits ◽  
Negative Outcomes ◽  
The Mean ◽  
Using Data

Abstract The purpose of this study was to describe polypharmacy in AL settings. We hypothesized that: (1) age, gender, race, setting, multimorbidity and cognitive status would influence polypharmacy; and (2) polypharmacy would be associated with falls, emergency room visits and hospitalizations. This was a descriptive study using data from the first cohort of the FFC-AL-EIT Study. A total of 242 participants from 26 AL settings were included. Participants had a mean age of 86.86 (SD=7.0), the majority were women 179(74%) and white (N=232, 96%) with 5 (SD=2) comorbidities. The mean number of drugs was 7 (SD=3.56) and 51% were exposed to polypharmacy, 24% fell at least once, 9% were sent to the hospital and 13% to the emergency room. Neither hypothesis was supported. Continued research is needed to explore the factors that influence polypharmacy and to identify if there are negative outcomes associated with polypharmacy in this population.

scholarly journals A MIXED-METHODS STUDY OF NURSING HOME RESIDENTS’ EXPERIENCES OF RELATIONSHIPS AND DAY-TO-DAY SOCIAL INTERACTIONS

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S555-S555
Author(s):  
Allyson M Washburn ◽  
Susan Williams
Keyword(s):  
Nursing Home ◽  
Social Cognition ◽  
Social Interactions ◽  
Nursing Home Residents ◽  
Social Experiences ◽  
Cognitive Status ◽  
Mixed Methods Study ◽  
Conventional Content Analysis ◽  
Using Data ◽  
Nursing Home Stay

Abstract Nursing home residents with and without cognitive impairment (N=38) answered open-ended questions about their day-to-day social interactions and ongoing relationships with family and friends. One author (SW) completed a conventional content analysis of the transcripts and the other (AW), a phenomenological-hermeneutic analysis. Findings from these analyses were combined and examined further using data from measures of social cognition and staff ratings of social behavior. Participants’ social experiences appeared to be determined not only by long-established habits and preferences and length of nursing home stay but also by their cognitive status and social cognition competencies. A central theme was the importance of managing ongoing relationships and day-to-day interactions so as to reduce one’s own stress as well as the burden on others. This presentation details how findings from distinct analytic strategies were combined to characterize the researchers’ understanding of participants’ lives in their networks of care from their own perspective.

scholarly journals Factors related to low social participation in older adults: findings from the Fibra study, Brazil

2017 ◽  
Vol 25 (3) ◽  
pp. 286-293 ◽  
Author(s):  
Juliana Martins Pinto ◽  
Anita Liberalesso Neri
Keyword(s):  
Social Support ◽  
Older Adults ◽  
Social Participation ◽  
Perceived Social Support ◽  
Cognitive Status ◽  
Vision Impairment ◽  
Health Conditions ◽  
Active Aging ◽  
Using Data ◽  
Vulnerable Elderly

Abstract Objective To investigate the factors related to low social participation in older adults. Method A hierarchical model was drawn using data from 2,251 participants of the Fibra study, aged 65 years or more, without cognitive impairment suggestive of dementia, who were living in seven Brazilian cities. Three blocks of variables were considered: macrostructural, socioeconomic and health conditions. Results Factors related to low social participation were low perceived social support (OR:2.18;CI:0.73-1.53; <0.001), vision impairment (OR:2.04; CI:1.16-3.61;0.014), age over 80 years (OR:2.03;CI:1.22-3.38;0.006), depressive symptoms (OR:1.86;CI:1.29-2.68; <0.001), low cognitive status (OR:1.85;CI:1.20-2.85;0.005) and slowness (OR:1.83;CI:1.26-2.65;0.001). Older adults with those conditions have higher odds to be less socially engaged than their counterparts. Conclusion Personal conditions, such as socioeconomic and health status were predictors of low social participation in older adults. Initiatives aiming at active aging promotion should focus primarily on vulnerable elderly, especially those with health and/or social disadvantages.

Shall I Stay or Shall I Go? The Choice to Remain in the Nursing Home Among Residents With High Potential for Discharge

2018 ◽  
Vol 39 (8) ◽  
pp. 863-870 ◽  
Author(s):  
Kathleen Abrahamson ◽  
Zachary Hass ◽  
Greg Arling
Keyword(s):  
Nursing Home ◽  
Daily Living ◽  
Cognitive Status ◽  
Cognitively Impaired ◽  
Care Needs ◽  
Health Related ◽  
Community Initiative ◽  
Small Decline ◽  
Using Data ◽  
Perception Of Health

Minnesota’s Return to Community Initiative (RTCI) assists private-pay nursing home (NH) residents to return to the community. Using data from a 1-year admission cohort of RTCI-targeted NH residents, we examined why residents who at admission expressed a desire for discharge, were paying privately, and had relatively low-care needs chose to remain in the NH. Characteristics of those who remained were compared with those who discharged using logistic regression, and barriers to discharge were summarized. Residents who were older, more cognitively impaired (OR = 1.8), unmarried (OR = 1.4), had behavior problems (OR = 1.6), or diagnosed with dementia (OR = 2.0) were more likely to remain than discharge to the community. Between admission and their 90-day assessment, residents remaining in the facility had a small decline in cognitive status, yet their continence improved and they became more independent in activities of daily living (ADLs). Seventy-four percent reported a perception of health-related barriers to discharge.

scholarly journals REJECTION OF CARE IN PERSONS WITH DEMENTIA

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S183-S183
Author(s):  
Natalie G Regier ◽  
Scott Choi ◽  
Laura N Gitlin
Keyword(s):  
Behavioral Problems ◽  
Rating Scale ◽  
Neuropsychiatric Symptoms ◽  
Cognitive Status ◽  
Communication Style ◽  
Principle Components Analysis ◽  
Behavior Study ◽  
Clinician Rating ◽  
Components Analysis ◽  
Using Data

Abstract Most individuals with dementia develop significant behavioral problems, also known as neuropsychiatric symptoms (NPS). One problem that continues to plague measurement of NPS is inconsistency of terminology used to describe NPS. For example, in the Neuropsychiatric Inventory-Clinician Rating Scale (NPI-C), a gold standard for measuring NPS, rejection of care (rejection) is not differentiated from agitation or aggression. Rather, behaviors indicative of rejection are categorized as agitation. Using data from 250 persons with dementia who participated in the Dementia Behavior Study, principle components analysis of the NPI-C domain of Agitation identified four behavioral clusters: 1=rejection of care, 2=restlessness, 3=exiting behaviors, and 4=hiding/hoarding. Rejection was associated with a more distant relationship with the caregiver, lower cognitive status, and more negative caregiver communication style. Rejection was predictive of higher levels of caregiver burden. Findings support the argument that rejection is a clinically distinct NPS, and likely requires different nonpharmacological management than agitation.

scholarly journals The Association between the Usage of Non-Steroidal Anti-Inflammatory Drugs and Cognitive Status: Analysis of Longitudinal and Cross-Sectional Studies from the Global Alzheimer’s Association Interactive Network and Transcriptomic Data

2020 ◽  
Vol 10 (12) ◽  
pp. 961
Author(s):  
Robert Morris ◽  
Kyle Armbruster ◽  
Julianna Silva ◽  
Daniel James Widell ◽  
Feng Cheng
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Arachidonic Acid ◽  
Cognitive Status ◽  
Cross Sectional ◽  
Transcriptomic Data ◽  
Age Related ◽  
Interactive Network ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

The degenerative cognitive and physical decline of Alzheimer patients, coupled with the extensive psychological and economic tolls imposed on family members that serve as caretakers, necessitate the discovery of effective cures and preventative measures for age-related cognitive depreciation. In the journey of Alzheimer’s disease treatment discovery, several cross-sectional and longitudinal studies have delineated a noticeable association between the use of nonsteroidal anti-inflammatory drugs (NSAIDs), a class of low-cost drugs with minimal side effects, and the alleviation of age-related memory impairment. In this study, four datasets (two cross-sectional and two longitudinal studies) derived from the Global Alzheimer’s Association Interactive Network (GAAIN) were analyzed. The significant association between the usage of NSAIDs and better cognitive status was observed. The results agree with the findings of previous studies that the use of NSAIDs may be beneficial in the early stages of Alzheimer’s disease. Transcriptomic data show that ibuprofen treatment results in upregulation of several genes involved in arachidonic acid metabolism including PPARγ, Cyp4a12b, Cyp2c66, and Cyp2c37 in the hippocampus. The increase in conversion of arachidonic acid into anti-inflammatory 16C and 18C dicarboxylic acids as well as epoxyeicosatrienoic acids may play a role in reducing the risk of Alzheimer’s disease development.

Sign in / Sign up

Export Citation Format

Share Document