P2-503: COGNITIVE PERFORMANCE FOR VERBAL MEMORY AND SEMANTIC VERBAL FLUENCY AS A FUNCTION OF TAU PROTEIN LEVELS

2006 ◽  
Vol 14 (7S_Part_17) ◽  
pp. P923-P924
Author(s):  
Emilie Thomas ◽  
Tharick A. Pascoal ◽  
Melissa Savard ◽  
Laurie-Anne Dion ◽  
Mira Chamoun ◽  
...  
Keyword(s):  
Cognitive Performance ◽  
Tau Protein ◽  
Verbal Memory ◽  
Verbal Fluency ◽  
Semantic Verbal Fluency ◽  
Protein Levels

scholarly journals Is there a link between TNF gene expression and cognitive deficits in depression?

1970 ◽  
Vol 64 (1) ◽  
Author(s):  
Kinga Bobińska ◽  
Elżbieta Gałecka ◽  
Janusz Szemraj ◽  
Piotr Gałecki ◽  
Monika Talarowska
Keyword(s):  
Gene Expression ◽  
Verbal Memory ◽  
Verbal Fluency ◽  
Depressive Disorders ◽  
Verbal Learning ◽  
Test Group ◽  
Entire Group ◽  
Expression Levels ◽  
Protein Levels ◽  
Tnf Α

Neuroinflammation is a known factor in the pathogenesis of recurrent depressive disorders. Depression is accompanied by activated immune-inflammatory pathways including increased levels of TNFα, sTNFR1and sTNFR2.The purpose of this study was to analyse the TNF-α, TNFRSF1A and TNFRSF1B genes on both mRNA and protein levels in patients with rDD, and to investigate the relationship between TNF-α,TNFRSF1A and TNFRSF1B gene expression and cognitive performance. The study comprised 158 subjects: patients with recurrent depressive disorder (n=89) and healthy subjects (n=69). Cognitive function assessment was based on: Trail Making Test, The Stroop Test, Verbal Fluency Test and Auditory Verbal Learning Test. Both mRNA and protein expression levels of all genes were significantly higher in rDD subjects when compared to healthy controls. No statistically significant correlations were observed between the analysed variables in both the rDD group and the HS test group. The only exception was noticed in the HS test group, where increased expression of TNFRSF1A and TNFRSF1B gene negatively affected the performance of the AVLT test. However, statistically significant correlations between TNF, TNFRSF1A, TNFRSF1B mRNA gene expression levels and all the neuropsychological tests used in the survey for the entire group were observed. 1.The results of our study show increased expression of the TNF, TNFRSF1A and TNFRSF1B genes on both mRNA and protein levels in depression. 2. Elevated expression of TNF-α, TNFRSF1A and TNFRSF1B negatively correlates with cognitive efficiency: working memory, executive functions, attention, auditory-verbal memory, effectiveness of learning processes and verbal fluency.

scholarly journals Cognitive Performance among Cognitively Healthy Adults Aged 30–100 Years

2019 ◽  
Vol 9 (1) ◽  
pp. 11-23 ◽  
Author(s):  
Minna Alenius ◽  
Sanna Koskinen ◽  
Ilona Hallikainen ◽  
Tiia Ngandu ◽  
Jari Lipsanen ◽  
...  
Keyword(s):  
Cognitive Performance ◽  
Verbal Memory ◽  
Test Performance ◽  
Verbal Fluency ◽  
Word List ◽  
Education Level ◽  
Healthy Adults ◽  
Cognitive Test ◽  
Normative Values ◽  
And Gender

Background/Aims: To detect cognitive decline in older adults, measures of verbal fluency and verbal memory are widely used. Less is known about performance in these measures in younger persons or according to education level and gender. We investigated cognitive performance according to age, education and gender among cognitively healthy adults aged 30–100 years. Methods: The study population comprised 4,174 cognitively healthy persons participating in the nationally representative Finnish Health 2011 survey. Cognitive assessment included verbal fluency, word list memory, word list recall and word list savings from the Consortium to Establish a Registry for Alzheimer’s Disease neuropsychological battery. Results: Total variance in the cognitive test performance explained by age, education and gender varied from 12.3 to 31.2%. A decreasing trend in cognitive performance existed in all subtests by advancing age, with differences appearing between 50 and 55 years. Persons with the highest-education level performed best for all measures. For the participants < 55 years, education explained part of the variance, while age and gender did not. Conclusions: When assessing cognition, age and education should be accounted for in more detail in research and clinical practice. Additionally, the cohort effect and its potential impact on the renewal cycle of future normative values for cognitive tests should be considered.

scholarly journals Dysfunctional Learning and Verbal Memory in Patients with Elevated Tau Protein Levels and Serum Recoverin Autoantibodies—Case Series and Review

2021 ◽  
Vol 12 (1) ◽  
pp. 15
Author(s):  
Niels Hansen ◽  
Claudia Bartels ◽  
Kristin Rentzsch ◽  
Winfried Stöcker ◽  
Dirk Fitzner
Keyword(s):  
Cognitive Impairment ◽  
Pineal Gland ◽  
Tau Protein ◽  
Verbal Memory ◽  
Late Onset ◽  
Case Series ◽  
Depressive Mood ◽  
Formal Thought Disorder ◽  
Autoimmune Retinopathy ◽  
Protein Levels

Recoverin-antibody-related disease is currently restricted to late-onset ataxia and autoimmune retinopathy, which can be paraneoplastic or not. However, cognitive dysfunction associated with recoverin antibodies has not been reported so far in a homogeneous patient group. Our case series is dedicated to describing the novel phenotype of cognitive impairment associated with recoverin antibodies. We included five patients with cognitive impairment who presented serum recoverin autoantibodies detected by immunoblots in our case series investigation. We also analyzed their psychopathology, clinical data, cerebrospinal fluid (CSF), and neuroimaging data. Five patients with cognitive impairment associated with serum recoverin antibodies exhibited profound dysfunctional learning and verbal memory. In the CSF of 40% of them, we also diagnosed axonal neurodegeneration entailing elevated tau and phosphorylated tau protein levels. Psychopathologies such as affective symptoms (restlessness, depressive mood, anxiety, complaintiveness) and formal thought disorder, such as rumination, were detected in 25–75% of the patients. We hypothesized a role of recoverin autoimmunity in the pineal gland involving consecutive modulation of hippocampus-based memory caused by an altered release of melatonin. We describe a novel phenotype of possible recoverin autoimmunity in patients with cognitive impairment. However, no clear diagnostic clues can be extracted because of the low diagnostic validity of the testing strategies applied. The possibility of recoverin antibody autoimmunity in the pineal gland correlating with a modulation of hippocampus-based memory should be further investigated.

An APOA1 promoter polymorphism is associated with cognitive performance in patients with multiple sclerosis

2008 ◽  
Vol 15 (2) ◽  
pp. 174-179 ◽  
Author(s):  
G Koutsis ◽  
M Panas ◽  
E Giogkaraki ◽  
G Karadima ◽  
C Sfagos ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cognitive Performance ◽  
Verbal Fluency ◽  
Promoter Polymorphism ◽  
Stroop Interference ◽  
Interference Task ◽  
Cognitive Domains ◽  
Semantic Verbal Fluency ◽  
Dementia Risk ◽  
Better Than

Background Elevated ApoA1 levels have been associated with decreased dementia risk. The A-allele of the APOA1 –75G/A promoter polymorphism has been associated with elevated ApoA1 levels. Objective We sought to investigate the effect of the APOA1 –75G/A promoter polymorphism on cognitive performance in patients with multiple sclerosis (MS). Methods A total of 138 patients with MS and 43 controls were studied and underwent neuropsychological assessment with Rao’s Brief Repeatable Battery and the Stroop test. All patients were genotyped for APOA1. Results APOA1 A-allele carriers displayed superior overall cognitive performance compared with non-carriers ( P 0.008) and had a three-fold decrease in the relative risk of overall cognitive impairment (OR 0.29, 95% CI 0.11–0.74). Regarding performance on individual cognitive domains, although APOA1 A-allele carriers performed better than non-carriers on all tests, this was significant only for semantic verbal fluency and the Stroop interference task ( P 0.036 and 0.018, respectively). Conclusions We found an association of the APOA1 –75G/A promoter polymorphism with cognitive performance in MS. This effect was most prominent on semantic verbal fluency and the Stroop interference task.

scholarly journals Effects of Cancer, Chemotherapy and Cytokines on Subjective and Objective Cognitive Functioning Among Patients with Breast Cancer

Cancers ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 2576
Author(s):  
Vincent Chin-Hung Chen ◽  
Chin-Kuo Lin ◽  
Han-Pin Hsiao ◽  
Bor-Show Tzang ◽  
Yen-Hsuan Hsu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cognitive Function ◽  
Cognitive Abilities ◽  
Verbal Fluency ◽  
Control Group ◽  
Control Groups ◽  
Semantic Verbal Fluency ◽  
Cytokine Levels ◽  
Chemotherapy Patients ◽  
And Control

Background: We aimed to investigate the associations of breast cancer (BC) and cancer-related chemotherapies with cytokine levels, and cognitive function. Methods: We evaluated subjective and objective cognitive function in BC patients before chemotherapy and 3~9 months after the completion of chemotherapy. Healthy volunteers without cancer were also compared as control group. Interleukins (IL) 2, 4, 5, 6, 10, 12p70, 13, 17A, 1β, IFNγ, and TNFα were measured. Associations of cancer status, chemotherapy and cytokine levels with subjective and objective cognitive impairments were analyzed using a regression model, adjusting for covariates, including IQ and psychological distress. Results: After adjustment, poorer performance in semantic verbal fluency was found in the post-chemotherapy subgroup compared to controls (p = 0.011, η2 = 0.070); whereas pre-chemotherapy patients scored higher in subjective cognitive perception. Higher IL-13 was associated with lower semantic verbal fluency in the post-chemotherapy subgroup. Higher IL-10 was associated with better perceived cognitive abilities in the pre-chemotherapy and control groups; while IL-5 and IL-13 were associated with lower perceived cognitive abilities in pre-chemotherapy and control groups. Our findings from mediation analysis further suggest that verbal fluency might be affected by cancer status, although mediated by anxiety. Conclusions: Our findings suggest that verbal fluency might be affected by cancer status, although mediated by anxiety. Different cytokines and their interactions may have different roles of neuroinflammation or neuroprotection that need further research.

Patients with amnestic MCI Fail to Adapt Executive Control When Repeatedly Tested with Semantic Verbal Fluency Tasks

2021 ◽  
pp. 1-8
Author(s):  
Johannes Tröger ◽  
Hali Lindsay ◽  
Mario Mina ◽  
Nicklas Linz ◽  
Stefan Klöppel ◽  
...  
Keyword(s):  
Executive Control ◽  
Verbal Fluency ◽  
Fixed Time ◽  
Semantic Space ◽  
Semantic Knowledge ◽  
Semantic Verbal Fluency ◽  
Amnestic Mci ◽  
Retrieval Processes ◽  
Theoretical View ◽  
First Time

Abstract Objective: Semantic verbal fluency (SVF) tasks require individuals to name items from a specified category within a fixed time. An impaired SVF performance is well documented in patients with amnestic Mild Cognitive Impairment (aMCI). The two leading theoretical views suggest either loss of semantic knowledge or impaired executive control to be responsible. Method: We assessed SVF 3 times on 2 consecutive days in 29 healthy controls (HC) and 29 patients with aMCI with the aim to answer the question which of the two views holds true. Results: When doing the task for the first time, patients with aMCI produced fewer and more common words with a shorter mean response latency. When tested repeatedly, only healthy volunteers increased performance. Likewise, only the performance of HC indicated two distinct retrieval processes: a prompt retrieval of readily available items at the beginning of the task and an active search through semantic space towards the end. With repeated assessment, the pool of readily available items became larger in HC, but not patients with aMCI. Conclusion: The production of fewer and more common words in aMCI points to a smaller search set and supports the loss of semantic knowledge view. The failure to improve performance as well as the lack of distinct retrieval processes point to an additional impairment in executive control. Our data did not clearly favour one theoretical view over the other, but rather indicates that the impairment of patients with aMCI in SVF is due to a combination of both.

scholarly journals Aggregated Tau-PHF6 (VQIVYK) Potentiates NLRP3 Inflammasome Expression and Autophagy in Human Microglial Cells

Cells ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1652
Author(s):  
Chinmaya Panda ◽  
Clara Voelz ◽  
Pardes Habib ◽  
Christian Mevissen ◽  
Thomas Pufe ◽  
...  
Keyword(s):  
Tau Protein ◽  
Nlrp3 Inflammasome ◽  
Time Dependent ◽  
Microglial Cells ◽  
Inflammasome Activation ◽  
Dependent Manner ◽  
Progressive Dementia ◽  
Microglial Polarization ◽  
Protein Levels ◽  
Pyrin Domain

Intra-neuronal misfolding of monomeric tau protein to toxic β-sheet rich neurofibrillary tangles is a hallmark of Alzheimer’s disease (AD). Tau pathology correlates not only with progressive dementia but also with microglia-mediated inflammation in AD. Amyloid-beta (Aβ), another pathogenic peptide involved in AD, has been shown to activate NLRP3 inflammasome (NOD-like receptor family, pyrin domain containing 3), triggering the secretion of proinflammatory interleukin-1β (IL1β) and interleukin-18 (IL18). However, the effect of tau protein on microglia concerning inflammasome activation, microglial polarization, and autophagy is poorly understood. In this study, human microglial cells (HMC3) were stimulated with the unaggregated and aggregated forms of the tau-derived PHF6 peptide (VQIVYK). Modulation of NLRP3 inflammasome was examined by qRT-PCR, immunocytochemistry, and Western blot. We demonstrate that fibrillar aggregates of VQIVYK upregulated the NLRP3 expression at both mRNA and protein levels in a dose- and time-dependent manner, leading to increased expression of IL1β and IL18 in HMC3 cells. Aggregated PHF6-peptide also activated other related inflammation and microglial polarization markers. Furthermore, we also report a time-dependent effect of the aggregated PHF6 on BECN1 (Beclin-1) expression and autophagy. Overall, the PHF6 model system-based study may help to better understand the complex interconnections between Alzheimer’s PHF6 peptide aggregation and microglial inflammation, polarization, and autophagy.

scholarly journals Quantitative and qualitative analysis of semantic verbal fluency in patients with temporal lobe epilepsy

2020 ◽  
Vol 35 (1) ◽  
pp. 1-9
Author(s):  
A.G. Jaimes-Bautista ◽  
M. Rodríguez-Camacho ◽  
I.E. Martínez-Juárez ◽  
Y. Rodríguez-Agudelo
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Qualitative Analysis ◽  
Temporal Lobe ◽  
Verbal Fluency ◽  
Semantic Verbal Fluency

scholarly journals Recruiting the right hemisphere: Sex differences in inter-hemispheric communication during semantic verbal fluency

2020 ◽  
Vol 207 ◽  
pp. 104814 ◽  
Author(s):  
Andrea Scheuringer ◽  
Ti-Anni Harris ◽  
Belinda Pletzer
Keyword(s):  
Sex Differences ◽  
Verbal Fluency ◽  
Right Hemisphere ◽  
Semantic Verbal Fluency ◽  
The Right ◽  
Hemispheric Communication

scholarly journals Familial ALS with G298S Mutation in TARDBP: A Comparison of CSF Tau Protein Levels with those in Sporadic ALS

2010 ◽  
Vol 49 (12) ◽  
pp. 1209-1212 ◽  
Author(s):  
Ichiro Nozaki ◽  
Makoto Arai ◽  
Kazuya Takahashi ◽  
Tsuyoshi Hamaguchi ◽  
Hiroaki Yoshikawa ◽  
...  
Keyword(s):  
Tau Protein ◽  
Protein Levels ◽  
Sporadic Als ◽  
Familial Als
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