An APOA1 promoter polymorphism is associated with cognitive performance in patients with multiple sclerosis

2008 ◽  
Vol 15 (2) ◽  
pp. 174-179 ◽  
Author(s):  
G Koutsis ◽  
M Panas ◽  
E Giogkaraki ◽  
G Karadima ◽  
C Sfagos ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cognitive Performance ◽  
Verbal Fluency ◽  
Promoter Polymorphism ◽  
Stroop Interference ◽  
Interference Task ◽  
Cognitive Domains ◽  
Semantic Verbal Fluency ◽  
Dementia Risk ◽  
Better Than

Background Elevated ApoA1 levels have been associated with decreased dementia risk. The A-allele of the APOA1 –75G/A promoter polymorphism has been associated with elevated ApoA1 levels. Objective We sought to investigate the effect of the APOA1 –75G/A promoter polymorphism on cognitive performance in patients with multiple sclerosis (MS). Methods A total of 138 patients with MS and 43 controls were studied and underwent neuropsychological assessment with Rao’s Brief Repeatable Battery and the Stroop test. All patients were genotyped for APOA1. Results APOA1 A-allele carriers displayed superior overall cognitive performance compared with non-carriers ( P 0.008) and had a three-fold decrease in the relative risk of overall cognitive impairment (OR 0.29, 95% CI 0.11–0.74). Regarding performance on individual cognitive domains, although APOA1 A-allele carriers performed better than non-carriers on all tests, this was significant only for semantic verbal fluency and the Stroop interference task ( P 0.036 and 0.018, respectively). Conclusions We found an association of the APOA1 –75G/A promoter polymorphism with cognitive performance in MS. This effect was most prominent on semantic verbal fluency and the Stroop interference task.

scholarly journals Factors associated with cognitive performance in elderly caregivers

2018 ◽  
Vol 76 (10) ◽  
pp. 685-691 ◽  
Author(s):  
Sofia Cristina Iost Pavarini ◽  
Allan Gustavo Brigola ◽  
Ana Carolina Ottaviani ◽  
Bruna Moretti Luchesi ◽  
Érica Nestor Souza ◽  
...  
Keyword(s):  
Cognitive Performance ◽  
Verbal Fluency ◽  
Family Income ◽  
Healthcare Services ◽  
Cognitive Domains ◽  
Factors Associated ◽  
Dependent Variables ◽  
Attention Memory ◽  
Elderly Caregivers ◽  
Addenbrooke’S Cognitive Examination

Abstract Objectives: To explore the socioeconomic, demographic and psychosocial factors associated with cognitive performance in elderly caregivers from Brazil. Methods: We evaluated 351 Brazilian elderly caregivers attending primary healthcare services regarding sociodemographic and care variables. Addenbrooke's Cognitive Examination-Revised (ACE-R) domains of orientation/attention, memory, verbal fluency, language and visuospatial were used as dependent variables in the Tobit model. Results: Literacy and family income were positively associated with all ACE-R domains. Age, gender, time of care (days/week) were negatively associated with some cognitive domains. Moreover, receiving emotional help and the level of hope were positively associated with specific domains. Discussion: The results may be useful for planning interventions aimed at elderly caregivers in order to prevent deficits in the different cognitive domains.

P2-503: COGNITIVE PERFORMANCE FOR VERBAL MEMORY AND SEMANTIC VERBAL FLUENCY AS A FUNCTION OF TAU PROTEIN LEVELS

2006 ◽  
Vol 14 (7S_Part_17) ◽  
pp. P923-P924
Author(s):  
Emilie Thomas ◽  
Tharick A. Pascoal ◽  
Melissa Savard ◽  
Laurie-Anne Dion ◽  
Mira Chamoun ◽  
...  
Keyword(s):  
Cognitive Performance ◽  
Tau Protein ◽  
Verbal Memory ◽  
Verbal Fluency ◽  
Semantic Verbal Fluency ◽  
Protein Levels

scholarly journals Aerobic Capacity Is Not Associated with Most Cognitive Domains in Patients with Multiple Sclerosis—A Cross-Sectional Investigation

2018 ◽  
Vol 7 (9) ◽  
pp. 272 ◽  
Author(s):  
Martin Langeskov-Christensen ◽  
Søren Eskildsen ◽  
Egon Stenager ◽  
Henrik Boye Jensen ◽  
Helle Hvilsted Nielsen ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cognitive Impairment ◽  
Cognitive Performance ◽  
Aerobic Capacity ◽  
Z Score ◽  
Vo2 Max ◽  
Cross Sectional ◽  
Cognitive Domains ◽  
Impaired Group ◽  
Z Scores

(1) Background: Cognitive impairment is highly prevalent in multiple sclerosis (MS). Staying physically fit may be associated with preservation of cognitive performance in persons with MS (pwMS); (2) Objective: To investigate the association between aerobic capacity and the cognitive domains of information processing, learning and memory, and verbal fluency as well as single and composite z-scores of the Brief Repeatable Battery of Neuropsychological tests (BRBNT) in pwMS; (3) Methods: All subjects first performed the BRBNT and then a maximal oxygen consumption (VO2-max) test on a bicycle ergometer as a measure of aerobic capacity. Simple and multiple (adjusting for age, sex, and education level) regression analyses were performed to evaluate the relationship between aerobic capacity and cognitive performance in different domains. Published international norms were used to compute z-scores for each individual and composite BRBNT score. Furthermore, cognitive impairment was defined as one or more z-scores ≤−1.5 standard deviation (SD) of healthy controls; (4) Results: Eighty-four subjects were included (44.9 ± 9 years, 16.3 ± 2 education years, Expanded Disability Status Scale (EDSS): 2.6 ± 1.4, MS-type (relapsing-remitting, primary progressive, or secondary progressive): 73/6/5, disease duration: 9.9 ± 7 years, VO2-max: 28.4 ± 7.0 mL O2/min/kg). No significant associations between aerobic capacity and cognitive performance in the individual BRBNT tests were found, except that a weak relationship was found between aerobic capacity and the composite processing speed z-score (R2 = 0.06, p = 0.02). The average global BRBNT z-score (−0.2 ± 0.66) was not associated with aerobic capacity. Comparison of the cognitively impaired group (34.5%) with the nonimpaired group (65.5%) showed lower aerobic capacity in the impaired group (25.9 ± 1 vs. 29.7 ± 1 mLO2/min/kg, p = 0.02); (5) Conclusions: Limited support was found for an association between performance in most cognitive domains and aerobic capacity in the present MS group with a third of patients showing signs of cognitive impairments.

Cognitive dysfunction in primary progressive multiple sclerosis: a neuropsychological and MRI study

2009 ◽  
Vol 15 (9) ◽  
pp. 1055-1061 ◽  
Author(s):  
M Ukkonen ◽  
T Vahvelainen ◽  
P Hämäläinen ◽  
P Dastidar ◽  
I Elovaara
Keyword(s):  
Multiple Sclerosis ◽  
Cognitive Performance ◽  
Cognitive Dysfunction ◽  
Neuropsychological Tests ◽  
Brain Lesion ◽  
Progressive Multiple Sclerosis ◽  
Primary Progressive Multiple Sclerosis ◽  
Cognitive Domains ◽  
Primary Progressive ◽  
Mri Study

Although cognitive dysfunction is known to occur in multiple sclerosis (MS), only few studies have reported cognitive performance in patients with primary progressive MS (PPMS). To find out the pattern of cognitive performance in PPMS, 28 PPMS patients underwent an extensive battery of neuropsychological tests. The results were compared to those of healthy controls ( n = 20) and patients with secondary progressive MS (SPMS, n = 28). Furthermore, the results of neuropsychological tests in PPMS were correlated to magnetic resonance imaging findings. Our study showed that the PPMS patients have deficits in several cognitive domains when compared to age-matched and education-matched controls, but the cognitive impairment in the PPMS and SPMS patients appeared to be similar. Cognitive deficits in PPMS patients correlated with diffuse brain lesion, T1- and T2-lesion load, but no correlations were found with atrophy.

scholarly journals Sex, diabetes status and cognition: findings from the study of longevity in diabetes

2021 ◽  
Vol 9 (1) ◽  
pp. e001646
Author(s):  
Chris Moran ◽  
Paola Gilsanz ◽  
Michal S Beeri ◽  
Rachel A Whitmer ◽  
Mary E Lacy
Keyword(s):  
Cognitive Performance ◽  
Verbal Memory ◽  
Visual Memory ◽  
Cognitive Outcomes ◽  
Kaiser Permanente ◽  
Cross Sectional ◽  
Cognitive Domains ◽  
People With Dementia ◽  
Dementia Risk ◽  
Diabetes Status

IntroductionWomen comprise two-thirds of people with dementia, making female sex a significant dementia risk factor. Both type 1 diabetes (T1D) and type 2 diabetes (T2D) are known dementia risk factors with an increasing global incidence. Understanding whether subtle sex differences persist in cognitive function prior to dementia in the context of diabetes may help elucidate the magnitude of sex effects on dementia risk.Research design and methodsWe examined cross-sectional data from the Study of Longevity in Diabetes (SOLID), a prospective cohort study of members of Kaiser Permanente Northern California aged 60 years and older with T1D (n=758), T2D (n=232) and without either T1D or T2D (n=247). We used factor analysis to generate summary scores of cognitive domains and used regression analyses to examine the associations between sex and cognition adjusting for sociodemographic and cardiovascular confounders.ResultsWe included 1237 participants (630 women and 607 men) with mean age 68 years. By design, the distribution of men and women in T1D, T2D and no diabetes was similar. Women had better cognitive performance than men in global cognition (β=0.21, 95% CI 0.16 to 0.26), language (β=0.08, 95% CI 0.004 to 0.15), executive function (β=0.13, 95% CI 0.05 to 0.20), episodic verbal memory (β=0.68, 95% CI 0.59 to 0.77) and attention (β=0.20, 95% CI 0.11 to 0.28) but not in episodic visual memory (β=0.006, 95% CI −0.07 to 0.09) adjusting for age and education independent of diabetes status. We did not find an interaction between sex and diabetes status for any of the cognitive outcomes.ConclusionsWomen in late mid-life have better cognitive performance than men in many cognitive domains independent of the presence of T1D or T2D. Further work is required to understand whether these differences change over time or in older cohorts and to understand their relationship to subsequent dementia.

scholarly journals Association between Neurocognitive Impairment and the Short Allele of the 5-HTT Promoter Polymorphism in Depression: A Pilot Study

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Hely Kalska ◽  
Ullamari Pesonen ◽  
Sanna Lehikoinen ◽  
Jan-Henry Stenberg ◽  
Jari Lipsanen ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Pilot Study ◽  
Cognitive Performance ◽  
Promoter Region ◽  
Promoter Polymorphism ◽  
Healthy Controls ◽  
Allele Polymorphism ◽  
Short Allele ◽  
Cognitive Domains ◽  
Depressed Patients

Depression has been shown to be associated with cognitive deficits in various cognitive domains. However, it is still unclear which factors contribute to cognitive impairment. The objective of this study was to find out whether a functional polymorphism in the promoter region of the serotonin transporter (5-HTTLPR) gene is associated with the impairment of cognitive functioning among depressed patients. In a pilot study, a sample of 19 patients with major depressive disorder (MDD) and 19 healthy controls was investigated with an extensive psychiatric and neuropsychological examination. All participants were genotyped for 5-HTTLPR. Depressed patients with the short allele of the 5-HTT promoter region exhibited inferior cognitive performance compared to patients with the long allele polymorphism. In healthy controls, no association between genotype and cognitive performance was found. The result suggests that in MDD patients with the short allele of the 5-HTTLPR polymorphism the vulnerability to cognitive impairment is increased compared to MDD patients without the short allele inheritance. These preliminary findings need to be confirmed in a larger cohort of MDD patients.

General Measures of Cognition

2003 ◽  
Vol 15 (S1) ◽  
pp. 215-217 ◽  
Author(s):  
Steven H. Ferris
Keyword(s):  
Working Memory ◽  
Clinical Trials ◽  
Cognitive Impairment ◽  
Executive Function ◽  
Vascular Dementia ◽  
Cognitive Performance ◽  
Verbal Fluency ◽  
Primary Outcome ◽  
Cognitive Domains ◽  
Reasonable Approach

A general cognitive performance battery is needed as a primary outcome in vascular dementia clinical trials. Because there is considerable overlap between vascular dementia and Alzheimer's disease (AD) in the pattern of cognitive impairment, a reasonable approach to developing an optimal vascular dementia battery is to begin with a widely used AD measure and improve its sensitivity to the cognitive domains that are more prominent in vascular dementia. Thus the VaDAS-cog has evolved, which comprises the ADAS-cog with additional frontal lobe subtests covering attention, working memory, executive function, and verbal fluency. Validation of this new cognitive instrument will be supported by its successful use in vascular dementia clinical trials.

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