scholarly journals P2-300: THE BLOOD PRESSURE LEVEL IS ASSOCIATED WITH PLASMA AMYLOID-β LEVELS: A CROSS-SECTIONAL STUDY IN THE SUBURBS OF XI'AN, CHINA

2019 ◽  
Vol 15 ◽  
pp. P701-P701
Author(s):  
Qiumin Qu ◽  
Meilin She
2019 ◽  
Vol 37 (1) ◽  
pp. 53-59 ◽  
Author(s):  
H. Ödesjö ◽  
S. Adamsson Eryd ◽  
S. Franzén ◽  
P. Hjerpe ◽  
K. Manhem ◽  
...  

2020 ◽  
Author(s):  
danhong Fang ◽  
Gaojun Wu ◽  
Qinfen Chen ◽  
Jiansheng Wu ◽  
Shengjie Wu ◽  
...  

Abstract Background: Serum uric acid (SUA) is strongly associated with hypertension and is associated with a variety of cardiovascular diseases. In this study we aimed to investigate the predictive effect of SUA and blood pressure on the left atrial (LA) size in Chinese south population. Methods: In this cross-sectional study, we investigated the association between SUA and LA diameter and studied the risk of LA enlargement among subjects with and without hyperuricemia (HU) in different grades of blood pressure in a single-center database (n=5392). Results: The LA diameter was significantly correlated with SUA(r=0.31, P<0.001). The incidence of LA enlargement was significantly greater in subjects with HU than in those without HU [25.7% vs. 14.2%, P<0.001; odds ratio (OR) = 2.09, 95% confidence interval (CI) = (1.78,2.45)], especially in women [21.8% vs. 7.4%, P<0.001; OR=3.50, 95%CI= (2.35, 5.22)]. In subjects with hypertension (≥140/90 mmHg) and HU, the risk of LA enlargement was 7.90 times higher than those with ideal blood pressure (< 120/80 mmHg) and normal SUA [33.1% vs. 5.9%; P<0.001, OR=7.90, 95% CI= (5.87,10.63)]. At the same blood pressure level, the risk of LA enlargement in HU subjects was higher than that in normal SUA (P<0.01). After adjustment for blood pressure, the effect of HU on LA size still exists[public OR=1.82, 95% CI=(1.54,2.14), P<0.001]. Conclusions: HU is an independent risk factor of LA enlargement in Chinese south population. SUA and blood pressure play a synergistic role in predicting the increase of LA diameter. Keywords: Uric acid, Hyperuricemia, Blood pressure, Left atrium


2017 ◽  
Vol 20 (1) ◽  
pp. 17-21
Author(s):  
Nadezhda V. Izmozherova ◽  
Artem A. Popov

Aim: to assess tolerability and efficacy of cardiovascular comorbidities pharmacotherapy in osteoporotic postmenopausal women. Methods: cross-sectional study included 112 osteoporotic postmenopausal women aged from 49 to 85. Results: 95 persons (84.8%) had indications for angiotensine-convertising enzyme inhibitors (ACEI) prescription. Cough was associated with significantly higher odds of coronary heart disease, congestive heart failure and a trend to multiple bone fractures. Valsartan was initiated in 32 coughing patients. Target blood pressure level was reached in 15 women. In 15 cases blood pressure levels decreased by 30% of baseline level. Conclusion: efficacy of cardiovascular diseases in osteoporotic postmenopausal women treatment needs to be assessed in specially designed clinical trials.


2021 ◽  
Vol 62 (4) ◽  
Author(s):  
Hoang Van Binh ◽  
Tran Thi Nhu Quynh

 A cross-sectional study was carried out in 2017, with the method of cluster sampling (PPS) to select30 communes/wards in 8 districts/cities in Thai Binh province. A total of 1450 adults from 25 ago ormore the results showed that:The prevalence rate of hypertension was 29.8%, of which men account for 36.5%, 22.0% higherthan that of women (p<0.05), mainly high blood pressure level 1 (42.3%), level 2 (35.4%) and level3 (22.3%).The rate of hypertension tends to increase gradually by age group, the group aged 70 and overaccounts for the highest proportion (36.4%), the age group 60-69 was 34.8%, the age group 40-59was 31.5% and the lowest of 25-39 age group (16.1%) (p<0.05).


2021 ◽  
Vol 13 ◽  
Author(s):  
Meilin She ◽  
Suhang Shang ◽  
Ningwei Hu ◽  
Chen Chen ◽  
Liangjun Dang ◽  
...  

Objectives: Amyloid-β (Aβ) deposition in the brain is the hallmark of Alzheimer’s disease (AD) pathology. Hypertension is a risk factor for AD, but the effects of hypertension on Aβ deposition are not fully determined. Considering peripheral Aβ closely relates to Aβ deposition in the brain, we investigated the relationships between blood pressure (BP) level and plasma Aβ concentrations.Methods: One-thousand and sixty-nine participants (age above 45) from a village in the suburbs of Xi’an, China were enrolled. Questionnaires and validated Chinese versions of the Mini-Mental State Examination (MMSE) were used to collect information about vascular risk factors and assess cognition function. The apolipoprotein E (ApoE) genotype was detected using PCR and sequencing. Plasma Aβ levels were measured using ELISA. The associations between BP and plasma Aβ levels were analyzed by using multivariate linear regression.Results: Plasma Aβ1–40 level was higher in high BP group than that in normal BP group (53.34 ± 8.50 pg/ml vs. 51.98 ± 8.96 pg/ml, P = 0.013), in high SBP group than that in normal SBP group (53.68 ± 8.69 pg/ml vs. 51.88 ± 8.80 pg/ml, P = 0.001) and in high MABP group than that in normal MABP group (54.05 ± 8.78 pg/ml vs. 52.04 ± 8.75 pg/ml, P = 0.001). After controlling for the confounding factors, SBP (b = 0.078, P &lt; 0.001), DBP (b = 0.090, P = 0.008) and MABP (b = 0.104, P &lt; 0.001) correlated with plasma Aβ1–40 level positively in ApoE ε4 non-carriers, but not ApoE ε4 carriers.Conclusions: Elevated BP levels were associated with increased plasma Aβ1–40 levels in middle-aged and elderly ApoE ε4 non-carriers.


Author(s):  
José João Mendes ◽  
João Viana ◽  
Filipe Cruz ◽  
Dinis Pereira ◽  
Sílvia Ferreira ◽  
...  

We aimed to investigate the association between blood pressure (BP) and tooth loss and the mediation effect of age. A cross-sectional study from a reference dental hospital was conducted from September 2017 to July 2020. Single measures of BP were taken via an automated sphygmomanometer device. Tooth loss was assessed through oral examination and confirmed radiographically. Severe tooth loss was defined as 10 or more teeth lost. Additional study covariates were collected via sociodemographic and medical questionnaires. A total of 10,576 patients were included. Hypertension was more prevalent in severe tooth loss patients than nonsevere tooth lost (56.1% vs. 39.3%, p < 0.001). The frequency of likely undiagnosed hypertension was 43.4%. The adjusted logistic model for sex, smoking habits and body mass index confirmed the association between continuous measures of high BP and continuous measures of tooth loss (odds ratio (OR) = 1.05, 95% CI: 1.03–1.06, p < 0.001). Age mediated 80.0% and 87.5% of the association between periodontitis with both systolic BP (p < 0.001) and diastolic BP (p < 0.001), respectively. Therefore, hypertension and tooth loss are associated, with a consistent mediation effect of age. Frequency of undiagnosed hypertension was elevated. Age, gender, active smoking, and BMI were independently associated with raised BP.


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