Development of a Healthy Aging Score in the Population-Based Rotterdam Study: Evaluating Age and Sex Differences

Introduction: However, the reference ranges for echocardiography might be varying due to ethnicity, gender and age. Therefore, the normal reference ranges obtained from the healthy Asians are important for clinical utility of echocardiography in Asia. Methods: Population-based echocardiography dataset from 6,023 healthy ethnic Asians (47.1±10.9 years, 61.3% men) were divided into 6 age decades: ≤29, 30-39, 40-49, 50-59, 60-69 and ≥70 years. We explored age- and sex-related structural/functional alterations according to 2016 American Society of Echocardiography (ASE) diastolic dysfunction (DD) criteria and their correlates with clinical N-terminal pro-brain natriuretic peptide (NT-proBNP) cut-off for heart failure (HF). Racial comparisons were made using data from London Life Sciences Prospective Population (LOLIPOP) study. Results: Age- and sex-based normative reference ranges (including mean, median, 10% and 90% lower and upper reference values) were extracted from our large healthy population. In fully adjusted models, advanced age (treated as linear) was independently associated with cardiac structural remodeling and worsened diastolic parameters: larger indexed LA volume (LAVi), lower e’, higher E/e’, and higher TR velocity; all p <0.001), and were broadly more prominent in women (P interaction : <0.05). in general, markedly lower e’, higher E/e’ and smaller LAVi were observed in ethnic Asians compared to Whites. DD defined by 2016 ASE criteria, despite at low prevalence (0.42%) in current healthy population, increased drastically with advanced age and performed perfectly in excluding abnormal NT-proBNP (≥125 pg/ml) (Specificity: 99.8%, NPV: 97.6%). Conclusions: This is to date the largest cohort exploring the normative reference values using guideline-centered diastolic parameters from healthy Asians, with senescence process played as central role in diastolic dysfunction. Observed sex and ethnic differences in defining healthy diastolic cut-offs likely impact future clinical definition for DD.

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Population-Based Study of Age and Sex Differences in Bone Volumetric Density, Size, Geometry, and Structure at Different Skeletal Sites

Journal of Bone and Mineral Research ◽

10.1359/jbmr.040916 ◽

2004 ◽

Vol 19 (12) ◽

pp. 1945-1954 ◽

Cited By ~ 581

Author(s):

B Lawrence Riggs ◽

L Joseph Melton ◽

Richard A Robb ◽

Jon J Camp ◽

Elizabeth J Atkinson ◽

...

Keyword(s):

Sex Differences ◽

Population Based ◽

Population Based Study ◽

Volumetric Density ◽

Bone Volumetric Density ◽

Age And Sex

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FRAILTY IN HEALTHY OLDEST OLD: CHARACTERIZING THE FRAILTY INDEX OF SUPER-SENIORS

Innovation in Aging ◽

10.1093/geroni/igz038.3330 ◽

2019 ◽

Vol 3 (Supplement_1) ◽

pp. S913-S913

Author(s):

Betty Chinda ◽

Xiaowei Song* ◽

Shirromi Sarveswaran ◽

Kenneth Rockwood ◽

Angela Brooks-Wilson*

Keyword(s):

Sex Differences ◽

Healthy Aging ◽

Genetic Factors ◽

Oldest Old ◽

Frailty Index ◽

Distribution Patterns ◽

Limit Values ◽

Aged Group ◽

Aging Study ◽

Age And Sex

Abstract People at advanced ages often have multiple comorbidities and high frailty. We characterized frailty in “Super-Seniors”, individuals 85 or older who have never been diagnosed with cancer, cardiovascular or lung disease, diabetes or dementia. Super-Seniors were enrolled in the Vancouver Healthy Aging Study that consisted of Phase1 (2004-2007; n=486; age=88.6±3.1 years; female=67.5%) and Phase2 (2014-2019; n=167; age=89.2±3.8 years; female=65.3%). A frailty index (FI) that assesses the accumulation of health deficits was calculated as the proportion of deficits present over those considered (here, 30). The FI distribution patterns, mean, median, 99% limit values, relationship to age, and sex differences were analyzed. The FI of Super-Seniors is right-skewed, with a mean of 0.19±0.09 (median=0.17; limit=0.54) in Phase1 and 0.22±0.08 (median=0.21; limit=0.47) in Phase2. Most Super-Seniors (79% and 61% in Phases 1 and 2) had ≤8 of the 30 deficits; FI≤0.24. The FI increased with age (r’s=0.29 and 0.24); women showed a higher mean FI than men. Data demonstrated the known and consistent characteristics of the FI. The Super-Seniors, who are healthier than the general population of oldest old, have a significantly lower FI that is more typical of individuals aged about 65. The low FI of these healthy oldest old is consistent with their health and high physical and cognitive function, and underscores their suitability for study as a healthy aged group. Further research will investigate how the FI of Super-Seniors is related to lifestyle and genetic factors and health outcomes.

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Trends in occurrence and 30-day mortality of infective endocarditis in adults: population-based registry study in Finland

BMJ Open ◽

10.1136/bmjopen-2018-026811 ◽

2019 ◽

Vol 9 (4) ◽

pp. e026811 ◽

Cited By ~ 9

Author(s):

Elina Ahtela ◽

Jarmo Oksi ◽

Pekka Porela ◽

Tommi Ekström ◽

Paivi Rautava ◽

...

Keyword(s):

Sex Differences ◽

Infective Endocarditis ◽

Incidence Rate ◽

Hospital Admissions ◽

Temporal Trends ◽

Population Based ◽

Mortality Data ◽

Annual Increase ◽

Rate Ratios ◽

Age And Sex

ObjectivesInfective endocarditis (IE) is a life-threatening disease associated with significant mortality. We studied recent temporal trends and age and sex differences in the occurrence and short-term mortality of IE.DesignPopulation based retrospective cohort study.SettingData of IE hospital admissions in patients aged ≥18 years in Finland during 2005–2014 and 30-day all-cause mortality data were retrospectively collected from mandatory nationwide registries from 38 hospitals.OutcomesTrends and age and sex differences in occurrence. Thirty-day mortality.ResultsThere were 2611 cases of IE during the study period (68.2% men, mean age 60 years). Female patients were significantly older than males (62.0 vs 59.0 years, p=0.0004). Total standardised annual incidence rate of IE admission was 6.33/100 000 person-years. Men had significantly higher risk of IE compared with women (9.5 vs 3.7/100 000; incidence rate ratios [IRR] 2.49; p<0.0001) and difference was most prominent at age 40–59 years (IRR 4.49; p<0.0001). Incidence rate varied from 5.7/100 000 in 2005 to 7.1/100 000 in 2012 with estimated average 2.1% increase per year (p=0.036) and similar trends in both sexes. Significant increasing trend was observed in patients aged 18–29 years and 30–39 years (estimated annual increase 7.6% and 7.2%, p=0.002) and borderline in patients aged 40–49 years (annual increase 3.8%, p=0.08). In older population, IE incidence rate remained stable. The overall 30-day mortality after IE admission was 11.3%. Mortality was similar between sexes, increased with ageing, and remained similar during the study period.ConclusionsOccurrence of IE is increasing in young adults in Finland. Men, especially middle-aged, are at higher risk for IE compared with women. Thirty-day mortality has remained stable at 11%, increased with ageing, and was similar between sexes.

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Multiple meningiomas: does quantity matter? a population-based survival analysis with underlined age and sex differences

Journal of Neuro-Oncology ◽

10.1007/s11060-020-03620-7 ◽

2020 ◽

Vol 149 (3) ◽

pp. 413-420 ◽

Cited By ~ 1

Author(s):

Andres Ramos-Fresnedo ◽

Ricardo A. Domingo ◽

Tito Vivas-Buitrago ◽

Larry Lundy ◽

Daniel M. Trifiletti ◽

...

Keyword(s):

Sex Differences ◽

Survival Analysis ◽

Population Based ◽

Multiple Meningiomas ◽

Age And Sex

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Socioeconomic position is associated with N-terminal pro-brain natriuretic peptide (NT-proBNP)—Results of the population-based Heinz Nixdorf Recall study

PLoS ONE ◽

10.1371/journal.pone.0255786 ◽

2021 ◽

Vol 16 (8) ◽

pp. e0255786

Author(s):

Marina Rudman ◽

Mirjam Frank ◽

Carina Emmel ◽

Emanuel Matusch ◽

Kaffer Kara ◽

...

Keyword(s):

Risk Factors ◽

Coronary Heart Disease ◽

Sex Differences ◽

Heart Disease ◽

Brain Natriuretic Peptide ◽

Population Based ◽

Cvd Risk Factors ◽

Cvd Risk ◽

Size Estimates ◽

Age And Sex

Objectives N-Terminal pro Brain Natriuretic Peptide (NT-proBNP) is a diagnostic marker for heart failure and a prognostic factor for cardiovascular disease (CVD). The aim of this study was to examine the association of socioeconomic position (SEP) with NT-proBNP while assessing sex-differences and the impact of CVD risk factors and prevalent CVD on the association. Methods Baseline data of 4598 participants aged 45–75 years of the Heinz Nixdorf Recall Study were used. Income and education were used as SEP indicators. Age- and sex-adjusted linear regression models were fitted to calculate effect size estimates and 95% confidence intervals (95%-CIs) for the total effect of SEP indicators on NT-proBNP, while potential mediation was assessed by additionally accounting for traditional CVD risk factors (i.e., systolic blood pressure, HDL cholesterol, LDL cholesterol, diabetes, anti-hypertensive medication, lipid-lowering medication, BMI, current smoking). Education and income were included separately in the models. Results With an age- and sex-adjusted average change in NT-proBNP of -6.47% (95%-CI: -9.91; -2.91) per 1000€, the association between income and NT-proBNP was more pronounced compared to using education as a SEP indicator (-0.80% [95%-CI: -1.92; 0.32] per year of education). Sex-stratified results indicated stronger associations in men (-8.43% [95%-CI: -13.21; -3.38] per 1000€; -1.63% [95%-CI: -3.23; -0.001] per year of education) compared to women (-5.10% [95%-CI: -9.82; -0.01] per 1000€; -1.04% [95%-CI: -2.59; 0.50] per year of education). After adjusting for CVD risk factors some of the observed effect size estimates were attenuated, while the overall association between SEP indicators and NT-proBNP was still indicated. The exclusion of participants with prevalent coronary heart disease or stroke did not lead to a substantial change in the observed associations. Conclusions In the present study associations of education and income with NT-proBNP were observed in a population-based study sample. Only parts of the association were explained by traditional CVD risk factors, while there were substantial sex-differences in the strength of the observed association. Overt coronary heart disease or stroke did not seem to trigger the associations.

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