Cytotoxic and genotoxic effects of aqueous extracts of five medicinal plants on Allium cepa Linn.

2007 ◽  
Vol 112 (3) ◽  
pp. 470-475 ◽  
Author(s):  
A. Akinboro ◽  
A.A. Bakare
Keyword(s):  
Medicinal Plants ◽  
Allium Cepa ◽  
Aqueous Extracts ◽  
Genotoxic Effects

Anti-mitotic and anti-genotoxic effects of Plantago lanceolata aqueous extract on Allium cepa root tip meristem cells

Biologia ◽  
2006 ◽  
Vol 61 (6) ◽  
Author(s):  
Tülay Aşkin Çelik ◽  
Özlem Aslantürk
Keyword(s):  
Traditional Medicine ◽  
Allium Cepa ◽  
Tap Water ◽  
Plantago Lanceolata ◽  
Negative Control ◽  
Root Tip ◽  
Aqueous Extracts ◽  
Genotoxic Effects ◽  
H2o2 Treatment ◽  
Onion Bulbs

AbstractPlantago is the most important genus of Plantaginaceae family and is used in traditional medicine around the world for different purposes. Plantago coronopus L., Plantago major L., Plantago media L. and Plantago lanceolata L. are most commonly used species of Plantago in traditional medicine in Turkey. The main goal of this study was to investigate the eventual anti-mitotic and anti-genotoxic effects of P. lanceolata L. leaf aqueous extracts (15 g/L and 30 g/L) on Allium cepa L. root tip meristem cells which were treated with 0.7% hydrogen peroxide. For this purpose, two different experiments were performed under the same conditions. In the first experiment, Allium cepa onion bulbs were treated with 0.7% H2O2 for 1 h. After the H2O2 treatment, the onion bulbs were treated with two different concentrations (15 g/L and 30 g/L) of P. lanceolata extracts for 24 h. In the second experiment, A. cepa onion bulbs were treated with two different extract concentrations (15 g/L and 30 g/L) for 24 h and then with 0.7% H2O2 for 1 h. The test concentrations were determined according to doses which are recommended in alternative medicinal usage by people. As positive and negative control 0.7% H2O2 and tap water was used, respectively. As a result, it was determined that aqueous extracts reduced mitotic index and chromosome aberrations in treatment groups in comparison with controls. These results showed that P. lanceolata aqueous extracts have anti-mitotic and anti-genotoxic effects.

In Vivo antimalarial activity of aqueous extracts from Kenyan medicinal plants and their Chloroquine (CQ) potentiation effects against a blood-induced CQ-resistant rodent parasite in mice

2007 ◽  
Vol 21 (4) ◽  
pp. 337-343 ◽  
Author(s):  
Francis W. Muregi ◽  
Akira Ishih ◽  
Tohru Suzuki ◽  
Hideto Kino ◽  
Teruaki Amano ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Antimalarial Activity ◽  
Aqueous Extracts

The Impact of several Antihypertensive drugs and Medicinal herbs on Induced hypertension in rabbits

2021 ◽  
pp. 4832-4836
Author(s):  
Hayder Sabah Hasan ◽  
Imad Hashim ◽  
Zaid Al-Attar
Keyword(s):  
Blood Pressure ◽  
Blood Flow ◽  
Medicinal Plants ◽  
Urine Output ◽  
Effective Drug ◽  
Aqueous Extracts ◽  
Plantago Major ◽  
Induced Hypertension ◽  
Teucrium Polium ◽  
The Impact

Objective: To assess the antihypertensive efficacy of the medicinal plants used Hibiscus subdariffa, Plantago major, Teucrium polium. Moreover, we aim to Investigate the mechanisms of actions of tested agents. Design: Induced hypertension in experimental animals is tested against several drugs and medicinal plants extracts. Animals and materials: Hypertension was induced in experimental rabbits with phenylephrine 0.2mg/kg i.v. with increasing the dose (until Blood pressure>130/90mmHg). Rabbits were divided to 7 groups: Control, atenolol, furosemide, candesartan, Hibiscus subdariffa, Plantago major, Teucrium polium. ANOVA with Dunnett's test was implemented for statistical calculations with p<0.05 as significance level. Results: Candesartan was the most effective in lowering both systolic and diastolic blood pressure. Concerning the blood flow, candesartan was found to be the most significantly effective drug in increasing blood flow followed by furosemide and Hibiscus subdariffa respectively. Concerning the urine output furosemide was found to be the most significantly effective drug in increasing urine output followed by Hibiscus subdariffa. The aqueous extracts of Plantago major and Teucrium polium showed no significant effect. Conclusions: Hibiscus subdariffa is effective as diuretic agent at the concentration mentioned. Its action involves diuretic and vasodilator effect. While aqueous extracts of Plantago major and Teucrium polium are not effective.

scholarly journals Molluscicidal Effects of Aqueous Extracts of Selected Medicinal Plants from Makueni County, Kenya

2015 ◽  
Vol 6 (11) ◽  
Author(s):  
Kimeu B Mwonga ◽  
Njagi ENM waniki ◽  
Yole S Dorcas ◽  
Ngugi M Piero
Keyword(s):  
Medicinal Plants ◽  
Aqueous Extracts

scholarly journals Physicochemical Analysis of the Aqueous Extracts of Six Nigerian Medicinal Plants

2010 ◽  
Vol 9 (2) ◽  
Author(s):  
SJ Ameh ◽  
F Tarfa ◽  
TM Abdulkareem ◽  
MC Ibe ◽  
C Onanuga ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Physicochemical Analysis ◽  
Aqueous Extracts

scholarly journals Antifeedant Activity of Leaf Aqueous Extracts of Selected Medicinal Plants on VI Instar Larva of Helicoverpa Armigera (Hubner)

2020 ◽  
Vol 8 (05) ◽  
pp. 62-66
Author(s):  
G. Ravi ◽  
Dr.G. Sundararajan
Keyword(s):  
Mortality Rate ◽  
Medicinal Plants ◽  
Aqueous Extract ◽  
Helicoverpa Armigera ◽  
Botanical Insecticides ◽  
Tribulus Terrestris ◽  
Aqueous Extracts ◽  
Antifeedant Activity ◽  
Leaf Aqueous Extract ◽  
Helicoverpa Armígera

Phytochemicals, especially botanical insecticides are currently of interest because of their successful application in plant protection as biocontrol agents. Biological activity of leaf aqueous extract of ten selected medicinal plants were evaluated against the fourth-instar larvae of gram pod borer Helicoverpa armigera (H¨ubner), (Lepidoptera: Noctuidae). Antifeedant activity of leaf aqueous extracts of Abutilon indicum L., Achyranthus aspera L., Aerva lanata L., Albiziz amara (Roxb), Andrographis paniculata Ness., Cardiospermum halicacabum L., Cassia tora L., Catharanthus roseus L (G) Don., Datura metal L. and Tribulus terrestris L. were evaluated in this study. Preliminary screening after 24 h of exposure with leaf aqueous extracts of the selected plants at a concentration of 1,000 ppm exhibited significant larval mortality rate. The percentage mortality rate ranged considerably from 10.8 to 72.8. The mortality rate was observed in the decreasing order of A. paniculata > C. roseus > D. metal > A. amara > C. halicacabum > A. indicum > C. tora > T. terrestris > A. aspera >A. lanata against the larvae of H. armigera. The results imply that leaf aqueous extract of A. paniculata, C. roseus and D. metal can potentially be used as eco-friendly pest control agents against the larva of H. armigera.

scholarly journals Phytochemical screening and evaluation of antioxidant capacities of Allium cepa, Allium sativum, and Monodora myristica using in vitro and in vivo models

2021 ◽  
Vol 1 (1) ◽  
pp. 41-52
Author(s):  
Chioma E. Irozuru Irozuru ◽  
Janet O. Olugbodi ◽  
Uche Okuu Arunsi ◽  
Olusola Ladeji
Keyword(s):  
Ascorbic Acid ◽  
Allium Cepa ◽  
Plant Extracts ◽  
Allium Sativum ◽  
Reducing Power ◽  
Aqueous Extracts ◽  
In Vivo Models ◽  
Monodora Myristica

Background: Allium cepa, Allium sativum, and Monodora myristica are commonly sourced food condiments in every household in Nigeria. In the present study, we investigated the phytochemical compositions, in vitro and in vivo antioxidant activity of these plants. Methods: The aqueous extracts from the A. cepa, A. sativum, and M. myristica were evaluated for phytochemical composition using standard protocols while the antioxidant activities were evaluated using the reducing power assay. Forty-five (45) Male Wistar rats (weighing 185±10 g) were divided into five groups (n=9) and were orally administered with 100 mg/kg BW each of A. sativum, M. myristica, A. cepa, and ascorbic acid while the control group received 0.5 mL/kg BW distilled water alone. Animals (n=3) from each group were sacrificed after the 20th, 25th, and 30th days of oral administration. The blood and tissue samples were collected for the analysis of biochemical parameters. Result: Our results revealed the presence of flavonoids, alkaloids, tannins, saponins, and terpenes in the plant extracts. A. sativum had the highest reducing power capacity followed by M. myristica and then A. cepa. The in vitro antioxidants activities demonstrated by the plant extracts were higher than that of ascorbic acid but less than butylated hydroxytoluene. In vivo antioxidant studies showed a marked increase (p<0.05) in the level of catalase with a concurrent decrease (p<0.05) in the levels of MDA and H2O2 in the liver and kidney of rats administered with aqueous extracts of the condiments compared to the normal control and ascorbic acid in the following order control < ascorbic acid < A. cepa < M. myristica < A. sativum. Conclusion: Based on these findings, we infer that the aqueous extracts of A. cepa, A. sativum, and M. myristica are rich in antioxidants and as a result could serve as promising novel functional foods and nutraceuticals

scholarly journals Medicinal Plants Used for Malaria Treatment in Gamba Village, North Region of Cameroon: Ethnopharmacological Survey; In Vivo Antimalarial Activity of Aqueous Extracts of Khaya Senegalensis Bark.

2021 ◽  
Author(s):  
Davy-Hyacinthe Anguechia Gouissi ◽  
Roselyne Teponging Nzangue ◽  
Josue Haskandi Kalaza ◽  
Willy Pabo ◽  
Siméon Pierre Fodouop Chegaing
Keyword(s):  
Medicinal Plants ◽  
Traditional Medicine ◽  
Aqueous Extract ◽  
Antimalarial Activity ◽  
Traditional Healers ◽  
Positive Control ◽  
Control Group ◽  
Aqueous Extracts ◽  
Khaya Senegalensis

Abstract Background: In traditional medicine, the floral diversity permits the inhabitants of North Cameroon to use a great number of plants to fight against Malaria. The aim of this study was to identify plants used in traditional medicine to treat malaria, and to verify the scientific basis for the use of one of these plants in the locality of Gamba.Methods: An Ethnopharmacological survey was carried out on 15 traditional healers. We collected data on use of medicinal plants using questionnaires. Then in-vivo antimalarial activity of the decoctioned and macerated aqueous extracts of khaya senegalensis trunk bark was evaluated. The 4-day suppressive peters test was realised on mus musculus swiss albino mice. On day one, mice were infected with 107 plasmodium berghei parasitized red blood cells through intra-peritoneal inoculation. 2 hours after infestation, mice in batches of 6 were treated orally at a dose of 75, 150.300 mg/Kg for macerated aqueous extract and 65, 120.260 mg/Kg for decoctioned extract daily during 3 days at an administration volume of 10 ml/Kg. An extract was considered (% reduction): Highly active (between 100-90 %); moderate (between 90-50 %); weak (between 50-10 %); Inactive (between 0 %). P-values <0.05 were considered statistically significant.Results: A total of 18 plant species belonging to 12 families were identified for the preparation of 12 recipes. The decocted aqueous extract of khaya senegalensis showed moderate anti-plasmodial activity (% reduction = 52.46%) at the highest dose of 260 mg/kg with p<0.001 compared to the positive control group. The aqueous macerate at doses of 150 and 300mg/kg gave respectively a percentage reduction of parasitaemia of 59.42% and 71.80% and also showed moderate anti-plasmodial activity; with p<0.001 between the different extracts and the positive control (99.18%).Conclusion: In conclusion, extracts of khaya senegalensis showed moderate anti-plasmodial activity. It would therefore be necessary to evaluate the anti-malarial activity in-vivo and the toxicity of the aqueous extracts macerated using other solvents and also test the other plants listed.

Sign in / Sign up

Export Citation Format

Share Document