Gamma-oryzanol prevents ethanol-induced liver injury by ameliorating oxidative stress and modulating apoptosis-related protein expression in mice

2019 ◽  
Vol 62 ◽  
pp. 103532 ◽  
Author(s):  
Lijuan Zhu ◽  
Siting Xiang ◽  
Zhaoping Ou ◽  
Chaoyang Ma ◽  
Xianglian Yi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Liver Injury ◽  
Protein Expression ◽  
Related Protein ◽  
Apoptosis Related Protein ◽  
Gamma Oryzanol

Protective Effects of Serotonin and its Derivatives, N-Feruloylserotonin and N-(p-Coumaroyl) Serotonin, Against Cisplatin-Induced Renal Damage in Mice

2019 ◽  
Vol 47 (02) ◽  
pp. 369-383 ◽  
Author(s):  
Chan Hum Park ◽  
Ah Young Lee ◽  
Ji Hyun Kim ◽  
Su Hui Seong ◽  
Eun Ju Cho ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Body Weight ◽  
Renal Damage ◽  
Pleiotropic Effect ◽  
Protective Effects ◽  
Related Protein ◽  
Renoprotective Effect ◽  
Serotonin Derivatives ◽  
Mitogen Activated Protein ◽  
Apoptosis Related Protein

This study examined whether serotonin and two of its derivatives, [Formula: see text]-feruloylserotonin and [Formula: see text]-([Formula: see text]-coumaroyl) serotonin, have a renoprotective effect in a mouse model of cisplatin-induced acute renal failure. Cisplatin (20[Formula: see text]mg/kg body weight) was administered by intraperitoneal injection to male BALB/c mice that had received oral serotonin, [Formula: see text]-feruloylserotonin or [Formula: see text]-([Formula: see text]-coumaroyl) serotonin (7.5[Formula: see text]mg/kg body weight per day) during the preceding 2 days. At 3 days after the cisplatin injection, serum and renal biochemical factors, oxidative stress, inflammation and apoptosis-related protein expression were evaluated, and histological examinations were performed. Cisplatin caused reduction in body weight and an increase in kidney weight; however, [Formula: see text]-([Formula: see text]-coumaroyl) serotonin and [Formula: see text]-feruloylserotonin attenuated these effects. Moreover, the serotonin derivatives significantly decreased serum urea nitrogen and creatinine levels. They also significantly reduced the level of reactive oxygen species and upregulated the expression of glutathione peroxidase in the kidney. Furthermore, the serotonin derivatives improved the abnormal expression of mitogen-activated protein kinases activation-dependent inflammation- and apoptosis-related protein and caused less renal damage. These results provide important evidence that [Formula: see text]-([Formula: see text]-coumaroyl) serotonin and [Formula: see text]-feruloylserotonin exert a pleiotropic effect on several parameters related to oxidative stress, inflammation and apoptosis. The derivatives also have a renoprotective effect in cisplatin-treated mice; however, this effect is higher with [Formula: see text]-([Formula: see text]-coumaroyl) serotonin.

scholarly journals Gamma Oryzanol Treats Obesity-Induced Kidney Injuries by Modulating the Adiponectin Receptor 2/PPAR-α Axis

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Fabiane Valentini Francisqueti ◽  
Artur Junio Togneri Ferron ◽  
Fabiana Kurokawa Hasimoto ◽  
Pedro Henrique Rizzi Alves ◽  
Jéssica Leite Garcia ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Renal Function ◽  
Protein Expression ◽  
Metabolic Diseases ◽  
Adiponectin Receptor ◽  
Whole Body ◽  
Antioxidant Enzyme Activities ◽  
High Sugar ◽  
Adiponectin Receptor 2 ◽  
Gamma Oryzanol

The kidney is an important organ in the maintenance of body homeostasis. Dietary compounds, reactive metabolites, obesity, and metabolic syndrome (MetS) can affect renal filtration and whole body homeostasis, increasing the risk of chronic kidney disease (CKD) development. Gamma oryzanol (γOz) is a compound with antioxidant and anti-inflammatory activity that has shown a positive action in the treatment of obesity and metabolic diseases. Aim. To evaluate the effect of γOz to recover renal function in obese animals by high sugar-fat diet by modulation of adiponectin receptor 2/PPAR-α axis Methods. Male Wistar rats were initially randomly divided into 2 experimental groups: control and high sugar-fat diet (HSF) for 20 weeks. When proteinuria was detected, HSF animals were allocated to receive γOz or maintain HSF for more than 10 weeks. The following were analyzed: nutritional and biochemical parameters, systolic blood pressure, and renal function. In the kidney, the following were evaluated: inflammation, oxidative stress, and protein expression by Western blot. Results. After 10 weeks of γOz treatment, γOz was effective to improve inflammation, increase antioxidant enzyme activities, increase the protein expression of adiponectin receptor 2 and PPAR-α, and recover renal function. Conclusion. These results permit us to confirm that γOz is able to modulate PPAR-α expression, inflammation, and oxidative stress pathways improving obesity-induced renal disease.

scholarly journals Chronic oxidative stress upregulates Drusen-related protein expression in adult human RPE stem cell-derived RPE cells: A novel culture model for dry AMD

Aging ◽  
2012 ◽  
Vol 5 (1) ◽  
pp. 51-66 ◽  
Author(s):  
David M. Rabin ◽  
Richard L. Rabin ◽  
Timothy A. Blenkinsop ◽  
Sally Temple ◽  
Jeffrey H. Stern
Keyword(s):  
Oxidative Stress ◽  
Stem Cell ◽  
Protein Expression ◽  
Related Protein ◽  
Rpe Cells ◽  
Adult Human ◽  
Chronic Oxidative Stress ◽  
Culture Model ◽  
Dry Amd
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