scholarly journals The protective effects of human milk components, 2′-fucosyllactose and osteopontin, against 2,4-dinitrochlorobenzene-induced atopic dermatitis in mice

2021 ◽  
Vol 87 ◽  
pp. 104806
Author(s):  
Xi Chen ◽  
Chunyan Yang ◽  
Jiaqi Zeng ◽  
Zhengyumeng Zhu ◽  
Liyun Zhang ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Human Milk ◽  
Protective Effects ◽  
Milk Components

Immunohistochemical detection of human milk components aspirated in lungs of an infant

1997 ◽  
Vol 90 (1-2) ◽  
pp. 77-84 ◽  
Author(s):  
K Iwadate ◽  
N Sakamoto ◽  
S.H Park ◽  
M Doy ◽  
H Iwase ◽  
...  
Keyword(s):  
Human Milk ◽  
Immunohistochemical Detection ◽  
Milk Components

scholarly journals Brown Fat–Activating Lipokine 12,13-diHOME in Human Milk Is Associated With Infant Adiposity

2020 ◽  
Author(s):  
Danielle Wolfs ◽  
Matthew D Lynes ◽  
Yu-Hua Tseng ◽  
Stephanie Pierce ◽  
Valerie Bussberg ◽  
...  
Keyword(s):  
Linoleic Acid ◽  
Human Milk ◽  
Octadecenoic Acid ◽  
Brown Fat ◽  
Protective Effects ◽  
Z Score ◽  
Anthropometric Measures ◽  
Medical Centers ◽  
Academic Medical ◽  
Infant Weight Gain

Abstract Context Little is known about the specific breastmilk components responsible for protective effects on infant obesity. Whether 12,13-dihydroxy-9Z-octadecenoic acid (12,13-diHOME), an oxidized linoleic acid metabolite and activator of brown fat metabolism, is present in human milk, or linked to infant adiposity, is unknown. Objective To examine associations between concentrations of 12,13-diHOME in human milk and infant adiposity. Design Prospective cohort study from 2015 to 2019, following participants from birth to 6 months of age. Setting Academic medical centers. Participants Volunteer sample of 58 exclusively breastfeeding mother-infant pairs; exclusion criteria included smoking, gestational diabetes, and health conditions with the potential to influence maternal or infant weight gain. Main Outcome Measures Infant anthropometric measures including weight, length, body mass index (BMI), and body composition at birth and at 1, 3, and 6 months postpartum. Results We report for the first time that 12,13-diHOME is present in human milk. Higher milk 12,13-diHOME level was associated with increased weight-for-length Z-score at birth (β = 0.5742, P = 0.0008), lower infant fat mass at 1 month (P = 0.021), and reduced gain in BMI Z-score from 0 to 6 months (β = −0.3997, P = 0.025). We observed similar associations between infant adiposity and milk abundance of related oxidized linoleic acid metabolites 12,13-Epoxy-9(Z)-octadecenoic acid (12,13-epOME) and 9,10-Dihydroxy-12-octadecenoic acid (9,10-diHOME), and metabolites linked to thermogenesis including succinate and lyso-phosphatidylglycerol 18:0. Milk abundance of 12,13-diHOME was not associated with maternal BMI, but was positively associated with maternal height, milk glucose concentration, and was significantly increased after a bout of moderate exercise. Conclusions We report novel associations between milk abundance of 12,13-diHOME and adiposity during infancy.

scholarly journals Comprehensive Proteomic Analysis of Human Milk-derived Extracellular Vesicles Unveils a Novel Functional Proteome Distinct from Other Milk Components

2016 ◽  
Vol 15 (11) ◽  
pp. 3412-3423 ◽  
Author(s):  
Martijn J.C. van Herwijnen ◽  
Marijke I. Zonneveld ◽  
Soenita Goerdayal ◽  
Esther N.M. Nolte – 't Hoen ◽  
Johan Garssen ◽  
...  
Keyword(s):  
Human Milk ◽  
Extracellular Vesicles ◽  
Proteomic Analysis ◽  
Milk Components

scholarly journals Infant milk-feeding practices and food allergies, allergic rhinitis, atopic dermatitis, and asthma throughout the life span: a systematic review

2019 ◽  
Vol 109 (Supplement_1) ◽  
pp. 772S-799S ◽  
Author(s):  
Darcy Güngör ◽  
Perrine Nadaud ◽  
Concetta C LaPergola ◽  
Carol Dreibelbis ◽  
Yat Ping Wong ◽  
...  
Keyword(s):  
Systematic Review ◽  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Human Milk ◽  
Systematic Reviews ◽  
Childhood Asthma ◽  
Included Study ◽  
Food Allergies ◽  
Review Team ◽  
Milk Feeding

ABSTRACT Background During the Pregnancy and Birth to 24 Months Project, the USDA and Department of Health and Human Services initiated a review of evidence on diet and health in these populations. Objectives The aim of these systematic reviews was to examine the relation of 1) never versus ever feeding human milk, 2) shorter versus longer durations of any human milk feeding, 3) shorter versus longer durations of exclusive human milk feeding prior to infant formula introduction, 4) feeding a lower versus higher intensity of human milk to mixed-fed infants, and 5) feeding a higher intensity of human milk by bottle versus breast with food allergies, allergic rhinitis, atopic dermatitis, and asthma. Methods The Nutrition Evidence Systematic Review team conducted systematic reviews with external experts. We searched CINAHL, Cochrane, Embase, and PubMed for articles published between January 1980 and March 2016, dual-screened the results according to predetermined criteria, extracted data from and assessed the risk of bias for each included study, qualitatively synthesized the evidence, developed conclusion statements, and graded the strength of the evidence. Results The systematic reviews numbered 1–5 above included 44, 35, 1, 0, and 0 articles, respectively. Moderate, mostly observational, evidence suggests that 1) never versus ever being fed human milk is associated with higher risk of childhood asthma, and 2) among children and adolescents who were fed human milk as infants, shorter versus longer durations of any human milk feeding are associated with higher risk of asthma. Limited evidence does not suggest associations between 1) never versus ever being fed human milk and atopic dermatitis in childhood or 2) the duration of any human milk feeding and allergic rhinitis and atopic dermatitis in childhood. Conclusions Moderate evidence suggests that feeding human milk for short durations or not at all is associated with higher childhood asthma risk. Evidence on food allergies, allergic rhinitis, and atopic dermatitis is limited.

Protective Effects of Chijabaegpi-tang on Atopic Dermatitis in TNF-α/IFNγ-induced HaCaT Cells

2018 ◽  
Vol 32 (4) ◽  
pp. 226-231
Author(s):  
So Young Eun ◽  
Jung Joo Yoon ◽  
Hye Yoom Kim ◽  
You Mee Ahn ◽  
Byung Hyuk Han ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Hacat Cells ◽  
Protective Effects ◽  
Tnf Α

scholarly journals The Relationship Between Breast Milk Components and the Infant Gut Microbiota

2021 ◽  
Vol 8 ◽  
Author(s):  
Gaëlle Boudry ◽  
Elise Charton ◽  
Isabell Le Huerou-Luron ◽  
Stéphanie Ferret-Bernard ◽  
Sophie Le Gall ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Human Milk ◽  
Maternal Diet ◽  
Milk Composition ◽  
Bacteria Growth ◽  
Gut Colonization ◽  
Milk Components ◽  
And Behavior ◽  
The Impact

The assembly of the newborn's gut microbiota during the first months of life is an orchestrated process resulting in specialized microbial ecosystems in the different gut compartments. This process is highly dependent upon environmental factors, and many evidences suggest that early bacterial gut colonization has long-term consequences on host digestive and immune homeostasis but also metabolism and behavior. The early life period is therefore a “window of opportunity” to program health through microbiota modulation. However, the implementation of this promising strategy requires an in-depth understanding of the mechanisms governing gut microbiota assembly. Breastfeeding has been associated with a healthy microbiota in infants. Human milk is a complex food matrix, with numerous components that potentially influence the infant microbiota composition, either by enhancing specific bacteria growth or by limiting the growth of others. The objective of this review is to describe human milk composition and to discuss the established or purported roles of human milk components upon gut microbiota establishment. Finally, the impact of maternal diet on human milk composition is reviewed to assess how maternal diet could be a simple and efficient approach to shape the infant gut microbiota.

scholarly journals Human Milk Oligosaccharides and Infant Weight in the First 6 Months of Life (P11-053-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Paige Berger ◽  
Jasmine Plows ◽  
Roshonda Jones ◽  
Tanya Alderete ◽  
Chloe Yonemitsu ◽  
...  
Keyword(s):  
Weight Gain ◽  
Human Milk ◽  
Kidney Diseases ◽  
Total Sample ◽  
Human Milk Oligosaccharides ◽  
Milk Oligosaccharides ◽  
Secretor Status ◽  
Funding Sources ◽  
Milk Components ◽  
Infant Weight Gain

Abstract Objectives The effects of breastfeeding on reduced risk of obesity are inconclusive, although smaller studies suggest that specific human milk components may be relevant to infant weight gain. The primary aim of this study was to determine whether individual human milk oligosaccharides (HMOs) in the first month of life are associated with infant weight in the first 6 months of life. A secondary aim was to assess associations separately by HMO secretor status. Methods Participants were 156 Hispanic mother-infant pairs. Breast milk was collected at 1 month. HMO composition was analyzed using high-pressure liquid chromatography, and HMO secretor status was determined by the presence or near absence of 2’-fucosyllactose or lacto-N-fucopentaose (LNFP) I. Infant weight was measured at 1 and 6 months, and infant weight-for-age z scores (WAZ) and WAZ changes were calculated. Multiple linear regressions were used to examine the effect of HMO composition on WAZ, adjusting for maternal age, pre-pregnancy BMI, infant age, sex, and birth weight. Results In the total sample, HMO composition at 1 month was not significantly associated with WAZ at 1 month. In the total sample, higher LNFPII at 1 month predicted lower WAZ gain (β = –0.27, P = 0.01) and lower WAZ status (β = –0.26, P = 0.01) at 6 months. In infants of secretor mothers, higher LNFPII at 1 month predicted lower WAZ gain at 6 months (β = –0.23, P = 0.02); in infants of non-secretor mothers, LNFPII at 1 month predicted lower WAZ status at 6 months (β = –0.40, P = 0.03). Similar significant associations were observed when infant weight replaced WAZ in the models. No other HMOs were significantly related to infant WAZ or weight. Conclusions Our data suggest that greater exposure to LNFPII in the first month of life may be protective against rapid infant weight gain in the first 6 months, regardless of HMO secretor status. These findings provide additional evidence that specific human milk components may diminish infant obesity risk. Funding Sources Supported by the National Institute of Diabetes and Digestive and Kidney Diseases (NIH R01 DK110793) and the Gerber Foundation.

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