scholarly journals Functional analysis of the relationship between intestinal microbiota and the expression of hepatic genes and pathways during the course of liver regeneration

2016 ◽  
Vol 64 (3) ◽  
pp. 641-650 ◽  
Author(s):  
Hui-Xin Liu ◽  
Clarissa Santos Rocha ◽  
Satya Dandekar ◽  
Yu-Jui Yvonne Wan
Keyword(s):  
Functional Analysis ◽  
Liver Regeneration ◽  
Intestinal Microbiota ◽  
Hepatic Genes ◽  
The Relationship

Influence of the Intestinal Microbiota on Diabetes Management

2020 ◽  
Vol 21 (15) ◽  
pp. 1603-1615
Author(s):  
Eva Alvarez-Vieites ◽  
Arora López-Santamarina ◽  
José M. Miranda ◽  
Alicia del Carmen Mondragón ◽  
Alexandre Lamas ◽  
...  
Keyword(s):  
Immune System ◽  
Intestinal Microbiota ◽  
Diabetes Management ◽  
Scientific Evidence ◽  
Focused Attention ◽  
Economic Implications ◽  
Experimental Animals ◽  
Low Intensity ◽  
New Treatments ◽  
The Relationship

In recent decades, there has been a very rapid increase in the prevalence of diabetes globally, with serious health and economic implications. Although today there are several therapeutic treatments for this disease, these do not address the causes of the disease and have serious side effects, so it is necessary to seek new treatments to replace or complement the existing ones. Among these complementary treatments, a strong link between the intestinal microbiota and diabetes has been demonstrated, which has focused attention on the use of biotherapy to regulate the function of the intestinal microbiota and, thus, treat diabetes. In this way, the main objective of this work is to provide a review of the latest scientific evidence on diabetes, gathering information about new trends in its management, and especially, the influence of the intestinal microbiota and microbiome on this pathology. It is possible to conclude that the relationship between the intestinal microbiota and diabetes is carried out through alterations in energy metabolism, the immune system, changes in intestinal permeability, and a state of low-intensity systemic inflammation. Although, currently, most of the experimental work, using probiotics for diabetes management, has been done on experimental animals, the results obtained are promising. Thus, the modification of the microbiota through biotherapy has shown to improve the symptoms and severity of diabetes through various mechanisms related to these alterations.

scholarly journals Improvement of intestinal flora: accompany with the antihypertensive effect of electroacupuncture on stage 1 hypertension

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Jun-meng Wang ◽  
Ming-xiao Yang ◽  
Qiao-feng Wu ◽  
Ji Chen ◽  
Shu-fang Deng ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Intestinal Microbiota ◽  
Antihypertensive Effect ◽  
Intestinal Flora ◽  
Hypertensive Patients ◽  
Healthy Group ◽  
Oscillometric Device ◽  
Intestinal Dysbiosis ◽  
Stage 1 ◽  
The Relationship

Abstract Background Increasing evidence have indicated the relationship between intestinal dysbiosis and hypertension. We aimed to evaluate the effect of the electroacupuncture (EA) on intestinal microbiota in patients with stage 1 hypertension. Methods 93 hypertensive patients and 15 healthy subjects were enrolled in this study. Applying a highly accurate oscillometric device to evaluate the antihypertensive effect of EA. 16S rRNA sequencing was used to profile stool microbial communities from Healthy group, Before treatment (BT) group and After treatment (AT) group, and various multivariate analysis approaches were used to assess diversity, composition and abundance of intestinal microbiota. Results In this study, EA significantly decreased the blood pressure (BP) of hypertensive patients. Higher abundance of Firmicutes and lower Bacteroidetes abundance were observed in the BT group compared to the Healthy group. And EA treatment significantly decreased the Firmicutes/Bacteroidetes ratio compared to the BT group. Moreover, at the genus level, there was an increased abundance of Escherichia-Shigella in patients with hypertension, while Blautia were decreased, and EA reversed these changes. Conclusions Our study indicates that EA can effectively lower BP and improve the structure of intestinal microbiota which are correlate with the alteration of blood pressure by electroacupuncture. Trial registration: Clinicaltrial.gov, NCT01701726. Registered 5 October 2012, https://clinicaltrials.gov/ct2/show/study/NCT01701726

scholarly journals Formation of Autoimmune Lesions Is Independent of Antibiotic Treatment in NOD Mice

2021 ◽  
Vol 22 (6) ◽  
pp. 3239
Author(s):  
 Mami Sato ◽  
Rieko Arakaki ◽  
Hiroaki Tawara ◽  
Takaaki Tsunematsu ◽  
Naozumi Ishimaru
Keyword(s):  
Intestinal Microbiota ◽  
Flow Cytometric Analysis ◽  
Nod Mice ◽  
Antibiotic Administration ◽  
T And B Cells ◽  
Spleen Cells ◽  
Flow Cytometric ◽  
Enteral Microbiota ◽  
The Relationship

The relationship between autoimmunity and changes in intestinal microbiota is not yet fully understood. In this study, the role of intestinal microbiota in the onset and progression of autoimmune lesions in non-obese diabetic (NOD) mice was evaluated by administering antibiotics to alter their intestinal microenvironment. Flow cytometric analysis of spleen cells showed that antibiotic administration did not change the proportion or number of T and B cells in NOD mice, and pathological analysis demonstrated that autoimmune lesions in the salivary glands and in the pancreas were also not affected by antibiotic administration. These results suggest that the onset and progression of autoimmunity may be independent of enteral microbiota changes. Our findings may be useful for determining the appropriate use of antibiotics in patients with autoimmune diseases who are prescribed drugs to maintain systemic immune function.

scholarly journals The intestinal microbiota-driven dopamine level influences social interaction and innate color preference in zebrafish larvae

2021 ◽  
Author(s):  
Ju Wang ◽  
Feng Zheng ◽  
Lifeng Yin ◽  
Shengnan Shi ◽  
bing hu ◽  
...  
Keyword(s):  
Social Interaction ◽  
Intestinal Microbiota ◽  
Social Contact ◽  
Social Recognition ◽  
Color Preference ◽  
Dopamine Level ◽  
Zebrafish Larvae ◽  
The Social ◽  
Shoaling Behavior ◽  
The Relationship

Gut microbiota influence neurodevelopment of brain and programing of behaviors. However, the mechanism underlining the relationship between shoals' behaviors and intestinal microbiota remain controversial and the roles of neurotransmitters are still unclear. Here we show that, shoaling behavior affected the innate color preference of shoals, indicating that shoals tended to choose a favorable color environment that benefits social contact. Meanwhile, administration of D1-R antagonist disrupted the social interaction which led to the deficits of color preference. More importantly, the altered microbiota caused by an antibiotic OTC decreased the sociability and weakened shoals' color preference. When given a supplement of LGG after OTC exposure, fish exhibited an unexpectedly recovery capability in social cohesion and color preference. Our findings show that dopamine level of brain could mediate both social recognition and color preference, and highlight the pathway of microbial metabolites through the microbiota-gut-brain axis that coordinate the production of dopamine.

scholarly journals Social Bonding dalam Pengelolaan Hutan Rakyat: Upaya Menuju Masyarakat Hutan yang Sejahtera

2019 ◽  
Vol 1 (1) ◽  
pp. 57
Author(s):  
Khabib Bima Setiyawan
Keyword(s):  
Functional Analysis ◽  
Forest Management ◽  
Management Strategies ◽  
Social Bonding ◽  
The Other ◽  
Tourist Attraction ◽  
Government Institutions ◽  
Bonding Capital ◽  
The Village ◽  
The Relationship

<div><p class="ABSTRAKen">The forest is the source of livelihood of the community around it, forest sustainbility management become important thing to do to ensure the sustainbility of the forest. This research discusses about forest management strategies in the Berjo village, in which consist of three different institutions, they are Taman Hutan Raya (Tahura), Perusahaan Hutan Negara Indonesia (Perhutani), and Lembaga Masyarakat Desa Hutan (LMDH). the aim of this research is to find out the forest management strategies, methode in this research is qualitaive with case studies approach, this research conducted in the village of Berjo, Karangayar city. Purposive sampling is used to select the respondents. Data collection is done by observation, interviews, and documentation. The analysis of the data using the in interactive functional analysis and validation of data using triangulation of sources. The results showed that forest management is achieved by collaboration among Government and non government institutions with their Sosial Bonding Capital which allows for interaction in sharing knowledge as well as glue relations between groups. Social Bonding is owned by LMDH and Tahura are on the intermediate level which means they obey formal but on the other hand they approach at the level of values, culture, and perception. While the relationship between the LMDH (a unit of BUMN) and Tahura (units of goverment departmen) are on the level of social capital that embraced a formalvalue corresponding their jobs desk which are conservation and production of the forest. LMDH along with Perhutani in forest management through partnership relationship. They work togehter in the safeguarding of forests and open tourist attraction. Whereas in the greening of the forest, the Perhutani, the LMDH Tahura and do reforestation.</p></div><p><em><br /></em></p>

scholarly journals Polylinguism and multiculturalism in the communication and educational space

2021 ◽  
Vol 14 ◽  
pp. 121-127
Author(s):  
Tatyana Lipai ◽  
Evgeniya Khinevich
Keyword(s):  
Functional Analysis ◽  
Foreign Language ◽  
Social Background ◽  
Professional Communication ◽  
Expert Interviews ◽  
Sociological Approach ◽  
The Social ◽  
The World ◽  
The Relationship ◽  
Linguistic Material

The problems of the relationship between language and society attract the attention of researchers from different countries representing various scientific areas: philosophy, history, biology, linguistics, theology, pedagogy, psychology, etc. This study actualizes the sociological approach to the study of the social determinants of the formation of polylingualism as a means of professional communication. According to the sociological results, about 70% of the world's population, to one degree or another, speaks two or more languages, which imposes additional obligations on workers providing international professional communications (Beacco, 2002). Modern multilingual interaction should not be one-sidedly understood only as a borrowing of professional foreign language terminology. It includes the social background of the linguistic material: traditions, mimic and pantomimic codes, the national picture of the world - and becomes the most important factor in professionalization. Methods of systemic and functional analysis, comparison. generalization and collection of empirical data (expert interviews, content analysis).

scholarly journals Advantages of osteoarthritis combined treatment with symptomatic slow-acting drugs

2021 ◽  
Vol 15 (2) ◽  
pp. 126-131
Author(s):  
E. V. Zonova
Keyword(s):  
Cardiovascular Diseases ◽  
Intestinal Microbiota ◽  
Combined Treatment ◽  
Pleiotropic Effects ◽  
Immunological Activity ◽  
Inflammatory Phenotypes ◽  
The Relationship ◽  
Combined Drugs ◽  
Development Risk ◽  
Overall Mortality

The effectiveness of combined drugs, consisting of chondroitin and glucosamine (GA) in the treatment of osteoarthritis (OA) is discussed. Due to their high safety and pleiotropic effects, these drugs can be used in patients with OA (primarily with metabolic and inflammatory phenotypes) and comorbid diseases. The effect of oral chondroitin and GA on the intestinal microbiota is described: regulation of the composition, metabolic and immunological activity of intestinal microbiota. The relationship between the regular administration of chondroitin and GA and decrease in overall mortality and mortality from cardiovascular diseases, as well as the decrease of malignancy development risk is marked.

scholarly journals Intestinal microbiota: its role in pathogenesis of arterial hypertension

2017 ◽  
Vol 95 (2) ◽  
pp. 123-126
Author(s):  
K. A. Aitbaev ◽  
Ilkham Torobekovich Murkamilov
Keyword(s):  
Arterial Hypertension ◽  
Intestinal Microbiota ◽  
Intestinal Dysbiosis ◽  
Relationship Of ◽  
Dietary Strategies ◽  
The Relationship

The review presents data on the relationship of intestinal microbiota and the development of arterial hypertension. Mechanisms through which intestinal dysbiosis may contribute to the development of this disease are reviewed. Results of studies on modulation of intestinal microbiota in patients with arterial hypertension with the use of probiotics and antibiotics are presented. It is concluded that the development of innovative dietary strategies ensuring restoration of the balance in the intestinal microbiota will allow to effectively control and treat arterial hypertension.

Examining the Relationship Between Heart Rate and Problem Behavior: A Case Study of Severe Skin Picking in Prader-Willi Syndrome

2013 ◽  
Vol 118 (6) ◽  
pp. 460-474 ◽  
Author(s):  
Scott S. Hall ◽  
Jennifer L. Hammond ◽  
Kristin M. Hustyi
Keyword(s):  
Heart Rate ◽  
Functional Analysis ◽  
Single Case ◽  
Automatic Reinforcement ◽  
Activity Level ◽  
Prader Willi Syndrome ◽  
Activity Levels ◽  
Skin Picking ◽  
The Relationship

Abstract Few studies have examined the relationship between heart rate and self-injurious behavior (SIB) shown by individuals with IDD (intellectual and developmental disabilities). In this single-case study, we simultaneously monitored heart rate and activity levels during a functional analysis of severe skin picking behavior exhibited by a young man with Prader-Willi syndrome (PWS). Results of the functional analysis indicated that the participant's skin picking was maintained by automatic reinforcement. A within-session analysis of the data indicated that skin picking bouts resulted in an increase in heart rate, suggesting a positive- automatic reinforcement function. These data indicate that inclusion of heart rate and activity-level monitoring during a functional analysis may provide important additional information concerning the determinants of SIB.

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