scholarly journals Toxic effects of glyphosate-based herbicide, Excel Mera 71 on gill, liver, and kidney of Heteropneustes fossilis under laboratory and field conditions

2016 ◽  
Vol 4 (3) ◽  
pp. 147 ◽  
Author(s):  
ApurbaRatan Ghosha ◽  
Palas Samanta ◽  
AlokeKumar Mukherjee ◽  
Sandipan Pal ◽  
Debraj Kole
Keyword(s):  
Field Conditions ◽  
Toxic Effects ◽  
Heteropneustes Fossilis ◽  
Liver And Kidney ◽  
Excel Mera 71

scholarly journals Further evidence that cyclosporin A protects mitochondria from calcium overload by inhibiting a matrix peptidyl-prolyl cis-trans isomerase. Implications for the immunosuppressive and toxic effects of cyclosporin

1991 ◽  
Vol 274 (2) ◽  
pp. 611-614 ◽  
Author(s):  
E J Griffiths ◽  
A P Halestrap
Keyword(s):  
Cyclosporin A ◽  
Mechanism Of Action ◽  
Adenine Nucleotide ◽  
Calcium Overload ◽  
Toxic Effects ◽  
The Novel ◽  
Fk 506 ◽  
Previous Hypothesis ◽  
Liver And Kidney ◽  
Pore Opening

The Ki values of cyclosporins A, G and H for the peptidyl-prolyl cis-trans isomerase (PPIase) of liver and heart mitochondria are about 2, 20 and 500 nM respectively. This parallels their profile as inhibitors of non-specific pore opening of mitochondria induced by supraphysiological Ca2+ concentrations. The novel immunosuppressant FK-506 gave little inhibition of either process at 5 microM. These data support our previous hypothesis [Halestrap & Davidson (1990) Biochem. J. 268, 153-160] that pore opening involves an interaction between matrix PPIase and the adenine nucleotide translocase. It is suggested that this model may help to clarify the mechanism of action of cyclosporin as an immunosuppressant and its toxic effects on the liver and kidney following prolonged therapy.

Acute toxic effects of trinitrotoluene on rat brain, liver and kidney: role of radical production

1982 ◽  
Vol 51 (1) ◽  
pp. 53-64 ◽  
Author(s):  
Antti Zitting ◽  
Grażyna Szumańska ◽  
Juha Nickels ◽  
Heikki Savolainen
Keyword(s):  
Rat Brain ◽  
Toxic Effects ◽  
Radical Production ◽  
Liver And Kidney ◽  
Acute Toxic

scholarly journals Isolation of Aeromonas hydrophila from EUS Affected Shing Heteropneustes fossilis of a Fish Farm in Mymensingh

2013 ◽  
Vol 19 (1) ◽  
pp. 117-124 ◽  
Author(s):  
MM Rashid ◽  
MA Hasan ◽  
K Mostafa ◽  
MA Islam
Keyword(s):  
Aeromonas Hydrophila ◽  
Bacterial Load ◽  
Clinical Signs ◽  
Bacterial Pathogen ◽  
Fish Farm ◽  
Heteropneustes Fossilis ◽  
Biochemical Tests ◽  
Liver And Kidney ◽  
Physiological And Biochemical

Aeromonas hydrophila bacteria was isolated from the suspected EUS-affected shing fish, Heteropneustes fossilis (Bloch). The disease investigations were primarily based on clinical signs and subsequently confirmed by the isolation of bacterial pathogen Aeromonas hydrophila from lesion of liver and kidney. The A. hydrophila isolates were identified by a series of morphological, physiological and biochemical tests. The total bacterial load in liver, intestine and kidney were 1.67 × 104 to 6.46 × 108 CFU/g, 1.71 × 103 to 1.18 × 109 CFU/g and 1.47 × 104 to 3.70 × 108 CFU/g respectively.DOI: http://dx.doi.org/10.3329/pa.v19i1.17362 Progress. Agric. 19(1): 117 - 124, 2008 

scholarly journals GC–MS analysis, toxicological and oral glucose tolerance assessments of methanolic leaf extract of Eucalyptus globulus

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Bamidele Stephen Ajilore ◽  
Tolulope Olamide Oluwadairo ◽  
Olubukola Sinbad Olorunnisola ◽  
Olumide Samuel Fadahunsi ◽  
Peter Ifeoluwa Adegbola
Keyword(s):  
Glucose Tolerance ◽  
Eucalyptus Globulus ◽  
Leaf Extract ◽  
Extraction Procedure ◽  
Toxic Effects ◽  
Gas Chromatography Mass Spectrometry ◽  
Oral Glucose ◽  
Oral Glucose Tolerance ◽  
Liver And Kidney

Abstract Background Eucalyptus globulus leaf has shown promising potential in its efficacy to manage some diseases but little is known about its safety and its use in the management of diabetes. This study was designed to identify the bioactive compounds present in Eucalyptus globulus leaf extract (EGLEX), assess its toxic effects and its oral glucose tolerance ability. Powdered Eucalyptus globulus leaf was extracted with methanol using standard extraction procedure. Preliminary phytochemistry, gas chromatography–mass spectrometry (GCMS) analysis of the extract, its acute and subacute toxic effects and on its glucose tolerance (in-vivo) capability were assessed using standard laboratory techniques. Results EGLEX was tested positive for the presence of alkaloids, cardiac glycosides, flavonoids, tannins, phlobatannins and terpenoids. Nine compounds were identified by GCMS analysis of the leaf extract. EGLEX (up to 300 mg/kg bwt) showed no toxicity in all the rats dosed for the period of 14 days. The histomorphological study of the liver and kidney tissues harvested from rats dosed with 2000 mg/kg bwt showed features of histoarchitectural distortions in the two tissues. EGLEX (200 mg/kg bwt) further demonstrated effective glucose utilization as insulin and metformin. Conclusions The results obtained deduced that EGLEX is safe at a lower dose of 300 mg/kg bwt but toxic at higher dose of 2000 mg/kg bwt, and that single dose (200 mg/kg bwt) of the plant extract prevented hyperglycemia in normal rats.

scholarly journals Toxic Effects of Furosine by Oral Intake on Liver and Kidney and Toxicokinetics Research in Mice Acute Toxicity Model

2020 ◽  
Vol 26 (4) ◽  
pp. 495-500
Author(s):  
Qianqian Yao ◽  
Huiying Li ◽  
Huaigu Yang ◽  
Jiaqi Wang ◽  
Nan Zheng
Keyword(s):  
Acute Toxicity ◽  
Oral Intake ◽  
Toxic Effects ◽  
Liver And Kidney

Toxic Effects of Lead Nitrate Pb(NO3)2 on Testis in the Catfish Heteropneustes fossilis

Pharmacologia ◽  
2015 ◽  
Vol 6 (2) ◽  
pp. 63-72
Author(s):  
Radha Chaube ◽  
Mayank Choubey ◽  
Keerikkattil P. Joy
Keyword(s):  
Lead Nitrate ◽  
Toxic Effects ◽  
Heteropneustes Fossilis

scholarly journals Evaluation of Metabolic Enzymes in Response to Excel Mera 71, a Glyphosate-Based Herbicide, and Recovery Pattern in Freshwater Teleostean Fishes

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Palas Samanta ◽  
Sandipan Pal ◽  
Aloke Kumar Mukherjee ◽  
Apurba Ratan Ghosh
Keyword(s):  
Aquatic Organisms ◽  
Metabolic Enzymes ◽  
Heteropneustes Fossilis ◽  
Fish Tissues ◽  
Compensatory Response ◽  
Anabas Testudineus ◽  
Recovery Pattern ◽  
Glyphosate Formulation ◽  
Excel Mera 71 ◽  
Alt Activity

Metabolic enzymes such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) were evaluated in Indian teleostean fishes, namely,Anabas testudineus(Bloch) andHeteropneustes fossilis(Bloch), for an exposure to 30 days of Excel Mera 71 (17.2 mg/L), a glyphosate formulation, and subsequent depuration under Liv.52, a plant extract at a dose of 187.5 mg/d/250 L for the same period in the same tissues under laboratory condition. ALT activity was significantly increased (P<0.05) in all the tissues and raised up to 229.19% in liver ofA. testudineus(229.19%) and 128.61% in liver ofH. fossilis. AST also increased significantly (P<0.05) and was maximum in liver ofH. fossilis(526.19%) and minimum in gill ofA. testudineus(124.38%). ALP activity was also raised highly in intestine ofH. fossilis(490.61%) but was less in kidney ofH. fossilis(149.48%). The results indicated that Excel Mera 71 caused alterations in the metabolic enzymatic activities in fish tissues and AST showed the highest alteration in both the fishes, while lowest in ALP and ALT inA. testudineusandH. fossilis, respectively. During depuration under Liv.52, all the enzyme activities came down towards the control condition which indicated the compensatory response by the fish against this herbicidal stress and it was in the following order: AST > ALT > ALP, inA. testudineus, whileH. fossilisshowed the following trend: ALT > AST > ALP. Therefore, these parameters could be used as indicators of herbicidal pollution in aquatic organisms and were recommended for environmental monitoring for investigating the mechanism involved in the recovery pattern.

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