The impact of physical activity level on the short- and long-term pain relief from supervised exercise therapy and education: a study of 12,796 Danish patients with knee osteoarthritis

Background: Age-related changes in biological processes such as physiological dysregulation (the progressive loss of homeostatic capacity) vary considerably among older adults and may influence health profiles in late life. These differences could be related, at least in part, to the impact of intrinsic and extrinsic factors such as sex and physical activity level (PAL). Objectives: The objectives of this study were (1) to assess the magnitude and rate of changes in physiological dysregulation in men and women according to PAL and (2) to determine whether/how sex and PAL mediate the apparent influence of physiological dysregulation on health outcomes (frailty and mortality). Methods: We used data on 1,754 community-dwelling older adults (age = 74.4 ± 4.2 years; women = 52.4%) of the Quebec NuAge cohort study. Physiological dysregulation was calculated based on Mahalanobis distance of 31 biomarkers regrouped into 5 systems: oxygen transport, liver/kidney function, leukopoiesis, micronutrients, and lipids. Results: As expected, mean physiological dysregulation significantly increased with age while PAL decreased. For the same age and PAL, men showed higher levels of physiological dysregulation globally in 3 systems: oxygen transport, liver/kidney function, and leukopoiesis. Men also showed faster global physiological dysregulation in the liver/kidney and leukopoiesis systems. Overall, high PAL was associated with lower level and slower rate of change of physiological dysregulation. Finally, while mortality and frailty risk significantly increased with physiological dysregulation, there was no evidence for differences in these effects between sexes and PAL. Conclusion: Our results showed that both sex and PAL have a significant effect on physiological dysregulation levels and rates of change. Also, although a higher PAL was associated with lower level and slower rate of change of physiological dysregulation, there was no evidence that PAL attenuates the effect of physiological dysregulation on subsequent declines in health at the end of life. Substantial work remains to understand how modifiable behaviors impact the relationship between physiological dysregulation, frailty, and mortality in men and women.

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The impact of supervised exercise intervention on short-term postprogram leisure time physical activity level in cancer patients undergoing chemotherapy: 1- and 3-month follow-up on the body & cancer project

Palliative & Supportive Care ◽

10.1017/s1478951506060044 ◽

2006 ◽

Vol 4 (1) ◽

pp. 25-35 ◽

Cited By ~ 14

Author(s):

JULIE MIDTGAARD ◽

ANDERS TVETERÅS ◽

MIKAEL RØRTH ◽

REINHARD STELTER ◽

LIS ADAMSEN

Keyword(s):

Physical Activity ◽

Cancer Patients ◽

Physical Activity Level ◽

Leisure Time Physical Activity ◽

Exercise Adherence ◽

The Body ◽

Activity Level ◽

Supervised Exercise ◽

Cancer Project

Background:Exercise is becoming an important component of cancer rehabilitation programs. A consistent finding across studies is that patients experience improved physical fitness and reduced fatigue. However, sustained physical activity is essential if the benefits are to be preserved over the course of cancer survivorship.Objective:This study examined self-reported short-term exercise adherence following a 6-week, supervised exercise program (muscle strength, cardiovascular fitness, relaxation, body awareness, and massage) in a heterogeneous group of 61 cancer patients (mean age 42.9 years, 82% oncological and 18% haematological) from the Body & Cancer Project.Methods:Semistructured interviews were used to quantitatively assess leisure time physical activity level 1 and 3 months after completion of the program. The study furthermore included 3-month follow-up assessment of psychological distress (Hospital Anxiety and Depression Scale—HADS). Patient statements were selected that best illustrated trends found in the statistical material.Results:There was a significant postprogram reduction in physical activity from 6 to 10 weeks and from 6 to 18 weeks. However, the patients (half of whom were still undergoing treatment at the time of follow-up) reported a higher physical activity level postprogram compared to their baseline levels. The analyses showed a positive association between the 3-month postprogram physical activity level and pre-illness physical activity level, treatment, and postprogram changes in depression.Significance of research:Given the significant decrease in postprogram PA level, especially in subjects still undergoing cancer treatment, the study suggests that continuous supervised programs may be required in order to encourage and support exercise adherence in this population. However, randomized clinical controlled trials and more follow-up studies are needed to establish the optimal program length and content for sustained exercise adherence in cancer patients.

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Serum Myostatin Levels Are Higher in Fitter, More Active, and Non-Frail Long-Term Nursing Home Residents and Increase after a Physical Exercise Intervention

Gerontology ◽

10.1159/000494137 ◽

2018 ◽

Vol 65 (3) ◽

pp. 229-239 ◽

Cited By ~ 7

Author(s):

Haritz Arrieta ◽

Gotzone Hervás ◽

Chloe Rezola-Pardo ◽

Fátima Ruiz-Litago ◽

Miren Iturburu ◽

...

Keyword(s):

Physical Activity ◽

Body Composition ◽

Nursing Home ◽

Physical Fitness ◽

Physical Activity Level ◽

Exercise Intervention ◽

Nursing Home Residents ◽

Exercise Program ◽

Activity Level

Background: Myostatin has been proposed as a candidate biomarker for frailty and sarcopenia. However, the relationship of myostatin with these conditions remains inconclusive. Objective: To determine the association of serum myostatin concentration with body composition, physical fitness, physical activity level, and frailty in long-term nursing home residents. We also aimed to ascertain the effect of an exercise program on myostatin levels. Methods: We obtained study data on 112 participants from long-term nursing homes. Participants were randomly assigned to a control or an intervention group and performed a 6-month multicomponent exercise program. Serum myostatin levels were analyzed by ELISA. Assessments also included body composition (anthropometry and bioelectrical impedance), physical fitness (Senior Fitness Test), physical activity level (accelerometry), and frailty (Fried frailty criteria, Clinical Frailty Scale, and Tilburg frailty indicator). Results: The concentration of myostatin at baseline was positively correlated with: a leaner body composition (p < 0.05), and a higher number of steps per day and light and moderate-vigorous physical activity in women (p < 0.005); greater upper and lower limb strength, endurance, and poorer flexibility (p < 0.05) in men; and better performance (less time) in the 8-ft timed up-and-go test in both women (p < 0.01) and men (p < 0.005). We observed higher concentrations of serum myostatin in non-frail than in frail participants (p < 0.05). Additionally, we found that the implemented physical exercise intervention, which was effective to improve physical fitness, increased myostatin concentration in men (p < 0.05) but not in women. The improvements in physical condition were related with increases in serum myostatin only in men (p < 0.05–0.01). Conclusions: Higher serum levels of myostatin were found to be associated with better physical fitness. The improvements in physical fitness after the intervention were positively related to increases in myostatin concentrations in men. These results seem to rule out the idea that high serum myostatin levels are indicative of frailty in long-term nursing home residents. However, although the direction of association was opposite to that expected for the function of myostatin, the use of this protein as a biomarker for physical fitness, rather than frailty, merits further study.

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Relation of physical activity level with quality of life, sleep and depression in patients with knee osteoarthritis

Northern Clinics of Istanbul ◽

10.14744/nci.2015.95867 ◽

2016 ◽

Cited By ~ 2

Author(s):

Erkan Mesci

Keyword(s):

Quality Of Life ◽

Physical Activity ◽

Knee Osteoarthritis ◽

Physical Activity Level ◽

Activity Level

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Can a Multicomponent-Overnight Camp Increase Physical Activity Among Danish Children? A Retrospective Cross-Sectional Study

Journal of Physical Activity and Health ◽

10.1123/jpah.2020-0101 ◽

2020 ◽

pp. 1-7

Author(s):

Dorthe Dalstrup Jakobsen ◽

Jasper Schipperijn ◽

Jens Meldgaard Bruun

Keyword(s):

Physical Activity ◽

Physical Activity Level ◽

Vigorous Physical Activity ◽

Cross Sectional Study ◽

Activity Level ◽

Cross Sectional ◽

Physically Active ◽

And Behavior ◽

Children’S Physical Activity

Background: In Denmark, most children are not sufficiently physically active and only a few interventions have been found to increase long-term physical activity among overweight and obese children. The aim of our study was to investigate if children are physically active in correspondence to Danish recommendations after attending a multicomponent-overnight camp. Methods: A questionnaire was developed to estimate children’s physical activity level and behavior and investigate how transport, economy, availability, time, motivation, and knowledge about physical activity affect children’s physical activity level and behavior. Results: In this study, 60.9% of the children did vigorous physical activity (VPA) minimum 30 minutes 3 times per week up to 3 years after camp. Most children were physically active at a sports club (44.3%) and only 5.7% of the children did not participate in physical activity. Parental physical activity and child motivation toward physical activity were significantly (P < .05) associated with children doing VPA. Conclusion: Our findings suggest that 60.9% of children who attended camp engage in VPA after camp, which compared with a recent Danish study, is more frequent than children who did not attend camp. Further investigations are needed to determine the long-term health effects in children attending interventions such as multicomponent-overnight camps.

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Can Fear of Movement, Depression and Functional Performance be a Predictor of Physical Activity Level in Patients With Knee Osteoarthritis?

Archives of Rheumatology ◽

10.5606/archrheumatol.2019.7160 ◽

2019 ◽

Vol 34 (3) ◽

pp. 274-280 ◽

Cited By ~ 3

Author(s):

Hasan Kılınç

Keyword(s):

Physical Activity ◽

Knee Osteoarthritis ◽

Physical Activity Level ◽

Functional Performance ◽

Activity Level ◽

Fear Of Movement

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Physical activity level and quality of life in long term lung cancer survivors

Lung Cancer ◽

10.1016/j.lungcan.2012.05.096 ◽

2012 ◽

Vol 77 (3) ◽

pp. 611-616 ◽

Cited By ~ 41

Author(s):

Lise Solberg Nes ◽

Heshan Liu ◽

Christi A. Patten ◽

Sarah M. Rausch ◽

Jeff A. Sloan ◽

...

Keyword(s):

Quality Of Life ◽

Physical Activity ◽

Lung Cancer ◽

Cancer Survivors ◽

Physical Activity Level ◽

Activity Level

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Recent leisure physical activity level is not associated with increased odds of incident knee osteoarthritis - data from the Osteoarthritis Initiative

Osteoarthritis and Cartilage ◽

10.1016/j.joca.2013.02.510 ◽

2013 ◽

Vol 21 ◽

pp. S248

Author(s):

G.H. Lo ◽

T.E. McAlindon ◽

J. Driban ◽

L.L. Price ◽

N. Petersen ◽

...

Keyword(s):

Physical Activity ◽

Knee Osteoarthritis ◽

Physical Activity Level ◽

Activity Level ◽

Osteoarthritis Initiative ◽

Leisure Physical Activity

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Use of Physical Activity Monitoring Devices by Families in Rural Communities: Qualitative Approach (Preprint)

10.2196/preprints.10658 ◽

2018 ◽

Author(s):

Iryna Sharaievska ◽

Rebecca A Battista ◽

Jennifer Zwetsloot

Keyword(s):

Physical Activity ◽

Rural Communities ◽

Family Members ◽

Activity Level ◽

Activity Tracking ◽

Entire Family ◽

Physical Activity Monitoring ◽

Tracking Devices ◽

The Impact

BACKGROUND Several studies support the impact of information communication technology–based interventions to promote physical activity among youth. However, little is known on how technology can be used by the entire family to encourage healthy behavior. Previous studies showed that children and youth rely and are dependent upon the decisions and values of their caregivers when it comes to having a healthy lifestyle. Thus, the exploration of behavior and attitudes of the entire family is needed. OBJECTIVE The study aimed to explore (1) perceptions of how the use of physical activity tracking devices (Fitbit Zip) by families in rural communities influence their patterns of participation in physical activity, (2) how attitudes toward physical activity change as a result of using physical activity tracking devices as a family, and (3) what factors influence participation in physical activity among families in rural communities. METHODS A total of 11 families with 1 to 3 children of different ages (7-13 years) took part in semistructured group interviews following 2 weeks of using physical activity tracking devices (Fitbit Zip) as a family. The participants were asked to discuss their experience using the Fitbit Zip as a family, the motivation to be physically active, the changes in their pattern of participation in those activities, the level of engagement by different family members, and the factors that affected their participation. All interviews were voice-recorded with the participants’ permission and later transcribed verbatim using pseudonyms. To analyze the data, the principal investigator (IS) used open, axial, and selective coding techniques. RESULTS A total of 3 themes and several subthemes appeared from the data. The families in rural communities reported no or minimal changes in physical activities as a result of using physical activity tracking devices (Fitbit Zip) because of a lack of interest or an already active lifestyle. However, the attitude toward physical activity was altered. The family members reported an increased awareness of their activity level, introduced more conversations about active and healthy lifestyles, and changed their view of physical activity to a more positive one. The participants described the changes they were able to make and the constraining factors that stopped them from making further changes in their lifestyle. CONCLUSIONS Technology might serve as a facilitator to participation in physical activity among families. Technology can motivate the change in attitude toward active recreation. As long-term changes in lifestyle require internal motivation, the change in the attitude might have a more long-lasting impact than the change in the immediate behavior. More longitudinal studies are needed to further explore long-term change in both behavior and attitude toward physical activity. Additional exploration of constraints to participation in physical activity among families is also an important area of exploration.

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