Effects of Sex and Physical Activity Level on Serum Biomarker-Based Physiological Dysregulation: The Impact to Predict Frailty and Mortality in the Quebec NuAge Cohort

Gerontology ◽  
2021 ◽  
pp. 1-14
Author(s):  
Ahmed Ghachem ◽  
Frédérik Dufour ◽  
Tamas Fülöp ◽  
Pierrette Gaudreau ◽  
Alan A. Cohen
Keyword(s):  
Physical Activity ◽  
Older Adults ◽  
Kidney Function ◽  
Oxygen Transport ◽  
Physical Activity Level ◽  
Rate Of Change ◽  
Activity Level ◽  
Men And Women ◽  
Physiological Dysregulation ◽  
The Impact

<b><i>Background:</i></b> Age-related changes in biological processes such as physiological dysregulation (the progressive loss of homeostatic capacity) vary considerably among older adults and may influence health profiles in late life. These differences could be related, at least in part, to the impact of intrinsic and extrinsic factors such as sex and physical activity level (PAL). <b><i>Objectives:</i></b> The objectives of this study were (1) to assess the magnitude and rate of changes in physiologi­cal dysregulation in men and women according to PAL and (2) to determine whether/how sex and PAL mediate the apparent influence of physiological dysregulation on health outcomes (frailty and mortality). <b><i>Methods:</i></b> We used data on 1,754 community-dwelling older adults (age = 74.4 ± 4.2 years; women = 52.4%) of the Quebec NuAge cohort study. Physiological dysregulation was calculated based on Mahalanobis distance of 31 biomarkers regrouped into 5 systems: oxygen transport, liver/kidney function, leukopoiesis, micronutrients, and lipids. <b><i>Results:</i></b> As expected, mean physiological dysregulation significantly increased with age while PAL decreased. For the same age and PAL, men showed higher levels of physiological dysregulation globally in 3 systems: oxygen transport, liver/kidney function, and leukopoiesis. Men also showed faster global physiological dysregulation in the liver/kidney and leukopoiesis systems. Overall, high PAL was associated with lower level and slower rate of change of physiological dysregulation. Finally, while mortality and frailty risk significantly increased with physiological dysregulation, there was no evidence for differences in these effects between sexes and PAL. <b><i>Conclusion:</i></b> Our results showed that both sex and PAL have a significant effect on physiological dysregulation levels and rates of change. Also, although a higher PAL was associated with lower level and slower rate of change of physiological dysregulation, there was no evidence that PAL attenuates the effect of physiological dysregulation on subsequent declines in health at the end of life. Substantial work remains to understand how modifiable behaviors impact the relationship between physiological dysregulation, frailty, and mortality in men and women.

Physical Activity Level and Motor Aptitude: Motor Domains and Identification Capacity of Brazilian Insufficiently Active Older Adults

2020 ◽  
Vol 13 ◽  
Author(s):  
Lucia Maria Andreis ◽  
Fernando de Aguiar Lemos ◽  
Lorenna Walesca de Lima Silva ◽  
Cassiana Luiza Pistorello Garcia ◽  
Gabrielli Veras ◽  
...  
Keyword(s):  
Physical Activity ◽  
Older Adults ◽  
Physical Activity Level ◽  
Area Under The Curve ◽  
The Elderly ◽  
Activity Level ◽  
General Motor ◽  
Body Scheme ◽  
Significant Difference ◽  
Global Coordination

Background: A decrease in the physical activity level in old age is common, which results in an increase in the number of falls and chronic conditions. Associated with that occurs the decline in motor skills as a result of the deficit in the interaction of cognitive and motor processes. Physical activity level can be associated differently with each motor domains. Objective: We analyzed the relationship between physical activity level and motor aptitude, and to identify which motor domains were most sensitive to detect insufficiently active level in older adults. Methods: Participated in the study 385 elderly people of both sexes. For the evaluation of the subjects were adopted the International Questionnaire on Physical Activity and the Motor Scale for Older Adults. Results: The majority of the elderly were active. In the comparison of motor aptitude between active and insufficiently active (IAC) elders a significant difference was found in the Global Coordination, Balance, Body Scheme and General Motor Aptitude. From the analysis of the area under the curve (AUC), we verified that these domains also were the ones that presented adequate diagnostic accuracy to identify IAC elderly. Besides that active elderly have presented the General Motor Aptitude classified within normality while the IAC below the normal. Conclusion: Our data suggest that IAC older adults present lower motor aptitude than the active elderly, especially in the domains of Global Coordination, Balance, Body Scheme and General Motor Aptitude, and that these domains were sensitive to indicate IAC older adults.

scholarly journals INFLUENCE OF CUT-POINTS TO MEASURE AND CLASSIFY THE PHYSICAL ACTIVITY LEVEL OF OLDER ADULTS

2017 ◽  
Vol 28 (1) ◽  
Author(s):  
Fernanda Christina de Souza Guidarini ◽  
Samantha Nahas Guimarães ◽  
Pablo Antonio Bertasso de Araujo ◽  
Adriano Ferreti Borgatto ◽  
Tânia Rosane Bertoldo Benedetti
Keyword(s):  
Physical Activity ◽  
Older Adults ◽  
Physical Activity Level ◽  
Activity Level ◽  
Cut Points

scholarly journals INFLUENCE OF CUT-POINTS TO MEASURE AND CLASSIFY THE PHYSICAL ACTIVITY LEVEL OF OLDER ADULTS

2017 ◽  
Vol 28 (1) ◽  
Author(s):  
Fernanda Christina de Souza Guidarini ◽  
Samantha Nahas Guimarães ◽  
Pablo Antonio Bertasso de Araujo ◽  
Adriano Ferreti Borgatto ◽  
Tânia Rosane Bertoldo Benedetti
Keyword(s):  
Physical Activity ◽  
Older Adults ◽  
Physical Activity Level ◽  
Activity Level ◽  
Cut Points

Reaction Time, Strength, and Physical Activity in Women Aged 20–89 Years

2001 ◽  
Vol 9 (1) ◽  
pp. 32-42 ◽  
Author(s):  
Sandra K. Hunter ◽  
Martin W. Thompson ◽  
Roger D. Adams
Keyword(s):  
Physical Activity ◽  
Regression Analysis ◽  
Reaction Time ◽  
Lower Limb ◽  
Physical Activity Level ◽  
Predictor Variable ◽  
Community Dwelling ◽  
Rate Of Change ◽  
Activity Level ◽  
Knee Extensors

The purposes of this study were to investigate the rate of change with age of simple lower-limb reaction time (RT) in women and determine the relationship among RT. strength, and physical activity. Independent, community-dwelling women aged 20–89 years (N = 217) were assessed for knee-extension RT, maximal voluntary isometric contractions of the knee extensors (KE), and physical activity level. Trend analysis by ANOVA and regression analysis on RT were performed. Lower-limb RT increased and KE strength and physical activity level decreased linearly across age groups (p < .001). Active women had faster RTs than those of inactive women of the same age (p < .01). From multiple-regression analysis on RT, only 1 predictor variable. KE strength, emerged. Stronger women had faster RTs than those of weaker women (p < .0001), regardless of age and physical activity. Although RT was slower in older women, higher levels of strength and physical activity were associated with faster RTs in this group.

scholarly journals Effect of age and physical activity level on functional fitness in older adults

2009 ◽  
Vol 6 (2) ◽  
pp. 99-106 ◽  
Author(s):  
Hulya Donat Tuna ◽  
Ayse Ozcan Edeer ◽  
Mehtap Malkoc ◽  
Gazanfer Aksakoglu
Keyword(s):  
Physical Activity ◽  
Older Adults ◽  
Physical Activity Level ◽  
Activity Level ◽  
Functional Fitness ◽  
Effect Of Age

scholarly journals The Relationship Between Physical Activity Level with Quality of Life and General Health among COVID-19 Recovered Individuals

2021 ◽  
Author(s):  
Mahnaz Azmodeh ◽  
Rastegar Hoseini ◽  
Ehsan Amiri
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Physical Activity Level ◽  
General Health ◽  
Short Form ◽  
Pearson Correlation ◽  
Activity Level ◽  
Men And Women ◽  
The Relationship

Abstract Background: New coronavirus (COVID-19) has a major impact on the individual's physical activity level (PAL); The COVID-19 quarantine outbreak caused a decrease in the PAL. Accordingly, it might also affect the general health and quality of life (QoL). This study aimed to evaluate the relationship between PAL with QoL and general health (GH) among COVID-19 recovered individuals (CRI).Methods: In this descriptive-analytical study, using the multi-stage (Cluster) sampling techniques, 890 CRI (male (n = 438) and female (n = 452)) were volunteered from different COVID-19 testing centers in Kermanshah province. After filling out the consent form, the PAL, GH, and QoL questionnaires were completed and anthropometric parameters were measured. The PAL was assessed using the international physical activity questionnaire (IPAQ-SF), GH was assessed using the GHQ questionnaire and the QoL was measured by the QoL questionnaire (short-form-SF-12). The independent t-test was used to compare the mean of variables between men and women and the Pearson correlation coefficient test was used to evaluate the relationship between variables using SPSS software version 24 at a significant level of (P≤0.05). Results: The findings of the present study showed that men and women with COVID-19 had inadequate PAL (876.11±40.23;739.08±27.02), insufficient GH (50.13±3.1; 54.15±4.28), and poor QoL (22.02±2.28; 19.23±1.87), respectively. The results also showed that men had significantly higher PAL (P=0.035), GH (P=0.047), and QoL (P=0.023) compared to women. Also, the results show that increasing the PAL improves GH and QoL. Conclusions: Considering the prevalence of COVID-19 and its negative impact on GH and QoL, maintaining adequate PAL can be considered as one of the effective strategies for improving physical and GH, and immune systems, by observing the hygiene protocol.

scholarly journals Do weather changes influence physical activity level among older adults? – The Generation 100 study

PLoS ONE ◽  
2018 ◽  
Vol 13 (7) ◽  
pp. e0199463 ◽  
Author(s):  
Nils Petter Aspvik ◽  
Hallgeir Viken ◽  
Jan Erik Ingebrigtsen ◽  
Nina Zisko ◽  
Ingar Mehus ◽  
...  
Keyword(s):  
Physical Activity ◽  
Older Adults ◽  
Physical Activity Level ◽  
Activity Level ◽  
Weather Changes
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