Serum C-reactive protein and lipid hydroperoxides in predicting short-term clinical outcome after spontaneous intracerebral hemorrhage

2011 ◽  
Vol 18 (2) ◽  
pp. 247-252 ◽  
Author(s):  
Margarita L. Alexandrova ◽  
Maya P. Danovska
Keyword(s):  
Clinical Outcome ◽  
Intracerebral Hemorrhage ◽  
Lipid Hydroperoxides ◽  
Spontaneous Intracerebral Hemorrhage ◽  
C Reactive Protein ◽  
Short Term ◽  
Reactive Protein

scholarly journals Impact of Early C-Reactive Protein/Albumin Ratio on Intra-Hospital Mortality Among Patients with Spontaneous Intracerebral Hemorrhage

2020 ◽  
Vol 9 (4) ◽  
pp. 1236 ◽  
Author(s):  
Michael Bender ◽  
Kristin Haferkorn ◽  
Michaela Friedrich ◽  
Eberhard Uhl ◽  
Marco Stein
Keyword(s):  
Regression Analysis ◽  
Intracerebral Hemorrhage ◽  
Hospital Mortality ◽  
Cox Regression ◽  
Spontaneous Intracerebral Hemorrhage ◽  
C Reactive Protein ◽  
Albumin Ratio ◽  
Cox Regression Analysis ◽  
Reactive Protein ◽  
The Impact

Objective: The impact of increased C-reactive protein (CRP)/albumin ratio on intra-hospital mortality has been investigated among patients admitted to general intensive care units (ICU). However, it was not investigated among patients with spontaneous intracerebral hemorrhage (ICH). This study aimed to investigate the impact of CRP/albumin ratio on intra-hospital mortality in patients with ICH. Patients and Methods: This retrospective study was conducted on 379 ICH patients admitted between 02/2008 and 12/2017. Blood samples were drawn upon admission and the patients’ demographic, medical, and radiological data were collected. The identification of the independent prognostic factors for intra-hospital mortality was calculated using binary logistic regression and COX regression analysis. Results: Multivariate regression analysis shows that higher CRP/albumin ratio (odds ratio (OR) = 1.66, 95% confidence interval (CI) = 1.193–2.317, p = 0.003) upon admission is an independent predictor of intra-hospital mortality. Multivariate Cox regression analysis indicated that an increase of 1 in the CRP/albumin ratio was associated with a 15.3% increase in the risk of intra-hospital mortality (hazard ratio = 1.153, 95% CI = 1.005–1.322, p = 0.42). Furthermore, a CRP/albumin ratio cut-off value greater than 1.22 was associated with increased intra-hospital mortality (Youden’s Index = 0.19, sensitivity = 28.8, specificity = 89.9, p = 0.007). Conclusions: A CRP/albumin ratio greater than 1.22 upon admission was significantly associated with intra-hospital mortality in the ICH patients.

scholarly journals CORRELATION C-REACTIVE PROTEIN LEVELS WITH CLINICAL OUTCOME INTRACEREBRAL HEMORRHAGE STROKE PATIENTS

2015 ◽  
Vol 1 (1) ◽  
pp. 23-27
Author(s):  
Catur Ari Setianto ◽  
Hari Purnomo ◽  
Eko Arisetijono ◽  
Widodo Mardi Santoso
Keyword(s):  
Clinical Outcome ◽  
Intracerebral Hemorrhage ◽  
C Reactive Protein ◽  
Stroke Patients ◽  
Protein Levels ◽  
Reactive Protein

Prognostic Value of Serum C-Reactive Protein in Spontaneous Intracerebral Hemorrhage: When Should We Take the Sample?

2017 ◽  
Vol 26 (5) ◽  
pp. 1007-1012 ◽  
Author(s):  
Youssef Zied Elhechmi ◽  
Malek Hassouna ◽  
Mohamed A. Chérif ◽  
Rym Ben Kaddour ◽  
Ines Sedghiani ◽  
...  
Keyword(s):  
Intracerebral Hemorrhage ◽  
Prognostic Value ◽  
Spontaneous Intracerebral Hemorrhage ◽  
C Reactive Protein ◽  
Reactive Protein

scholarly journals Association of C-Reactive Protein Level and Short Term Clinical Outcome among Spontaneous Intracerebral Haemorrhage Patients

2018 ◽  
Vol 3 (2) ◽  
pp. 89-93
Author(s):  
Md Mamnur Rashid ◽  
Chandra Shekhar Bala ◽  
MS Jahirul Hoque Choudhury ◽  
Mohammad Selim Shahi ◽  
Md Merazul Islam Shaikh ◽  
...  
Keyword(s):  
Clinical Outcome ◽  
Functional Outcome ◽  
Intracerebral Haemorrhage ◽  
C Reactive Protein ◽  
Short Term ◽  
Poor Functional Outcome ◽  
Term Outcome ◽  
Reactive Protein ◽  
Group I ◽  
Spontaneous Intracerebral Haemorrhage

Background: C-reactive protein is a biomarker among the spontaneous intracerebral haemorrhage patients.Objective: The purpose of this present study was to see the association of CRP level with the short term clinical outcome among spontaneous intracerebral haemorrhage patients.Methodology: This prospective cohort study was conducted in the Department of Neurology at Dhaka Medical College and Hospital, Dhaka, Bangladesh from July 2012 to June 2014 for a period of two (02) years. Patients presented with first ever spontaneous intracerebral haemorrhage with the age group of more than or equal to 18 years with both sexes and hospital admission within 48 hours of onset were included for this study. Admission plasma CRP was measured and study population were divided into group I (plasma CRP≥6 mg/L) and group II (plasma CRP<6 mg/L). The patients were observed daily till 1 week after admission with special attention to vital parameters and clinical outcome which were mortality, functional outcome and early neurological worsening. Finally findings were analyzed and clinical outcome were compared in patient with different level of admission plasma CRP.Result: Early neurological worsening at the end of first week was 37(38%) patients. Poor functional outcome (GOS 2-3) at the end of first week was found in 51(52%) patients. Overall mortality within that period was 16(17%) patients. Elevated CRP level was associated with higher proportion of GCS score < 9 at day seven. Early neurological worsening and poor functional outcome (GOS2-3) was also found more in these patients.Conclusion: High admission plasma CRP level may be associated with higher proportions of poor short term outcome (GOS 2-3), early neurological worsening at the end of the first week after onset and mortality within this period in the patients with spontaneous intracerebral haemorrhage.Journal of National Institute of Neurosciences Bangladesh, 2017;3(2): 89-93

scholarly journals C-Reactive Protein Level Measurement Improves Mortality Prediction When Added to the Spontaneous Intracerebral Hemorrhage Score

Stroke ◽  
2011 ◽  
Vol 42 (5) ◽  
pp. 1230-1236 ◽  
Author(s):  
Mario Di Napoli ◽  
Daniel Agustin Godoy ◽  
Veronica Campi ◽  
Marta del Valle ◽  
Gustavo Piñero ◽  
...  
Keyword(s):  
Intracerebral Hemorrhage ◽  
Protein Level ◽  
Mortality Prediction ◽  
Spontaneous Intracerebral Hemorrhage ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Level Measurement

Tumoral C-reactive protein and nuclear factor kappa-B expression are associated with clinical outcome in patients with prostate cancer

2012 ◽  
Vol 10 (2) ◽  
pp. 91-99 ◽  
Author(s):  
Pamela McCall ◽  
Jamie Catlow ◽  
Peter A McArdle ◽  
Donald C McMillan ◽  
Joanne Edwards
Keyword(s):  
Prostate Cancer ◽  
Clinical Outcome ◽  
Nuclear Factor Kappa B ◽  
Nuclear Factor ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Nuclear Factor Kappa

scholarly journals Utility of procalcitonin, C-reactive protein and white blood cells alone and in combination for the prediction of clinical outcomes in community-acquired pneumonia

2015 ◽  
Vol 53 (4) ◽  
Author(s):  
Andriy Zhydkov ◽  
Mirjam Christ-Crain ◽  
Robert Thomann ◽  
Claus Hoess ◽  
Christoph Henzen ◽  
...  
Keyword(s):  
Clinical Outcome ◽  
Clinical Outcomes ◽  
Blood Cells ◽  
White Blood Cells ◽  
Community Acquired Pneumonia ◽  
Adverse Clinical Outcome ◽  
C Reactive Protein ◽  
Prognostic Information ◽  
Reactive Protein

AbstractThe added value of biomarkers, such as procalcitonin (PCT), C-reactive protein (CRP), and white blood cells (WBC), as adjuncts to clinical risk scores for predicting the outcome of patients with community-acquired pneumonia (CAP) is in question. We investigated the prognostic accuracy of initial and follow-up levels of inflammatory biomarkers in predicting death and adverse clinical outcomes in a large and well-defined cohort of CAP patients.We measured PCT, CRP and WBC on days 1, 3, 5, and 7 and followed the patients over 30 days. We applied multivariate regression models and area under the curve (AUC) to investigate associations between these biomarkers, the clinical risk score CURB-65, and clinical outcomes [i.e., death and intensive care unit (ICU) admission].Of 925 patients with CAP, 50 patients died and 118 patients had an adverse clinical outcome. None of the initial biomarker levels significantly improved the CURB-65 score for mortality prediction. Follow-up biomarker levels showed significant independent association with mortality at days 3, 5, and 7 and with improvements in AUC. Initial PCT and CRP levels were independent prognostic predictors of adverse clinical outcome, and levels of all biomarkers during the course of disease provided additional prognostic information.This study provides robust insights into the added prognostic value of inflammatory markers in CAP. Procalcitonin, CRP, and to a lesser degree WBC provided some prognostic information on CAP outcomes, particularly when considering their kinetics at days 5 and 7 and when looking at adverse clinical outcomes instead of mortality alone.

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