The impact of morbid obesity on solid organ injury in children using the ATOMAC protocol at a pediatric level I trauma center

2017 ◽  
Vol 52 (2) ◽  
pp. 345-348 ◽  
Author(s):  
Nathan Vaughan ◽  
Jeff Tweed ◽  
Cynthia Greenwell ◽  
David M. Notrica ◽  
Crystal S. Langlais ◽  
...  
2019 ◽  
Vol 4 (1) ◽  
pp. e000318 ◽  
Author(s):  
Allen K Chen ◽  
David Jeffcoach ◽  
John C Stivers ◽  
Kyle A McCullough ◽  
Rachel C Dirks ◽  
...  

BackgroundThe obese (body mass index, BMI > 30) have been identified as a subgroup of patients in regards to traumatic injuries. A recent study found that high-grade hepatic injuries were more common in obese than non-obese pediatric patients. This study seeks to evaluate whether similar differences exist in the adult population and examine differences in operative versus non-operative management between the obese and non-obese in blunt abdominal trauma.MethodsPatient with trauma evaluated at an American College of Surgeons verified Level I trauma center from February 2013 to November 2016 were retrospectively reviewed. All patients aged >18 years with blunt mechanism of injury and a BMI listed in the trauma registry were included. Patients were excluded for incomplete data, including BMI or inability to grade hepatic or splenic injury. Data collected included age, gender, BMI, injury severity score, hospital length of stay, procedures on liver or spleen, and mortality. Organ injuries were scored using the American Association for the Surgery of Trauma grading scales, and were determined by either imaging or intraoperative findings. Obesity was classified as BMI > 30 compared with non-obese with BMI < 30.ResultsDuring the study period, 9481 patients were included. There were 322 spleen injuries and 237 liver injuries, with 64 patients sustaining both liver and splenic injuries. No differences existed in the percentage of high-grade hepatic or splenic injuries between the obese and non-obese. Obese patients with liver injuries were more likely to have procedural intervention than non-obese liver injuries and had higher rates of mortality. No differences were found in intervention for splenic injury between obese and non-obese.ConclusionsContrary to prior studies on adult and pediatric patients with trauma, this study found no difference between obese and non-obese patients in severity of solid organ injury after blunt abdominal trauma in the adult population. However, there was an increased rate of procedural intervention and mortality for obese patients with liver injuries.Level of Evidence3.


2019 ◽  
Vol 43 (11) ◽  
pp. 2797-2803 ◽  
Author(s):  
Morgan Schellenberg ◽  
Kenji Inaba ◽  
Subarna Biswas ◽  
Patrick Heindel ◽  
Elizabeth Benjamin ◽  
...  

2014 ◽  
Vol 8 (5) ◽  
pp. 29 ◽  
Author(s):  
Manpreet Kaur ◽  
Babita Gupta ◽  
PM Singh ◽  
Amit Gupta ◽  
Subodh Kumar ◽  
...  

2021 ◽  
pp. 000313482110475
Author(s):  
Andrew B. Nordin ◽  
Michael M. Wach ◽  
Kabir Jalal ◽  
Clairice A. Cooper ◽  
Jeffrey M. Jordan

Background Non-operative management (NOM) of traumatic solid organ injury (SOI) has become commonplace. This paradigm shift, along with reduced resident work hours, has significantly impacted surgical residents’ operative trauma experiences. We examined ongoing changes in residents’ operative SOI experience since duty hour restriction implementation, and assessed whether missed operative experiences were gained elsewhere in the resident experience. Methods We examined data from American College of Graduate Medical Education case log reports from 2003 to 2018. We collected mean case volumes in the categories of non-operative trauma, trauma laparotomy, and splenic, hepatic, and pancreatic trauma operations; case volumes for comparable non-traumatic solid organ operations were also collected. Solid organ injury operative volumes were compared against non-traumatic cases, and change over time was analyzed. Results Over the study period, both trauma laparotomies and non-operative traumas increased significantly ( P < .001). In contrast, operative volumes for splenic, hepatic, and pancreatic trauma all significantly decreased ( P < .001; P = .014; P < .001, respectively). Non-traumatic spleen cases also significantly decreased ( P < .001), but liver cases and distal pancreatectomies increased ( P < .001; P = .017). Pancreaticoduodenectomies increased, albeit not to a significant degree ( P = .052). Conclusions Continuing increases in NOM of SOI correlate with declining resident experience with operative solid organ trauma. These decreases can adversely affect residents’ technical skills and decision-making, although trends in specific non-traumatic areas may help to mitigate such losses. Further work should determine the impact of these trends on resident competence and autonomy.


2016 ◽  
Vol 51 (3) ◽  
pp. 499-502 ◽  
Author(s):  
Arash Safavi ◽  
Erik D. Skarsgard ◽  
Peter Rhee ◽  
Bardiya Zangbar ◽  
Narong Kulvatunyou ◽  
...  

2021 ◽  
Vol 12 (8) ◽  
Author(s):  
Li Ning ◽  
Xiong Rui ◽  
Wang Bo ◽  
Geng Qing

AbstractHistone deacetylase 3 (HDAC3) plays a crucial role in chromatin remodeling, which, in turn, regulates gene transcription. Hence, HDAC3 has been implicated in various diseases, including ischemic injury, fibrosis, neurodegeneration, infections, and inflammatory conditions. In addition, HDAC3 plays vital roles under physiological conditions by regulating circadian rhythms, metabolism, and development. In this review, we summarize the current knowledge of the physiological functions of HDAC3 and its role in organ injury. We also discuss the therapeutic value of HDAC3 in various diseases.


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