A case–control study of membrane cofactor protein mutations in two populations of patients with early pregnancy loss

AbstractMaternal hypercoagulability is a possible cause of miscarriage during the eighth and ninth weeks of pregnancy, when the placenta replaces the yolk sac. We thus examined associations between putative markers of an acquired hypercoagulable state and the risk of first miscarriage. We conducted a case-control study comparing 743 women who miscarried in weeks 8 and 9 with 743 women who underwent a first provoked abortion, matched for age, number of pregnancies, and time elapsed since abortion. Levels of plasma homocysteine and of various antiphospholipid/antiprotein and hemostasis-related autoantibodies were categorized in 4 strata (percentiles 1-80, 81-95, 96-99, 100 among control patients) and analyzed in conditional logistic regression models. Pregnancy loss was independently associated with positive lupus anticoagulant (matched odds ratio [OR], 2.6; 95% confidence interval [CI], 1.1-6.0), high levels of immunoglobulin M (IgM) antibodies against cardiolipin (OR for percentile 100 versus 0-80, 3.5; CI, 1.2-10.1) and against phosphatidylethanolamine (OR, 4.7; CI, 1.9-12.1), high levels of IgG antibodies against annexin V (OR, 3.2; CI, 1.1-9.1) and against tissue-type plasminogen activator (OR, 19.5; CI, 7.9-48.0), and high homocystinemia (OR, 4.1; CI, 1.3-12.5). A first early pregnancy loss is associated with increased levels of several autoantibodies and of homocysteine. (Blood. 2003;102:3504-3513)

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PENGARUH FAKTR USIA DAN GRAVIDA IBU TERHADAP PERDARAHAN ANTEPARTUM DI RSUD CILACAP PERIODE TAHUN 2016-2018

Jurnal Kesehatan Al-Irsyad ◽

10.36746/jka.v13i1.51 ◽

2020 ◽

Vol 13 (1) ◽

pp. 56-63

Author(s):

Sohimah ◽

Yogi Andhi Lestari ◽

Arief Hendrawan

Keyword(s):

World Bank ◽

Early Pregnancy ◽

Pregnancy Loss ◽

Case Control ◽

P Value ◽

Early Pregnancy Loss ◽

Chi Square ◽

Key Word

Berdasarkan Laporan World Bank Tahun 2017, dalam sehari ada empat Ibu di Indonesia yang meninggal akibat melahirkan. Angka ini menempatkan Indonesia sebagai Negara dengan angka kematian tertinggi kedua di Asia Tenggara setelah Laos dengan AKI 357 per 100 ribu (WHO,2017). Penyebab kematian Ibu terdiri dari penyebab langsung dan tidak langsung. Penyebab langsung kematian ibu disebabkan karena perdarahan sampai saat ini masih memegang peranan penting sebagai penyeba utama kematian maternal. Perdarahan dapat terjadi disetiap usia kehamilan, pada kehamilan muda ssering dikaitkan dengan abortus, misscariiage, early pregnancy loss. Perdarahan yang terjadi pada umur kehamilan yang lebih tua terutama setelah melewati trimester III disebut perdarahan antepartum. Survey pendahuluan yang dilakukan pada tanggal 4 Januari 2019 dan didukung data pada Profil Dinas Kesehatan Kabupaten Cilacap, Kematian ibu selama tahun 2016 sebanyak 25 kasus, 2017 sebanyak 20 kasus dan 22 kasus selama Tahun 2018. Penyebab kematian ibu sebagian besar terjadi pada saat persalinan dan segera setelah persalinan yaitu perdarahan (30,37%), eklampsia (32,97%), infeksi (4,34%), Gangguan sistem peredaran darah 8%, Gangguan metabolism 4,34 %, dan lain-lain 0,87 % . Tujuan dari penelitian ini adalah untuk Mengetahui Pengaruh Usia dan Gravida Ibu terhadap kejadian perdarahan antepartum di RSUD Cilacap Tahun 2016 – 2018. Desain penelitian ini adalah deskriptif analitik dengan metode pendekatan case control yang bertujuan mengetahui analisis Pengaruh fektor usia dan Gravida ibus terhadap kejadian perdarahan antepartum di RSUD Cilacap. Tekhnik pengambilan sampel pada penelitian ini adalah dengan total sampling dengan kriteria inklusi rekam medik lengkap. Uji statistik yang digunakan adalah Chi-Square. Hasil Penelitian: Berdasarkan hasil analisis Faktor usia ibu berpengaruh terhadap kejadian perdarahan antepartum dengan p value 0.001. Faktor gravida berpengaruh terhadap kejadian perdarahan antepartum dengan p value 0.000. Faktor usia merupakan faktor yang paling berisiko terhadap kejadian perdarahan antepartum, dengan OR: 2,098. Kesimpulan: Usia ibu yang berisiko berpengaruh 2.098 kali lebih besar terhadap perdarahan antepartum dibanding dengan usia yang tidak berisiko Key Word : Gravida, Perdarahan Antepartum, Usia Ibu

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Hyperglycemia Recognized in Early Pregnancy Is Phenotypically Type 2 Diabetes Mellitus Not Gestational Diabetes Mellitus: A Case Control Study

Obstetrical & Gynecological Survey ◽

10.1097/01.ogx.0000742388.73339.a2 ◽

2021 ◽

Vol 76 (3) ◽

pp. 133-135

Author(s):

Rochan Agha-Jaffar ◽

Nick S. Oliver ◽

Melina Kostoula ◽

Ian F. Godsland ◽

Christina Yu ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Early Pregnancy ◽

Case Control Study ◽

Case Control ◽

Control Study

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Association between pregnancy loss and ambient PM2·5 using survey data in Africa: a longitudinal case-control study, 1998–2016

The Lancet Planetary Health ◽

10.1016/s2542-5196(19)30047-6 ◽

2019 ◽

Vol 3 (5) ◽

pp. e219-ee225 ◽

Cited By ~ 7

Author(s):

Tao Xue ◽

Tong Zhu ◽

Guannan Geng ◽

Qiang Zhang

Keyword(s):

Survey Data ◽

Pregnancy Loss ◽

Case Control Study ◽

Case Control ◽

Control Study

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Pregnancy loss is associated with type 2 diabetes: a nationwide case–control study

Diabetologia ◽

10.1007/s00125-020-05154-z ◽

2020 ◽

Vol 63 (8) ◽

pp. 1521-1529 ◽

Cited By ~ 1

Author(s):

Pia Egerup ◽

Anders P. Mikkelsen ◽

Astrid Marie Kolte ◽

David Westergaard ◽

Steen Rasmussen ◽

...

Keyword(s):

Type 2 Diabetes ◽

Pregnancy Loss ◽

Case Control Study ◽

Case Control ◽

Control Study

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Trimethylamine N-Oxide Metabolites in Early Pregnancy and Risk of Gestational Diabetes: A Nested Case-Control Study

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2019-00710 ◽

2019 ◽

Vol 104 (11) ◽

pp. 5529-5539 ◽

Cited By ~ 3

Author(s):

Xiaoxu Huo ◽

Jing Li ◽

Yun-Feng Cao ◽

Sai-Nan Li ◽

Ping Shao ◽

...

Keyword(s):

Gestational Diabetes ◽

Early Pregnancy ◽

Case Control Study ◽

Conditional Logistic Regression ◽

Full Range ◽

Case Control ◽

Conversion Ratio ◽

Additive Interaction ◽

Nested Case Control ◽

Control Study

Abstract Objectives This study aimed to investigate the associations between trimethylamine N-oxide (TMAO) and related metabolites in early pregnancy and the risk of gestational diabetes mellitus (GDM). Design A prospective cohort of 22,302 pregnant women from 2010 to 2012 in Tianjin, China, was used to perform a nested case-control study. A total of 243 women with GDM and 243 women without GDM matched by maternal age (±1 year) were used as cases and controls, respectively. Conditional logistic regression and restricted cubic spline were used to examine the full-range risk associations between individual TMAOs metabolites at the first antenatal care visit with GDM. Trimethylamine conversion ratio (TMAR) was defined as trimethylamine (TMA)/its precursors, and trimethylamine N-oxide conversion ratio (TMAOR) was defined as TMAO/TMA. An additive interaction between high TMAR and low TMAOR indicates a state of TMA accumulation, and a mathematical interaction between high TMAR and high TMAOR indicates accumulation of TMAO. Results TMA was linearly associated with GDM, whereas TMA precursors and TMAO were inversely associated with GDM with clear threshold effects, i.e., 16 nmol/mL for TMAO, 200 nmol/mL for betaine, 112 nmol/mL for l-carnitine, and 110 and 270 nmol/mL for cholinechloride (a U-shaped relationship). Copresence of TMAR >0.35 and TMAOR ≤0.15 was associated with a markedly higher OR (11.16; 95% CI, 5.45 to 22.8), compared with TMAR >0.35 only (OR = 1.71; 95% CI, 0.42 to 6.95) or TMAOR ≤0.15 only (OR = 2.06; 95% CI, 1.09 to 3.90), with a significant additive interaction. However, the mathematical interaction was nonsignificant. Conclusions TMAO metabolites in the early pregnancy were associated with the risk of GDM, whereas TMA was more likely to play a causal role in GDM.

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