Long-term outcome of using Prosthetic Replacement of Ocular Surface Ecosystem (PROSE) as a drug delivery system for bevacizumab in the treatment of corneal neovascularization

Ongoing aortic wall degeneration and subsequent aneurysm exclusion failure are major concerns after an endovascular aneurysm repair with a stent-graft. An ideal solution would be a drug therapy that targets the aortic wall and inhibits wall degeneration. Here, we described a novel drug delivery system, which allowed repetitively charging a graft with therapeutic drugs and releasing them to the aortic wall in vivo. The system was composed of a targeted graft, which was labeled with a small target molecule, and the target-recognizing nanocarrier, which contained suitable drugs. We developed the targeted graft by decorating a biotinylated polyester graft with neutravidin. We created the target-recognizing nanocarrier by conjugating drug-containing liposomes with biotinylated bio-nanocapsules. We successfully demonstrated that the target-recognizing nanocarriers could bind to the targeted graft, both in vitro and in blood vessels of live mice. Moreover, the drug released from our drug delivery system reduced the expression of matrix metalloproteinase-9 in mouse aortas. Thus, this hybrid system represents a first step toward an adjuvant therapy that might improve the long-term outcome of endovascular aneurysm repair.

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LONG-TERM FOLLOW-UP OF PARKINSON´S DISEASE PATIENTS TREATED WITH PEG-J DRUG DELIVERY SYSTEM

10.1055/s-0040-1704805 ◽

2020 ◽

Author(s):

I Boeva ◽

P Karagyozov ◽

I Tishkov

Keyword(s):

Drug Delivery ◽

Drug Delivery System ◽

Delivery System ◽

Long Term Follow Up

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Long‐Term Retarded Release for the Proteasome Inhibitor Bortezomib through Temperature‐Sensitive Dendritic Glycopolymers as Drug Delivery System from Calcium Phosphate Bone Cement

Macromolecular Rapid Communications ◽

10.1002/marc.202100083 ◽

2021 ◽

pp. 2100083

Author(s):

Thu Hang Lai ◽

Bettina Keperscha ◽

Xianping Qiu ◽

Brigitte Voit ◽

Dietmar Appelhans

Keyword(s):

Drug Delivery ◽

Calcium Phosphate ◽

Bone Cement ◽

Drug Delivery System ◽

Delivery System ◽

Proteasome Inhibitor ◽

Temperature Sensitive ◽

Calcium Phosphate Bone Cement

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Development of biodegradable polyesters based on a hydroxylated coumarin initiator towards fluorescent visible paclitaxel-loaded microspheres

Journal of Materials Chemistry B ◽

10.1039/c8tb02952k ◽

2019 ◽

Vol 7 (14) ◽

pp. 2261-2276 ◽

Cited By ~ 3

Author(s):

Yufei Bian ◽

Zhiyong Wei ◽

Zefeng Wang ◽

Zhu Tu ◽

Liuchun Zheng ◽

...

Keyword(s):

Drug Delivery ◽

Drug Release ◽

Physical Properties ◽

Drug Delivery System ◽

Delivery System ◽

Controlled Drug Release ◽

Biodegradable Polyesters ◽

Biomedical Field

A facile method of end-functionalization was used to synthesize a series of fluorescent biodegradable polyesters with tailorable physical properties, which can promisingly be applied in the biomedical field as a controllable and traceable drug delivery system, especially for long-term controlled drug release.

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Preparation of keratin/chlorhexidine complex nanoparticles for long-term and dual stimuli-responsive release

RSC Advances ◽

10.1039/c5ra16253j ◽

2015 ◽

Vol 5 (100) ◽

pp. 82334-82341 ◽

Cited By ~ 16

Author(s):

Xuelian Zhi ◽

Yanfang Wang ◽

Pengfei Li ◽

Jiang Yuan ◽

Jian Shen

Keyword(s):

Drug Delivery ◽

Complex Formation ◽

Drug Delivery System ◽

Delivery System ◽

Convenient Method ◽

Stimuli Responsive ◽

Polyion Complex

Nanoscale polyion complex formation via the electrostatic complexation of a polyelectrolyte and a charged drug is the most convenient method for building a drug delivery system that simultaneously realizes the carrier preparation and drug embedding.

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