Keeping those telomeres short! an innovative intratumoral long-term drug delivery system

2014 ◽  
Vol 141 (1) ◽  
pp. 23-34 ◽  
Author(s):  
B. H. Laster ◽  
C. Isaacson ◽  
E. Perets ◽  
M. Msamra ◽  
E. Priel ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System

Development of biodegradable polyesters based on a hydroxylated coumarin initiator towards fluorescent visible paclitaxel-loaded microspheres

2019 ◽  
Vol 7 (14) ◽  
pp. 2261-2276 ◽  
Author(s):  
Yufei Bian ◽  
Zhiyong Wei ◽  
Zefeng Wang ◽  
Zhu Tu ◽  
Liuchun Zheng ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Physical Properties ◽  
Drug Delivery System ◽  
Delivery System ◽  
Controlled Drug Release ◽  
Biodegradable Polyesters ◽  
Biomedical Field

A facile method of end-functionalization was used to synthesize a series of fluorescent biodegradable polyesters with tailorable physical properties, which can promisingly be applied in the biomedical field as a controllable and traceable drug delivery system, especially for long-term controlled drug release.

Preparation of keratin/chlorhexidine complex nanoparticles for long-term and dual stimuli-responsive release

RSC Advances ◽  
2015 ◽  
Vol 5 (100) ◽  
pp. 82334-82341 ◽  
Author(s):  
Xuelian Zhi ◽  
Yanfang Wang ◽  
Pengfei Li ◽  
Jiang Yuan ◽  
Jian Shen
Keyword(s):  
Drug Delivery ◽  
Complex Formation ◽  
Drug Delivery System ◽  
Delivery System ◽  
Convenient Method ◽  
Stimuli Responsive ◽  
Polyion Complex

Nanoscale polyion complex formation via the electrostatic complexation of a polyelectrolyte and a charged drug is the most convenient method for building a drug delivery system that simultaneously realizes the carrier preparation and drug embedding.

Long term venous access using a totally implantable drug delivery system in patients with cystic fibrosis and bronchiectasis

1989 ◽  
Vol 83 (5) ◽  
pp. 429-431 ◽  
Author(s):  
A.B.S. Ball ◽  
F.R. Duncan ◽  
F.J. Foster ◽  
T.I. Davidson ◽  
R.M. Watkins ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cystic Fibrosis ◽  
Drug Delivery System ◽  
Delivery System ◽  
Venous Access

scholarly journals Long-term intravenous infusion of antiarrhythmic drugs using a totally implanted drug delivery system

1982 ◽  
Vol 49 (8) ◽  
pp. 1954-1958 ◽  
Author(s):  
Jeffrey L. Anderson ◽  
Elton M. Tucker ◽  
Stanislaw Pasyk ◽  
Eugene Patterson ◽  
Arthur B. Simon ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Intravenous Infusion ◽  
Antiarrhythmic Drugs

scholarly journals A gum Arabic assisted sustainable drug delivery system for adult Drosophila

Biology Open ◽  
2020 ◽  
Vol 9 (6) ◽  
pp. bio052241
Author(s):  
Qiying Liang ◽  
Peng Ma ◽  
Qi Zhang ◽  
Youjie Yin ◽  
Ping Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Large Scale ◽  
Gum Arabic ◽  
Glass Capillary ◽  
Acacia Senegal ◽  
High Throughput Drug Screening ◽  
Compound Screening

ABSTRACTLarge-scale compound screening in adult flies is hampered by the lack of continuous drug delivery systems and poor solubility of numerous compounds. Here we found that gum Arabic (Acacia/Senegal gum), a widely used stabilizer, can also emulsify lipophilic compounds and profoundly increase their accessibility to target tissues in Drosophila and mice. We further developed a gum Arabic-based drug delivery system, wherein the drug was ground into gum Arabic and emulsified in liquid food fed to flies by siphoning through a U-shape glass capillary. This system did not affect food intake nor cell viability. Since drugs were continuously delivered by siphoning, minimal compound waste and less frequent food changes make this system ideal for large-scale long-term screenings. In our pilot screening for antitumor drugs in the NCI DTP library, we used a Drosophila model of colorectal cancer and identified two drugs that are especially hydrophobic and were not identified in previous screenings. Our data demonstrated that gum Arabic facilitates drug delivery in animal models and the system is suitable for long-term high-throughput drug screening in Drosophila. This system would accelerate drug discovery for chronic and cognitive conditions.

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